Flaxseed Secoisolariciresinol Diglucoside Extraction

2021 ◽  
Author(s):  
Yingxue Hu ◽  
Venkatesh Meda ◽  
Martin Reaney
Keyword(s):  
Secoisolariciresinol Diglucoside

Secoisolariciresinol diglucoside induces caspase‐3‐mediated apoptosis in monolayer and spheroid cultures of human colon carcinoma cells

2021 ◽  
Author(s):  
Meltem Özgöçmen ◽  
Dilek Bayram ◽  
Gülçin Yavuz Türel ◽  
Vehbi Atahan Toğay ◽  
Nilüfer Şahin Calapoğlu
Keyword(s):  
Colon Carcinoma ◽  
Caspase 3 ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Secoisolariciresinol Diglucoside ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma

Weekly excretion of the mammalian lignan enterolactone in milk of dairy cows fed flaxseed meal

2009 ◽  
Vol 76 (4) ◽  
pp. 455-458 ◽  
Author(s):  
Nathalie Gagnon ◽  
Cristiano Côrtes ◽  
Hélène V Petit
Keyword(s):  
Mammary Gland ◽  
Dairy Cows ◽  
Baseline Level ◽  
Significant Interaction ◽  
Control Diet ◽  
Secoisolariciresinol Diglucoside ◽  
Milk Samples ◽  
Flaxseed Meal ◽  
Ruminal Microbiota ◽  
Feeding Regimen

Flaxseed meal (FM) is rich in the plant lignan secoisolariciresinol diglucoside (SDG) which is converted to the mammalian lignans enterodiol and enterolactone (EL) by ruminal microbiota. Feeding FM to dairy cows increases linearly EL concentration in milk but enterodiol is not detected. The objectives of the study were to determine the length of time to obtain peak EL concentration in the milk of dairy cows fed 20% FM and the length of time to return to EL baseline level in milk when cows are switched from high to low intake of flax SDG. A total of 12 multiparous lactating Holstein cows were assigned randomly to one of two feeding regimens: the control (CO) diet was fed for 6 weeks or the FM diet was fed from week 0 to 3 inclusive and then cows were switched to the control diet from week 3 to 6 inclusive. Milk samples were taken weekly for EL analysis. There was a significant interaction between feeding regimen and week for milk concentration of EL as a result of higher concentration of EL from week 1 to 3 for cows on the FM regimen compared with those on the CO regimen. Concentrations of milk EL on the FM regimen maintained uniform high levels from week 1 to 3 and they decreased significantly from week 3 to 4 when the CO diet was reintroduced in week 3. This study suggests that the conversion of SDG to the mammalian lignan EL and the transfer of EL to the mammary gland are well established after one week of feeding 20% FM in the diet of dairy cows and that milk concentration of EL returns to baseline level after one week of FM deprivation.

scholarly journals A Review of Lignan Metabolism, Milk Enterolactone Concentration, and Antioxidant Status of Dairy Cows Fed Flaxseed

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 41 ◽  
Author(s):  
André Brito ◽  
Yu Zang
Keyword(s):  
Dairy Cows ◽  
Wide Spectrum ◽  
Animal Health ◽  
Dietary Manipulation ◽  
Limited Information ◽  
Health It ◽  
Biological Functions ◽  
Secoisolariciresinol Diglucoside ◽  
Major Site ◽  
Ruminal Microbiota

Lignans are polyphenolic compounds with a wide spectrum of biological functions including antioxidant, anti-inflammatory, and anticarcinogenic activities, therefore, there is an increasing interest in promoting the inclusion of lignan-rich foods in humans’ diets. Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside—a compound found in the outer fibrous-containing layers of flax. The rumen appears to be the major site for the conversion of secoisolariciresinol diglucoside to the enterolignans enterodiol and enterolactone, but only enterolactone has been detected in milk of dairy cows fed flaxseed products (whole seeds, hulls, meal). However, there is limited information regarding the ruminal microbiota species involved in the metabolism of secoisolariciresinol diglucoside. Likewise, little is known about how dietary manipulation such as varying the nonstructural carbohydrate profile of rations affects milk enterolactone in dairy cows. Our review covers the gastrointestinal tract metabolism of lignans in humans and animals and presents an in-depth assessment of research that have investigated the impacts of flaxseed products on milk enterolactone concentration and animal health. It also addresses the pharmacokinetics of enterolactone consumed through milk, which may have implications to ruminants and humans’ health.

Synthetic Lignan Secoisolariciresinol Diglucoside Reduces Cerebral Leukocyte Mobilization after Traumatic Brain Injury

2018 ◽  
Vol 227 (4) ◽  
pp. e64-e65
Author(s):  
Christina L. Jacovides ◽  
Syed M. Ahmed ◽  
Yujin Suto ◽  
Lewis J. Kaplan ◽  
C. William Schwab ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Secoisolariciresinol Diglucoside ◽  
Leukocyte Mobilization

scholarly journals Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Min Lu ◽  
Lin Tan ◽  
Xiao-Gang Zhou ◽  
Zhong-Lin Yang ◽  
Qing Zhu ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Body Movement ◽  
Mrna Level ◽  
Secoisolariciresinol Diglucoside ◽  
Neuroprotective Effects ◽  
Sesame Seeds ◽  
C Elegans ◽  
Age Related ◽  
6 Hydroxydopamine ◽  
And Oxidative Stress

Secoisolariciresinol diglucoside (SDG) is a phytoestrogen and rich in food flaxseed, sunflower seeds, and sesame seeds. Among the beneficial pharmacological activities of SDG on health, many are age related, such as anticancer, antidiabetes, antioxidant, and neuroprotective effects. Thus, we investigated if SDG had an effect on antiaging in Caenorhabditis elegans (C. elegans). Our results showed that SDG could extend the lifespan of C. elegans by up to 22.0%, delay age-related decline of body movement, reduce the lethality of heat and oxidative stress, alleviate dopamine neurodegeneration induced by 6-hydroxydopamine (6-OHDA), and decrease the toxicity of Aβ protein in C. elegans. SDG could increase the expression of the downstream genes of DAF-16, DAF-12, NHR-80, and HSF-1 at mRNA level. SDG could not extend the lifespan of mutants from genes daf-16, hsf-1, nhr-80, daf-12, glp-1, eat-2, and aak-2. The above results suggested that SDG might enhance the stress resistance, delay the progression of aging-related diseases, and extend the lifespan of C. elegans via DAF-16 and HSF-1.

scholarly journals Secoisolariciresinol Diglucoside of Flaxseed and Its Metabolites: Biosynthesis and Potential for Nutraceuticals

2018 ◽  
Vol 9 ◽  
Author(s):  
Parfait Kezimana ◽  
Alexey A. Dmitriev ◽  
Anna V. Kudryavtseva ◽  
Elena V. Romanova ◽  
Nataliya V. Melnikova
Keyword(s):  
Secoisolariciresinol Diglucoside

Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside

2011 ◽  
Vol 92 (1) ◽  
pp. 159-168 ◽  
Author(s):  
Lucia Roncaglia ◽  
Alberto Amaretti ◽  
Stefano Raimondi ◽  
Alan Leonardi ◽  
Maddalena Rossi
Keyword(s):  
Secoisolariciresinol Diglucoside
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