scholarly journals A Review of Lignan Metabolism, Milk Enterolactone Concentration, and Antioxidant Status of Dairy Cows Fed Flaxseed

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 41 ◽  
Author(s):  
André Brito ◽  
Yu Zang
Keyword(s):  
Dairy Cows ◽  
Wide Spectrum ◽  
Animal Health ◽  
Dietary Manipulation ◽  
Limited Information ◽  
Health It ◽  
Biological Functions ◽  
Secoisolariciresinol Diglucoside ◽  
Major Site ◽  
Ruminal Microbiota

Lignans are polyphenolic compounds with a wide spectrum of biological functions including antioxidant, anti-inflammatory, and anticarcinogenic activities, therefore, there is an increasing interest in promoting the inclusion of lignan-rich foods in humans’ diets. Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside—a compound found in the outer fibrous-containing layers of flax. The rumen appears to be the major site for the conversion of secoisolariciresinol diglucoside to the enterolignans enterodiol and enterolactone, but only enterolactone has been detected in milk of dairy cows fed flaxseed products (whole seeds, hulls, meal). However, there is limited information regarding the ruminal microbiota species involved in the metabolism of secoisolariciresinol diglucoside. Likewise, little is known about how dietary manipulation such as varying the nonstructural carbohydrate profile of rations affects milk enterolactone in dairy cows. Our review covers the gastrointestinal tract metabolism of lignans in humans and animals and presents an in-depth assessment of research that have investigated the impacts of flaxseed products on milk enterolactone concentration and animal health. It also addresses the pharmacokinetics of enterolactone consumed through milk, which may have implications to ruminants and humans’ health.

Weekly excretion of the mammalian lignan enterolactone in milk of dairy cows fed flaxseed meal

2009 ◽  
Vol 76 (4) ◽  
pp. 455-458 ◽  
Author(s):  
Nathalie Gagnon ◽  
Cristiano Côrtes ◽  
Hélène V Petit
Keyword(s):  
Mammary Gland ◽  
Dairy Cows ◽  
Baseline Level ◽  
Significant Interaction ◽  
Control Diet ◽  
Secoisolariciresinol Diglucoside ◽  
Milk Samples ◽  
Flaxseed Meal ◽  
Ruminal Microbiota ◽  
Feeding Regimen

Flaxseed meal (FM) is rich in the plant lignan secoisolariciresinol diglucoside (SDG) which is converted to the mammalian lignans enterodiol and enterolactone (EL) by ruminal microbiota. Feeding FM to dairy cows increases linearly EL concentration in milk but enterodiol is not detected. The objectives of the study were to determine the length of time to obtain peak EL concentration in the milk of dairy cows fed 20% FM and the length of time to return to EL baseline level in milk when cows are switched from high to low intake of flax SDG. A total of 12 multiparous lactating Holstein cows were assigned randomly to one of two feeding regimens: the control (CO) diet was fed for 6 weeks or the FM diet was fed from week 0 to 3 inclusive and then cows were switched to the control diet from week 3 to 6 inclusive. Milk samples were taken weekly for EL analysis. There was a significant interaction between feeding regimen and week for milk concentration of EL as a result of higher concentration of EL from week 1 to 3 for cows on the FM regimen compared with those on the CO regimen. Concentrations of milk EL on the FM regimen maintained uniform high levels from week 1 to 3 and they decreased significantly from week 3 to 4 when the CO diet was reintroduced in week 3. This study suggests that the conversion of SDG to the mammalian lignan EL and the transfer of EL to the mammary gland are well established after one week of feeding 20% FM in the diet of dairy cows and that milk concentration of EL returns to baseline level after one week of FM deprivation.

scholarly journals Antioxidants and dairy production: the example of flax

2009 ◽  
Vol 38 (spe) ◽  
pp. 352-361 ◽  
Author(s):  
Hélène V. Petit
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Fatty Liver ◽  
Dairy Cows ◽  
Antioxidant Status ◽  
Animal Health ◽  
Dairy Production ◽  
Expression Of Genes ◽  
Ruminal Microbiota ◽  
Plant Lignans

This manuscript reports on the main problems decreasing productivity of dairy cows (e.g. fatty liver syndrome and poor fertility) and how antioxidants could enhance it. High producing dairy cows are prone to oxidative stress, and the situation can be exacerbated under certain environmental, physiological, and dietary conditions. Antioxidants have important effects on the expression of genes involved in the antioxidant status, which may enhance animal health and reproduction. Moreover, antioxidants may contribute to decrease the incidence of spontaneous oxidized flavour in milk enriched in polyunsaturated fatty acids. Plant lignans are strong antioxidants and flax is the richest source of plant lignans. Flax lignans are converted in the mammalian lignans enterolactone and enterodiol. The main mammalian lignan in milk is enterolactone and flax lignans are converted in enterolactone mainly under the action of ruminal microbiota. Therefore, ruminal microbiota may be the most important flora to target for plant lignan metabolism in order to increase concentration of mammalian lignan antioxidants in milk of dairy cows. However, more research is required to improve our knowledge on metabolism of other antioxidants in dairy cows and how they can contribute in decreasing milk oxidation.

scholarly journals The Potential Utilization of High-Fiber Agricultural By-Products as Monogastric Animal Feed and Feed Additives: A Review

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2098
Author(s):  
Wen-Yang Chuang ◽  
Li-Jen Lin ◽  
Hsin-Der Shih ◽  
Yih-Min Shy ◽  
Shang-Chang Chang ◽  
...  
Keyword(s):  
Dietary Fiber ◽  
Animal Feed ◽  
Animal Health ◽  
Feed Additives ◽  
Health It ◽  
High Fiber ◽  
Monogastric Animal ◽  
Animal Growth ◽  
Positive Effect ◽  
By Products

With the increase in world food demand, the output of agricultural by-products has also increased. Agricultural by-products not only contain more than 50% dietary fiber but are also rich in functional metabolites such as polyphenol (including flavonoids), that can promote animal health. The utilization of dietary fibers is closely related to their types and characteristics. Contrary to the traditional cognition that dietary fiber reduces animal growth, it can promote animal growth and maintain intestinal health, and even improve meat quality when added in moderate amounts. In addition, pre-fermenting fiber with probiotics or enzymes in a controlled environment can increase dietary fiber availability. Although the use of fiber has a positive effect on animal health, it is still necessary to pay attention to mycotoxin contamination. In summary, this report collates the fiber characteristics of agricultural by-products and their effects on animal health and evaluates the utilization value of agricultural by-products.

Keys to the Trematoda. Volume II (ed. Jones, A., Bray, R. A. and Gibson, D. I.), pp. 768. Commonwealth Agricultural Bureau International (CABI Publishing), UK and The Natural History Museum, London, UK, 2005. ISBN 0 85199 587 X. £150.00.

Parasitology ◽  
2006 ◽  
Vol 132 (1) ◽  
pp. 153-154
Author(s):  
TOMÁš SCHOLZ
Keyword(s):  
Natural History ◽  
Wide Spectrum ◽  
Animal Health ◽  
Life Cycles ◽  
Huge Number ◽  
History Museum ◽  
Cabi Publishing ◽  
Vertebrate Hosts ◽  
Commonwealth Agricultural Bureau

Trematodes (flukes or digeneans) are by far the most abundant group of parasitic flatworms (Neodermata), and their importance for human and animal health is indisputable. In addition, they exhibit a variety of unique adaptations to parasitism and, probably most remarkably, possess extraordinarily complicated life-cycles. Classification of trematodes represents a very difficult task due to the huge number of existing species and variety of morphological forms, sites of infection within invertebrate and vertebrate hosts and ability to infect a wide spectrum of animals. Therefore, identification of any trematode may represent a problem even for an experienced specialist. This is the reason why I appreciated so much the publication of the first volume of the Keys to the Trematoda in 2002.

scholarly journals Molecular characterization of virulence factors in Staphylococcus aureus isolated from bovine subclinical mastitis in central Ethiopia

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Desiye Tesfaye Tegegne ◽  
Gezahegne Mamo ◽  
Hika Waktole ◽  
Yohannes Equar Messele
Keyword(s):  
Staphylococcus Aureus ◽  
Dairy Cows ◽  
Virulence Factors ◽  
Virulence Genes ◽  
Animal Health ◽  
Subclinical Mastitis ◽  
Biochemical Tests ◽  
Milk Samples ◽  
Lactating Dairy Cows ◽  
Genomic Study

Abstract Purpose Staphylococcus aureus (S. aureus) is the most important pathogen involved in bovine mastitis in dairy production. S. aureus produces a spectrum of extracellular protein toxins and virulence factors which are thought to contribute to the pathogenicity of the organism. The aim of this work was to isolate and molecular characterize S. aureus associated with bovine subclinical mastitis in the central part of Ethiopia. Methods A total of 265 lactating dairy cows from various dairy farms in four different geographical locations were screened by the California mastitis test (CMT) for bovine subclinical mastitis. One hundred thirty CMT-positive milk samples were collected and transported to the laboratory. Different biochemical tests and polymerase chain reaction (PCR) were used for the identification of S. aureus isolates. Finally, PCR was performed for molecular detection of virulence genes. Results From a total of 265 lactating dairy cows screened, 49% (n = 130) were positive for bovine subclinical mastitis. One hundred thirty mastitic milk samples were subjected to bacterial culturing, and one hundred (76%) S. aureus isolates were identified based on phenotypic characters. Sixty-eight confirmed S. aureus isolates were obtained using PCR. The confirmed S. aureus isolates were tested for six virulence genes (tsst-1, hlb, eta, sea, clfA, and icaD) using PCR. Of the six virulence genes screened from all the isolates, only two (clfA and eta) were detected in the isolates. Out of 68 isolates, 25% and 22% were possessed the eta and clfA genes, respectively. Conclusion The presence of Staphylococcus aureus having virulence genes (eta and clfA) revealed that mastitis is a major concern nowadays affecting animal health, milk quality, and yield. Further genomic study of these isolates will provide broad new insights on virulence.

scholarly journals Illumina sequencing analysis of the ruminal microbiota in high-yield and low-yield lactating dairy cows

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0198225 ◽  
Author(s):  
Jinjin Tong ◽  
Hua Zhang ◽  
Delian Yang ◽  
Yonghong Zhang ◽  
Benhai Xiong ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Illumina Sequencing ◽  
High Yield ◽  
Sequencing Analysis ◽  
Lactating Dairy Cows ◽  
Ruminal Microbiota

1384 Effects of Peptein supplementation on ruminal microbiota and feed digestibility in dairy cows

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 669-669
Author(s):  
A. Arís ◽  
J. Polo ◽  
C. Rodriguez ◽  
A. Bach
Keyword(s):  
Dairy Cows ◽  
Feed Digestibility ◽  
Ruminal Microbiota

Bioconversion of Heptachlor Epoxide by Wood-Decay Fungi and Detection of Metabolites

2012 ◽  
Vol 518-523 ◽  
pp. 29-33 ◽  
Author(s):  
Peng Fei Xiao ◽  
Toshio Mori ◽  
Ryuichiro Kondo
Keyword(s):  
Wide Spectrum ◽  
Wood Decay ◽  
Heptachlor Epoxide ◽  
Hydroxyl Group ◽  
Epoxide Ring ◽  
Limited Information ◽  
Decay Fungi ◽  
Wood Decay Fungi ◽  
Metabolic Products ◽  
Phlebia Brevispora

Although heptachlor epoxide is one of the most persistent organic pollutants (POPs) that cause serious environmental problems, there is very limited information of the biodegradation of heptachlor epoxide by microorganisms, and no systematic study on the metabolic products and pathway of endrin by microorganisms has been conducted. Wood-decay fungi can degrade a wide spectrum of recalcitrant organopollutants, including polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated biphenyls (PCBs). In this study, 18 wood-decay fungi strains of genus Phlebia were investigated for their ability to degrade heptachlor epoxide, and Phlebia acanthocystis, Phlebia brevispora, Phlebia lindtneri and Phlebia aurea removed about 16, 16, 22 and 25% of heptachlor epoxide, respectively, after 14 days of incubation. Heptachlor diol and 1-hydroxy-2,3-epoxychlordene were detected in these fungal cultures as metabolites by gas chromatography and mass spectrometry (GC/MS), suggesting that the hydrolysis reaction in the epoxide ring and substitution of chlorine atom with hydroxyl group in C1 position occur in bioconversion of heptachlor epoxide by selected wood-decay fungi, respectively. This is the first report describing the metabolites of heptachlor epoxide by microorganisms.

scholarly journals Economic impact of polyherbal mixtures containing choline, lysine and methionine on milk production and health of dairy cows

2020 ◽  
pp. 864
Author(s):  
Nora Idolina Ortega Alvarez ◽  
Germán David Mendoza Martínez ◽  
Ricardo Barcena Gama ◽  
Pedro Abel Hernández García ◽  
Enrique Espinosa Ayala ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Economic Impact ◽  
Milk Production ◽  
Animal Health ◽  
Lower Number ◽  
Residual Effects ◽  
Control Group ◽  
Health Cost ◽  
Immune Stimulants ◽  
Economic Improvement

The objective of this study was to evaluate the economic impact of supplementing dairy cows with mixtures of polyherbal products supplying conjugates of choline (BioCholine, BC), lysine (OptiLysine, L) and methionine (OptiMethionine, M), considering the costs of veterinary treatments, the nutraceutical effects of the mixtures, the partial cost and returns of milk production. Eighty postpartum Holstein cows were randomly assigned to individually receive. The pellets no containing (Control, 20 cows) and containing polyherbal products (g/d) (BC20, 19 cows; BC40, 17 cows; BC20+L40+M20, 12 cows, and BC40+L80+M40, 12 cows) were offered to cows during the milking through automatic feeders in the course of 90 days in a commercial farm. Treatment costs were grouped in terms of antibiotics, healing, anti-inflammatories, glucogenics, hormonal, intra-mammary treatments, restorative and vitamins. Milk production was not affected (P>0.05) by polyherbal additives but there were numerical differences in the number of treatments and costs; animal health cost per cow showed a high variation coefficient (average 347%). Cows receiving BC40 and BC20+L40+M20 had reduced animal health cost per cow but only the treatment BC40 showed residual effects post experiment with an economic improvement of 2.1% over the control group, showing benefits associated to a reduction in the number of doses with antibiotics and doses of immune-stimulants. Cows receiving BC40 had the best milk yield numerically in combination with the lower number of animal health costs which resulted in the highest income.

scholarly journals The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

2021 ◽  
Author(s):  
Thomas Spruce ◽  
Mireya Plass ◽  
André Gohr ◽  
Debashish Ray ◽  
María Martínez de Lagrán ◽  
...  
Keyword(s):  
Resource Allocation ◽  
Cellular Differentiation ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
Sequence Evolution ◽  
Biological Functions ◽  
Double Knockout ◽  
Major Site ◽  
Genetic Conflict ◽  
Splicing Regulator

AbstractThe eutherian placenta is a major site for parental genetic conflict. Here, we identify the X-linked Mbnl3 gene as a novel player in this dispute. Mbnl3 belongs to an RNA binding protein family whose members regulate alternative splicing and other aspects of RNA metabolism in association with cellular differentiation. We find that, in eutherians, Mbnl3 has become specifically expressed in placenta and has undergone accelerated sequence evolution leading to changes in its RNA binding specificities. Although its molecular roles are partly redundant with those of Mbnl2, Mbnl3 has also acquired novel biological functions. In particular, whereas Mbnl2;Mbnl3 double knockout mice display severe placental maturation defects leading to strong histological and functional abnormalities, Mbnl3 knockout alone results in increased placental growth and favors placental and fetal resource allocation during limiting conditions.

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