The effect of Gokshura Churna over Tilanalakshara Yoga in the management of Mutrashmari - A Randomized Comparative Clinical Study

Author(s):  
Dr. Anil M. Sanshi ◽  
Dr.Pallavi A. Hegde

Background: Mutrashmari is a stone like structure anywhere in the Mutravaha Srothas which can be compared with renal calculi and one among the Astamahagada, clinical features as renal angle pain, haematuria, pyuria and dysuria. Peak age is 3rd to 5th decade while majority of patients report regarding onset of disease in 2nd decade of life and male to female ratio is 3:1. Objectives: To compare the effect of Gokshura Churna over Tilanalakshara Yoga in the management of Mutrashmari with special reference to Renal calculi. Materials and Methods: 30 patients were selected on the basis of inclusion criteria and divided into 2 groups with 15 patients in each group by chit method. Group A was treated with standard drug Tilanalakshara Yoga and Group B was traeted with trial drug Gokshura Churna. Results: It was found that standard group reduced the abdominal pain by 85.1%, dysuria by 89.4%, renal angle tenderness 88.4%, haematuria 100%, pyuria 100%, size of renal calculus 41.9% by 21st day of treatment. In study group it was observed that abdominal pain reduced by 92%, dysuria 96.1%, renal angle tenderness 91.6%, haematuria 100%, pyuria 100% and size of renal calculus 48.5% by 21st day of treatment. Conclusion: This assessment showed Gokshura Churna had significant result over Tilanala Kshara Yoga in both subjective and objective parameters with P value less than 0.0001.

Author(s):  
Nitish Pathania ◽  
Umesh C C ◽  
Gopala Krishna G ◽  
Monika Pathania

Hypertension is the most pressing public health challenges. It is estimated that approximately 1 billion people are suffering from high blood pressure and the numbers are to increase to 2.5 billion by 2025. Raktachaapadhikya is the coined term for increased blood pressure given by recent authors where it can be understood as the pathology of Vyanvayu. The usage of Guduchyadi Yoga has been highlighted in the classics of Ayurveda for targeting the Hridaya sthitha vayu, which has not been evaluated yet. Aim: To evaluate and compare the efficacy of Navahridaya Kalpa (standard drug) and Guduchyadi Yoga (trial drug) for management of essential hypertension. Materials and Methods: A simple randomized controlled clinical study where 40 patients were equally divided as group A: Navahridaya kalpa (standard drug) and Group B: Guduchyadi yoga (trial drug) for a period of one month. Observations and results: The study result revealed that both the groups were beneficial in reducing high blood pressure however with no statistically significant difference found between the groups with p value being 0.339 for standard drug and 0.363 for trial drug. The group B was also found to be effective in reducing systolic blood pressure of stage I hypertension with p value .044 on comparing between the groups. Conclusion: The Guduchyadi yoga acts as Rasayana with the property of rejuvenation and antihypertensive which will check the high blood pressure at a very minimum cost without having any major adverse effects in the patients and hence can be advocated for use on a daily a basis.


Author(s):  
Manish Kumar Singh ◽  
P. Ramesh Bhat ◽  
Sweta Tyagi

Vrana chikitsha is very significant in field of Shalya tantra. Healing of Vrana is depends on many factors. Among them growth of microorganism play essential role to slow the process of healing. In Dusta Vrana to improve the healthy granulation and to reduce the colony count of microorganism specific Krimghna dravya is required for that in Shasthi upkrama under Krimighna karma Gomutra Arka is advised. Which has additional property of Lekhana and Ropana. Gomutra Arka is given importance in many oral classical formulation of Ayurveda to treat the Krimi, which is not evaluated for local application on Dusta Vrana yet. Materials and Methods: A simple randomized controlled clinical study where 50 patients were equally divided as group A: Gomutra Arka (trial drug) and Group B: Povidone-iodine (standard drug) for 14 days. Observations and results: The study result revealed that Gomutra Arka proved to be better Antimicrobial agents than povidone-iodine with a highly significant p-value of 0.04 in comparison to 0.68. It was also established in the study that 10mlGomutra Arka proved to be more effective on different microorganisms that are Staphylococcus Aureus, Pseudomonas Aeruginosa, Shigella, Salmonella, E. Coli, and Candida Albicans. Conclusion: The Gomutra Arka acts as an antimicrobial agent due to its property like Katu tikta kashya rasa which are Krimighna in nature by this inhibition of microorganism could happen also due to the Ushna tikshna and Kshara guna gives unfavorable environment for bacterial growth. The presence of constituents like copper, aurum, urea, ammonia further helps in antimicrobial activity. Therefore, Gomutra Arka can be used in regular practice as its available at a low cost, affordable and the study proves its efficiency over the Povidone-iodine controlled group.


2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Mubashar Hussain

Abstract Aims To study if right lower abdominal pain could be managed safely on ambulatory basis when referred from emergency department or primary healthcare as suspected acute appendicitis to surgical ambulatory unit (SAU). Methods Data collated prospectively involving 586 patients, who presented with right iliac fossa/right-sided pelvic pain from january 2019 to January 2021. Results 0ut of 586 patients, 234 (40%) were admitted and 352 (60%) managed in ambulatory settings after being reviewed by Consulant-lead surgical oncall team. Age ranged from 3 to 92 years. Male to female ratio was 3:2. Their management included clinical history/and examination, urinalysis and blood tests. 157 (44%) patients had scans, 43 (12%) had CT scans and 114 (32%) had pelvic USS the same day or the following morning/day and were reviewed by oncall-surgeons and 107 (30%) patients had repeat blood tests. 39 (11%) out of 352 paitents were admitted the following day review, of which 18 (5%) patients underwent laproscopic appendicectomy (LA) and 8 (2.2%) patients treated conservatively. 9 (1.98%) patients represented with persistent/or worsening symptoms and 5 (1.4%) patients of these had LA and 2 (0.56%) patients had pelvic collection, drained radiologically and 2 (0.56%) had wound infections treated with antibiotics. Complications rate in ambulatory patients compared to in-patients was insignificant, P-value set at 0.05% using Mann-Whitney U test. Conclusions


2017 ◽  
Vol 24 (09) ◽  
pp. 1331-1335
Author(s):  
Khalid Hussain ◽  
Maria Tarique ◽  
Attiq ur Rehman Khan ◽  
Asim Bukhari ◽  
Bilal Akhter ◽  
...  

Objectives: To compare Tamsulosin versus ESWL for lower ureteric stonesexpulsion. Study Design: Randomized controlled trial. Setting: Outpatient Department ofUrology at Services Hospital, Lahore. Period: January 2015 to December 2015. Material& Methods: Total 50 patients were enrolled in study. Patients were divided into 2 groups.In group A, 25 patients received daily oral treatment of 0.4mg Tamsulosin for 28 days, andin group B, 25 patients were treated with ESWL. A stone-free condition, was defined as thecomplete absence of any stone based on plain abdominal X-rays observed and during followupvisits at the time of treatment of stone was noted. Results: The mean age of the patientswere recorded as 33.20±9.23 years. There were 40(80%) males and 10(20%) females with maleto female ratio of 4:1. Out of 50 patients, 16(32%) presented with hematuria, 3(6%) had feverwhile 31(62%) appeared with no complication status. Out of 50 patients, 21(42%) presentedwith expulsion time 08-14 days in which 14(28%) were from tamsulosin group and 07(14%)were from ESWL group, similarly 19(38%) patients appeared with expulsion time of 15-28 daysin which 10(20%) were from tamsulosin group and 09(18%) were from ESWL group. Statisticallythere is insignificant difference between the groups i.e. p-value=0.28 Ns. Conclusion: Thisstudy suggests that the tamsulosin helps in the earlier clearance of stone fragments andreduces the complications as compared to ESWL.


Author(s):  
Arif Ali ◽  
Suhail Dilawar ◽  
Bilal Suria ◽  
Safiullah Sohu ◽  
Ghulam Mujtaba ◽  
...  

Objective: To evaluate the efficacy of tamsulosin in reducing post operative flank pain during voiding, in patients with ureteric stent. Study Design: This is a Randomized control trial (RCT) study. Place and Duration: Study carried out at Department of Urology, Jinnah Post Graduate Medical Centre, Hospital, Karachi, Pakistan, from June 2016 to November 2016. Methodology: 60 patients aged between 15 – 45years, undergone placement of ureteric stent to treat ureteric and renal calculi and have pain score >4, were included in the study. Divided into two groups ‘group A’ and ‘group B’. In group ‘A’ and group ‘B’ Tamsulosin and Placebo was given respectively in patients with ureteric stent and reduction in post-operative flank pain was measured and compared. Tamsulosin was given post operatively when NPO is broken after 2 hours – 6 hours.  Patients having uretral trauma, patients having BPH,  patient underwent TURP or TURBT, patent having urinary tract infection and  patients with pregnancy or lactating females were excluded. All patients were received intravenous antibiotic (Ceftrixone 1gr). Also all patients were receive oral analgesic (diclofenic sodium 50mg BID) and antispasmodics (Drotaverine 80mg BID). Patients were discharged after 24 hours. Postoperatively stent related flank pain during voiding was assessed via Pain Scale. Results: 60 Patients who got operated for ureteric stent. In group ‘A’ there were 21 males (70%) and 9 females (30%), the mean age of group A was 35.67±5.99 as In group ‘B’ there were of 21 males (70%) and 9 females (30%) and mean age of group B was 35.04±6.42 (Table 1). Mean Pain score in ‘Group A’ (Tamsulosin) in week 1, 2, 3, 4, 5, 6 was 4.1, 3.5, 2.9, 2.3, 1.9, 1.3 respectively as shown in Table 2. Mean Pain score in ‘group B’ (Placebo) in week1, 2, 3, 4, 5, 6 was 6.9, 6.3, 5.9, 5.6, 5, 4.2 respectively as shown in Table 2.  Average pain score in ‘group A’ and ‘group B’ came out to be 2.67 and 5.64 respectively (P value 0.005).  Conclusion: Alpha blockers reduces the post-operative flank pain and voiding complaints in patients with ureteric stent. Our study shows that the efficacy of Tamsulosin in reducing post-operatice flank pain in patients with uretercic stent is better than placebo.


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Suheena Khanday ◽  
Mohd. Afsahul Kalam ◽  
Ansar Ahmad ◽  
Aamir Yousuf ◽  
Sajad Salim ◽  
...  

Hasah al-Kulya (renal calculi) is one of the leading problems affecting kidney. Recurrence of kidney stone formation is approximately 50%, after 2-3 years of recovery. This makes the prevention of its recurrence an essential problem to address. Despite substantial progress in medical therapy, there is no drug with satisfactory effect. Furthermore, the drugs those are being used for its treatment have many side effects. Baranjasif (Achillea millefolium Linn.) is one of the drugs used in Unani Medicine that has been extensively used for the management of urolithiasis. The aim of this study is to evaluate the lithotriptic action of Baranjasif in-vitro. In this study, calcium oxalate stones were prepared experimentally followed by the preparation of semipermeable membrane by dissolving the outer shell of egg in 2M HCl overnight. Calcium oxalate stones weighing 10mg were then allowed to react with 7 extracts of A. millefolium L. viz, Pet-ether, Chloroform, Ethyl Acetate, Methanol, Acetone, Hydro-alcohol and Aqueous by packing them together in semipermeable membrane. The reaction was performed on three different concentrations of each extract i.e., 50 mg, 100 mg and 150 mg. In addition to 7 groups, two more groups were taken, i) a negative group containing only the stone of weight 10 mg and ii) standard group consisting of stone weighing 10 mg and cystone (in concentrations of 50 mg, 100 mg and 150 mg). Statistical methods like mean standard deviation, percentage dissolution, percentage inhibition, IC and Pearson's correlation were applied to understand the extent of dissolution of stones 50 in each group. The study advocates that Baranjasif reveals lithotriptic activity comparable to standard drug. The efficacy of the drug is directly proportional to its concentration. Ethyl acetate extract of the plant showed the most promising results.


2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Shahid Sarwar ◽  
Bushra Muhyuddin ◽  
Abdul Aleem ◽  
Muhammad Arif Nadeem

Objective: To compare efficacy of high vs low dose rifaximin for primary prophylaxis of portosystemic encephalopathy (PSE) in decompensated liver cirrhosis. Methods: In a quasi-experimental double blind randomized study at Services Institute of Medical Sciences (SIMS), Lahore from August 2017 to August 2018, patients of decompensated cirrhosis with no previous PSE were randomized to receive twice daily rifaximin 200mg in Group-A and 550mg in Group-B. Patients were followed for 6 months for development of PSE. Results: In 75 included patients, mean age was 53.8(±10.7) years and male/female ratio was 0.97/1(37/38). After randomization, 34 (45.3%) patients were included in Group-A and 41 (54.7%) patients in Group-B. During 6 month follow up 24 (32%) patients developed PSE, 12 (35.2%) in Group-A and 12 (29.2%) in Group-B, difference was not significant (p value 0.57). In 6 months, 13 (17.3%) patient died, 6 (17.6%) in Group-A and 7 (17.07%) patients in Group-B, difference not significant (p value 0.94). Patients who died had higher bilirubin (p < 0.00), higher serum creatinine (p 0.05), high CTP score (p 0.04) and worse MELD score (p 0.004). Conclusion: Rifaximin is not effective for primary prophylaxis of overt hepatic encephalopathy in decompensated cirrhosis patients. doi: https://doi.org/10.12669/pjms.35.5.549 How to cite this:Sarwar S, Muhyuddin B, Aleem A, Nadeem MA. Primary prophylaxis of hepatic encephalopathy in decompensated cirrhosis: Low dose vs. full dose rifaximin. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.549 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2006 ◽  
Vol 13 (04) ◽  
pp. 563-571
Author(s):  
MUHAMMAD TARIQ NADEEM ◽  
MAZHAR ABBAS ◽  
TAQI HASSAN ◽  
Shahid Masood

Objective: To assess the association between the Helicobacter Pylori (H.pylori) infection andrecurrent abdominal pain (RAP) by documenting the frequency of Helicobacter pylori infection in children aged 5 to 15years in our setup. Design: A comparative study. Place and Duration of Study: The study was conducted in pediatricunit Military Hospital Rawalpindi over one year period from 1st Apr 200 to 31st Mar 2002. Subject and Methods: Wedivided the patients into two groups; group A or the study group and the group B or the control group. In group A, atotal of 87 Children aged 5 to 15 years presenting with RAP in which no underlying cause was found on initialassessment underwent upper gastrointestinal tract (GIT) endoscopic examination. In group B (control) we included 68children in whom upper GIT endoscopy was done for any reason other than the RAP. In both the groups thegastroduodenal biopsy samples were sent for culture and histological examination for the diagnosis of H. pyloriinfection. The signs and symptoms of these patients were analyzed in detail. Results: In group A, out of 87 patientswho were endoscoped there were 44 female and 43 male. 54(62%) were found positive and 33(38%) were foundnegative for H.pylori on histopathology and culture examination of biopsy samples. In the control group (B) thefrequency of H.pylori infection was 35% (24 of 68) which was significantly lower than the study group (p-value .001).The frequency of H.pylori increased significantly with advancement in age (p-value .003) and lowering of thesocioeconomic status (p-value.002). The commonest endoscopic finding was antral gastritis (31 of 87; 35.6%). Antralnodularity was observed in 8(26%) out of 36 cases of antral gastritis and in 23(74%) cases there was antral erythemawithout nodularity. The remaining endoscopic findings were pan-gastritis (14 of 87;16%), duodenal ulcer (10 of87;11.5%), duodenitis (4 of 87;4.6%) and gastric ulcer (2 of 87;2.3%). The less frequent findings were gastric andduodenal erosions and esophagitis (about 1% each).Their was no abnormal finding in 22(25.3%) cases. Childrenpredominantly (52%) had the symptoms characteristics of ulcer-like dyspepsia. Recurrent epigastric pain wassignificantly more common in the H.pylori positive than the H. pylori negative children (44 of 87 vs 16 of 33 [p-value.001]). There was no difference for other symptom characteristics when comparing infected with non-infected children.Conclusion: The frequency of H.pylori infection is high in children with recurrent abdominal pain and there is a high degree of association between recurrent abdominal pain, endoscopic findings (chronic gastritis, duodenitis, gastric andduodenal ulcer) and the H. pylori infection.


2015 ◽  
Vol 31 (2) ◽  
pp. 102-109
Author(s):  
Md Abdus Shakoor ◽  
- Shamsunnahar ◽  
Nayeem Anwar ◽  
Md Muhibbur Rahman ◽  
Fatema Zohra ◽  
...  

Background:Pain in the neck is a common complaint of the patients attending the hospital. In clinical practice, neck pain is seen frequently as a presenting symptom and sometimes it becomes disabling and compromises the working capacity. One of the most common causes of pain in the neck is cervical spondylosis. Rehabilitation treatment may play an important role to improve the condition of the patients. For this purpose, the study was done to find out the effects of rehabilitation treatment on chronic neck pain to improve the present situation regarding treatment. Methodology: A randomized clinical trial was conducted in the department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. A total of 150 patients were included and they were divided into two groups: group-A and group-B. Group-A was treated with selective rehabilitation and Group –B was treated with NSAID only. History, clinical examination and relevant investigations were done. The findings were recorded at first attendance and follow up was done weekly for six weeks. The results were expressed as mean ± SD and the level of significance was expressed by p-value unless otherwise stated. Student’s ‘t’ tests was done to test the hypothesis. Results: Among the study subjects 48(32 %)were male and 102 (68 %) were female. The male female ratio was 1: 2.12. There was significant improvement in both the group after treatment ( P= 0.001). But in comparison between two groups, all the baseline criteria were identical. There was no significant improvement between two groups up to 5th weak( P>05) but significant improvement was seen in Group-B than Group-A after six weeks treatment (P= 0.03). This results indicates that the improvement of the patient with cervical spondylosis was seen in selective rehabilitation group and in NSAIDs group. And improvementwas same in both the group up to 5th week and after six weeks more improvement was found in NSAIDs group. Conclusions: By this study, it may be concluded that to reduce symptom and disability, rehabilitation treatment can be used effectively for the treatment of chronic neck pain without analgesics and by this way nephropathy due to NSAIDs can be avoided. Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 102-109


2015 ◽  
Vol 22 (04) ◽  
pp. 476-482
Author(s):  
Muhammad Azeem Akhund ◽  
Karam Ali Shah ◽  
Allah Nawaz Abbasi ◽  
Zulfiqar Ali Mastoi

The femur fractures usually happen with oomph forces like motor vehicleaccidents. Objectives: To assess the mode of injury and complications of the management, indiaphyseal femoral fractures, in comparison of close versus open intramedullary interlockingnail (IMN). Study Design: Experimental and comparative study. Period: April 2013 to March2014. Setting: Department of Orthopaedic Surgery, Peoples University of Medical & Healthsciences, Nawabshah. Methods: The cases were divided into two groups A and B. Group Awas treated by open nailing (n = 20) and group B by close nailing (n = 20), all the cases wereoperated within 48 hours of admission. All the data were recorded on well structured proforma.Serial radiographies were performed at 3, 6, 12 weeks, and 6 months; additional radiographieswere performed as needed postoperatively. Knee, ankle, and hip motions were begun andprotected weight bearing was started on the second day postoperatively and increasedgradually to full WB depending on x-ray findings of callus formation. The patients were followedfor two years. Results of open and closed I.M.N were assessed and the complications if anywere observed over a mean follow-up period of two years. Results: The mean age in groupA was 29.40 years and the mean age in group B was 30.45 years. Out of 40 cases, 32(80.0%)were males with male to female ratio 1:4. Mean ± SD hospital stay was 19.80 ± 14.60 days ingroup A, and 17.90 ± 5.95 days in group B (p value 0.55). Average time between injury andadmission was 1.53 days (n = 40), in the group A it was 1.05 days, and in the group B it was2.0 days (p value 0.03). The average of time between injury and operation in the group A was8.75 days, and in the group B, it was 8.20 days, (p value 0.71). The average of time betweenadmission and discharge in the group A was 11.0 days, and in the group B was 9.15 days,(p value 0.55). Mean ± SD union time was 11.70 ± 6.45 weeks, in group A and 11.90 ± 5.77weeks, in group B. (p value 0.91). All the patients had full ranged of hip motion and 2 (10.0%)patients of group A had mild limitation of knee motion with a flexion ranges between 80 and110 degrees. Final functional results based on Thoresen BO criteria16. Excellent results wereobserved in 19 (47.5%) cases, out of them 5(25.0%) were in group A and 14(70.0%) were ingroup B. Good results were found in 13(32.5%) patients, out of these 7(35.0%) were in group Aand 6(30.0%) were in group. Fair and poor results were detected in 4(10.0%) cases of group A.Conclusions: Road traffic accidents by motorcycle was found the commonest (47.5%) causeof femur fracture, a few complications were observed in open interlocking nailing as comparedto closed interlocking nails.


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