scholarly journals A CLINICAL EVALUATION OF ANTIMICROBIAL ACTIVITY OF GOMUTRA ARKA IN DUSTA VRANA

2020 ◽  
pp. 27-35
Author(s):  
Manish Kumar Singh ◽  
P. Ramesh Bhat ◽  
Sweta Tyagi
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Povidone Iodine ◽  
Low Cost ◽  
P Value ◽  
Standard Drug ◽  
Classical Formulation ◽  
Group A ◽  
Group B ◽  
Trial Drug

Vrana chikitsha is very significant in field of Shalya tantra. Healing of Vrana is depends on many factors. Among them growth of microorganism play essential role to slow the process of healing. In Dusta Vrana to improve the healthy granulation and to reduce the colony count of microorganism specific Krimghna dravya is required for that in Shasthi upkrama under Krimighna karma Gomutra Arka is advised. Which has additional property of Lekhana and Ropana. Gomutra Arka is given importance in many oral classical formulation of Ayurveda to treat the Krimi, which is not evaluated for local application on Dusta Vrana yet. Materials and Methods: A simple randomized controlled clinical study where 50 patients were equally divided as group A: Gomutra Arka (trial drug) and Group B: Povidone-iodine (standard drug) for 14 days. Observations and results: The study result revealed that Gomutra Arka proved to be better Antimicrobial agents than povidone-iodine with a highly significant p-value of 0.04 in comparison to 0.68. It was also established in the study that 10mlGomutra Arka proved to be more effective on different microorganisms that are Staphylococcus Aureus, Pseudomonas Aeruginosa, Shigella, Salmonella, E. Coli, and Candida Albicans. Conclusion: The Gomutra Arka acts as an antimicrobial agent due to its property like Katu tikta kashya rasa which are Krimighna in nature by this inhibition of microorganism could happen also due to the Ushna tikshna and Kshara guna gives unfavorable environment for bacterial growth. The presence of constituents like copper, aurum, urea, ammonia further helps in antimicrobial activity. Therefore, Gomutra Arka can be used in regular practice as its available at a low cost, affordable and the study proves its efficiency over the Povidone-iodine controlled group.

The effect of Gokshura Churna over Tilanalakshara Yoga in the management of Mutrashmari - A Randomized Comparative Clinical Study

2018 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Anil M. Sanshi ◽  
Dr.Pallavi A. Hegde
Keyword(s):  
Abdominal Pain ◽  
Renal Calculi ◽  
Renal Calculus ◽  
P Value ◽  
Standard Group ◽  
Standard Drug ◽  
Female Ratio ◽  
Comparative Clinical Study ◽  
Group B ◽  
Trial Drug

Background: Mutrashmari is a stone like structure anywhere in the Mutravaha Srothas which can be compared with renal calculi and one among the Astamahagada, clinical features as renal angle pain, haematuria, pyuria and dysuria. Peak age is 3rd to 5th decade while majority of patients report regarding onset of disease in 2nd decade of life and male to female ratio is 3:1. Objectives: To compare the effect of Gokshura Churna over Tilanalakshara Yoga in the management of Mutrashmari with special reference to Renal calculi. Materials and Methods: 30 patients were selected on the basis of inclusion criteria and divided into 2 groups with 15 patients in each group by chit method. Group A was treated with standard drug Tilanalakshara Yoga and Group B was traeted with trial drug Gokshura Churna. Results: It was found that standard group reduced the abdominal pain by 85.1%, dysuria by 89.4%, renal angle tenderness 88.4%, haematuria 100%, pyuria 100%, size of renal calculus 41.9% by 21st day of treatment. In study group it was observed that abdominal pain reduced by 92%, dysuria 96.1%, renal angle tenderness 91.6%, haematuria 100%, pyuria 100% and size of renal calculus 48.5% by 21st day of treatment. Conclusion: This assessment showed Gokshura Churna had significant result over Tilanala Kshara Yoga in both subjective and objective parameters with P value less than 0.0001.

scholarly journals COMPARISON OF RESPONSE TO TREATMENT OF OTOMYCOSIS USING TOPICAL BETADINE AND CLOTRIMAZOLE DROPS

2019 ◽  
pp. 1-2
Author(s):  
Rajendra K. Teharia
Keyword(s):  
Developing Countries ◽  
Fungal Infection ◽  
External Auditory Canal ◽  
Povidone Iodine ◽  
Low Cost ◽  
Response To Treatment ◽  
Group A ◽  
Study Support ◽  
Group B ◽  
Nose And Throat

INTRODUCTION: Otomycosis is the fungal infection of EAC (External Auditory Canal) that is very commonly seen in Ear , Nose and Throat clinics .Local debridement and antifungals , topical or systemic is the treatment of choice but recurrences are very common and resistant to treatment. METHODS:Total 220 patients, divided into two groups each 110 in 'A' and 'B' were subjected to betadine (povidone - iodine )10% solution and Clotrimazole (1 %) drops treatment and response of treatment assessed on 5th , 10th and 20th day and analyzed. RESULTS :Out of 110 patients in each group on 5th day 21.8 % patients in group 'A', and 23.6 % in group B' showed no response. 70.9 % in group 'A' and 72.7 % in group 'B' were showed good response at evaluation of 20th day of treatment. CONCLUSION :In our study, betadine (10% solution) and Clotrimazole (1 %) drops were equally effective in treatment of otomycosis. Betadine(10% solution) is low cost, non-ototoxic, nonresistant and equally effective in bacterial and fungal infection. That's why this study support betadine 10% solution as treatment of choice for otomycosis specially in developing countries .

scholarly journals TO EVALUATE THE EFFICACY OF GUDUCHYADI YOGA IN THE MANAGEMENT OF RAKTACHAPADHIKYATA OR ESSENTIAL HYPERTENSION-A RANDOMIZED CONTROLLED CLINICAL TRIAL

2020 ◽  
pp. 13-20
Author(s):  
Nitish Pathania ◽  
Umesh C C ◽  
Gopala Krishna G ◽  
Monika Pathania
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
High Blood Pressure ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Standard Drug ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Group B ◽  
Trial Drug

Hypertension is the most pressing public health challenges. It is estimated that approximately 1 billion people are suffering from high blood pressure and the numbers are to increase to 2.5 billion by 2025. Raktachaapadhikya is the coined term for increased blood pressure given by recent authors where it can be understood as the pathology of Vyanvayu. The usage of Guduchyadi Yoga has been highlighted in the classics of Ayurveda for targeting the Hridaya sthitha vayu, which has not been evaluated yet. Aim: To evaluate and compare the efficacy of Navahridaya Kalpa (standard drug) and Guduchyadi Yoga (trial drug) for management of essential hypertension. Materials and Methods: A simple randomized controlled clinical study where 40 patients were equally divided as group A: Navahridaya kalpa (standard drug) and Group B: Guduchyadi yoga (trial drug) for a period of one month. Observations and results: The study result revealed that both the groups were beneficial in reducing high blood pressure however with no statistically significant difference found between the groups with p value being 0.339 for standard drug and 0.363 for trial drug. The group B was also found to be effective in reducing systolic blood pressure of stage I hypertension with p value .044 on comparing between the groups. Conclusion: The Guduchyadi yoga acts as Rasayana with the property of rejuvenation and antihypertensive which will check the high blood pressure at a very minimum cost without having any major adverse effects in the patients and hence can be advocated for use on a daily a basis.

A Clinical Study to evaluate the efficacy of Papaya Ksheera based Sphatika Ksharasutra in Bhagandara w.s.r. to fistula-in-ano

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Amulya H ◽  
Shilpa PN ◽  
Madhunayak R
Keyword(s):  
Effective Treatment ◽  
Wound Management ◽  
Control Group ◽  
Standard Drug ◽  
Fistula In Ano ◽  
Post Operative Pain ◽  
Group A ◽  
Group B ◽  
Trial Drug ◽  
Made In

Background: Bhagandara is one among Ashtamahagadas mentioned by Acharya Sushruta and is one of the most common ailments pertaining to ano rectal region. Management of Fistula -in-ano has become a challenge to Allopathy Surgeons because of its complications like post-operative pain, wound management, recurrence and incontinence. In Ayurveda, the effective treatment is Ksharasutra ligation. Snuhi Ksheera based Apamarga Ksharasutra is the standard one and is proved effective treatment in the management of Fistula-in-ano. But, burning sensation, pain, local irritation during the course of therapy and difficulty in manufacturing process has limited its use. To overcome these lacunas, present study has been carried out. Objectives: To evaluate the significance of Papaya Ksheera based Sphatika Ksharasutra by comparing with the efficacy of Snuhi Ksheera based Apamarga Ksharasutra in the management of Bhagandara. Materials and methods: A total of 40 patients were randomly allotted into two groups namely Group A with trail drug i.e. Papaya Ksheera based Sphatika Ksharasutra and Group B as Control group i.e. Snuhi Ksheera based Apamarga Ksharasutra with 20 patients in each group. Results: Assessment of Pain, Discharge, Pruritis ani, length of track was made. In Group A, overall result is 98.5% and Group B overall result is 91.5%. The test shows that the treatment is statistically not significant in Group B when compared to Group A. Conclusion: This study showed that the trial drug was as effective as the standard drug in the treatment of Bhagandara.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES

2018 ◽  
Vol 7 (6) ◽  
Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Fungal Strain ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Gram Negative ◽  
E Coli

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.

COMPARISON OF EFFECTIVENESS OF MOBILIZATION AND SELF-EXERCISES IN ADHESIVE CAPSULITIS OF SHOULDER

2018 ◽  
Vol 7 (1) ◽  
pp. 35-41
Author(s):  
Muhammad Usman Khan ◽  
Ghazala Noor Nizami ◽  
Ali Farhad
Keyword(s):  
Pain Intensity ◽  
Adhesive Capsulitis ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
T Test ◽  
P Value ◽  
Group A ◽  
Group B

OBJECTIVE To compare the effectiveness of mobilization and self-exercises in the management of adhesive capsulitis of shoulder STUDY DESIGN Randomized Control Trial SAMPLE SELECTION 30 patients of adhesive capsulitis of shoulder from physiotherapy department of tertiary care hospitals of Karachi were selected through simple random sampling technique. PROCEDURE Treatment was continued for 5 days per week for the period of 3 weeks followed by assessment. Patients were randomly divided into two equal groups. Group A was treated with midrange mobilization while group B performed self-exercises. Both groups received TENS and hot pack prior to the exercises. Mean ± SD, frequencies and percentages were used for descriptive analysis. ROM via goniometry and pain intensity through VAS was analyzed by paired t-test within the groups and by independent t-test between the groups, using SPSS. P-value of less than 0.05 was considered significant. RESULTS 60% were females (n=18) and 40% were males (n=12) with mean age of 50.17±6.37 years. Significant improvement (p-value <0.05) in pain and shoulder ROM was observed among patients of Group A as compared to Group B. Pain intensity was decreased to 1.67 ± 0.62 in group A, whereas ROMs in these patients were also better than other group.

Moxifloxacin Based Triple Therapy as Alternative to Standard Therapy in Helicobacter Pylori Eradication.

2020 ◽  
Vol 18 ◽  
Author(s):  
Mohammed Hussien Ahmed ◽  
Sherief Abd-Elsalam ◽  
Aya Mohammed Mahrous
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Therapy Group ◽  
Low Cost ◽  
High Rate ◽  
Helicobacter Pylori Eradication ◽  
Treatment Regimens ◽  
Group A ◽  
H Pylori ◽  
Group B

Introduction: Helicobacter pylori eradication remains a problematic issue. We are in an urgent need for finding a treatment regimen that achieves eradication at a low cost and less side effect. Recent published results showing a high rate of resistance and with clarithromycin-based treatment regimens. The aim of the study was to compare moxifloxacin therapy and classic clarithromycin triple therapy in H. pylori eradication. Methods: This was a pilot study that enrolled 60 patients with helicobacter pylori associated gastritis. Diagnosis was done by assessment of H. pylori Ag in the stool. The patients were randomly assigned to receive either moxifloxacin based therapy (Group A), or clarithromycin based therapy (Group B) for two weeks. We stopped the treatment for another two weeks then reevaluation for cure was done. Results: 90 % of patients had negative H. pylori Ag in the stool after 2 weeks of stoppage of the treatment in group A versus 66.7 % in Group B. None of the patients in both groups had major side effects. Conclusion: Moxifloxacin-based therapy showed higher eradication power and less resistance when compared to clarithromycin triple therapy.

CONVENTIONAL VERSUS THREE-DIMENSIONAL CONFORMAL EXTERNAL RADIOTHERAPY IN CANCER CERVIX: A COMPARATIVE STUDY FOR COMPLIANCE, RESPONSE AND TOXICITY

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Richa Gupta ◽  
Piyush Kumar ◽  
D. P. Singh ◽  
Arvind Kumar Chauhan ◽  
Kamal Sahni
Keyword(s):  
Clinical Response ◽  
Three Dimensional ◽  
Common Side Effect ◽  
P Value ◽  
High Dose ◽  
Cancer Cervix ◽  
Conventional Radiotherapy ◽  
Radiation Fields ◽  
Group A ◽  
Group B

INTRODUCTION: Cervical cancer is the second most frequent cancer among Indian women. Radiotherapy is the cornerstone of treatment in all its stages. Three-dimensional conformal radiotherapy (3DCRT) combines multiple radiation fields to deliver precise dose of radiation to the affected area. Tailoring each of the radiation fields to focus on the tumor delivers a high dose of radiation to the tumor and avoids nearby healthy tissue. The present study is done to compare conventional radiotherapy versus 3DCRT in cancer cervix for compliance, clinical response and toxicity. MATERIAL AND METHODS: Fifty patients were enrolled and randomised into two radiotherapy plans with radical intent - Group A treated by conventional radiotherapy and group B treated by 3DCRT. Concurrent cisplatin was delivered on weekly (35mg/m2) or tri-weekly (75mg/m2) basis during external beam Radiotherapy and was followed by High Dose Radiotherapy Brachytherapy. Clinical response and complication assessment were evaluated.Collected data was analyzed using standard statistical methods and softwares to calculate level of significance using “p” value by chi square test. RESULTS: In this study mean age of the patients was 48 years (26-67 years). The anemia was the most common side effect seen in both groups (96% vs 88%, p=0.29). Neutropenia was more in group B (36% vs 44%, p= 0.56). Lower GI toxicity was seen only in patients in group A (20% vs 0%, p=0.018). In follow up there were no significant early rectal and bladder reactions in both groups and 2 patients in each group had late rectal reactions of grade I and II (p= 0.312). No significant skin, bladder and small intestinal toxicity were seen in both groups. CONCLUSION: Conventional radiotherapy gives equally efficacious response though accompanied by toxicities which were acceptable.

scholarly journals Integration of a Virtual Dispensing Simulator “MyDispense” in an Experiential Education Program to Prepare Students for Community Introductory Pharmacy Practice Experience

Pharmacy ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 48
Author(s):  
Ashley E. Johnson ◽  
Jillian Barrack ◽  
Jill M. Fitzgerald ◽  
Diana M. Sobieraj ◽  
Lisa M. Holle
Keyword(s):  
Community Pharmacy ◽  
Experiential Education ◽  
Self Care ◽  
Pharmacy Practice ◽  
Pharmacy Education ◽  
P Value ◽  
Community Practice ◽  
Practice Experience ◽  
Group A ◽  
Group B

Background: Technology is increasingly used to enhance pharmacy education. We sought to evaluate student learning and preparedness for community introductory pharmacy practice experiences (IPPEs) after implementation of “MyDispense” into experiential education. Methods: Both first-year pharmacy students and assigned community IPPE preceptors were eligible. Students were stratified based on previous community pharmacy experience (< or ≥ 50 h), then randomized to complete MyDispense exercises before IPPE (group A) or after 24–32 h of IPPE (group B). We evaluated preceptors’ assessment of student readiness using a 6-item Likert scale survey and students’ readiness and opinion of MyDispense using an anonymous 9-item survey. Descriptive statistics were used to characterize data. The Mann–Whitney U test was used to compare groups and a p-value < 0.05 was considered statistically significant. Results: Of 177 eligible students, 155 were randomized and 56 completed study. Group A included 32 students; 56.3% had prior community practice experience. Group B included 24 students; 50% had prior community practice experience. Forty-eight preceptors were enrolled. Students who completed exercises before rotation received higher preceptor scores for patient counseling of self-care and of medications (p < 0.05 for both). Students self-assessed their counseling skills lower than all other skills; 30.4% and 42.9% of students felt mostly or always prepared to counsel for self-care and medications, respectively. Students found MyDispense straightforward, realistic, and appreciated the ability to practice in a safe, electronic, community pharmacy, patient-care environment. Conclusion: Simulation-based software, such as MyDispense, can enhance learner understanding of the prescription fill and counseling process in a community pharmacy practice setting.

scholarly journals 465 No Role for Postoperative Antibiotics in Uncomplicated Appendicitis

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
N Ayoub ◽  
Y Tryliskyy ◽  
M K Baig
Keyword(s):  
Wound Infection ◽  
P Value ◽  
Nice Guidelines ◽  
Uncomplicated Appendicitis ◽  
Perforated Appendix ◽  
Group A ◽  
Preoperative Antibiotics ◽  
Group B ◽  
Variable Practice

Abstract Introduction Several studies have shown benefit from use of preoperative antibiotics in reducing postoperative infection after appendectomy as well as efficacy of postoperative antibiotics in complicated appendicitis (defined as perforated appendix or presence of pus in peritoneum). While for uncomplicated appendicitis, several studies showed no benefit from antibiotics postoperatively but there are no clear NICE guidelines till now and so surgeons have different practice based on their preferences. Method This study included patients who had appendectomy for uncomplicated appendicitis in Worthing hospital from 1st July 2019 till 30th June 2020. The end point was 30-day follow up postoperatively for wound infection or collection. Results 90 patients were admitted with uncomplicated appendicitis with age 6-80 years (mean of 31.3). 46 patients (51%) did not receive postoperative antibiotics (group A) and 44 (49%) received postoperative antibiotics (group B) with a variable practice from one dose to 8-day course. postoperatively, only 1 patient (2.1%) in group A developed wound infection requiring drainage while none in group B developed complications (p-value=1). Conclusions Administration of postoperative antibiotics in uncomplicated appendicitis showed no superiority over non-administration. in addition, they add extra cost on NHS. So, their routine use postoperatively is not recommended, however, larger studies are required to confirm this.

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