scholarly journals THE EFFECT OF DURATION OF ACETYLCHOLINE-ESTERASE INHIBITOR ON MMSE, CDT AND BARTHEL INDEX SCORING ON PATIENTS WITH VASCULAR DEMENSIA

2021 ◽  
Vol 7 (2) ◽  
pp. 104-108
Author(s):  
Sri Budhi Rianawati ◽  
Ria Damayanti ◽  
Harun Al Rasyid ◽  
Nyoman Artha Megayasa
Keyword(s):  
Cognitive Function ◽  
Vascular Dementia ◽  
Barthel Index ◽  
Acetylcholine Esterase ◽  
Clock Drawing Test ◽  
Dementia Patients ◽  
The Many ◽  
State Examination ◽  
Acetylcholine Esterase Inhibitor ◽  
Esterase Inhibitor

Background: Vascular dementia is a cognitive decline with functional deterioration caused by cerebrovascular disease. It is the second leading cause of dementia. A number of screening questionnaires and models have been developed to help in assessing cognitive function and activity daily living (ADL) in patients with dementia. Mini Mental State Examination (MMSE), Clock Drawing Test (CDT) and Barthel Index are instruments to evaluate cognitive function and ADL of vascular dementia patients. Objective: To determine the role of achetylcholine-esterase inhibitor therapy on cognitive function and ADL in patients with vascular dementia in Saiful Anwar General Hospital. Methods: This study is an analytical study assessing the improvement of cognitive function and ADL of patients with vascular dementia after administration of acethylcholine-esterase inhibitor by assessing the MMSE, CDT and Barthel Index scoring in 1, 3, 6 and 12 month period consecutively. Results: From 15 study subjects, individuals who have been given treatment for 12 months consecutively have the highest increase in MMSE and CDT whilst for Barthel Index has shown highest improvement in one month period. Conclusion: The administration of acetylcholine-esterase inhibitor drugs has the potential to improve and maintain cognitive function and improve ADL. The limited number of study subjects and the many confounding factors that we did not evaluate were the drawbacks of this study. The results of this study cannot be generalized to all patients with vascular dementia and only apply to 15 patients who were the subjects of this study.

scholarly journals Classifying Non-Dementia and Alzheimer’s Disease/Vascular Dementia Patients Using Kinematic, Time-Based, and Visuospatial Parameters: The Digital Clock Drawing Test

2021 ◽  
Vol 82 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Anis Davoudi ◽  
Catherine Dion ◽  
Shawna Amini ◽  
Patrick J. Tighe ◽  
Catherine C. Price ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Area Under The Curve ◽  
Clock Drawing Test ◽  
Digital Clock ◽  
Clock Drawing ◽  
Drawing Test ◽  
Dementia Patients ◽  
Optimal Area

Background: Advantages of digital clock drawing metrics for dementia subtype classification needs examination. Objective: To assess how well kinematic, time-based, and visuospatial features extracted from the digital Clock Drawing Test (dCDT) can classify a combined group of Alzheimer’s disease/Vascular Dementia patients versus healthy controls (HC), and classify dementia patients with Alzheimer’s disease (AD) versus vascular dementia (VaD). Methods: Healthy, community-dwelling control participants (n = 175), patients diagnosed clinically with Alzheimer’s disease (n = 29), and vascular dementia (n = 27) completed the dCDT to command and copy clock drawing conditions. Thirty-seven dCDT command and 37 copy dCDT features were extracted and used with Random Forest classification models. Results: When HC participants were compared to participants with dementia, optimal area under the curve was achieved using models that combined both command and copy dCDT features (AUC = 91.52%). Similarly, when AD versus VaD participants were compared, optimal area under the curve was, achieved with models that combined both command and copy features (AUC = 76.94%). Subsequent follow-up analyses of a corpus of 10 variables of interest determined using a Gini Index found that groups could be dissociated based on kinematic, time-based, and visuospatial features. Conclusion: The dCDT is able to operationally define graphomotor output that cannot be measured using traditional paper and pencil test administration in older health controls and participants with dementia. These data suggest that kinematic, time-based, and visuospatial behavior obtained using the dCDT may provide additional neurocognitive biomarkers that may be able to identify and tract dementia syndromes.

scholarly journals Etiological Pattern of Dementia in Bangladesh

2016 ◽  
Vol 32 (2) ◽  
pp. 85-90
Author(s):  
MRK Khan ◽  
AN Rizvi ◽  
MA Habib ◽  
MK Hasan ◽  
A Mamun ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Neurodegenerative Disorder ◽  
Psychosocial Interventions ◽  
Cross Sectional Study ◽  
Chronic Subdural Haematoma ◽  
Cross Sectional ◽  
Dementia Patients ◽  
Dsm Iv ◽  
Medical University ◽  
State Examination

Background: Dementia is a chronic & progressive neurodegenerative disorder affecting usually older people of more than 65 years in which there are disturbances of multiple higher cortical functions including memory, thinking, orientation & others. Dementia patients are increasing in number as the population of older age group is increasing. All types of dementia are treatable, at least with psychosocial interventions. So, accurate diagnosis and evaluation of etiological pattern is essential. Methods: This cross sectional study was carried out in the Department of Neurology, Bangabandu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2012 to December 2012 on 88 patients with dementia diagnosed on the basis of mini mental state examination and DSM-IV criteria. Results: Vascular dementia was the underlying diagnosis in most of the cases (43.3 %) followed by Alzheimers Disease (20.2%) and Parkinson Disease (9%). Other causes were Mixed Dementia, Intracranial Space Occupying Lesion, Post Encephalitic, Hypoxic Encephalitic, Chronic Subdural Haematoma and Tubercular Meningitis. Conclusion: Vascular dementia is more than Alzheimer’s Dementia in Bangladesh. Multiple vascular risk factors contribute to this. Bangladesh Journal of Neuroscience 2016; Vol. 32 (2): 85-90

Modulation of In Vivo T Cell Activation by an Acetylcholine-Esterase Inhibitor in Patients Chronically Infected with HIV

2007 ◽  
Vol 123 ◽  
pp. S46
Author(s):  
Carlos Cantu-Brito ◽  
Sergio Ivan Valdes-Ferrer ◽  
Jose Crispin ◽  
Francisco Belaunzaran ◽  
Maria Ines Vargas Rojas ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Acetylcholine Esterase ◽  
Acetylcholine Esterase Inhibitor ◽  
Esterase Inhibitor

scholarly journals PENERAPAN ART THERAPY MEMBATIK COLET SEBAGAI UPAYA MEMELIHARA FUNGSI KOGNITIF LANSIA DI POSYANDU BAROKAH, KELURAHAN KLAMPIS NGASEM, KECAMATAN SUKOLILO, KOTA SURABAYA, PROVINSI JAWA TIMUR

2020 ◽  
Vol 6 (1) ◽  
pp. 41-45
Author(s):  
Elida Ulfiana ◽  
Makhfudli ◽  
Kusnul Chotimah ◽  
Zenitha Rani
Keyword(s):  
Cognitive Function ◽  
Art Therapy ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Community Partnership ◽  
Clock Drawing Test ◽  
Drawing Test ◽  
Dementia Prevention ◽  
State Examination ◽  
Partnership Program

Klampis Ngasem is one of the areas in East Surabaya, precisely in Sukolilo sub-district, Surabaya. The target group in the community partnership program (PKM) is the Elderly Posyandu "Barokah" in RW 3. Problems that occur in the Elderly Barokah Posyandu are less varied activities and innovation so that some elderly are less interested and bored to follow routinely as indicated by the presence of the elderly < 75%, the absence of efforts to prevent dementia that is carried out regularly and continue for the elderly, lack of elderly knowledge about changes in cognitive function and efforts to maintain cognitive function so as to prevent dementia, and the availability of leisure time for the elderly in addition to routine posyandu activities and those that have not been utilized to be useful and productive. The solution to overcome these problems is through the application of Art Therapy to make colet batik. The purpose of this community service is to help express themselves, maintain the cognitive function of the elderly and provide new skills in making batik as an activity in the Posyandu Elder Barokah Klampis Ngasem Village. The activities carried out are screening to see the cognitive function of the elderly using Mini mental state examination (MMSE) and clock drawing test (CDT), counseling about prevention of dementia which includes knowing dementia, prevention of dementia, and art therapy, batik colet training with demonstration methods, and simulation. The results of batik colet will be processed again with the help of cadres or the elderly who have sewing skills to be used as sofa pillowcases. From this process, a work or product will be produced from the batik colet method.

scholarly journals Regioselective Asymmetric Alkynylation of N–Alkyl Pyridiniums

2021 ◽  
Author(s):  
Thiago A. Grigolo ◽  
Ariana R. Subhit ◽  
Joel Smith
Keyword(s):  
Asymmetric Synthesis ◽  
Acetylcholine Esterase ◽  
Reaction Conditions ◽  
Asymmetric Addition ◽  
Simple Reaction ◽  
Stereochemical Control ◽  
Acetylcholine Esterase Inhibitor ◽  
Esterase Inhibitor

Disclosed in this communication is a novel asymmetric addition of alkynyl nucleophiles to <i>N</i>-alkyl pyridinium electrophiles. The coupling is effected under mild and simple reaction conditions, affording dihydropyridine products with complete regiochemical and stereochemical control. In addition to several manipulations of the dihyropyridine products, the utility of this transformation is demonstrated through a concise, dearomative, and asymmetric synthesis of (+)-lupinine, a natural acetylcholine esterase inhibitor.

scholarly journals GAMBARAN FUNGSI KOGNITIF PADA PASIEN RAWAT JALAN DENGAN RIWAYAT STROKE DI POLIKLINIK SARAF RSUP PROF. DR. R.D. KANDOU MANADO

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Tirzha N. Paparang ◽  
Corry N. Mahama ◽  
Denny J. Ngantung
Keyword(s):  
Cognitive Function ◽  
Mini Mental State Examination ◽  
Trail Making Test ◽  
Cross Sectional ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test ◽  
Trail Making ◽  
Cross Sectional Design ◽  
State Examination

Abstract: Stroke is a major cause of cognitive dysfunction. The incidences of cognitive dysfunction increase three-fold after strokes, usually involving impairement of abilities in visuo-spacial, memory, orientation, speech, attention, and performance functions. The rapid, practical, and approved examinations used to evaluate and confirm the decline in cognitive functions are the Mini Mental State Examination (MMSE), the Clock Drawing Test (CDT), and the Trail Making Test (TMT). This study aimed to reveal the cognitive functions of outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado by using the above mentioned examinations. This was a descriptive study with a cross-sectional design conducted in November 2012. The results showed that there were 51 respondents who fulfilled the inclusion criteria consisting of 32 males and 19 females. The highest decline of cognitive function by age, the educational level, and employment was 60-79 years, more than 9 years of education, and retired workers, respectively. The results of the MMSE, CDT, and TMT examinations for cognitive impairment evaluation were as follow: MMSE 62.75%, CDT 56.86%, TMT A 96.08%, and TMT B 84.31%. Conclusion: Most of the outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado showed cognitive impairments. Keywords: CDT, cognitive function, MMSE, stroke, TMT-A and B.   Abstrak: Stroke merupakan penyebab utama gangguan fungsi kognitif. Insiden gangguan kognitif meningkat tiga kali lipat setelah stroke, dan biasanya melibatkan kemampuan visuospasial, memori, orientasi, bahasa, perhatian dan fungsi eksekutif. Pemeriksaan yang digunakan untuk mengevaluasi dan mengonfirmasi penurunan  fungsi kognitif yang cepat dan praktis namun bernilai tinggi ialah Mini Mental State Examination (MMSE), Clock Drawing Test (CDT), dan Trail Making Test (TMT). Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado. Penelitian ini bersifat deskriptif dengan cross-sectional design dan dilaksanakan selama bulan November 2012. Hasil penelitian memperlihatkan bahwa 51 responden memenuhi kriteria inklusi, terdiri dari 32 laki-laki dan 19 perempuan. Berdasarkan usia, tingkat pendidikan, dan pekerjaan, penurunan fungsi kognitif terbanyak pada usia 60-79 tahun, tingkat pendidikan terakhir >9 tahun, dan pekerjaan pensiunan. Hasil pemeriksaan MMSE, CDT, dan TMT terhadap fungsi kognitif responden ialah: MMSE 62,75%, CDT 56,86%, TMT A 96,08%, dan TMT B 84,31%. Simpulan: Sebagian besar pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado telah memperlihatkan gagguan fungsi kognitif.Kata kunci: stroke, fungsi kognitif, MMSE, CDT, TMT-A dan B.

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