scholarly journals Pengaruh Perbedaan Konsentrasi Surfaktan Non Ionik terhadap Karaktersitik Niosom Pterostilben

2020 ◽  
Vol 6 (1) ◽  
pp. 21-26
Author(s):  
Kartika Zulfa ◽  
◽  
Ferri Widodo ◽  
Oktavia Eka Puspita ◽  
◽  
...  
Keyword(s):  
Particle Size ◽  
Uv Light ◽  
Gene Mutations ◽  
Ionic Surfactant ◽  
Skin Damage ◽  
Surfactant Vesicles ◽  
Optimum Formulation ◽  
Span 80 ◽  
Span 60 ◽  
Cellular Dna

Excessive radiation from UV light can cause skin damage to melanoma, especially UVB rays. Chronic effects from exposure of excessive UVB rays can induce gene mutations because the exposure of excessive UVB rays directly causes damage to cellular DNA by producing ROS in the epidermis, dermis, and skin epithelium cells. The use of sunscreen is very necessary to prevent skin damage. Sunscreen containing antioxidants are highly recommended to protect the skin from free radicals UVB rays. Pterostilbene is one of the phenolic compounds, which has the pharmacological activity of antioxidants and UV filters to be one of the recommended compounds for sunscreen components. A good delivery system is needed to be formulated to improve the pharmacological effects of pterostilbene on topical use. Niosomes are non-ionic surfactant vesicles which are one of the amphiphilic carrier systems which can carry hydrophobic active ingredients such as pterostilbene, which are expected to increase the pharmacological effect by increasing the penetration of pterostilbene into the skin. Pterostilbene niosome using non-ionic surfactant (span 80 and span 60) by thin layer hydration method. The research aimed to examine the effect of surfactant concentration (span 80 and span 60) 2, 4, and 6 g toward the characterization of niosome pterostilbene and determine the optimum formulation by particle size. The results of the study showed that the particle size was smaller with an increase in span concentration. Based on these results, the optimum formulation of pterostilbene niosomes is obtained using span 60 with a concentration of 6 g.

Acute and Subacute Toxicity of Sorbitan Monostearate (Span 60) Non-ionic Surfactant Vesicles (Niosomes) in Sprague Dawley Rats

2016 ◽  
Vol 14 (2) ◽  
pp. 1-9 ◽  
Author(s):  
Jankie Satish ◽  
Johnson Jenelle ◽  
Pinto-Pereira Lexley ◽  
Adebayo Amusa ◽  
Pillai Gopalakrishna
Keyword(s):  
Sorbitan Monostearate ◽  
Ionic Surfactant ◽  
Sprague Dawley ◽  
Subacute Toxicity ◽  
Surfactant Vesicles ◽  
Sprague Dawley Rats ◽  
Span 60

scholarly journals Optimization study on Niosome Loaded Ficus Deltodia Extract.

2018 ◽  
Vol 192 ◽  
pp. 03025
Author(s):  
Noorazwani Zainol ◽  
Chen Siew Chin ◽  
Nor Rashidah Ahmed ◽  
Noorazwani Zainol ◽  
Azila Abdul Aziz ◽  
...  
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Research Study ◽  
Process Condition ◽  
Entrapment Efficiency ◽  
Skin Penetration ◽  
Ficus Deltoidea ◽  
Optimization Study ◽  
Optimum Formulation ◽  
Span 60

Ficus deltoidea (FD) plant extract is not able to cross the lipidic biomembranes of the skin as they are hydrophilic in nature. In order to overcome this problem FD were encapsulated with noisome, a novel lipid delivery system that potentially increases the absorption. This research study on optimum formulation and process condition of niosome loaded FD extract. The factors involved in formulation were amount of Span 60, amount of cholesterol and amount of Labrasol. Their corresponding responses for the design were entrapment efficiency (EE), particle size (PS) and zeta potential (ZP). The optimum formulation obtained were 0.6 mmol of Span 60, 0.4 of mmol Cholesterol, and 0.1 mmol of Labrasol. Results obtained showed improved activity on skin penetration compared to free FD.

scholarly journals ENHANCED INTESTINAL ABSORPTION AND BIOAVAILABILITY VIA PRONIOSOMES FOR BAZEDOXIFENE ACETATE DRUG

2020 ◽  
pp. 31-42
Author(s):  
SMITHA GANDRA
Keyword(s):  
Particle Size ◽  
Oral Bioavailability ◽  
Ex Vivo ◽  
Angle Of Repose ◽  
In Vivo Studies ◽  
In Vitro Dissolution ◽  
Ionic Surfactant ◽  
Enhanced Absorption ◽  
Span 60

Objective: The main objective of the present study was to develop proniosomal formulations to enhance the oral bioavailability of bazedoxifene acetate by improving solubility, dissolution and intestinal permeability. Methods: Proniosomal powder formulations were prepared with bazedoxifene acetate drug varying the span 60 and cholesterol ratio in the range of 0.8:0.2 to 0.2:0.8 using maltodextrin as carrier by slurry method. The prepared proniosomal powder was filled into capsules. The bioavailability enhancement of proniosomes loaded with drug was studied focusing on non-ionic surfactants composition and drug: span 60 ratio. Prepared proniosomes were characterized for their particle size distribution, zeta potential, entrapment efficiency, in vitro dissolution study and thermal characteristics to understand the phase transition behavior. Further, the formulated proniosomes were subjected to stability behavior, ex vivo permeation studies using rat intestine followed by in vivo studies. Results: Physico-chemical studies among various formulations helped in optimization of batch. Good flow properties confirmed from angle of repose values indicate easy filling into capsules. Enhancement in dissolution is due to incorporation of bazedoxifene acetate into the non-ionic surfactant and change in the physical state from crystalline to amorphous, thus improving oral bioavailability. Solid state characterization studies prove the transformation to amorphous form with small particle size improving permeation. No drug excipient interaction was observed and sample is stable in refrigerated conditions. Ex vivo studies show significant permeation enhancement across gastrointestinal membrane compared to control. Invivo studies proved enhanced absorption of bazedoxifene acetate drug by oral route. Conclusion: In conclusion, proniosomes provide a powerful and functional way of distribution of inadequately soluble bazedoxifene acetate drug which is proved from in vivo studies based on the enhanced oral delivery.

Optimasi Proses Pembuatan dan Karakterisasi Fisik Niosom Sinkonin

2019 ◽  
Vol 16 (2) ◽  
pp. 178
Author(s):  
Hariyanti Hariyanti ◽  
Sophi Damayanti ◽  
Sasanti Tarini
Keyword(s):  
Differential Scanning Calorimetry ◽  
Particle Size ◽  
Hair Follicle ◽  
Scanning Calorimetry ◽  
Span 60

Sinkonin praktis tidak larut dalam air, sedikit larut dalam kloroform dan alkohol. Hal ini berdampak pada rendahnya penetrasi transfollicular sinkonin, karena hanya bahan aktif hidrofilik yang mampu melewati hair follicle. Dengan demikian dibutuhkan satu sistem penghantaran yang mampu menurunkan hidrofobisitas sinkonin untuk meningkatkan penetrasi sinkonin ke follicle. Niosom merupakan vesikel ampifilik dengan struktur lapisan rangkap yang terbentuk dari hidrasi kombinasi surfaktan nonionik dan kolesterol yang mampu menurunkan hidrofobisitas sinkonin. Penelitian ini bertujuan untuk menentukan proses pembuatan niosom sinkonin yang optimum. Pembuatan niosom sinkonin diawali dengan menentukan temperatur gelasi (Tg) dari span 60 dengan Differential Scanning Calorimetry (DSC), kemudian dilanjutkan dengan optimasi proses meliputi: optimasi kecepatan rotavapor pembentukan film lapis tipis, temperatur hidrasi, kecepatan rotavapor hidrasi, waktu hidrasi, dan waktu sonikasi. Karakteristik vesikel niosom yang optimal meliputi: ukuran partikel dan indeks polidispersitas dengan menggunakan Particle Size Analized (PSA) serta efisiensi penjeratan sinkonin dengan menggunakan KCKT. Temperatur gelasi (Tg) span 60 45±2 oC, kecepatan rotavapor pembentukan film lapis tipis niosom 210 rpm, temperatur hidrasi 55±2 oC, kecepatan rotavapor hidrasi 210 rpm, waktu hidrasi 20 menit, waktu sonikasi suspensi niosom 1 menit. Ukuran vesikel yang diperoleh adalah 100–200 nm, indeks polidispersitas 0,2–0,4 dan efisiensi penjeratan niosom sinkonin 84,49±0,0025%. Proses pembuatan niosom sinkonin memiliki pengaruh besar terhadap hasil ukuran vesikel dan efisiensi penjeratan niosom sinkonin.

scholarly journals Awareness of aerosol-related transmission of COVID-19 among the dentists of Nepal

BDJ Open ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Nashib Pandey ◽  
Buddha Bahadur Basnet ◽  
Sushmit Koju ◽  
Anju Khapung ◽  
Alka Gupta
Keyword(s):  
Social Sciences ◽  
Particle Size ◽  
High Efficiency ◽  
Emergency Services ◽  
Uv Light ◽  
Ventilation System ◽  
Age Groups ◽  
Air Filtration ◽  
Online Questionnaire ◽  
Dental Practitioners

Abstract Objective To access the awareness of dental practitioners of Nepal towards COVID-19 transmission through aerosols. Materials and methods The study involved 384 dentists from all over Nepal and was conducted for a period of 3 months. A self-reported online questionnaire was developed using Google forms and the link was shared. It emphasized the awareness related to the aerosol and ventilation system in their daily practices was prepared. The data were analyzed in Statistical Package for Social Sciences version 20.0 software. Results The majority of participants were female 52.9% (n = 203) and within the age groups of <30 years 57% (n = 219). Participants from Bagmati Province were 60.4% (n = 232), with least from Sudurpaschim Province 0.5% (n = 2). 60% of participants provided only emergency services during the COVID-19 pandemic and few (7%) provided consultations via telephone. The current ventilation system used was a well-ventilated room with open windows 65.4% (n = 251). However, 52.8% (n = 203) preferred specialized operatory incorporating high-efficiency particulate air (HEPA) filters and ultraviolet (UV) light. More than 60% of respondents were unaware of the particle size of the aerosol. Conclusions The obtained results signify the need for the proper ventilation system with appropriate air filtration systems in dental clinical setups.

Role of ZnO Nanoparticles for improvement of Antibacterial Activity in Food Packaging

2021 ◽  
pp. 128-131
Author(s):  
Saira Sehar ◽  
Amiza Amiza ◽  
I. H Khan
Keyword(s):  
Antimicrobial Activity ◽  
Particle Size ◽  
Surface Area ◽  
Zno Nanoparticles ◽  
Food Packaging ◽  
Antimicrobial Agents ◽  
Uv Light ◽  
Zno Nps ◽  
Long Time

Nanotechnology advancement leads to development of antimicrobial agents like ZnO nanoparticles. These nanoparticle have their main applications in food packaging. when these nanoparticles incorporate into the food surface, it will kill all bacterias residing on the surface and food become free of bacteria. In this way, food can be stored for a long time because its shelf life is improved. Antimicrobial activity of ZnO nanoparticles can be improved by increasing surface area, reducing particle size and large concentration of ZnO –NPS. Antimicrobial activity increases by increasing intensity of UV light. As UV light fall on ZnO nanoparticles, it increases ZnO surface area and hence anrtimicrobial activity will be increased. Exact mechanism of Antimicrobial activity is still unknown but some processes have been presented.

Cockayne Syndrome: A Cellular Sensitivity to Ultraviolet Light

PEDIATRICS ◽  
1977 ◽  
Vol 60 (2) ◽  
pp. 135-139
Author(s):  
R. D. Schmickel ◽  
E. H. Y. Chu ◽  
J. E. Trosko ◽  
C. C. Chang
Keyword(s):  
Ultraviolet Light ◽  
Uv Light ◽  
Cockayne Syndrome ◽  
Fibroblast Cultures ◽  
Cellular Sensitivity ◽  
X Irradiation ◽  
Increased Sensitivity ◽  
Cellular Dna ◽  
Thymidine Dimer ◽  
Enzymatic Defect

Two unrelated children, a boy 2½ years old and a girl 4 years old, were affected with the cachectic dwarfism of Cockayne syndrome. Fibroblast cultures derived from these patients exhibited increased sensitivity to ultraviolet (UV) light, but not to x-irradiation, as measured by colony-forming ability. In both Cockayne fibroblast cultures, the rate of removal of thymidine dimer from the irradiated cellular DNA was normal. This demonstration of a cellular defect in Cockayne cells suggests that there may be an enzymatic defect in the repair of UV light-induced damage.

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