Analysis of Anti-Mosquito and Antimicrobial Activities of The Extract of Nigella sativa (Black seeds)

: Obesity is associated with many diseases, including diabetes, hypertension, dyslipidemia, coronary heart disease, stroke, fatty liver disease, cancer, osteoarthritis and many others. The prevalence of obesity is increasing every year among the global population. The persons being overweight or obese may consider traditional herbal medicines as a good strategy to manage chronic conditions due to various reasons. Nigella sativa (Black seeds) has been used to treat various conditions, including obesity, diabetes, hypertension, cancer, etc. Hence, the anti-obesity potential of N. sativa is analyzed in this review. The databases, including Medline/PMC/PubMed, Google Scholar, Science Direct, and reference lists, were searched to identify relevant randomized controlled clinical trials. Significant reduction of body weight, body mass index and waist circumference have been observed in many randomized controlled clinical trials (RCTs) by using N. sativa. Hence, the individuals willing to reduce their body weight can effectively use N. sativa along with lifestyle modifications.

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Effect of Black Seeds (Nigella Sativa) on Some Parasitic Diseases: A Review

Central European Journal of Botany ◽

10.13187/cejb.2021.1.3 ◽

2021 ◽

Vol 7 (1) ◽

Keyword(s):

Nigella Sativa ◽

Parasitic Diseases ◽

Black Seeds

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Comparison of Chemical Composition and Antibacterial Activity of Nigella sativa Seed Essential Oils Obtained by Different Extraction Methods

Journal of Food Protection ◽

10.4315/0362-028x-71.12.2475 ◽

2008 ◽

Vol 71 (12) ◽

pp. 2475-2480 ◽

Cited By ~ 47

Author(s):

L. KOKOSKA ◽

J. HAVLIK ◽

I. VALTEROVA ◽

H. SOVOVA ◽

M. SAJFRTOVA ◽

...

Keyword(s):

Gas Chromatography ◽

Essential Oils ◽

Steam Distillation ◽

Nigella Sativa ◽

Antimicrobial Activities ◽

Gas Chromatography Mass Spectrometry ◽

Major Constituent ◽

Chemical Compositions ◽

Gram Positive ◽

Broth Microdilution Method

Nigella sativa L. seed essential oils obtained by hydrodistillation (HD), dry steam distillation (SD), steam distillation of crude oils obtained by solvent extraction (SE-SD), and supercritical fluid extraction (SFE-SD) were tested for their antibacterial activities, using the broth microdilution method and subsequently analyzed by gas chromatography and gas chromatography–mass spectrometry. The results showed that the essential oils tested differed markedly in their chemical compositions and antimicrobial activities. The oils obtained by HD and SD were dominated by p-cymene, whereas the major constituent identified in both volatile fractions obtained by SD of extracted oils was thymoquinone (ranging between 0.36 and 0.38 g/ml, whereas in oils obtained by HD and SD, it constituted only 0.03 and 0.05 g/ml, respectively). Both oils distilled directly from seeds showed lower antimicrobial activity (MICs ≥ 256 and 32 μg/ml for HD and SD, respectively) than those obtained by SE-SD and SFE-SD (MICs ≥ 4 μg/ml). All oil samples were significantly more active against gram-positive than against gram-negative bacteria. Thymoquinone exhibited potent growth-inhibiting activity against gram-positive bacteria, with MICs ranging from 8 to 64 μg/ml.

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