scholarly journals Study on Platelet Indices in Benign Paroxysmal Positional Vertigo

2021 ◽  
Vol 20 (4) ◽  
pp. 141-146
Author(s):  
Byeong Min Lee ◽  
Chae Dong Yim ◽  
Dong Gu Hur ◽  
Seong-Ki Ahn
Keyword(s):  
Benign Paroxysmal Positional Vertigo ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Platelet Indices ◽  
Positional Vertigo ◽  
Common Causes ◽  
And Control ◽  
Paroxysmal Positional Vertigo

Objectives: Benign paroxysmal positional vertigo (BPPV) is one of the most common causes of dizziness. Even though the etiology of BPPV has been widely studied, the exact mechanism remains still unclear. One of the possible factors explaining the pathophysiology of BPPV is ischemia of vestibule. In the present study, we have focused on the platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit (PCT) to assess a risk of vestibule ischemia causing BPPV.Methods: From January 2021 to March 2021, a retrospective review was performed on 39 patients diagnosed with BPPV through vestibular nystagmography. For each platelet indices, a comparative analysis was conducted between the patient group and control group.Results: There were no significant differences when the platelet, MPV, PDW, and PCT values were compared between the study and control group. Rather, the control group showed higher PDW value than the study group.Conclusions: Ischemia of vestibule is one of the well-known causes of BPPV, but the current study showed that BPPV cannot be explained by the vestibule ischemia itself. Further studies are needed to identify the potential of ischemia regarding BPPV by approaching with other methods with a large study group.

scholarly journals Is there a diagnostic value for the platelet indices patients in pulmonary embolism?

2017 ◽  
Vol 25 (2) ◽  
pp. 91-94
Author(s):  
İbrahim Çevik ◽  
Hüseyin Narcı ◽  
Güllü Akbaydoğan Dündar ◽  
Cüneyt Ayrık ◽  
Seyran B Babuş
Keyword(s):  
Pulmonary Embolism ◽  
Mean Platelet Volume ◽  
Area Under The Curve ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Platelet Indices ◽  
Platelet Number ◽  
D Dimer

Background: Pulmonary embolism is a common disease with a high mortality risk. It has recently been reported that platelet indices may be diagnostic in pulmonary embolism. Objective: In this study, we aimed to determine the diagnostic value of platelet indices in acute pulmonary embolism. Methods: The study group was composed of 61 patients diagnosed with pulmonary embolism and a control group of 67 subjects without pulmonary embolism. Patient age, sex, leukocyte and platelet number, hemoglobin concentration (Hb), mean platelet volume, platelet distribution width, red blood cell distribution width, C-reactive protein, D-Dimer, and troponin I levels were retrospectively analyzed and compared between the two groups. Results: There was no significant difference between age and platelet number of pulmonary embolism and control group. In pulmonary embolism group, platelet distribution width level was significantly high (p = 0.002), whereas mean platelet volume level was significantly lower (p = 0.038). Receiver operating characteristic curve analysis revealed that a mean platelet volume cut-off of 9 fL had a sensitivity of 35%, a specificity of 89.55%, and area under the curve of 0.589 for pulmonary embolism, while a platelet distribution width cut-off of 12.8 fL had a sensitivity of 61%, a specificity of 71.64%, and area under the curve of 0.661. Platelet distribution width and D-dimer levels had a significant positive correlation with each other, whereas there was no significant correlation between mean platelet volume and D-dimer. Conclusion: Platelet distribution width values of the pulmonary embolism group were higher than those of control group. Although the area under the curve of platelet distribution width is slightly better than for platelet number or mean platelet volume, it does not seem that this parameter has better diagnostic accuracy than the other two.

scholarly journals Association of platelet count and platelet indices with cranial meningioma

2020 ◽  
pp. 123-126
Author(s):  
Yasar Karatas ◽  
Fatih Keskin ◽  
Mehmet Fatih Erdi ◽  
Bulent Kaya ◽  
Densel Arac ◽  
...  
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Small Sample ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Healthy Group ◽  
Platelet Indices ◽  
Significant Difference

Introduction and Objectives: In this study, we aimed to investigate whether platelet count (PLT) and platelet indices included mean platelet volume (MPV), platecrit (PCT), platelet distribution width  (PDW) values can be used as diagnostic markers in cranial meningiomas. Materials and Methods: The study included results of 29 patient and 47 healthy contributors. Based on pathologies, the patients were divided into two groups. The first group included meningioma patients and the second one included healthy individuals. Healthy contributors named control group. Platelet count and platelet indices were determined using Sysmex XN 550 haematology analyzer. The preoperative platelet count (PLT) and platelet indices included mean platelet volume (MPV), platecrit (PCT), platelet distribution width  (PDW) values were recorded from the routine laboratory tests. Results: There was no statistically significant difference in PLT between the meningioma and healthy groups (p = 0.217). There was a statistically significant difference in PCT between the meningioma group and the healthy group (p = 0.002). There was a statistically significant difference in PDW between meningioma group and healthy group (p = 0.001). In terms of MPV, there was a statistically significant difference between meningioma group and the healthy group (p = 0.001) Conclusion: Platelet count and indices are easily available in the routine blood tests. Despite the retrospective design and small sample size, our findings suggest that altered MPV, PDW and PCT levels might serve as potential biomarkers for the diagnosis of meningiomas.

Residual Dizziness in Elderly Patients after Benign Paroxysmal Positional Vertigo

ORL ◽  
2021 ◽  
pp. 1-8
Author(s):  
Yaser Said Çetin ◽  
Aydın Çağaç ◽  
Ufuk Düzenli ◽  
Nazım Bozan ◽  
Sadi Elasan
Keyword(s):  
Benign Paroxysmal Positional Vertigo ◽  
Negative Impact ◽  
Control Group ◽  
Control Groups ◽  
Positional Vertigo ◽  
Obesity And Diabetes ◽  
Epley Maneuver ◽  
And Control ◽  
Mean Time ◽  
Paroxysmal Positional Vertigo

<b><i>Introduction:</i></b> The aim of this study was to compare the effects of Brandt-Daroff (BD) exercise and shopping exercise (SE) on the resolution of residual dizziness (RD) in patients with benign paroxysmal positional vertigo (BPPV) following a successful modified Epley canalith repositioning maneuver (CRP). <b><i>Methods:</i></b> This single-blind, randomized clinical trial included patients with posterior semicircular canal type of BPPV. Following the modified Epley maneuver, patients that experienced RD were randomly assigned to 3 groups: (i) BD, (ii) SE, and (iii) control groups. Primary outcomes were quantified using the Dizziness Handicap Inventory (DHI). <b><i>Results:</i></b> Following CRP, 240 (63%) participants experienced RD. All these patients were followed up weekly for RD. After the resolution of RD, patients were followed up monthly for recurrence. Mean time to recovery was 16.4 ± 10 (range, 5–49) days in the BD group, 11.5 ± 4.6 (range, 6–32) days in the SE group, and 23.4 ± 16.8 (range, 6–89) days in the control group. The SE group recovered significantly faster than the BD and control groups (<i>p</i> &#x3c; 0.001). Baseline emotional DHI (E-DHI) scores were significantly correlated with the duration of pre-CRP symptoms (<i>p</i> &#x3c; 0.001). Correlation analysis indicated that patients with obesity and diabetes mellitus (DM) recovered later than patients without these comorbidities. <b><i>Conclusion:</i></b> We found that RD improved significantly in the SE group compared to the BD and control groups. Additionally, a significant relationship was established between RD and high anxiety levels and DM, and obesity had a negative impact on the resolution of RD.

Treatment of Benign Paroxysmal Positional Vertigo: Necessity of Postmaneuver Patient Restrictions

2005 ◽  
Vol 16 (06) ◽  
pp. 357-366 ◽  
Author(s):  
Richard A. Roberts ◽  
Richard E. Gans ◽  
Jennifer L. DeBoodt ◽  
Jennifer J. Lister
Keyword(s):  
Benign Paroxysmal Positional Vertigo ◽  
Semicircular Canals ◽  
Control Group ◽  
Positional Vertigo ◽  
Restricted Group ◽  
The One ◽  
And Control ◽  
Activity Restrictions ◽  
Paroxysmal Positional Vertigo

Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo, resulting from migration of otoconia into the semicircular canals. Several treatment methods involving positioning maneuvers that return the otoconia to the utricle have been described. Following treatment, most patients are provided with a variety of activity restrictions. Previous studies suggest that, overall, BPPV treatment may be successful without these restrictions. The purpose of this study was to determine the necessity of postmaneuver restrictions using an experimental and control group with participants matched for age, gender, involved ear, and symptoms. A canalith repositioning maneuver was used to treat the BPPV. During postmaneuver instruction, the 21 participants assigned to the restricted group were provided with typical activity restrictions. Twenty-one participants assigned to the nonrestricted group were given no postmaneuver restrictions. Only one participant in the restricted group and two participants in the nonrestricted group were not clear at the one-week follow-up appointment. Results indicated that postmaneuver restrictions do not improve treatment efficacy.

Analysis of Residual Symptoms after Treatment in Benign Paroxysmal Positional Vertigo Using Questionnaire

2009 ◽  
Vol 141 (2) ◽  
pp. 232-236 ◽  
Author(s):  
No Hee Lee ◽  
Hee Jun Kwon ◽  
Jae Ho Ban
Keyword(s):  
Benign Paroxysmal Positional Vertigo ◽  
Control Group ◽  
Dizziness Handicap Inventory ◽  
Residual Symptoms ◽  
Positional Vertigo ◽  
Canalith Repositioning Procedure ◽  
And Control ◽  
Subsequent Comparison ◽  
Paroxysmal Positional Vertigo

OBJECTIVES: Canalith repositioning procedure (CRP) provides rapid and long-lasting relief of symptoms in most patients with benign paroxysmal positional vertigo. However, some patients express nonspecific symptoms such as anxiety or discomfort after treatment, even after the disappearance of nystagmus and vertigo. The purpose of this study was to assess the residual symptoms after CRP in patients with benign paroxysmal positional vertigo using the Dizziness Handicap Inventory (DHI) in a questionnaire format. STUDY DESIGN AND SETTING: Controlled, prospective study. SUBJECTS AND METHODS: CRP was performed in 135 patients until nystagmus and vertigo disappeared. Patients were asked to complete the questionnaire before and 5 to 7 days after treatment. A control group of 135 normal volunteers was selected and cross-matched according to the age and sex of the patient group. The data were compared for the pre-CRP, post-CRP, and control groups. RESULTS: There was a significant improvement in the DHI scores when comparing the pre- and post-CRP groups ( P = 0.000), although six items showed incomplete improvement. Subsequent comparison of DHI scores between the control group and the post-CRP group still showed a difference in some items so that the improvement was incomplete. CONCLUSION: Even after successful CRPs, Dizziness Handicap Inventory scores indicated that residual subjective symptoms may remain. Thus, additional follow-up and management are important for these patients.

RELATIONSHIP BETWEEN MIGRAINE AND THE OCCURANCE OF BENIGN PAROXYSMAL POSITIONAL VERTIGO (BPPV)

2020 ◽  
Vol 7 (8) ◽  
pp. 70-74
Keyword(s):  
Benign Paroxysmal Positional Vertigo ◽  
Control Group ◽  
Case Group ◽  
Vestibular Disorder ◽  
Inconsistent Result ◽  
Positional Vertigo ◽  
History Of ◽  
And Control ◽  
The Relationship ◽  
Paroxysmal Positional Vertigo

Introduction: Benign Paroxysmal Positional Vertigo (BPPV) is the most common vestibular disorder. Migren also common in general population. Several studies have shown inconsistent result for the relationship between migraine and BPPV.This study aims to determine relationship between migraine and the occurance of BPPV Methode: This case control study selected subjects with consecutive sampling techniques. Sampling was conducted at H. Adam Malik General Hospital Medan and network hospital. Thirty two patients with BPPV were selected as case group and matched with thirty two patients without BPPV as control group. Migraine history was taken in medical record. This study began in March until June 2020. Result: The majority of case and control group were female with eighteen subjects (56.2%) and median age about 60.5 (27-78) years old. We found eight patients (25.0%) with history of migraine in case group and in control group four patients (12,5%) with history of migraine. There is no significance relationship in migraine and the occurance of BPPV with p= 0.33 and OR=2.33 (95% CI = 0.62-8.71) Conclusion: There is no relationship between migraine and the occurance of BPPV.

Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

2021 ◽  
pp. 1-4
Author(s):  
D V K Irugu ◽  
A Singh ◽  
H Yadav ◽  
H Verma ◽  
R Kumar ◽  
...  
Keyword(s):  
Serum Level ◽  
Benign Paroxysmal Positional Vertigo ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Control Group ◽  
Positional Vertigo ◽  
The Difference ◽  
Control Study ◽  
Paroxysmal Positional Vertigo

Abstract Objectives This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals. Method This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18–75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Data analysis was carried out to compare the serum levels in the cases and controls. A p-value less than 0.05 was considered significant. Results A total of 70 age-matched individuals (cases, n = 40; controls, n = 30) were included in the study. The mean serum level of otolin-1 was 636.8 pg/ml (range, 259–981 pg/ml) in the group of patients with benign paroxysmal positional vertigo and 236.2 pg/ml (range, 189–370 pg/ml) in the control group. The difference was statistically significant (p = 0.0000). Conclusion The serum levels of otolin-1 in patients with benign paroxysmal positional vertigo are significantly higher compared with individuals without benign paroxysmal positional vertigo.

scholarly journals Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Zhe Fan ◽  
Jiyong Pan ◽  
Yingyi Zhang ◽  
Ziyi Wang ◽  
Ming Zhu ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Medical Condition ◽  
Roc Curves ◽  
Disease Diagnosis ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Gangrenous Appendicitis ◽  
Wbc Count

Introduction.Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA.Aims.To evaluate whether or not the MPV and PDW are suitable markers to diagnose AGA.Methods.A retrospective study of 160 patients with AGA and 160 healthy patients was undertaken. Disease diagnosis was confirmed based on the pathologic examination of surgical specimens. Patient white blood cell (WBC) count, neutrophil ratio (NR), platelet (PLT) count, MPV, PDW, and hematocrit (HCT) were analyzed. Receiver operating characteristic (ROC) curves were used to evaluate the sensitivity and specificity of these indices in AGA.Results.There were no significant differences between the AGA and control groups in age and gender. Compared to the control group, the WBC count, NR, and PDW were significantly higher (P<0.001, resp.) and the MPV and HCT were significantly lower (P<0.001, resp.) in the AGA group. The diagnostic specificities of the WBC count, NR, PLT count, MPV, PDW, and HCT were 86.3%, 92.5%, 58.1%, 81.7%, 83.9%, and 66.3%, respectively. Therefore, the NR had the highest diagnostic specificity for the diagnosis of AGA.Conclusions.This is the first study to assess the MPV and PDW in patients with AGA. Our present study showed that the MPV is reduced and the PDW is increased in patients with AGA; the sensitivity of PDW was superior to the MPV. A decreased MPV value and an increased PDW could serve as two markers to diagnose AGA. The NR had the highest specificity for the diagnosis of AGA.

scholarly journals A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259543
Author(s):  
Solomon Gebre Bawore ◽  
Wondimagegn Adissu ◽  
Berhanu Niguse ◽  
Yilma Markos Larebo ◽  
Nigussie Abebe Ermolo ◽  
...  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Mean Platelet Volume ◽  
Case Control Study ◽  
Case Control ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Platelet Indices ◽  
Control Study

Introduction Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting. Methods A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant. Results A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1). Conclusions Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.

scholarly journals Common causes of vertigo and dizziness in Gujarat

2016 ◽  
Vol 3 (4) ◽  
pp. 250 ◽  
Author(s):  
Mohan Bansal
Keyword(s):  
Prospective Study ◽  
Benign Paroxysmal Positional Vertigo ◽  
Vestibular Neuritis ◽  
Medical Conditions ◽  
Positional Vertigo ◽  
Common Causes ◽  
Common Ailment ◽  
The Common ◽  
Vestibular Neuronitis ◽  
Paroxysmal Positional Vertigo

<p class="abstract"><strong>Background:</strong> Dizziness is one of the most common complaints in medicine just second to headache. It frightens not only the patient but also frustrates the physicians. There is a long list of causes of dizziness but the common causes vary from place to place. The aim of this study was to know the common causes of dizziness and vertigo in Gujarat to generate the awareness among the doctors who get the patients with this common ailment so that they can better manage dizzy patients.</p><p class="abstract"><strong>Methods:</strong> This prospective study included thirty-five patients with dizziness and vertigo that came to the Department of ENT for their management.</p><p class="abstract"><strong>Results:</strong> Patients were divided into three categories. The first group of patients was having associated cochlear symptoms. Second group patients had isolated vertigo. Third group patients had associated CNS or medical conditions. The largest was the second group (37.5%) of isolated vertigo patients. The commonest diagnosis (18.75%) in this group was benign paroxysmal positional vertigo, followed by acute vestibular neuritis. Meniere’s disease and migraine and its variant were the most common causes in first and third group respectively.  </p><strong>Conclusions:</strong>The overall scenario of causes of dizziness and vertigo in our study follow the international trend. Benign paroxysmal positional vertigo, acute vestibular neuronitis, Menieres disease and migraine were found the most common causes of vertigo.<div> </div>

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