scholarly journals Special peculiarities of clinical course of osteoarthrosis of knee joints depending on 6-hydroxymelatonin-sulfate urinary excretion profile

2018 ◽  
Vol 25 (3) ◽  
Author(s):  
Oksana Humeniuk ◽  
Mykola Stanislavchuk ◽  
Nataliia Zaichko
Keyword(s):  
Urinary Excretion ◽  
Depressive Disorders ◽  
Emotional State ◽  
Clinical Course ◽  
Pain Syndrome ◽  
Knee Joints ◽  
Moderate Increase ◽  
Study Objective ◽  
Physical Functions ◽  
Radiological Stage

The study objective was to define the special features of the clinical course of knee joint osteoarthrosis depending on 6-sulfatoxymelatonin urinaryexcretion profile.Materials and methods.We surveyed 141 patients with radiological Stage II-III osteoarthrosis (OA) of the knee joints (18 female subjects). Diagnosis of OA was established on the basis of ACR criteria (1991) and EULAR (2010) recommendations. We determined the AO clinical indexes (Lequesne, WOMAC, KOOS), HAQ functional index, sleep quality and psycho-emotional state indicators. ELISA was used to assess 6-sulfatoxymelatonin urinary excretion profile.Results. It was established that 66% of patients with OA of knee joints had a reduced 6-sulfatoxymelatonin urinary excretion compared to this of practically healthy individuals. AO patients with low 6-SMT urinary excretion profiles had higher incidence of severe insomnia and depressive disorders. Reduction in 6-SMT excretion was associated with a moderate increase in pain syndrome and deterioration of physical functions by Lequesne, WOMAC, KOOS, and HAQ indexes.Conclusion.The reducedmelatonin production in ОА patients is a factor of more severe clinical course of the disease due to deterioration of the psycho-emotional state, the development of pain syndrome, and functional disorders.

Results of osteopathic correction of patients with post-traumatic coccygodynia

2019 ◽  
pp. 19-27
Author(s):  
Yu. V. Antonova ◽  
A. M. Iskandarov ◽  
I. B. Mizonova
Keyword(s):  
Quality Of Life ◽  
Emotional State ◽  
Pain Syndrome ◽  
Control Group ◽  
Life Questionnaire ◽  
Treatment Area ◽  
Diffi Cult ◽  
Osteopathic Treatment ◽  
Post Traumatic

Introduction.Coccygodynia is a multidisciplinary disease which is diffi cult to treat. It seriously limits the ability to work and signifi cantly affects the quality of life of patients. The study of somatic dysfunctions in patients with coccygodynia and the analysis of the results of osteopathic treatment of such patients makes it possible to justify the necessity of osteopathic correction of coccygodynia.Goal of the study— to determine the structure of the leading somatic dysfunctions in patients with coccygodynia and to study the effectiveness of osteopathic treatment of this pathology.Materials and methods.The study involved 44 patients from 25 to 65 years old, randomly divided into two groups. The main group of 24 people (20 women and 4 men) received osteopathic treatment, in accordance with the identifi ed leading somatic dysfunctions. Patients of the control group (16 women and 4 men) were treated locally with soft manual techniques (the treatment area was limited by the pelvic region). In order to assess the results of the treatment, we examined the intensity of the pain syndrome and the psycho-emotional state of patients. The severity of the pain syndrome was assessed in accordance with the visual analogue scale (VAS). The psycho-emotional state (with physical and mental components) was assessed with the help of the SF-36 quality of life questionnaire.Results.Somatic dysfunctions typical for patients with coccygodynia have been identifi ed. Osteopathic treatment has proven to be more effective in comparison with local manual therapy of coccygodynia both in early periods and in 3 months after the end of the treatment course.Conclusion.Osteopathic treatment of post-traumatic coccygodynia is effective, and can be recommended for treatment of such patients.

Pain Syndrome, Markers of Bone Metabolism in Patients with Osteoarthritis, Approaches to Drug Therapy and the Impact of Obesity

2016 ◽  
pp. 26-35
Author(s):  
Oleksandr Kuryata ◽  
Anna Cherkasova
Keyword(s):  
Neuropathic Pain ◽  
Bone Metabolism ◽  
Clinical Efficacy ◽  
Functional Ability ◽  
Analgesic Effect ◽  
Pain Syndrome ◽  
Knee Joints ◽  
Osteocalcin Level ◽  
Positive Effects ◽  
The Impact

The objective: to assess the nature of pain in patients with osteoarthritis, the impact of obesity on the clinical efficacy of treatment of osteoarthritis (OA) and dynamics of bone metabolism markers. Patients and methods. The research included 150 patients with OA, who were divided into two groups, according to the receiving therapy. Patients of the main group – received diacerein (drug «Flexirin» PC «Kyiv Vitamin Factory») and patients of control group – received only nonsteroidal anti1inflammatory drugs (NSAIDs). Results. The prevalence of neuropathic pain component in patients with OA was 64,7%, among which 80,7% use NSAIDs as an analgesic therapy. Obesity in patients with OA was associated with significantly higher levels of pain from the side of knee joints and higher degree of stiffness according to WOMAC index. The results of the study demonstrated a direct moderate correlation (R = 0,49; p = 0,04) between PICP level and the severity of pain at physical load from the side of hands and hip joints. The therapy by diacerein within 3 months resulted in a reliable decrease of pain syndrome intensity from the side of all articular zones, unlike to isolated NSAIDs use, where a reliable analgesic effect was demonstrated only from the side of knee joints. Obesity in patients with OA led to a significant decrease in clinical efficacy of therapy in point of functional status of the joints. Conclusions. Neuropathic pain is quite common among patients with OA, which at the same time is associated with the lack of patient’s awareness about possible risks during NSAID’s use. Medical treatment by diacerein (drug “Flexirin”) causes stability of osteocalcin level, in contrast to the isolated NSAIDs use, where priority changes have been demonstrated against osteocalcin level decrease. The use of diacerein also resulted to additional positive effects from the side of zonal prevalence of analgesic effect and improving of functional ability of joints. Obesity in patients with OA was associated with a reliable increase of pain level intensity from the side of knee joints and the higher degree of functional limitation, causing at the same time, reduction of clinical efficacy of therapy in point of achieving analgesic effect and improving functional ability of joints.

scholarly journals Developing a Predictive Model for Depressive Disorders Using Stacking Ensemble and Naive Bayesian Nomogram: Using Samples Representing South Korea

2022 ◽  
Vol 12 ◽  
Author(s):  
Haewon Byeon
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Fatty Acid ◽  
Depressive Disorders ◽  
Subjective Health ◽  
Bayesian Regression ◽  
Living Alone ◽  
Study Objective ◽  
Naive Bayesian ◽  
Naïve Bayesian

This study provided baseline data for preventing depression in female older adults living alone by understanding the degree of their depressive disorders and factors affecting these depressive disorders by analyzing epidemiological survey data representing South Koreans. To achieve the study objective, this study explored the main risk factors of depressive disorders using the stacking ensemble machine technique. Moreover, this study developed a nomogram that could help primary physicians easily interpret high-risk groups of depressive disorders in primary care settings based on the major predictors derived from machine learning. This study analyzed 582 female older adults (≥60 years old) living alone. The depressive disorder, a target variable, was measured using the Korean version of Patient Health Questionnaire-9. This study developed five single predictive models (GBM, Random Forest, Adaboost, SVM, XGBoost) and six stacking ensemble models (GBM + Bayesian regression, RandomForest + Bayesian regression, Adaboost + Bayesian regression, SVM + Bayesian regression, XGBoost + Bayesian regression, GBM + RandomForest + Adaboost + SVM + XGBoost + Bayesian regression) to predict depressive disorders. The naive Bayesian nomogram confirmed that stress perception, subjective health, n-6 fatty acid, n-3 fatty acid, mean hours of sitting per day, and mean daily sleep hours were six major variables related to the depressive disorders of female older adults living alone. Based on the results of this study, it is required to evaluate the multiple risk factors for depression including various measurable factors such as social support.

BETA-METHYLCROTONYL-CoA CARBOXYLASE DEFICIENCY: A NEW METABOLIC ERROR IN LEUCINE DEGRADATION

PEDIATRICS ◽  
1972 ◽  
Vol 49 (5) ◽  
pp. 726-735 ◽  
Author(s):  
Oddvar Stokke ◽  
Lorentz Eldjarn ◽  
Egil Jellum ◽  
Helene Pande ◽  
Per Erik Waaler
Keyword(s):  
Urinary Excretion ◽  
Inborn Error ◽  
Clinical Course ◽  
Degradation Pathway ◽  
Neurological Symptoms ◽  
Inborn Error Of Metabolism ◽  
Minimum Requirement ◽  
Leucine Metabolism ◽  
Daily Excretion

A new inborn error of metabolism, characterized by urinary excretion of substantial amounts of β-hydroxyisovaleric acid and β-methylcrotonylglycine, is described. The disorder is most likely due to a defect in the biotin-dependent enzyme β-methylcrotonyl-CoA carboxylase in the leucine degradation pathway. The patient, a 4½-month-old girl, suffered from neurological symptoms similar to those of Werdnig-Hoffmann's disease. No episodes of acidosis could be detected. In periods the urine had a peculiar odor, like that of cat's urine. Relatively large doses of biotin (0.25 mg/day) did not influence the condition. On a diet containing the minimum requirement of leucine, the daily excretion of β-hydroxyisovaleric acid dropped from 400 mg to about 50 mg and β-methylcrotonylglycine from 100 mg to 50 mg. However, the clinical course was unaltered and the patient died at 9 months of age from bronchopneumonia. Biochemically, as well as clinically, the findings are distinctly different from previously described errors in the leucine metabolism.

Urinary excretion of thymine and uracil in a two-year-old child with a malignant tumor of the brain.

1979 ◽  
Vol 25 (7) ◽  
pp. 1325-1328 ◽  
Author(s):  
G Berglund ◽  
J Greter ◽  
S Lindstedt ◽  
G Steen ◽  
J Waldenström ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Urinary Excretion ◽  
Malignant Tumor ◽  
Moderate Increase ◽  
Normal Children ◽  
Cultured Fibroblasts ◽  
The Brain

Abstract A two-year-old boy with a malignant tumor of the brain (medulloblastoma) excreted large amounts of thymine and uracil in his urine. The excretion was related to progress and regress of the disease, and reached a maximum of 3.0 mol of thymine per mole of creatinine and 2.6 mol of uracil per mole of creatinine. The excretion by 20 apparently normal children was less than 0.01 mol/mol of creatinine for each of the two pyrimidines. Three children with brain tumors, two with leukemias, and one with neuroblastoma were also studied; two of them had a moderate increase in urinary pyrimidine excretion, but only up to 0.07 mol/mol of creatinine. The activity of dihydrouracil dehydrogenase (NADP+) (EC 1.3.1.2) in cultured fibroblasts from the patient was somewhat lower than in control fibroblasts. The tumor was considered to be the likely cause of the increased excretion of pyrimidines, but an impaired degradation of pyrimidines in the liver could not be ruled out.

Urinary excretion of IgG and [alpha ]1-microglobulin predicts clinical course better than extent of proteinuria in membranous nephropathy

2001 ◽  
Vol 38 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Claudio Bazzi ◽  
Concetta Petrini ◽  
Virginia Rizza ◽  
Girolamo Arrigo ◽  
Alessandra Beltrame ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Membranous Nephropathy ◽  
Clinical Course ◽  
Better Than

Application of spinal cord stimulation in the treatment of persistent pain in failed back surgery syndrome

2018 ◽  
Vol 20 (2) ◽  
pp. 43-49
Author(s):  
A. В. Dmitriev ◽  
D. A. Rzaev ◽  
N. P. Denisova
Keyword(s):  
Spinal Cord ◽  
Hospital Discharge ◽  
Spinal Cord Stimulation ◽  
Pain Syndrome ◽  
Failed Back Surgery Syndrome ◽  
Drug Resistant ◽  
Neurogenic Pain ◽  
Study Objective ◽  
Failed Back Surgery ◽  
Back Surgery

The study objectiveis to demonstrate our experience of the spinal cord stimulation in the treatment of drug-resistant pain in patients with the failed back surgery syndrome (FBSS) and to evaluate its effectiveness and complications.Materials and methods.Systems for chronic spinal cord stimulation were implanted in 78 patients suffering from FBSS in Federal Neurosurgical Center (Novosibirsk) during 2013–2015. All patients had a drug-resistant neurogenic pain syndrome character and were undergone surgical intervention on the spine. Evaluating of the treatment effectiveness was carried out by visual analogue scale (VAS) and a scale Douleur Neuropathique en 4 Questions (DN4). Catamnesis ranged from 6 to 18 months.Results.The median preoperative VAS score evaluation was 6.7, at hospital discharge – 3.1, after 6 months – 3.2, after 12 months – 3.5, after 18 months – 3.4. Evaluation on a scale DN4 before surgery was 5.3, at hospital discharge – 2.1, after 6 months – 2.4, after 12 months – 2.5, after 18 months – 2.4. Complications in the form of migration, fracture of the electrodes and development of hemorrhage or inflammation at the site of implantation of the system were observed in 12 (15.3 %) cases and required revision surgery.Conclusion.Spinal stimulation is an effective and safe method of treatment of pain in FBSS, but it has specific complications associated with implantable systems.

Efficacy of selective agonist V2 vasopressin receptor, 1-dezamino-8-D-arginine-vasopressin, in the treatment of pain in patients with degenerative-dystrophic diseases of the spine

2016 ◽  
Vol 14 (3) ◽  
pp. 58-65
Author(s):  
Svetlana G. Belokoskova ◽  
Sergei G. Tsikunov
Keyword(s):  
Arginine Vasopressin ◽  
Vertebral Column ◽  
Depressive Disorders ◽  
Pain Syndrome ◽  
Control Group ◽  
Reduction Of Pain ◽  
Therapy Of Pain ◽  
V2 Vasopressin Receptor ◽  
Leading Symptom ◽  
The Impact

Pain is the leading symptom with degenerative-dystrophic diseases of the vertebral column. Now for the treatment of vertebral pain using pharmacological and non-pharmacological treatments. However, in some cases, the application of these techniques is contraindicated or ineffective. In this regard, relevant search for new methods of therapy of pain syndrome. It is known that arginine-vasopressin (AVP), along with the hormonal effects shows properties of neuromodulator. The experiment shows that AVP showed analgetic properties. AVP reduced the severity of pain in patients with renal colic, with migraine, pains due to cancer [24, 36, 37]. There is not data on the impact of AVP on vertebrogenic pain syndrome. In this context, the aim of the research was to assess the effectiveness of the agonist V2-receptors, 1-dezamino-8-D-arginine-vasopressin, DDAVP, in correction of pain syndrome in patients with degenerative-dystrophic diseases of the vertebral column. Treatment received 23 patients. DDAVP is injected intranasal drip in a daily dose of 1•10 -7 g. The control group consisted of 10 patients with vertebral pain who received traditional therapy. Therapeutic effect of DDAVP was in 87 % of cases. Pain decreased after 2.5-3 hours from the beginning of treatment in patients with moderate and mild pain. Along with reduction of pain regressed fatigue-depressive disorders. Thus, it was shown that the DDAVP was effective and safe in the treatment of vertebral pain.

scholarly journals Rehabilitation complex in treatment of chronic pelvic pain syndrome and erectile dysfunction in men

2019 ◽  
Vol 20 (3) ◽  
pp. 66-71
Author(s):  
V. V. Evdokimov ◽  
Sh. R. Satybaldyev ◽  
E. Sh. Satybaldyeva
Keyword(s):  
Erectile Dysfunction ◽  
Treatment Group ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Comparison Group ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Study Objective ◽  
Prostatic Fluid

The study objective is to evaluate the effectiveness of rehabilitation complex in treatment of chronic pelvic pain syndrome in men.Materials and methods. At the Kyrgyz Scientific Research Institute of Balneology and Rehabilitation, Ministry of Health of the Kyrgyz Republic, 86 patients aged between 18 and 55 years with chronic prostatitis, chronic pelvic pain syndrome in remission and erectile dysfunction (ED) were examined. In the treatment group (n = 56), rehabilitation complex (balneotherapy, physiotherapy, ultraviolet irradiation of autologous blood, psychotherapy) was used; in the comparison group (n = 30), only standard therapy was used. Blood and urine were tested; total testosterone, luteinizing, follicle-stimulating hormones were measured; ultrasound and rheography of the prostate and penis, color Doppler ultrasonography of the penile vessels, prostatic fluid cultures, spermogram analysis were performed.Results. In the treatment group, pain syndrome was diagnosed in 52 % of patients, severe ED – in 55 %; in the comparison group, pain syndrome was diagnosed in 33 % of patients, ED – in 23 %. Ultrasound of the prostate in both groups showed diffuse changes of moderate severity. After the rehabilitation complex, all patients of the treatment group showed improvement in general condition and microscopic content of the prostatic fluid, decreased pain syndrome, dysuria, sperm viscosity, increased sperm count, number of sperm with normal morphology and motility. Rheography showed increased volume of pulse blood filling of the lower pelvic organs, venous outflow to the prostate. Frequency of severe ED decreased in the treatment group from 55 to 26 %, in the comparison group – from 23 to 16 %.Conclusion. The results show the positive effect of rehabilitation complex on chronic nonbacterial prostatitis, especially in case of improvement of erectile function.

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