scholarly journals Primary Tumor Size Predicts Distant Metastasis of Mucosal Malignant Melanoma in Head and Neck

2018 ◽  
Vol 38 (11) ◽  
pp. 6485-6490 ◽  
Author(s):  
HIDENORI SUZUKI ◽  
GAKU TAKANO ◽  
NOBUHIRO HANAI ◽  
DAISUKE NISHIKAWA ◽  
YUSUKE KOIDE ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Head And Neck ◽  
Distant Metastasis ◽  
Tumor Size ◽  
Primary Tumor ◽  
Primary Tumor Size ◽  
Mucosal Malignant Melanoma

scholarly journals Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hosu Kim ◽  
Jaehoon Jung ◽  
Young-Seok Cho ◽  
Joon Young Choi ◽  
Hyunju Park ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Distant Metastasis ◽  
Tumor Size ◽  
Primary Tumor ◽  
Differentiated Thyroid Cancer ◽  
Pattern Analysis ◽  
Primary Tumor Size ◽  
Preoperative Serum ◽  
Serum Tsh ◽  
Tsh Levels

AbstractSerum thyrotropin (TSH) level after thyroid surgery affects the prognosis of differentiated thyroid cancer (DTC). However, the effects of preoperative serum TSH levels on the prognosis of DTC remain contradictory. In this study, to better understand the relationship between preoperative TSH levels and the prognosis of DTC, we performed pattern analysis of prognostic factors of DTC according to preoperative serum TSH levels. We retrospectively reviewed the clinical records of patients who were diagnosed and treated for DTC at the Samsung Medical Center, between 1994 and 2016. We reviewed preoperative serum TSH levels and performed a pattern analysis with prognostic risk factors for DTC. For pattern analysis, TSH was divided into 10 groups of equal fractions (TSH decile). We found a linear association between preoperative TSH levels and extra-thyroidal extension and lymph node metastasis. However, primary tumor size and initial distant metastasis showed a bimodal peak, which was similar to the pattern of overall and disease-specific death. We found that preoperative TSH range which showed the lowest mortality rate was about 0.8 to 1.59 mIU/L, which are slightly lower normal TSH levels. Although there was no linear trend, the primary tumor size, initial distant metastasis, and mortality of DTC were closely related with preoperative TSH decile and they showed a bimodal pattern. The results obtained in this study provide additional information for understanding the association between preoperative TSH levels and DTC prognosis.

High dose fraction radiotherapy for mucosal malignant melanoma of the head and neck

1998 ◽  
Vol 10 (4) ◽  
pp. 301-304
Author(s):  
Xiuying Liu ◽  
Huiling Li ◽  
Tianrong Zheng ◽  
Xiangsong Lin
Keyword(s):  
Malignant Melanoma ◽  
Head And Neck ◽  
High Dose ◽  
Mucosal Malignant Melanoma ◽  
Dose Fraction

scholarly journals Comparison of Primary Tumor Size in Stage I and III Epithelial Ovarian Cancer

2018 ◽  
Vol 38 (11) ◽  
pp. 6507-6511 ◽  
Author(s):  
EDGAR PETRU ◽  
CAROLA HUBER ◽  
EVA SAMPL ◽  
JOSEF HAAS
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Tumor Size ◽  
Primary Tumor ◽  
Stage I ◽  
Primary Tumor Size

scholarly journals Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

2002 ◽  
Vol 59 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Brano Topic ◽  
Nebojsa Stankovic ◽  
Dragutin Savjak ◽  
Slavko Grbic
Keyword(s):  
Prognostic Factors ◽  
Breast Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Size ◽  
Primary Tumor ◽  
Suppressor Gene ◽  
Nodal Status ◽  
Primary Tumor Size ◽  
Tumor Suppressor Gene P53

Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma.

Prognostic factors in head and neck mucosal malignant melanoma

2018 ◽  
Vol 45 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Şenol Çomoğlu ◽  
Beldan Polat ◽  
Mehmet Çelik ◽  
Bayram Şahin ◽  
Necati Enver ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Malignant Melanoma ◽  
Head And Neck ◽  
Mucosal Malignant Melanoma

Identification of a subgroup of patients with breast cancer and histologically positive axillary nodes receiving adjuvant chemotherapy who may benefit from postoperative radiotherapy.

1988 ◽  
Vol 6 (7) ◽  
pp. 1107-1117 ◽  
Author(s):  
B Fowble ◽  
R Gray ◽  
K Gilchrist ◽  
R L Goodman ◽  
S Taylor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Tumor Size ◽  
Primary Tumor ◽  
Postoperative Radiotherapy ◽  
Eastern Cooperative Oncology Group ◽  
Distant Metastases ◽  
Primary Tumor Size ◽  
Axillary Nodes ◽  
Postmastectomy Radiation

Risk factors for isolated local-regional (LR) recurrence following mastectomy for breast cancer were analyzed in a review of 627 women entered into Eastern Cooperative Oncology Group (ECOG) adjuvant chemotherapy trials between 1978 and 1982. Premenopausal patients were randomized to cyclophosphamide, methotrexate, and fluorouracil (5-FU) (CMF), cyclophosphamide, methotrexate, 5-FU, and prednisone (CMFP), or cyclophosphamide, methotrexate, 5-FU, prednisone, and tamoxifen (CMFPT). Postmenopausal patients were randomized to observation, CMFP, or CMFPT. Median follow-up time was 4.5 years. At 3 years, 225 patients relapsed and in 70 (31% of failures, 11% of all patients) the initial site was LR without distant metastases. In a multivariate analysis, the risk of an isolated LR recurrence significantly correlated with the number of positive axillary nodes, the primary tumor size, the presence of tumor necrosis, and the number of axillary nodes examined. Factors that significantly discriminated between an isolated LR recurrence and distant metastasis were the number of positive nodes and primary tumor size. Patients with four to seven positive nodes or tumor size greater than or equal to 5 cm had a chance of developing an isolated LR recurrence almost equal to the risk of distant metastases. These findings suggest a potential for improved survival in this subset of patients with the addition of postmastectomy radiation to chemotherapy, and continue to emphasize the presence of a group of patients at high risk for isolated LR recurrence despite adjuvant chemotherapy.

scholarly journals Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 82
Author(s):  
Hidenori Suzuki ◽  
Eiichi Sasaki ◽  
Risa Motai ◽  
Seiya Goto ◽  
Daisuke Nishikawa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Initial Treatment ◽  
Concurrent Chemotherapy ◽  
Carbon Ion Radiotherapy ◽  
Safety And Efficacy ◽  
Carbon Ion ◽  
Mucosal Malignant Melanoma ◽  
Salvage Neck Dissection

Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon–ion radiotherapy with concurrent chemotherapy are not well described, and carbon–ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon–ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis.

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