scholarly journals Infección por Virus del Papiloma Humano y citología cérvico-vaginal en mujeres indígenas del Cañar, Ecuador.

Bionatura ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 934-938
Author(s):  
Julia Irma Carrión Ordoñez ◽  
Yudira Soto Brito ◽  
Maritza Pupo Antúnez ◽  
Rita Loja Chango
Keyword(s):  
Hpv Infection ◽  
Cross Sectional Study ◽  
Single Women ◽  
Hormonal Contraceptives ◽  
Cervical Lesions ◽  
Cross Sectional ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
High Prevalence ◽  
Cytological Alterations

There are few studies on the circulation of Human Papilloma Virus (HPV) in indigenous Ecuadorian women. The aim of the study is to determine the circulation of HPV and identify cytological alterations in cervical samples of indigenous Ecuadorian women and to define the behavior of some socio-demographic and clinical-epidemiological variables. An analytical cross-sectional study was done between July 2017 and September 2018 to determine the presence of cytological alterations and HPV infection in 100 indigenous women between 15 and 55 years of age, residing in Cañar, Ecuador. The association between socio-demographic and clinical-epidemiological variables with viral infection was investigated. Was obtained a 98% of negative cytology for malignancy and 2% of cervical lesions. Cases with high-grade lesions were not diagnosed. In general, a 34% (34/100) tested was positive for HPV, predominating oncogenic genotypes. HPV 31 was the most frequent in 41.2% (14/34) of cases followed by HPV 16 in 20.6% (7/34). Women between 20 and 30 years of age were five times more likely to be infected with HPV (44.1%, 15/34). The frequency of infection was significantly higher in single women and in those who reported having 2 to 3 births. Infection with HPV 16 was associated with the use of hormonal contraceptives, in 57.1% (4/7) of the cases; p = 0.005, RP = 12.44 IC95% (2.40-64.62). The high prevalence of oncogenic HPV infection indicates the need to incorporate this indigenous population into early detection programs for cervical cancer.

scholarly journals Prevalence of human papillomavirus types associated with cervical lesions in Sergipe state, Northeastern Brazil: high frequency of a possibly carcinogenic type

2018 ◽  
Vol 146 (9) ◽  
pp. 1184-1193 ◽  
Author(s):  
I. G. S. S. Serra ◽  
E. D. Araujo ◽  
G. S. Barros ◽  
F. L. S. G. Santos ◽  
R. Q. Gurgel ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Cross Sectional Study ◽  
Geographic Region ◽  
Northeastern Brazil ◽  
Cervical Lesions ◽  
Cross Sectional ◽  
Hpv 16 ◽  
High Prevalence ◽  
Hpv Types

AbstractPersistent infection with high-risk human papillomavirus (HPV) is the main cause of cervical cancer and the prevalence of HPV types varies depending on the geographic region. Therefore, this study assessed the prevalence of HPV types in women with cervical lesions from Sergipe state, Northeastern Brazil. A cross-sectional study was conducted in women with cervical lesions from March to December 2014. These lesions were investigated by PCR and HPV types were identified by DNA sequencing. 432 patients were included, of which 337 patients tested positive for HPV. Eighteen different HPV types were detected, and high-risk HPV types were detected in 69.2%. HPV 16 (63.4%) was the most prevalent HPV type found, followed by HPV 66 (4.6%), HPV 18 (1.6%) and HPV 45 (1.4%). These results highlight the importance of the high prevalence of HPV 66, which is a possibly carcinogenic virus type not covered by the available vaccines. The prevalence of HPV 16 was high in the studied population, reaffirming the importance of young vaccination. However, the high prevalence of HPV 66 found in this study shows the importance of monitoring the diversity of HPV types in different populations and geographic regions to better understand the impacts of current HPV vaccines.

scholarly journals High-risk human papilloma virus infection and cervical neoplasm in female inflammatory bowel disease patients: a cross-sectional study

2019 ◽  
Vol 7 (5) ◽  
pp. 338-344
Author(s):  
Miao Li ◽  
Qing-Fan Yang ◽  
Qian Cao ◽  
Jian Tang ◽  
Yu Gao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Hpv Dna ◽  
Inflammatory Bowel ◽  
High Risk Hpv

Abstract Background and aim This cross-sectional study investigated the prevalence and risk factors of high-risk human papilloma virus (HPV) infection, especially types 16 and 18, and cervical neoplasia in female Inflammatory bowel disease (IBD) patients. Methods From July 2014 to January 2017, sexually active, female, Chinese IBD patients (21–60 years) and age-matched controls underwent cervical ThinPrep cytology testing (TCT) and high-risk HPV-DNA detection, and completed questionnaires about awareness of cervical cancer and HPV. Cervical dysplasia was categorized as cervical intraepithelial neoplasia (CIN) 1, 2 and 3. Results Of 124 IBD patients (30 ulcerative colitis and 94 Crohn’s disease), 17 (13.7%) had high-risk HPV among whom 9 (7.3%) had HPV 16/18 infection and 4 (3.2%) had cervical CIN (3 CIN 3, 1 CIN 1) by pathology. Among 372 controls, 33 (8.9%) had high-risk HPV and only 1 (0.3%) had HPV 16 infection. Cervical TCT detected atypical squamous cells of unknown significance in one control; no control had CIN. The HPV 16/18 infection rate and CIN prevalence were significantly higher in IBD patients than controls (both P < 0.001). The HPV-infection rate was higher in patients administered methotrexate [P = 0.005, odds ratio (95% confidence interval) 4.76 (1.471–15.402)] or more than two immunosuppressants [P = 0.013, odds ratio (95% confidence interval) 3.64 (1.255–10.562)]. Thiopurine, steroid, infliximab and disease behavior/location were not associated with HPV infection. Only 29.3% of patients had undergone cervical-cancer screening. Awareness of HPV infection and HPV-related cervical cancer was poor (28.2%). Conclusions Female IBD patients are at increased risk of high-risk HPV infection and cervical neoplasia, which may be associated with immunosuppressants. Education and routine follow-up with HPV-DNA testing and TCT are recommended, especially in female Chinese IBD patients.

scholarly journals Awareness and Knowledge about Human Papilloma Virus Infection among Students at Secondary Occupational Health School in China

2021 ◽  
Vol 18 (12) ◽  
pp. 6321
Author(s):  
Xin Wang ◽  
Taifeng Du ◽  
Xiaoling Shi ◽  
Kusheng Wu
Keyword(s):  
Occupational Health ◽  
Human Papilloma Virus ◽  
Healthcare Providers ◽  
Human Papilloma Virus Infection ◽  
First Grade ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Causal Link ◽  
Cross Sectional ◽  
Papilloma Virus

Cervical cancer (CC) is one of the most common causes of cancer-related deaths worldwide. CC is mainly caused by human papilloma virus (HPV), which can be prevented by vaccination. We conducted a cross-sectional study in secondary occupational health school (SOHS) through a questionnaire aimed to assess the awareness and knowledge regarding HPV infection of students. A total of 2248 students participated in the survey, 45.3% of them had heard about CC, while only 21.9% of them had heard about HPV; and 74.2% had no idea of the causal link between HPV infection and CC. Most participants displayed poor awareness and knowledge about HPV infection. The results suggested that age, grade, major, academic performance, etc. were correlated with higher awareness of CC, HPV and HPV infection (p < 0.05). In multivariable logistic analysis, third-grade students had the most increased awareness of CC (OR = 17.13, 95%CI: [8.11, 36.15]), HPV (OR = 6.59, 95%CI: [4.16, 10.43]) and HPV vaccine (OR = 2.78, 95%CI: [1.78, 4.32]) when compared to first-grade. Awareness and knowledge regarding HPV infection were insufficient among students in SOHS. As the future healthcare providers, these results highlight the need to supplement targeted education to improve their awareness and knowledge of HPV and vaccination.

scholarly journals Genotypic distribution of human oncogenic papillomaviruses in sexually active women in Burkina Faso: Central, Central-Eastern and Hauts-Bassins regions

2020 ◽  
Vol 11 (1) ◽  
pp. 125-136
Author(s):  
Rogomenoma Alice Ouedraogo ◽  
Théodora Mahoukèdè Zohoncon ◽  
Ina Marie Angèle Traore ◽  
Abdoul Karim Ouattara ◽  
Sindimalgdé Patricia Guigma ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Large Scale ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Sexually Active ◽  
Cervical Lesions ◽  
Cross Sectional ◽  
Genotypic Distribution ◽  
Hpv Genotypes ◽  
Central Eastern

AbstractObjectivethis study was conducted to determine the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women in the general population of three regions of Burkina Faso.MethodThis multicenter, descriptive cross-sectional study involved 1321 sexually active women in five cities in three regions of Burkina Faso: Central, Central-Eastern and Hauts-Bassins regions. After collection of endocervical specimens, pre-cervical lesions were screened by visual inspection with acetic acid and lugol (VIA / VILI). HR-HPV genotypes were characterized by multiplex real-time PCR after extraction of viral DNA.ResultsThe mean age of women was 31.98 ± 10.09 years. The HR-HPV infection in the three regions ranged from 26.16% to 43.26% with 35.42% as overall prevalence in women. The most common HR-HPV genotypes in descending order were: HPV 56, 52, 66, 59, 39, 51, 18, 35. The prevalence of bivalent vaccine genotypes (HPV16 / 18) was 7.83% against 63.78% of genotypes not covered by HPV vaccine; 36.32% (170/468) of women had multiple concomitant HR-HPV infections.Conclusionthis study showed significant regional variation and high prevalence of HR-HPV infection in women. The predominant genotypes differ from those covered by available vaccines in Burkina Faso. These results will help guide our health policies towards better prevention of cervical cancer. The diversity of oncogenic genotypes is sparking a large-scale study in the West African sub-region, particularly in cases of cancer and the introduction of the nonavalent vaccine which includes HPV 52 found among the predominant genotypes in this study.

scholarly journals Women’s Knowledge of Cervical Cancer

2021 ◽  
Author(s):  
Aisha Nasser Al Saadi ◽  
Aisha Hamed Al Muqbali ◽  
Eihab Dawi
Keyword(s):  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Pap Test ◽  
Final Analysis ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Human Papilloma Virus Vaccine ◽  
Cross Sectional ◽  
Papilloma Virus ◽  
Cervical Cancer Risk

Objectives: This study aimed to assess knowledge of cervical cancer and its prevention among Omani women aged 20 to 65 years. Method: This analytic cross-sectional study took place at primary healthcare institutions, in the Al Buraimi governorate, Oman, between November 2018 I believe that in response to comment #5 too much information may have been removed from the Results section, therefore we return the first two paragraphs that were removed to the Results section and make them more concise during the copy editing stage.  and February 2019. The study was carried out on the basis of a predesigned, validated, and self-administered 55 question questionnaire. Results: Data from seven hundred and ninety-one completed questionnaires were included in the final analysis, which represents a response rate of 79.1% of the total. The results of the study indicated that 86.7 percent of surveyed women had previously heard of cervical cancer, and 13.0 per cent assumed the possibility of this disease to affect them in the future. The results showed that women had low awareness of the association between Human Papilloma Virus (HPV) and cervical cancer (24.7%). Participants considered HPV infection and initiation of sexual intercourse at an age younger than 17 years as the lowest risks associated with cervical cancer. The results also indicated that 63.8% of women were unaware of a vaccination 'against HPV related cervical cancer' and many of respondents were unaware of Pap test. Women aged over 30 years, those married, and those with a high level of education were more likely to be aware of cervical cancer. Conclusion: General knowledge of cervical cancer among women aged 20 to 65 years is insufficient. Young women aged 20-30 are largely unaware. Thus, concerted efforts are needed to promote awareness among women in Oman. Keywords: Cervical cancer, risk factor, Human Papilloma Virus, vaccine, Pap test.

scholarly journals Human Papilloma Virus16 and 18 Infection and the Cervical Cytology Changes in Combined Hormonal Contraceptive Users

2018 ◽  
pp. 188
Author(s):  
Merdyana Darkuthni ◽  
Mardiah Tahir ◽  
Josephine L Tumedia
Keyword(s):  
Hormonal Contraceptive ◽  
Cross Sectional Study ◽  
Cervical Cytology ◽  
Hormonal Contraceptives ◽  
Chi Square ◽  
Cross Sectional ◽  
Hpv 16 ◽  
Significant Difference ◽  
Chi Square Test ◽  
Combined Hormonal Contraceptive

    Objective: To evaluate the correlation between HPV-16 and 18infection and the cervical cytology changes among combinationhormonal contraceptives users.   Methods: A cross-sectional study involved 40 women usingcombined hormonal contraceptive (oral or injection/DMPA contraceptive)and 40 women of non-hormonal contraceptive users wasconducted in Dr. Wahidin Sudirohusodo hospital, some affiliatedhospitals of Department of Obstetrics and Gynecology Faculty ofMedicine, Universitas Hasanuddin and a private clinic in Makassarfrom November 2015 and April 2016. HPV 16 and 18 genotypingin cervix using PCR method and cervical cytology changes usingliquid-based cytology (LBC) method were performed. HPV infectionand cervical cytology changes were analysis based on Fisher’s testand chi-square test.   Results: A significant difference found only in parity (p<0.05)between users and control of baseline characteristics. Neither usersnor control were significantly associated with HPV-16 and 18infection and changes in cervical cytology.   Conclusion: Combined hormonal contraceptives are not correlatedwith HPV-16 and 18 infection and changes in cervical cytology. Keywords: cervix, combined hormonal contraceptive, human papillomavirus

scholarly journals Cervical Dysplasia and High-Risk Human Papillomavirus Infections among HIV-Infected and HIV-Uninfected Adolescent Females in South Africa

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
David H. Adler ◽  
Melissa Wallace ◽  
Thola Bennie ◽  
Megan Mrubata ◽  
Beau Abar ◽  
...  
Keyword(s):  
High Risk ◽  
Pap Smear ◽  
Cervical Dysplasia ◽  
Pap Test ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Cervical Lesions ◽  
Cross Sectional ◽  
Hpv Dna ◽  
Increased Risk

Background.HIV-infected adolescents may be at higher risk for high-grade cervical lesions than HIV-uninfected adolescents. The purpose of this study was to compare the prevalence of high-risk HPV (HR-HPV) infections and Pap smear abnormalities between these two groups.Methods.In this cross-sectional study, we compared the HPV DNA and Pap smear results between 35 HIV-infected and 50 HIV-uninfected adolescents in order to determine the prevalence of HR-HPV genotypes and cervical cytological abnormalities. Comparisons were made using Pearsonχ2and independent-samplest-tests analyses, and associations between demographic and behavioral characteristics and HPV infections were examined.Results.HIV-infected participants were more likely to be infected with any HPV (88.6% versus 48.0%;P<0.001) and with at least one HR-HPV (60.0% versus 24.0%;P=0.001), and to have multiple concurrent HPV infections (68.6% versus 22.0%;P<0.001). HPV 16 and 18 were relatively underrepresented among HR-HPV infections. Abnormal Pap test results were more common among HIV-infected participants (28.8% versus 12.0%;P=0.054). A history of smoking was associated with HR-HPV infection.Conclusions.HIV-infected adolescents have an increased risk of infection with HR-HPV and of Pap test abnormalities. The majority of HR-HPV infections among our participants would not be prevented by the currently available vaccinations against HPV.

scholarly journals The prevalence of human papillomavirus and bacterial vaginosis among young women in China: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenyu Lin ◽  
Qiaoyu Zhang ◽  
Yaojia Chen ◽  
Lihua Chen ◽  
Binhua Dong ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Bacterial Vaginosis ◽  
Chinese Women ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Cervical Lesions ◽  
Dot Blot ◽  
Cross Sectional ◽  
Hpv Test ◽  
History Of

Abstract Background The natural history of human papillomavirus (HPV) is influenced by vaginal microenvironment disorders, such as bacterial vaginosis (BV). The objective of this study was to assess the epidemiology of HPV combined with BV prevalence among Chinese women aged 20–35 years. Methods A total of 2000 sexually active women aged 20–35 years voluntarily enrolled in this study and underwent a ThinPrep cytologic test and PCR-reverse dot blot human papillomavirus genotyping (PCR-RDB HPV test). BV was diagnosed if clue cells were observed (20% more than epithelial cells). Results The overall HPV infection rate in this population was 16.2% (324/2000). Compared with HPV-negative individuals, BV prevalence was higher in the High-risk human papillomavirus (HR-HPV) (5.9% vs. 3.1%, P < 0.001). BV and HPV-51, -52 infection were more commonly associated with each other. In patients with cervical lesions (≥ CIN 1), the BV prevalence rate was higher than in patients with negative for intraepithelial lesion or malignancy (NILM) (11.9% vs. 3.8%, P = 0.002). Conclusion BV was found to be related to HPV-51, -52 infections and cervical lesions. To better manage HPV infected population, more attention should be paid to the prevention and proper treatment of BV.

scholarly journals Genotyping of Human Papilloma Virus (HPV) in female condyloma acuminata patient in Dr. Soetomo Hospital, Surabaya

2019 ◽  
Author(s):  
Afria Arista ◽  
Dwi Murtiastutik ◽  
Trisniartami Setyaningrum ◽  
Gondo Mastutik
Keyword(s):  
Human Papilloma Virus ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Condyloma Acuminata ◽  
Multiple Infection ◽  
Transmitted Infection ◽  
Cross Sectional ◽  
Papilloma Virus ◽  
Sexually Transmitted ◽  
Polymerase Chain

Human Papilloma Virus (HPV) cause the most common sexually transmitted infection in women. HPV may lead to clinical manifestation as condyloma acuminata. The type of HPV are divided into two categories: low risk and high risk. Objective: To determine the type of HPV in female condyloma acuminata patient. Material and methods: A cross sectional study was conducted in Dermatology Venereology Outpatient Clinic Dr. Soetomo Hospital Surabaya from February, 2007 to May, 2007. A total of 13 female patients with condyloma acuminata were includ in this study. Nucleic acids amplification assays (Polymerase Chain Reaction) used to detect the HPV infection. Results: Condyloma acuminata mostly caused by HPV-11 (30,76%) and HPV-6 (23,07%). Only 1 patient in this study caused by HPV 18. 38% of condyloma acuminata in this study caused by multiple infection of HPV. Conclusion: Molecular assay are gold standard to identification of HPV in the condyloma acuminata patient.

scholarly journals Evaluation of Dynamic Thiol-Disulfide Homeostasis on Hpv Positive-Women in Progression to Cervical Intraepithelial Lesion

2021 ◽  
Author(s):  
Recep Erin ◽  
Yeşim Bayoğlu Tekin ◽  
Hatice Küçük ◽  
Özcan Erel
Keyword(s):  
Precancerous Lesions ◽  
Study Groups ◽  
Systemic Circulation ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Cervical Lesion ◽  
Cervical Lesions ◽  
Cross Sectional ◽  
Hpv Dna ◽  
Total Thiol

Abstract PURPOSE: Dynamic thiol disulfide homeostasis (TDH) is critical in cervical carcinogenesis at HPV infection as a sign of antioxidant consumption native and total thiol levels decrease in progress to cervical intraepithelial lesions. TDH is the main actor in signaling pathways, apoptosis, antioxidant and detoxification reactions. In this study, we aimed to evaluate the effect of TDH intraepithelial progression of cervical precancerous lesions on HPV positive women.METHODS: This was a prospective cross-sectional study. Subjects were selected from newly diagnosed high risk HPV DNA-positive patients. TDH results were calculated as the levels of disulfide, native and total thiol, the ratios of disulfide/total thiol (SS/SH+SS), disulfide/native thiol (SS/SH) and native thiol/total thiol (SH/SH+SS).RESULTS: A total of 146 women were included in the study. Study groups were as group one; control included 66 participants, group two; HPV DNA-positive women without preinvasive cervical lesion included 30 participants and group three; HPV DNA-positive women with preinvasive cervical lesion included 50 participants. Native and total thiol levels were elevated on HPV-positive women without preinvasive cervical lesions. There were no significant differences between groups related to the ratios of SS/SH, SS/ Total SH, SH/ Total SH levels. CONCLUSIONS: HPV infection related to oxidative stress has effects on oxidant/antioxidant balance and could be demonstrated in systemic circulation by TDH parameters. Consumption of thiol substances play role in the cervical neoplastic process, replacement with antioxidants would be a treatment option for HPV infections.

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