Clinical Applications of Mobile Health Wearable–Based Sleep Monitoring: Systematic Review (Preprint)

BACKGROUND Sleep disorders are a major public health issue. Nearly 1 in 2 people experience sleep disturbances during their lifetime, with a potential harmful impact on well-being and physical and mental health. OBJECTIVE The aim of this study was to better understand the clinical applications of wearable-based sleep monitoring; therefore, we conducted a review of the literature, including feasibility studies and clinical trials on this topic. METHODS We searched PubMed, PsycINFO, ScienceDirect, the Cochrane Library, Scopus, and the Web of Science through June 2019. We created the list of keywords based on 2 domains: wearables and sleep. The primary selection criterion was the reporting of clinical trials using wearable devices for sleep recording in adults. RESULTS The initial search identified 645 articles; 19 articles meeting the inclusion criteria were included in the final analysis. In all, 4 categories of the selected articles appeared. Of the 19 studies in this review, 58 % (11/19) were comparison studies with the gold standard, 21% (4/19) were feasibility studies, 15% (3/19) were population comparison studies, and 5% (1/19) assessed the impact of sleep disorders in the clinic. The samples were heterogeneous in size, ranging from 1 to 15,839 patients. Our review shows that mobile-health (mHealth) wearable–based sleep monitoring is feasible. However, we identified some major limitations to the reliability of wearable-based monitoring methods compared with polysomnography. CONCLUSIONS This review showed that wearables provide acceptable sleep monitoring but with poor reliability. However, wearable mHealth devices appear to be promising tools for ecological monitoring.

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Clinical Applications of Mobile Health Wearable–Based Sleep Monitoring: Systematic Review

JMIR mhealth and uhealth ◽

10.2196/10733 ◽

2020 ◽

Vol 8 (4) ◽

pp. e10733 ◽

Cited By ~ 9

Author(s):

Elise Guillodo ◽

Christophe Lemey ◽

Mathieu Simonnet ◽

Michel Walter ◽

Enrique Baca-García ◽

...

Keyword(s):

Clinical Trials ◽

Sleep Disorders ◽

Mobile Health ◽

Selection Criterion ◽

Feasibility Studies ◽

Well Being ◽

Clinical Applications ◽

Cochrane Library ◽

Sleep Monitoring ◽

The Impact

Background Sleep disorders are a major public health issue. Nearly 1 in 2 people experience sleep disturbances during their lifetime, with a potential harmful impact on well-being and physical and mental health. Objective The aim of this study was to better understand the clinical applications of wearable-based sleep monitoring; therefore, we conducted a review of the literature, including feasibility studies and clinical trials on this topic. Methods We searched PubMed, PsycINFO, ScienceDirect, the Cochrane Library, Scopus, and the Web of Science through June 2019. We created the list of keywords based on 2 domains: wearables and sleep. The primary selection criterion was the reporting of clinical trials using wearable devices for sleep recording in adults. Results The initial search identified 645 articles; 19 articles meeting the inclusion criteria were included in the final analysis. In all, 4 categories of the selected articles appeared. Of the 19 studies in this review, 58 % (11/19) were comparison studies with the gold standard, 21% (4/19) were feasibility studies, 15% (3/19) were population comparison studies, and 5% (1/19) assessed the impact of sleep disorders in the clinic. The samples were heterogeneous in size, ranging from 1 to 15,839 patients. Our review shows that mobile-health (mHealth) wearable–based sleep monitoring is feasible. However, we identified some major limitations to the reliability of wearable-based monitoring methods compared with polysomnography. Conclusions This review showed that wearables provide acceptable sleep monitoring but with poor reliability. However, wearable mHealth devices appear to be promising tools for ecological monitoring.

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Sleep monitoring and wearables : a systematic review of clinical trials and future applications (Preprint)

10.2196/preprints.13044 ◽

2018 ◽

Author(s):

Elise Guillodo ◽

Christophe Lemey ◽

Mathieu Simmonet ◽

Juliette Ropars ◽

Sofian Berrouiguet

Keyword(s):

Clinical Trials ◽

Sleep Disorders ◽

Feasibility Studies ◽

Well Being ◽

Cochrane Library ◽

Public Health Issue ◽

Review Of The Literature ◽

Sleep Monitoring ◽

Wide Range ◽

The Impact

BACKGROUND Sleep disorders are a major public health issue. Nearly one in two people will experience sleep disturbances during lifetime with a potential harmful impact on well-being, physical and mental health. The rise of connected objects is bringing new opportunities in sleep monitoring. OBJECTIVE To better understand the clinical value wearables-based sleep monitoring, we conducted a review of the literature, including feasibility studies and clinical trials on this topic. METHODS We searched PubMed, PsycINFO, ScienceDirect, the Cochrane Library, Scopus, and Web of Science up to June 2017. We created the list of keywords based on two domains: wearables and sleep. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses to identify, select, and critically appraise relevant research while minimizing bias. RESULTS The initial research collected 255 articles. 18 articles meeting the inclusion criteria were included in the final analysis. Out of the selected articles, four categories appeared. Feasibility studies propose testing new connected tools during sleep, on small samples of subjects. Population comparison studies propose to evaluate the sleep of patients compared to that of healthy subjects. Several studies evaluated connected objects in comparison with polysomnography, a reference test in sleep assessment. Finally, an article evaluates the impact of sleep disorders in the clinic. CONCLUSIONS We conducted a broad analysis of studies on the clinical and technical aspects of the use of wearables for sleep monitoring. This review of the literature showed that wearables are acceptable and promising monitoring tools in a wide range of clinical applications for sleep monitoring.

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Opportunities and challenges of incorporating clinical outcome assessments in brain tumor clinical trials

Neuro-Oncology Practice ◽

10.1093/nop/npy032 ◽

2018 ◽

Vol 6 (2) ◽

pp. 81-92 ◽

Cited By ~ 1

Author(s):

Emanuela Molinari ◽

Tito R Mendoza ◽

Mark R Gilbert

Keyword(s):

Clinical Trials ◽

Brain Tumor ◽

Clinical Outcome ◽

Clinical Trial Design ◽

Well Being ◽

Successful Implementation ◽

Outcome Assessments ◽

Tumor Studies ◽

Clinical Outcome Assessments ◽

The Impact

Abstract Regulatory agencies have progressively emphasized the importance of assessing broader aspects of patient well-being to better define therapeutic gain. As a result, clinical outcome assessments (COAs) are increasingly used to evaluate the impact, both positive and negative, of cancer treatments and in some instances have played a major factor in the regulatory approval of drugs. Challenges remain, however, in the routine incorporation of these measures in cancer clinical trials, particularly in brain tumor studies. Factors unique to brain tumor patients such as cognitive decline and language dysfunction may hamper their successful implementation. Study designs often relegated these outcome measures to exploratory endpoints, further compromising data completion. New strategies are needed to maximize the complementary information that COAs could add to clinical trials alongside more traditional measures such as progression-free and overall survival. The routine incorporation of COAs as either primary or secondary objectives with attention to minimizing missing data should define a novel clinical trial design. We provide a review of the approaches, challenges, and opportunities for incorporating COAs into brain tumor clinical research, providing a perspective for integrating these measures into clinical trials.

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A Review of Marital Intimacy-Enhancing Interventions among Married Individuals

Global Journal of Health Science ◽

10.5539/gjhs.v8n8p74 ◽

2015 ◽

Vol 8 (8) ◽

pp. 74 ◽

Cited By ~ 4

Author(s):

Maryam Kardan-Souraki ◽

Zeinab Hamzehgardeshi ◽

Ismail Asadpour ◽

Reza Ali Mohammadpour ◽

Soghra Khani

Keyword(s):

Clinical Trials ◽

Randomized Controlled Trials ◽

Cochrane Library ◽

Controlled Trials ◽

Main Concern ◽

Care Providers ◽

Marital Intimacy ◽

Randomized Controlled ◽

The Impact

BACKGROUND: Lack of intimacy is currently the main concern rather than main concern of the experts in psychology and counseling. It is considered as one of the most important causes for divorce and as such to improve marital intimacy a great number of interventions have been proposed in the literature. Intimacy training and counseling make the couples take effective and successful steps to increase marital intimacy. No study has reviewed the interventions promoting marital intimacy after marriage. Thus, this review study aimed to classify the articles investigating the impact of interventional programs on marital intimacy after marriage.SEARCH METHODS: In April 2015, we performed a general search in Google Scholar search engines, and then we did an advanced search the databases of Science Direct, ProQuest, SID, Magiran, Irandoc, Pubmed, Scopus, <a href="http://www.cochranelibrary.com/">Cochrane Library</a>, and Psych info; Cumulative Index to Nursing and Allied Health Literature (CINAHL). Also, lists of the references of the relevant articles were reviewed for additional citations. Using Medical Subject Headings (MESH) keywords: Intervention (Clinical Trials, Non-Randomized Controlled Trials, Randomized Controlled Trials, Education), intimacy, marital (Marriage) and selected related articles to the study objective were from 1995 to April 2015. Clinical trials that evaluated one or more behavioral interventions to improve marital intimacy were reviewed in the study.MAIN RESULTS: 39 trials met the inclusion criteria. Eleven interventions had follow-up, and 28 interventions lacked follow-up. The quality evidence for 22 interventions was low, for 15 interventions moderate, and for one intervention was considered high. Findings from studies were categorized in 11 categories as the intimacy promoting interventions in dimensions of emotional, psychological, physical, sexual, temporal, communicational, social and recreational, aesthetic, spiritual, intellectual intimacy, and total intimacy.AUTHORS’ CONCLUSIONS: Improving and promoting communication, problem solving, self-disclosure and empathic response skills and sexual education and counseling in the form of cognitive-behavioral techniques and based on religious and cultural context of each society, an effective step can be taken to enhance marital intimacy and strengthen family bonds and stability. Health care providers should consider which interventions are appropriate to the couple characteristics and their relationships.

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Impact of clinicopathological features on survival in patients treated with immune-based combinations for metastatic urothelial carcinoma: A meta-analysis of randomized clinical trials.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e16534 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e16534-e16534

Author(s):

Veronica Mollica ◽

Alessandro Rizzo ◽

Matteo Santoni ◽

Andrea Marchetti ◽

Matteo Rosellini ◽

...

Keyword(s):

Clinical Trials ◽

Liver Metastases ◽

Urothelial Carcinoma ◽

Meta Analysis ◽

Clinicopathological Features ◽

Cochrane Library ◽

Risk Of Death ◽

Metastatic Urothelial Carcinoma ◽

Ecog Ps ◽

The Impact

e16534 Background: Immune checkpoint inhibitors (ICIs) have recently revolutionized the treatment landscape of metastatic urothelial carcinoma (mUC). Nonetheless, little is known regarding the impact of clinicopathological features in this setting. We performed a meta-analysis aiming to evaluate the predictive value of ECOG-PS, age, gender, liver metastases, and histology in randomized controlled trials (RCTs) comparing ICI-based combinations versus chemotherapy in mUC patients. Methods: We retrieved all the relevant RCTs through PubMed/Med, Cochrane library, and EMBASE; additionally, proceedings of the main international oncological meetings were also searched for relevant abstracts. Eligible studies included RCTs comparing ICI-based combinations versus chemotherapy alone in mUC patients. The primary endpoint was overall survival (OS), measured as hazard ratio (HR) with corresponding 95% confidence interval (CI). All statistical analyses were performed using R studio software. Results: Overall, 1032 mUC patients were included in the analysis. Compared with chemotherapy, ICI-based combinations significantly decreased the risk of death in several clinicopathological subgroups, including no liver metastases (HR, 0.84; 95% CI, 0.74-0.95) and ECOG-PS 0 patients (HR, 0.84; 95% CI, 0.72-0.97). Similarly, ICI-based combinations were associated with prolonged OS in mUC patients who were < 65 years old (HR, 0.82; 95% CI, 0.72-0.95), as well as in male (HR, 0.90; 95% CI, 0.82-0.99) and female patients (HR, 0.81; 95% CI, 0.68-0.97). Conversely, a non-statistically significant benefit was observed for chemotherapy alone in mUC patients with liver metastases (HR, 1.06; 95% CI, 0.86-1.31). Conclusions: According to our results, the magnitude of benefit of ICI-based combinations over chemotherapy in mUC was consistent across a number of clinicopathological subgroups, while a proportion of patients could respond to chemotherapy alone.Despite several limitations affect our analysis, we believe these results could guide in everyday treatment decision-making, also assisting in the design and interpretation of future clinical trials on ICIs in mUC.

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Mobile health interventions to promote physical activity and reduce sedentary behaviour in the workplace: A systematic review

Digital Health ◽

10.1177/2055207619839883 ◽

2019 ◽

Vol 5 ◽

pp. 205520761983988 ◽

Cited By ~ 24

Author(s):

Sarah Ann Buckingham ◽

Andrew James Williams ◽

Karyn Morrissey ◽

Lisa Price ◽

John Harrison

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Sedentary Behaviour ◽

Mobile Health ◽

Technology Use ◽

Methodological Quality ◽

Experimental Studies ◽

Cochrane Library ◽

Behaviour Change Techniques ◽

The Impact

Objective This systematic review aimed to assess the effectiveness, feasibility and acceptability of mobile health (mHealth) technology (including wearable activity monitors and smartphone applications) for promoting physical activity (PA) and reducing sedentary behaviour (SB) in workplace settings. Methods Systematic searches were conducted in seven electronic databases (MEDLINE, SPORTDiscus, Scopus, EMBASE, PsycINFO, Web of Science and the Cochrane library). Studies were included if mHealth was a major intervention component, PA/SB was a primary outcome, and participants were recruited and/or the intervention was delivered in the workplace. Study quality was assessed using the Effective Public Health Practice Project (EPHPP) tool. Interventions were coded for behaviour change techniques (BCTs) using the Coventry, Aberdeen and London – Refined (CALO-RE) taxonomy. Results Twenty-five experimental and quasi-experimental studies were included. Studies were highly heterogeneous and only one was rated as ‘strong’ methodological quality. Common BCTs included self-monitoring, feedback, goal-setting and social comparison. A total of 14/25 (56%) studies reported a significant increase in PA, and 4/10 (40%) reported a significant reduction in sedentary time; 11/16 (69%) studies reported a significant impact on secondary outcomes including reductions in weight, systolic blood pressure and total cholesterol. While overall acceptability was high, a large decline in technology use and engagement was observed over time. Conclusions While methodological quality was generally weak, there is reasonable evidence for mHealth in a workplace context as a feasible, acceptable and effective tool to promote PA. The impact in the longer term and on SB is less clear. Higher quality, mixed methods studies are needed to explore the reasons for decline in engagement with time and the longer-term potential of mHealth in workplace interventions. Protocol registration: The review protocol was registered with PROSPERO: CRD42017058856

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Acupuncture Treatments for Post-stroke Depression: A Systematic Review and Network Meta-analysis

10.21203/rs.3.rs-951353/v1 ◽

2021 ◽

Author(s):

Lam Wai Ching ◽

Hui Juan Li ◽

Jianwen Guo ◽

Liang Yao ◽

Janita Chau ◽

...

Keyword(s):

Clinical Trials ◽

Randomized Clinical Trials ◽

Rating Scale ◽

Meta Analysis ◽

Cochrane Library ◽

Depression Symptoms ◽

Post Stroke ◽

Significant Difference ◽

Post Stroke Depression ◽

The Impact

Abstract Background: Depression is one of the most common complications after stroke, with a prevalence of 30-33%. Patients with post-stroke depression (PSD) usually experience anxiety, hopelessness, and insomnia, which have a negative impact on their daily activities and post-stroke rehabilitation. In this review, we aimed to explore the impact of acupuncture in alleviating symptoms of PSD and to evaluate the difference in effectiveness between acupuncture combined with pharmacotherapies and various non-pharmacotherapies in order to provide guides and advice for clinical personnel. Methods: Six databases (Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP Database) and two clinical trials registration platforms were searched from inception to May 2021. Randomized clinical trials (RCTs) comparing needle-based acupuncture with pharmacotherapy, and other non-pharmacotherapy or invalid group were included. Two independent reviewers identified eligible studies. Two reviewers independently abstracted and recorded data into a pre-made form. A Bayesian network meta-analysis (NMA) was conducted to assess and compare different techniques using RStudio 3.6.0. The primary outcome was the change in scores of scales measuring depressive symptoms. The secondary outcomes were changes in serotonin levels and in quality of life. Results: Fifty-nine RCTs were included. The results of this NMA showed that compared with western medicine (WM), acupuncture alone or with repetitive transcranial magnetic stimulation (RTMS), Traditional Chinese medicine (TCM) alone or with WM, were superior for alleviating depression symptoms. Compared to Usual Care, acupuncture alone or plus other therapies could significantly decrease scores of the Hamilton Depression Rating scale. However, there was no significant difference found among acupuncture, WM, TCM with AC plus any of other treatment.Conclusions: The results of this study indicate that acupuncture alone or combined with other therapies appear to be effective in improving depression symptoms of stroke survivors. Moreover, in comparison with WM, acupuncture alone or plus RTMS, TCM, TCM with WM, or WM, were more effective in improving depression symptoms. Also, acupuncture with RTMS seems to be the most effective with the highest probability.

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Life under COVID-19 for LGBT+ people in the UK: systematic review of UK research on the impact of COVID-19 on sexual and gender minority populations

BMJ Open ◽

10.1136/bmjopen-2021-050092 ◽

2021 ◽

Vol 11 (7) ◽

pp. e050092

Author(s):

Victoria J McGowan ◽

Hayley J Lowther ◽

Catherine Meads

Keyword(s):

Mental Health ◽

Sexual Orientation ◽

Gender Identity ◽

Well Being ◽

Cochrane Library ◽

Gender Minority ◽

Sexual And Gender Minority ◽

And Gender ◽

The Impact ◽

Health And Well Being

ObjectiveTo systematically review all published and unpublished evidence on the impact of the COVID-19 pandemic on the health and well-being of UK sexual and gender minority (LGBT+; lesbian, gay, bisexual, transgender, non-binary, intersex and queer) people.MethodsAny relevant studies with or without comparator were included, with outcomes of: COVID-19 incidence, hospitalisation rates, illness severity, death rates, other health and well-being. Six databases (platforms) were searched—CINAHL Plus (Ovid), Cochrane Central (Cochrane Library), Medline (Ovid), Embase (Ovid), Science Citation Index (Web of Science) and Scopus between 2019 and 2020 in December 2020, using synonyms for sexual and gender minorities and COVID-19 search terms. Data extraction and quality assessment (using the relevant Joanna Briggs checklist) were in duplicate with differences resolved through discussion. Results were tabulated and synthesis was through narrative description.ResultsNo published research was found on any outcomes. Eleven grey literature reports found to be of low quality were included, mostly conducted by small LGBT+ charities. Only four had heterosexual/cisgender comparators. Mental health and well-being, health behaviours, safety, social connectedness and access to routine healthcare all showed poorer or worse outcomes than comparators.ConclusionsLack of research gives significant concern, given pre-existing health inequities. Social and structural factors may have contributed to poorer outcomes (mental health, well-being and access to healthcare). Paucity of evidence is driven by lack of routinely collected sexual orientation and gender identity data, possibly resulting from institutional homophobia/transphobia which needs to be addressed. Men are more at risk of serious illness from COVID-19 than women, so using data from trans women and men might have started to answer questions around whether higher rates were due to sex hormone or chromosomal effects. Routine data collection on sexual orientation and gender identity is required to examine the extent to which COVID-19 is widening pre-existing health inequalities.PROSPERO registration numberCRD42020224304.

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The Impact of Social Prescribing on Mental Health: A Protocol for Two Randomised Wait-List Controlled Feasibility Studies, Social Prescribing in Mental Health Study (SPRING) and Mental Health Through Social Prescribing Project (PROSPECT)

10.21203/rs.3.rs-612412/v1 ◽

2021 ◽

Author(s):

Megan Elliott ◽

Mark Llewellyn ◽

Carolyn Wallace ◽

Sarah Wallace ◽

E Mark Williams

Keyword(s):

Mental Health ◽

Clinical Trials ◽

Service Use ◽

Well Being ◽

Health Study ◽

Randomised Control Trial ◽

Wait List ◽

Social Prescribing ◽

The Impact ◽

Health And Well Being

Abstract BackgroundSocial prescribing aims to connect citizens with sources of support in their communities to benefit their health and well-being. Despite its ongoing implementation within the United Kingdom, the evidence base for social prescribing has been criticised, citing a lack of rigour, high risk of bias and inconclusive findings to date.MethodsThis study protocol aims to examine the feasibility of using large, randomised control studies to assess the mental health and well-being impacts of social prescribing. Two wait-list control studies, each consisting of two parallel arm groups, SPRING and PROPSECT were designed. Participants were referred via their consulting healthcare professionals. The participants were randomised to receive the intervention immediately or after a delay of four weeks. The intervention in the SPRING study was a personal “what-matters” interview by a Link Worker consultation leading to a prescribed social service. Three month and six month follow up of service use was proposed. In PROPSECT, the intervention was a holistic social prescribing service. In both trials the primary outcomes were quality of life, service uptake, and participant experience.DiscussionSocial prescribing is becoming popular in community health and care services. It is believed to be an effective resource, and this is first randomised control trial to attempt to demonstrate the effectiveness of social prescribing for people with Mental Health and/or emotional well-being issues. A waiting-list control study is feasible in this context but would be suitable for larger randomised controlled trials.Trial Registration: SPRING, Clinical Trials, NCT04062903. Registered 17th September 2019, https://clinicaltrials.gov/ct2/show/NCT04062903?term=NCT04062903&draw=2&rank=1. PROSPECT, Clinical Trials, NCT04099095. Registered 23rd September 2019, https://clinicaltrials.gov/ct2/show/NCT04099095?term=NCT04099095&draw=2&rank=1

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The Impact of Virtual Nature Therapy on Stress Responses: A Systematic Qualitative Review

Forests ◽

10.3390/f12121776 ◽

2021 ◽

Vol 12 (12) ◽

pp. 1776

Author(s):

Sharifah Shuthairah Syed Abdullah ◽

Dayang Rohaya Awang Rambli ◽

Suziah Sulaiman ◽

Emad Alyan ◽

Frederic Merienne ◽

...

Keyword(s):

Stress Reduction ◽

Stress Responses ◽

Well Being ◽

Cochrane Library ◽

Original Research ◽

Natural Environments ◽

Stress Levels ◽

Stress Therapy ◽

Meta Analyses ◽

The Impact

This study aims to review the key findings of past studies that assessed the impact of virtual environments, such as nature and forests for stress therapy. Previous research has found that virtual reality (VR) experiences affect socio-affective behavior, indicating the potential of using VR for cognitive and psychological stress therapy. However, evidence for the impacts of virtual forest therapy as a stress-reduction technique is lacking, and the usefulness of these techniques has yet to be determined. This review was carried out following the preferred reporting items for meta-analyses and systematic reviews. It summarized the literature and provided evidence on virtual forest therapy (VFT) effectiveness in stress relief. We conducted a literature search considering VR-related studies published from 2013 until June 2021 for different databases, including Embase, Medline/PubMed, Hindawi, ScienceDirect, Scopus, Web of Science, Taylor & Francis, and the Cochrane Library, to see how effective VFT reduces stress levels and improves mental well-being. According to the set inclusion criteria, eighteen relevant papers detailing original research were eligible for inclusion. This overview suggests that VR provides benefits for assessing and reducing stress levels. While real natural environments effectively promote recovery from stress, virtual exposure to nature also positively affects stress. Thus, VR could be an effective technique for promoting relaxation, particularly during the COVID-19 pandemic, where stress levels rise globally. However, more in-depth studies are required to substantiate this potential field of VR relaxation.

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