scholarly journals The Suppressive effect of Potassium Iodine and Propylthiouracil on the Capacity of Reproductive System and Adrenal Gland in Female Rats

2016 ◽  
Vol 14 (2) ◽  
pp. 46-52
Author(s):  
N.L. Basalaeva ◽  
P.I. Garbuzov ◽  
S.V. Strizhikov ◽  
Ju.M. Kuznetsova
Keyword(s):  
Adrenal Gland ◽  
Reproductive System ◽  
Suppressive Effect ◽  
Female Rats ◽  
Potassium Iodine

Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in rats

Reproduction ◽  
2000 ◽  
pp. 151-156 ◽  
Author(s):  
E Diaz ◽  
D Pazo ◽  
AI Esquifino ◽  
B Diaz
Keyword(s):  
Body Weight ◽  
Reproductive System ◽  
Plasma Concentrations ◽  
Pituitary Hormones ◽  
Female Rats ◽  
Control Groups ◽  
Melatonin Treatment ◽  
Exogenous Melatonin ◽  
Reproductive Axis ◽  
Effect Of Age

The effect of age and melatonin on the activity of the neuroendocrine reproductive system was studied in young cyclic (3-5 months-old), and old acyclic (23-25 month-old) female rats. Pituitary responsiveness to a bolus of GnRH (50 ng per 100 g body weight) was assessed at both reproductive stages in control and melatonin-treated (150 micrograms melatonin per 100 g body weight each day for 1 month) groups. After this experiment, female rats were treated for another month to study the influence of ageing and melatonin on the reproductive axis. Plasma LH, FSH, prolactin, oestradiol and progesterone were measured. A positive LH response to GnRH was observed in both control groups (cyclic and acyclic). However, a response of greater magnitude was observed in old acyclic rats. Melatonin treatment reduced this increased response in acyclic rats and produced a pituitary responsiveness similar to that of young cyclic rats. FSH secretion was independent of GnRH administration in all groups, indicating desynchronization between LH and FSH secretion in response to GnRH in young animals and during senescence. No effect on prolactin was observed. Significantly higher LH (3009.11 +/- 1275.08 pg ml(-1); P < 0.05) and FSH concentrations (5879.28 +/- 1631.68 pg ml(-1); P < 0.01) were seen in acyclic control rats. After melatonin treatment, LH (811.11 +/- 89.71 pg ml(-1)) and FSH concentrations (2070 +/- 301.62 pg ml(-1)) decreased to amounts similar to those observed in young cyclic rats. However, plasma concentrations of oestradiol and progesterone were not reduced. In conclusion, the results of the present study indicate that, during ageing, the effect of melatonin is exerted primarily at the hypothalamo-pituitary axis rather than on the ovary. Melatonin restored the basal concentrations of pituitary hormones and pituitary responsiveness to similar values to those observed in young rats.

THE EFFECT OF ADRENOCORTICOTROPHIN ON THE NUCLEIC ACID METABOLISM OF THE RAT ADRENAL GLAND

1965 ◽  
Vol 32 (3) ◽  
pp. 303-312 ◽  
Author(s):  
R. C. IMRIE ◽  
T. R. RAMAIAH ◽  
F. ANTONI ◽  
W. C. HUTCHISON
Keyword(s):  
Nucleic Acid ◽  
Adrenal Gland ◽  
Dna Content ◽  
Adrenal Glands ◽  
Acid Metabolism ◽  
Female Rats ◽  
Nucleic Acid Metabolism ◽  
Prolonged Administration ◽  
Total Rna ◽  
Rna And Dna

SUMMARY Treatment of female rats with adrenocorticotrophin (ACTH) increased the RNA content of the adrenal glands progressively during a period of 3 days, the DNA content increased only after prolonged administration. By contrast, ACTH caused a decrease in the uptake of [32P]orthophosphate into the total RNA of the gland and into most of the RNA fractions of the subcellular components. A method of analysis for RNA and DNA based on the Schmidt-Thannhauser procedure has been evolved which eliminates extraction of nucleic acid by lipid solvents.

scholarly journals Pup removal suppresses estrogen-induced surges of LH secretion and activation of GnRH neurons in lactating rats

2006 ◽  
Vol 191 (1) ◽  
pp. 339-348 ◽  
Author(s):  
Atsushi Fukushima ◽  
Ping Yin ◽  
Maho Ishida ◽  
Nobuhiro Sugiyama ◽  
Jun Arita
Keyword(s):  
Third Ventricle ◽  
Acute Effect ◽  
Suppressive Effect ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Indwelling Catheter ◽  
Lh Surge ◽  
Gnrh Neurons ◽  
Double Immunohistochemical Staining ◽  
Lh Secretion

During lactation, the suckling stimulus exerts profound influences on neuroendocrine regulation in nursing rats. We examined the acute effect of pup removal on the estrogen-induced surge of LH secretion in ovariectomized lactating rats. Lactating and nonlactating cyclic female rats were given an estradiol-containing capsule after ovariectomy, and blood samples were collected through an indwelling catheter for serum LH determinations. In lactating, freely suckled ovariectomized rats, estrogen treatment induced an afternoon LH surge with a magnitude and timing comparable to those seen in nonlactating rats. Removal of pups from the lactating rats at 0900, 1100, or 1300 h, but not at 1500 h, suppressed the estrogen-induced surge that normally occurs in the afternoon of the same day. The suppressive effect of pup removal at 0900 h was completely abolished when the pups were returned by 1400 h. In contrast, pup removal was ineffective in abolishing the stimulatory effect of progesterone on LH surges. Double immunohistochemical staining for gonadotropin-releasing hormone (GnRH) and c-Fos, a marker for neuronal activation, revealed a decrease, concomitantly with the suppression of LH surges, in the number of c-Fos-immunoreactive GnRH neurons in the preoptic regions of nonsuckled rats. An LH surge was restored in nonsuckled rats when 0.1 μg oxytocin was injected into the third ventricle three times at 1-h intervals during pup removal. These results suggest that the GnRH surge generator of lactating rats requires the suckling stimulus that is not involved in nonlactating cyclic female rats.

Effects of metformin on the reproductive system of androgenized female rats

2011 ◽  
Vol 95 (4) ◽  
pp. 1507-1509 ◽  
Author(s):  
Roberta Rassi Mahamed ◽  
Carla Cristina Maganhin ◽  
Ricardo Santos Simões ◽  
Manuel de Jesus Simões ◽  
Edmund Chada Baracat ◽  
...  
Keyword(s):  
Reproductive System ◽  
Female Rats

Influence of Intracerebral Progesterone on the Reproductive System of Female Rats

Endocrinology ◽  
1969 ◽  
Vol 85 (6) ◽  
pp. 1129-1136 ◽  
Author(s):  
ERLA R. SMITH ◽  
RICHARD F. WEICK ◽  
JULIAN M. DAVIDSON
Keyword(s):  
Reproductive System ◽  
Female Rats

EFFECTS OF ADRENALECTOMY ON THE RELEASE OF FOLLICLE-STIMULATING HORMONE AND THE ONSET OF PUBERTY IN FEMALE RATS

1977 ◽  
Vol 75 (3) ◽  
pp. 419-426 ◽  
Author(s):  
H. M. A. MEIJS-ROELOFS ◽  
P. KRAMER
Keyword(s):  
Body Weight ◽  
Adrenal Gland ◽  
Follicle Stimulating Hormone ◽  
The Body ◽  
Biologically Active ◽  
Female Rats ◽  
Vaginal Opening ◽  
Uterine Weight ◽  
Body Weights ◽  
Adrenalectomized Rats

The involvement of the adrenal gland in the release of gonadotrophins and the onset of puberty in female rats was studied. Two and four days after adrenalectomy (ADX) on either day 5 or 10 after birth, a significant decrease in the concentration of FSH was found; 4 days after ADX on either day 15 or 20, FSH concentrations had increased significantly compared with sham-operated and/or intact controls. However, in the rats adrenalectomized on day 15 or 20, the body weights were lower than in control rats. Relative uterine weights (mg/100 g body wt) in adrenalectomized rats never differed from those of control rats. A delay in the time at which vaginal opening and the first oestrus occurred was found in rats adrenalectomized at 20 or 25 days of age; however this delay was accompanied in these rats by a retardation in the gain in body weight. It is argued that the effects of ADX on both the release of gonadotrophins and the onset of puberty are primarily, and presumably exclusively, due to the effects on general bodily development (expressed in body weight). The lack of effect of ADX on uterine weight supports the hypothesis that 'oestrogen-like' products from the adrenal gland are not biologically active as oestrogens.

THE STIMULATORY EFFECT OF PARACETAMOL AND ITS DERIVATIVES ON GROWTH AND THE RAT TIBIA TEST

1966 ◽  
Vol 36 (3) ◽  
pp. 257-NP ◽  
Author(s):  
S. DIKSTEIN ◽  
M. GROTTO ◽  
U. ZOR ◽  
M. TAMARI ◽  
F. G. SULMAN
Keyword(s):  
Food Intake ◽  
Adrenal Gland ◽  
Female Rats ◽  
Activity Relationship ◽  
Intact Female ◽  
Cartilage Growth ◽  
Structure Activity ◽  
Epiphysial Cartilage ◽  
Rat Tibia ◽  
Adrenalectomized Rats

SUMMARY Paracetamol (N-acetyl-p-aminophenol) given i.p. in doses of 3–20 mg./kg./24 hr. stimulated epiphysial cartilage growth in intact female rats. This stimulation was not a result of increased food intake. It may be mediated by the adrenal gland, since paracetamol stimulated cartilage growth in thyroidectomized but not in adrenalectomized rats. Of 12 paracetamol derivatives tested, most did not affect cartilage growth or were less active than paracetamol. A structure-activity relationship could be established. Our results suggest that the mechanism of the stimulatory effect of paracetamol on growth may be twofold: the drug probably stimulates somatotrophin (STH) production and/or potentiates STH action on growth.

scholarly journals ВПЛИВ ГЛУТАМАТУ МАНГАНУ НА РЕПРОДУКТИВНУ ФУНКЦІЮ ТА ЕМБРІОГЕНЕЗ ЩУРІВ

2015 ◽  
Vol 5 (03) ◽  
pp. 8-17
Author(s):  
O. V. Shtapenko ◽  
I. I. Hevkan ◽  
Yu. I. Slyvchuk ◽  
V. I. Syrvatka ◽  
S. V. Fyodorova
Keyword(s):  
Reproductive System ◽  
Essential Element ◽  
Experimental Results ◽  
Female Rats ◽  
Relative Mass ◽  
Control Group ◽  
Female Rat ◽  
Liposomal Form ◽  
High Biological Activity ◽  
Control Female

<p>Pregnancy is associated with increased nutritional needs due to the physiologic changes of the female and the metabolic demands of the embryo/fetus. The use of chelating compounds with high biological activity increased the fertility of female rats by stimulation metabolism and functional activity of the reproductive system. Manganese is an essential element utilized by antioxidants, including superoxide dismutase (MnSOD), and others metalloenzymes that take part in reduction reactions, in multiple physiological processes including reproductive system. The aim of the research was to determine the effect of subcutaneous injections of Mn glutamate in liposomal forms on the reproductive system and the process of embryogenesis of experimental female rat.</p> <p>The study was conducted on female rats aged 2.5-3 months with body weight of 180-200 g. Rats with dated gestation were divided into three groups: two experimental and control. Female rabbits of the 1<sup>th</sup> experimental group were subcutaneous injected of 2 mg/ml for Mn glutamate in liposomal form one week before fertilization and the animals of the 2<sup>th</sup> group were obtained the same preparation during fertilization. Rats were euthanized on the twentieth day, ovariens were singled out of fiber, visual inspection and counting the number of yellow bodies were performed, absolute and relative mass indexes were determined, Mn glutamate influence index was calculated.</p> <p>Experimental results showed that the administration of Mn glutamate 7 days before fertilization and during fertilization significant increased the number of corpora lutea of pregnancy (p&lt;0,001), number of live fetuses (p&lt;0,001) due to the decrease in general and pre-implantation embryonic mortality compared with the control group. The experimental results showed improvement in key indicators of embryonic development. We observed significant increase in the number of implanted embryos on 1 female at 10,7±0,26 and 11,3±0,21 (p&lt;0,001) (9,4±0,16 vs. control group) and decrease of the number of resorption in the female rats treated with Mn glutamate as compared with the control group. The results suggest a beneficial effect on the course of Mn glutamate embryogenesis of experimental animals.</p> <p><em>Key words: glutamate manganese, pregnancy, embryogenesis, liposomal preparation</em></p>

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