Correction of Vitamin D Deficiency and its Effects on Immunologic and Metabolic Disorders in Young Children Who Often Suffer from Respiratory Diseases

AbstractVitamin D deficiency is an under-recognized cause of motor delays in infants and young children. Retrospective chart review identified 17 infants, 11 boys and 6 girls, aged between 7 and 27 months with motor delays attributable to vitamin D deficiency. Diagnosis of vitamin D deficiency was made on the basis of clinical, radiological, and biochemical findings. Presenting symptoms were delay in motor milestones in 14 and hypocalcemic seizures in 3. On physical examination, clinical signs of rickets were present in all. Neurological examination displayed hypotonia with retained tendon reflexes. Thirteen and ten infants, respectively, underwent radiographical and biochemical investigations, and all had abnormalities consistent with rickets. All infants were treated with 6,00,000 IU of vitamin D. Four infants were lost to follow-up. Rapid recovery of motor development was observed in remaining 13 infants. Vitamin D deficiency should be considered in the differential diagnosis of motor delays in infants and young children.

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Are There Hallmarks of Child Abuse? I. Osseous Injuries

Academic Forensic Pathology ◽

10.23907/2016.056 ◽

2016 ◽

Vol 6 (4) ◽

pp. 568-590

Author(s):

Alfredo Walker ◽

Charis Kepron ◽

Christopher M. Milroy

Keyword(s):

Vitamin D ◽

Child Abuse ◽

Young Children ◽

Vitamin D Deficiency ◽

Bone Disease ◽

Metabolic Bone Disease ◽

Rib Fractures ◽

Metabolic Bone ◽

Deficiency Rickets ◽

Metaphyseal Fractures

Fractures are commonly found in cases regarded as child abuse. The most commonly encountered fractures are to the ribs and the metaphyses. This paper examines the specificity of the classical metaphyseal lesion (CML) and rib fractures as hallmarks of child abuse. Recently, vitamin D deficiency (rickets) has been proposed as an alternative cause for the appearances typically described in CML. The literature in this area is examined. Rib fractures have also been highly associated with child abuse, particularly posterior rib fractures. As well as metabolic bone disease, resuscitation has been examined as a cause of rib fractures in young children. The current literature remains strongly supportive of rib fractures and metaphyseal fractures being indicators of child abuse.

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Vitamin D Status among Young Children Aged 6 to 23 Months from 4 Different Ethnic Groups in Yunnan, China

Food and Nutrition Bulletin ◽

10.1177/0379572118765825 ◽

2018 ◽

Vol 39 (2) ◽

pp. 260-265

Author(s):

Yanhong Li ◽

Yan Li ◽

Xian Zhang ◽

Lin Zhao ◽

Liqin Chen ◽

...

Keyword(s):

Vitamin D ◽

Young Children ◽

Vitamin D Deficiency ◽

Ethnic Groups ◽

Venous Blood ◽

Hydroxyvitamin D ◽

Significant Difference ◽

25 Hydroxyvitamin D ◽

The Mean ◽

Venous Blood Sampling

Objectives: To determine the prevalence of vitamin D deficiency in 6- to 23-month-old children from 4 different ethnic groups, Han, Lisu, Hani, and Bai, in Yunnan Province of China. Methods: A large cohort of 938 young children aged 6 to 23 months who were living in Yunnan, China (23°28′-27°52′ N), were selected and recruited in this study. Venous-blood sampling was conducted in all the participants, and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. The children’s physical status was measured. Results: General mean serum 25(OH)D level was 21.46 ± 7.95 ng/mL, which was obtained from a total of 938 cases. No significant difference was found in age, gender, height, and weight of participants from different ethnic groups. The mean 25(OH)D level was significantly lower in children of Lisu ethnic groups compared with that of Han and Hani participants, respectively ( P < .05). In addition, Bai children had lower 25(OH)D content than Hani children ( P < .001). Among the children with 25(OH)D sufficiency, the number of Lisu participants was significantly lower than Han children ( P < .001). Conclusion: The prevalence of vitamin D deficiency varied among the ethnically different children in Yunnan, China, and significantly fewer Lisu children maintained vitamin D sufficiency compared with other ethnic children. Recognizing these ethnic differences in treating children with vitamin D deficiency may improve the therapeutic outcome.

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Independent association between air pollutants and vitamin D deficiency in young children in Isfahan, Iran

Paediatrics and International Child Health ◽

10.1179/2046905513y.0000000080 ◽

2013 ◽

Vol 34 (1) ◽

pp. 50-55 ◽

Cited By ~ 27

Author(s):

Roya Kelishadi ◽

Roksana Moeini ◽

Parinaz Poursafa ◽

Sanam Farajian ◽

Hosseinali Yousefy ◽

...

Keyword(s):

Vitamin D ◽

Young Children ◽

Vitamin D Deficiency ◽

Air Pollutants ◽

Independent Association

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Optimization of pharmacotherapy of patients with prostate adenoma with hormonal and metabolic disordes: correction of vitamin D deficiency with “Aquadetrim”

Research Results in Pharmacology ◽

10.3897/rrpharmacology.5.49414 ◽

2019 ◽

Vol 5 (4) ◽

pp. 57-67

Author(s):

Oleg I. Bratchikov ◽

Igor A. Tyuzikov ◽

Sergey O. Artishchev

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Metabolic Disorders ◽

Main Group ◽

Integrative Approach ◽

Control Group ◽

Practical Algorithms ◽

Prostate Adenoma ◽

Local Parameters

Introduction: Modern studies demonstrate an epidemiological and pathogenetic role of systemic hormonal and metabolic disorders in men with prostate adenoma (PA), so it is obvious that a pharmacotherapeutic correction of these disorders can increase the efficacy of the traditional therapy of the disease. Aim of study: To investigate the frequency, relationships among themselves and with PA local parameters of key systemic hormonal and metabolic disorders (obesity, insulin resistance, testosterone deficiency, vitamin D deficiency) and to develop practical algorithms for optimizing diagnosis and management based on an integrative approach. Material and Methods: The results of a comprehensive examination of 160 patients with PA (main group; average age 62.3 ± 4.2 years) and 30 healthy men without PA of the same age (control group), including: collection of anamnesis and complaints; questionnaires; physical, hormonal and sonographic studies, – are presented. Pharmacotherapeutic correction methods were tested in some patients of the main group. The data was processed using descriptive and comparative statistics. Results and Discussion: In the patients with PA, a significantly higher frequency of concomitant systemic hormonal and metabolic disorders formed at a younger age was established, compared to the men without PA, and significantly worse local characteristics of PA compared to the patients with PA without such (p < 0.05). Reliable connections of some studied systemic hormonal and metabolic disorders with one another and with local parameters of PA (p < 0.05) were revealed. A more severe vitamin D deficiency in the patients with PA compared to the control group was revealed, and the safety and a significant positive effect of its drug compensation on the parameters of hormonal and metabolic status and PA in D-deficient men with PA were shown (p < 0.05). Conclusion: The results of the study confirm an important role of the studied systemic hormonal and metabolic disorders in the pathogenesis of PA and the need for their diagnosis and pharmacotherapeutic correction in all patients with PA on the basis of an integrative approach, according to the proposed algorithms.

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Comparison of 300,000 and 600,000 IU Oral Vitamin-D Bolus for Vitamin-D Deficiency in Young Children

The Indian Journal of Pediatrics ◽

10.1007/s12098-016-2233-9 ◽

2016 ◽

Vol 84 (2) ◽

pp. 111-116 ◽

Cited By ~ 7

Author(s):

Jiyalal Harnot ◽

Sanjay Verma ◽

Sunit Singhi ◽

Naveen Sankhyan ◽

Naresh Sachdeva ◽

...

Keyword(s):

Vitamin D ◽

Young Children ◽

Vitamin D Deficiency ◽

Oral Vitamin

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High prevalence of vitamin D deficiency and its association with metabolic disorders in elderly patients

Family Medicine & Primary Care Review ◽

10.5114/fmpcr.2017.70809 ◽

2017 ◽

Vol 19 (4) ◽

pp. 372-376 ◽

Cited By ~ 1

Author(s):

Małgorzata Koziarska-Rościszewska ◽

Jacek Rysz ◽

Mariusz Stępień

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

Vitamin D Deficiency ◽

Metabolic Disorders ◽

High Prevalence

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Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy

Scientific Reports ◽

10.1038/s41598-021-85531-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jie Zhang ◽

Min Feng ◽

Lisha Pan ◽

Feng Wang ◽

Pengfei Wu ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Weight Loss ◽

Sleeve Gastrectomy ◽

Vitamin D Deficiency ◽

Hepatic Steatosis ◽

Metabolic Disorders ◽

Obese Mice ◽

Vertical Sleeve Gastrectomy ◽

Obesity And Diabetes

AbstractVertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries for the remission of obesity and diabetes. Its effects include weight loss, improved insulin resistance, and the improvement of hepatic steatosis. Epidemiologic studies demonstrated that vitamin D deficiency (VDD) is associated with many diseases, including obesity. To explore the role of vitamin D in metabolic disorders for patients with obesity after VSG. We established a murine model of diet-induced obesity + VDD, and we performed VSGs to investigate VDD's effects on the improvement of metabolic disorders present in post-VSG obese mice. We observed that in HFD mice, the concentration of VitD3 is four fold of HFD + VDD one. In the post-VSG obese mice, VDD attenuated the improvements of hepatic steatosis, insulin resistance, intestinal inflammation and permeability, the maintenance of weight loss, the reduction of fat loss, and the restoration of intestinal flora that were weakened. Our results suggest that in post-VSG obese mice, maintaining a normal level of vitamin D plays an important role in maintaining the improvement of metabolic disorders.

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