scholarly journals A NEW PHENOLIC COMPOUND FROM ACETONE EXTRACT OF LICHEN Usnea flexuosa Tayl.

2011 ◽  
Vol 11 (3) ◽  
pp. 290-294
Author(s):  
Maulidiyah Maulidiyah ◽  
A. Herry Cahyana ◽  
Wahyudi Priyono Suwarso
Keyword(s):  
Natural Product ◽  
Phenolic Compound ◽  
Usnic Acid ◽  
Spectroscopic Studies ◽  
Acetone Extract ◽  
Methyl Phenyl

Natural product, 2'-hydroxy-1'-(4-hydroxyl-5-methoxy-2-methyl-phenyl)-ethanon, (1), was isolated from the thalli lichen Usnea flexuosa Tayl. together with the known (-) - usnic acid (2). The structure of compounds 1 and 2 were determined by the spectroscopic studies.

Chemical Constituents of the Lichen Cladina macaronesica

1991 ◽  
Vol 46 (1-2) ◽  
pp. 12-18 ◽  
Author(s):  
Antonio G . González ◽  
Jaime Bermejo Barrera ◽  
Elsa Ma Rodríguez Pérez ◽  
Consuelo E. Hernández Padrón
Keyword(s):  
Natural Products ◽  
Phenolic Compounds ◽  
Silver Nitrate ◽  
Silica Gel ◽  
Column Chromatography ◽  
Chemical Constituents ◽  
Usnic Acid ◽  
Acetone Extract ◽  
First Time

Column chromatography of the acetone extract of the lichen Cladina macaronesica (Sephadex LH-20, silica gel and silver nitrate-im pregnated silica gel) afforded eight triterpenes identified by chemical and spectral m eans. α-Amyrenone, lupenone, taraxerol, taraxerone and /so-arborinol acetate were isolated for the first time from lichens and (-)-usnic acid and five mononuclear phenolic compounds were also obtained, four for the first time as natural products. The possible transformation of perlatolic acid into these phenolic compounds is briefly outlined.

Evaluation of the Antimicrobial Activity of the Acetone Extract of the Lichen Ramalina farinacea and its (+)-Usnic Acid, Norstictic Acid, and Protocetraric Acid Constituents

2004 ◽  
Vol 59 (5-6) ◽  
pp. 384-388 ◽  
Author(s):  
Turgay Tay ◽  
Ayşen Özdemir Türk ◽  
Meral Yılmaz ◽  
Hayrettin Türk ◽  
Merih Kıvanç
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Candida Albicans ◽  
Yersinia Enterocolitica ◽  
Aeromonas Hydrophila ◽  
Candida Glabrata ◽  
Usnic Acid ◽  
Acetone Extract ◽  
Ramalina Farinacea

The acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid constituent showed antimicrobial activity against Bacillus subtilis, Listeria monocytogenes, Proteus vul­garis, Staphylococcus aureus, Streptococcus faecalis. Yersinia enterocolitica, Candida albicans, and Candida glabrata. Norstictic acid was active against Aeromonas hydrophila as well as the above microorganisms except Yersinia enterocolitica. Protocetraric acid showed activity only against the tested yeasts Candida albicans and Candida glabrata. The MIC values of the extract as well as of the three substances were determined. No antifungal activity of the acetone extract has been observed against ten filamentous fungi.

scholarly journals Bio-Inspired Fabrication of Silver Nanoparticles Using High Altitude Squamulose Lichen Extract and Evaluation of its Antioxidant, Anticandida and Cytotoxic properties

2021 ◽  
Author(s):  
S Shanthi ◽  
V. Uma Maheshwari Nallal ◽  
Krishnan Anand ◽  
Balasubramani Ravindran ◽  
Soon Woong Chang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Silver Nanoparticles ◽  
High Altitude ◽  
Usnic Acid ◽  
Nanoparticle Synthesis ◽  
Spectroscopic Studies ◽  
Binding Energies ◽  
Average Size ◽  
Nano Medicine

Abstract Bio-inspired nanoparticle synthesis has attracted substantial interest among the scientific society owing to its eco-friendly and non-toxic nature. In the present study, Silver nanoparticles (AgNPs) were synthesized using high altitude squamulose lichen – Cladonia subradiata and characterized using different techniques. The antioxidant and anticandida activity of AgNPs were evaluated using multiple in-vitro assays. In-silico molecular docking analysis and in-vitro cytotoxic assay was performed to determine the anti-cancer potential of synthesized AgNPs. The results of the spectroscopic studies revealed the successful synthesis of AgNPs and the presence of different functional groups suggesting the involvement of phytocompounds in the reduction and capping of AgNPs. The average size of the AgNPs was 20 nm and predominantly spherical in shape. AgNPs demonstrated excellent DPPH free radicals scavenging activity with an IC50 value of 7.51 ± 0.4 µg/mL. C.albicans was identified as the most susceptible strain from the anticandida studies. Usnic acid and Pulvinic acid exhibited low binding energies and showed excellent inhibition interaction with EGFR lung cancer protein. The in-vitro cytotoxic results were impressive with an IC50 value of 28.75 µg/mL for A549 lung cancer cells treated with AgNPs. Thus, the study demonstrates the effective and non-toxic synthesis of AgNPs using a less explored lichen extract as a promising anticandida and anticancer agent in the field of nano-medicine.

scholarly journals Spectroscopic Studies on Enols. 4. Hydrogen Bonding in Usnic Acid.

1962 ◽  
Vol 16 ◽  
pp. 583-590 ◽  
Author(s):  
Sture Forsén ◽  
Martin Nilsson ◽  
Carl Axel Wachtmeister ◽  
K. Motzfeldt ◽  
Olof Theander ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Usnic Acid ◽  
Spectroscopic Studies

scholarly journals A Novel Iridoid from Plumeria Obtusa

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300
Author(s):  
Firdous Imran Ali ◽  
Imran Ali Hashmi ◽  
Bina Shaheen Siddiqui
Keyword(s):  
Natural Product ◽  
Stem Bark ◽  
Spectroscopic Studies ◽  
Chemical Transformations ◽  
Compound Identification ◽  
Synthetic Compound ◽  
First Report ◽  
Isolation And Characterization

Phytochemical investigations of fresh leaves and stem bark of Plumeria obtusa Linn. have led to the isolation and characterization of a new iridoid, p-methoxy- E-cinnamoyloxy plumieride (1), to which the trivial name champalinin has been assigned, and a triterpene lactone, 3β-hydroxy-urs-12-one-13β,28-olide (2). This is the first report of compound 2 as a natural product, although it has been reported earlier as a synthetic compound. Identification of these compounds was achieved through spectroscopic studies and chemical transformations.

scholarly journals A Comparison of the Bioactivity of Usnic Acid versus Methylphloroacetophenone

2018 ◽  
Vol 13 (12) ◽  
pp. 1934578X1801301
Author(s):  
Ratul Sarkar ◽  
Navriti Mittal ◽  
John Sorensen ◽  
Tuhinadri Sen
Keyword(s):  
Natural Products ◽  
Antibiotic Resistance ◽  
Natural Product ◽  
Biofilm Formation ◽  
Usnic Acid ◽  
Lichen Species ◽  
Rich Source ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Acid Versus

The identification of natural products that disrupt biofilm formation has become an area of recently expanded interest in combating antibiotic resistance. The formation of biofilms has been correlated with increased pathogenesis in many strains of Gram-negative bacteria. Molecules that disrupt the formation of biofilms therefore represent a potentially novel way to combat pathogenesis. Lichen natural products are an underexplored source of biofilm disrupting natural products. We have investigated the biofilm disrupting activity of the lichen natural product usnic acid (UA) in comparison to the biosynthetic precursor methylphloroacetophenone (MPA). We have observed in our assays that UA is more bioactive than MPA, suggesting a rationale for the biosynthesis of UA in a wide variety of lichen species. These results suggest that lichen natural products may prove to be a rich source of biofilm inhibitors.

Vibrational spectroscopic studies on the natural product, columbianadin

2003 ◽  
Vol 59 (1) ◽  
pp. 193-199 ◽  
Author(s):  
Jose P. Abraham ◽  
I.Hubert Joe ◽  
V. George ◽  
O.F. Nielsen ◽  
V.S. Jayakumar
Keyword(s):  
Natural Product ◽  
Spectroscopic Studies

scholarly journals Studies on Preparation and UHPLC Analysis of the Usnea Barbata (L) F.H.Wigg Dry acetone extract

2019 ◽  
Vol 70 (11) ◽  
pp. 3775-3777 ◽  
Author(s):  
Violeta Popovici ◽  
Laura Bucur ◽  
Teodor Costache ◽  
Daniela Gherghel ◽  
Gabriela Vochita ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Acid Content ◽  
High Performance ◽  
Biological Effects ◽  
Usnic Acid ◽  
Acetone Extract ◽  
Dry Extract ◽  
Representative Species ◽  
Therapeutic Properties

In the category of medicinal plants with remarkable therapeutic properties, lichens are also included. An important representative of this group is the Usnea Adans. genus, with over 650 species spread throughout the globe. Representative species of this genus were also found in Romania, so the studies were conducted on Usnea barbata (L.) F.H.Wigg., harvested from the Calimani Mountains, Suceava County. The objectives of this research are: obtaining the dry extract of the Usneae lichen followed by the identification and determination of the usnic acid content by ultra-high performance liquid chromatography (UHPLC) method. Usnic acid content determined in dry extract of Usnea barbata (L.) F.H.Wigg. was significant, of 16.53 � 6.53% (mean � RSD), which supports the continuation of the research with the evaluation of biological effects (antibacterial, antioxidant and antitumoral).

Methoxyabietane Diterpenoid from the Root of Salvia phlomoides and Structural Correction of Another Diterpene from Cryptomeria japonica

2003 ◽  
Vol 58 (4) ◽  
pp. 324-327 ◽  
Author(s):  
Benjamín Rodríguez
Keyword(s):  
Cryptomeria Japonica ◽  
Spectroscopic Data ◽  
Spectroscopic Studies ◽  
Acetone Extract ◽  
Partial Synthesis ◽  
Regioisomeric Structure

A reinvestigation of the acetone extract of the root of Salvia phlomoides (Labiatae) allowed the isolation of a new abietane diterpenoid whose structure (6,11-dihydroxy-12-methoxy-5,8,11,13-abietatetraen- 7-one) was established by exhaustive NMR spectroscopic studies and by partial synthesis from 14-deoxycoleon U, another abietane constituent of the same extract. The physical and spectroscopic data of the methoxyabietane isolated from S. phlomoides were identical to those reported for another diterpenoid previously found in Cryptomeria japonica (Taxodiaceae), to which the regioisomeric structure 6,12-dihydroxy-11-methoxy-5,8,11,13-abietatetraen-7-one had been erroneously attributed by other authors.

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