SHODHANA DECREASES NOOTROPIC ACTIVITY OF SEMECARPUS ANACARDIUM
<p>ABSTRACT<br />Objective: To evaluate the nootropic activity of methanolic extract of pre-shodhit and shodhit Semecarpus anacardium (SA) nuts and to observe the<br />effect of shodhana on nootropic activity of SA.<br />Methods: Spatial learning and working memory was considered for evaluation. The parameters used were spontaneous alternation behavior<br />(Y-maze), number of correct responses (radial maze), and transfer latency in day 1 (elevated plus maze). Scopolamine, an anticholinergic drug, was<br />used to induce cognitive deficit. % inhibition of acetylcholine esterase (AChE) was measured in vitro.<br />Results: Both pre-shodhit and shodhit drug reversed the scopolamine-induced a decrease in percentage spontaneous alternation behavior in Y-maze<br />and number of correct responses in radial maze. Scopolamine-induced increase in transfer latency in elevated plus maze was significantly decreased<br />by pre-shodhit drug only. Shodhit drug has no significant effect on transfer latency. Both pre-shodhit and shodhit drug showed dose-dependent<br />inhibition of AChE activity in vitro. Pre-shodhit drug showed a more nootropic activity than shodhit drug.<br />Conclusion: Methanolic extract of the nuts of S. anacardium possesses nootropic activity which may be attributed to inhibition of cholinesterase<br />activity. Shodhana of the nuts decreases nootropic activity.<br />Keywords: Semecarpus anacardium, Acetylcholine esterase, Shodhana, Nootropic.</p>