scholarly journals CURRENT MEASURES AGAINST OPHTHALMIC COMPLICATIONS OF DIABETES MELLITUS-A SHORT REVIEW

2021 ◽  
pp. 54-65
Author(s):  
MANORMA ◽  
RUPA MAZUMDER ◽  
ANJNA RANI ◽  
RAJAT BUDHORI ◽  
AYUSHI KAUSHIK
Keyword(s):  
Diabetes Mellitus ◽  
Drug Delivery ◽  
Drug Effect ◽  
Short Review ◽  
Ocular Drug Delivery ◽  
Present Review ◽  
Ocular Complications ◽  
Gradual Development ◽  
Novel Drug ◽  
Ophthalmic Formulation

Diabetes mellitus (DM) is a metabolic disorder, whose prevalence is predicted to rise shortly. The present review focuses on the various ocular complications associated with DM, and the various ophthalmic formulation approaches developed to treat the same. Diabetic macular edema (DME), diabetic retinopathy, cataracts, and glaucoma are some of the major vision-threatening complications linked to DM. The ocular route of drug delivery has undergone several advancements in recent decades, the introduction of various novel drug delivery systems (DDS), various modifications in the existing formulation approaches, development of custom-designed personalized medications, being some of the major developments introduced in the field of ocular drug delivery. Due to the application of state-of-the-art technologies in the field of innovations related to ocular DDS, patients have been immensely benefited by the current modes of ocular treatment imparting fewer side effects, enhanced penetration, sustained drug effect, and so on. The present review includes and emphasizes the gradual development that has occurred from the conventional ophthalmic dosage forms to the currently reported novel ocular drug delivery approaches along with the related clinical research works.

Short Review on Novel Dosage Form

2021 ◽  
pp. 301-303
Author(s):  
Tushar N. Sonawane ◽  
Pradip D. Dhangar ◽  
Sagar D Patil ◽  
Azam Z. Shaikh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Effects ◽  
Short Review ◽  
Delivery Systems ◽  
The Novel ◽  
Novel Drug Delivery System ◽  
Novel Drug

Novel Drug Delivery Systems are one of the widely use delivery system in the presence scenario. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. The novel drug delivery system is Increases bioavailability and it Can be used for long-term treatments of chronic illness, Sustained maintenance of plasma drug levels as well as it Decreased adverse drug effects in the total amount of drugs required thus reducing side effects it Improved patient compliance due to reduction in number and frequency of doses required. There is less damage sustained by normal tissue due to targeted drug delivery. In this paper our main focus to give the throughout knowledge of some newer (Novel drug delivery system) to understand the concept of the Novel dossage form.

scholarly journals Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

2020 ◽  
Vol 8 ◽  
Author(s):  
Haozhe Yu ◽  
Wenyu Wu ◽  
Xiang Lin ◽  
Yun Feng
Keyword(s):  
Drug Delivery ◽  
Structural Instability ◽  
Ocular Drug Delivery ◽  
Synthesis Process ◽  
Ocular Tissues ◽  
Drug Solubilization ◽  
Physiological Structure ◽  
Ocular System ◽  
Novel Drug ◽  
Drug Nanocarriers

Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.

scholarly journals Advancement in Ocular Drug Delivery System to Overcome Ocular Barrier

2021 ◽  
Vol 71 (2) ◽  
Author(s):  
Supriya Nikam ◽  
Abhilasha Ghule ◽  
Akash Inde ◽  
Anjali Jambhulkar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ocular Drug Delivery ◽  
Direct Access ◽  
Ocular Delivery ◽  
Hydrophilic Drugs ◽  
Delivery Planning ◽  
Delivery Routes ◽  
Novel Drug

The Ocular drug delivery system (ODDS) is the prominently challenging system faced by pharmaceutical researchers. Ophthalmic preparations are available in buffered, sterile and isotonic solutions. For the ocular delivery of drugs, various types of dosage forms are prepared and dispensed. As the drops are easier for the administration likewise more prescribed dosage form is the eye drop solution. For obtaining prolonged therapeutic effect ointment, suspensions and gelled systems are also used. The presence of various barriers as anatomical, physiological and physiochemical barriers makes difficulties in delivery of drugs in at the intended sites. Scientists invented alternate delivery routes to direct access at intended target sites. Second invention involves development of novel drug delivery systems providing better permeability, treatability and controlled release at target site. The liposomal delivery is beneficial because they have the ability of envelopment and both hydrophobic and hydrophilic drugs are suitable for delivery to both the anterior and posterior segment of the eye. Therefore, the uses of this alternative approach become quite a necessary. This formulation of novel devices will definitely help to the overcome ocular barriers and side effects with conventional topical drops. Current reviews on the conventional formulations of ocular delivery and their advancements followed by current nanotechnology based on the formulation developments. The recent incident with other ocular drug delivery planning consists of in situ gels, implants, contact lens and nano wafers are discussed. Drug delivery at ophthalmic route has been proven significant advancement for the future perspectives.

scholarly journals Preparation and Characterization of Novel Drug-Inserted-Montmorillonite Chitosan Carriers for Ocular Drug Delivery

2015 ◽  
Vol 04 (03) ◽  
pp. 70-84 ◽  
Author(s):  
Dongzhi Hou ◽  
Ruyi Gui ◽  
Sheng Hu ◽  
Yi Huang ◽  
Zuyong Feng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Novel Drug

scholarly journals Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1519 ◽  
Author(s):  
Alexandra Zamboulis ◽  
Stavroula Nanaki ◽  
Georgia Michailidou ◽  
Ioanna Koumentakou ◽  
Maria Lazaridou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tight Junctions ◽  
Antibacterial Properties ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Review Article ◽  
Present Review ◽  
Ocular Delivery ◽  
Ophthalmic Delivery ◽  
Permeability Enhancer

Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.

scholarly journals Current Approaches to Use Cyclodextrins and Mucoadhesive Polymers in Ocular Drug Delivery—A Mini-Review

2019 ◽  
Vol 87 (3) ◽  
pp. 15 ◽  
Author(s):  
Bíró ◽  
Aigner
Keyword(s):  
Drug Delivery ◽  
Retention Time ◽  
Short Review ◽  
Theoretical Background ◽  
Ocular Drug Delivery ◽  
Therapeutic Effects ◽  
Cyclodextrin Derivatives ◽  
Anatomical Structures ◽  
Mucoadhesive Polymers ◽  
Defensive Mechanisms

Ocular drug delivery provides a challenging opportunity to develop optimal formulations with proper therapeutic effects and acceptable patient compliance because there are many restricting factors involved, such as complex anatomical structures, defensive mechanisms, rapid drainage, and applicability issues. Fortunately, recent advances in the field mean that these problems can be overcome through the formulation of innovative ophthalmic products. Through the addition of solubility enhancer cyclodextrin derivatives and mucoadhesive polymers, the permeability of active ingredients is improved, and retention time is increased in the ocular surface. Therefore, preferable efficacy and bioavailability can be achieved. In this short review, the authors describe the theoretical background, technological possibilities, and the current approaches in the field of ophthalmology.

scholarly journals Recent advancesin the development of novel drug delivery systems for the prophylaxis of malaria

2018 ◽  
Vol 9 (3) ◽  
pp. 49
Author(s):  
Sahil Kumar ◽  
Kulvinder Singh ◽  
Rajesh K Singh ◽  
DN Prasad ◽  
TR Bhardwaj
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Methyl Cellulose ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Polyvinyl Pyrrolidone ◽  
Present Review ◽  
Targeted Drug ◽  
Novel Drug

<p>The present review high-lights the advancement in nanoparticles formulations for the prophylaxis of malaria. An attempt has been made to describe various novel drug delivery systems based on approaches such as polymeric, metallic, natural, chitosan/antisense (AS) and chitosan/sense (S) oligodeoxynucleotide based nanoparticles etc. for the treatment of malaria. The polymer such as chitosan, hydroxyl propyl methyl cellulose and polyvinyl pyrrolidone; the metal like gold and silver and other carriers such as glyceryl-dilaurate, albumin etc. have been explored for the development of novel nanoparticles formulations. These developed nanoparticles formulation have improved the targeted drug delivey of various clinically used antimalarial therapeutic agents such as hydroxychloroquine, curcumin, artemisinin, artemether and lumefantrine etc.</p>

scholarly journals Supercritical Fluids as a State-of-the-Art Formulation Method of Nanoparticles for Ocular Drug Delivery

2021 ◽  
pp. 9-20
Author(s):  
Naida Omerović ◽  
Edina Vranić
Keyword(s):  
Drug Delivery ◽  
Supercritical Fluid ◽  
Supercritical Fluids ◽  
State Of The Art ◽  
Dosage Forms ◽  
Ocular Drug Delivery ◽  
Additional Benefit ◽  
Full Potential ◽  
Drug Bioavailability ◽  
Novel Drug

Conventional ophthalmic dosage forms, although being simple to apply and presenting great patients' compliance, display poorer drug bioavailability and retention time on the eye surface. To cope with these problems, one must formulate novel drug delivery systems, such as nanosystems, for ocular drug delivery. Different formulation methods of nanoparticles have been developed, but some of them, such as the supercritical fluid method, have not reached their full potential in ocular drug delivery. This article aims to present the possibilities of the supercritical fluid method when preparing nanosystems for ocular drug delivery. This method could be used more frequently and efficiently because it is environmentally friendly and produces nanoparticles of the desired physicochemical properties, which is especially important in ocular drug delivery considering its peculiarities. Modifications of the supercritical fluid method can be used when a drug has some specific properties, which is an additional benefit in ocular drug delivery.

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