scholarly journals EFFECT OF MUCUNA COCHINCHINENSIS EXTRACTS ON EFFLUX PUMP IN FUNGAL STRAINS

2020 ◽  
pp. 94-96
Author(s):  
NATARAJAN K. ◽  
KUMARESH JAWAHAR N.
Keyword(s):  
Experimental Data ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Synergistic Effect ◽  
Efflux Pump ◽  
Methanolic Extract ◽  
Ethanolic Extract ◽  
Inhibition Activity ◽  
Fungal Strains ◽  
Efflux Pump Inhibition

Objective: To study the efflux pump inhibition activity of Mucunacochinchinensis extracts Methods: Sensitivity assay was performed by Kirby Bauer technique. Effluxing ability of microbe was done by accretion, accumulation and efflux pump assays. Results: Resistant fungal strains were subjected to efflux ability studies. Maximum effluxing ability was determined from the experimental data and it was found to be 105 min and 75 min by Candida albicans for methanolic extract of M. cochinchinenesis (MMC) and ethanolic extract of M. cochinchinensis (EMC) respectively and 45 min and 105 min by Aspergillus niger for MMC and EMC respectively. Profound synergistic effect of inhibition was observed with combined MMC and standard Clotrimoxazole when compared to the standard alone; against C. albicansindicates the modulating efficacy of MMC. Conclusion: M. cochinchinensis extracts showed efflux pump modulating activity.

scholarly journals A Novel Antimicrobial Phenanthrene Alkaloid from Bryopyllum pinnatum

2011 ◽  
Vol 8 (3) ◽  
pp. 1456-1461 ◽  
Author(s):  
Donatus Ebere Okwu ◽  
Fred Uchenna Nnamdi
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Ethanolic Extract ◽  
Klebsiella Pneumonia ◽  
Antimicrobial Studies ◽  
Prevention And Treatment ◽  
Kalanchoe Pinnata ◽  
Isolated Compound

Phenenthrene alkaloid identified as 1-ethanamino 7 hex-1-yne-5I-one phenanthrene was isolated from the ethanolic extract of the leaves ofBryophyllum pinnatum(syn. B. calcinum kalanchoe pinnata) a versatile Nigeria medicinal plant. The structure was elucidated using NMR, IR, UV and MS spectral data. Antimicrobial studies showed that the isolated compound successfully inhibitedPsuedomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli, Candida albicansandAspergillus niger. This result authenticates the use ofbryophyllum pinantumin phytomedicine for disease prevention and treatment of infections.

scholarly journals Antibactrial Activity of Asteriscus graveolens Methanolic Extract: Synergistic Effect with Fungal Mediated Nanoparticles against Some Enteric Bacterial Human Pathogens

2019 ◽  
Vol 5 (2) ◽  
pp. 89-98
Author(s):  
Ibtihal ALrawashdeh ◽  
Haitham Qaralleh ◽  
Muhamad Al-limoun ◽  
Khaled Khleifat
Keyword(s):  
Silver Nanoparticles ◽  
Synergistic Effect ◽  
Methanolic Extract ◽  
Ethanolic Extract ◽  
Resistant Bacteria ◽  
Human Pathogens ◽  
Maximum Increase ◽  
Etoh Extract ◽  
Antibactrial Activity ◽  
Conventional Antibiotics

Antibactrial activity of Asteriscus graveolens methanolic extract and its synergy effect with fungal mediated silver nanoparticles (AgNPs) against some enteric bacterial human pathogen was conducted. Silver nanoparticles were synthesized by the fungal strain namely Tritirachium oryzae W5H as reported early. In this study, MICs of AgNPs against E. aerogenes, Salmonella sp., E. coli and C. albicans in order were 2.13, 19.15, 0.08 and 6.38 µg/mL, respectively, while the MICs of A. graveolens ethanolic extract against the same bacteria were 4, 366, <3300 and 40 µg/mL, respectively. The MIC values at concentration less than 19.15 and 40 µg/ml indicating the potent bacteriostatic effect of AgNPs and A. graveolens ethanolic extract. Increasing in IFA was reported when Nitrofurantion and Trimethoprim were combined with Etoh extract with maximum increase in IFA by 6 and 12 folds for, respectively. Also, 10 folds increasing in IFA was reported when trimethoprim was combined with AgNPs: Etoh extract. But, there were no synergistic effect between the antifungal agents (Caspofungin and Micafungin) combined with AgNPs and or A. graveolens ethanolic extract against C. albicans. The potent synergistic effect of A. graveolens ethanolic extract and/or NPs with the conventional antibiotics is novel in inhibiting antibiotics resistant bacteria. In this study, remarkable increasing in the antibacterial activity, when the most resistant antibiotics combined with A. graveolens ethanolic extract and/or NPs was reported.

scholarly journals Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

2018 ◽  
Vol 9 ◽  
Author(s):  
Renee M. Fleeman ◽  
Ginamarie Debevec ◽  
Kirsten Antonen ◽  
Jessie L. Adams ◽  
Radleigh G. Santos ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Bacterial Pathogens ◽  
Drug Resistant ◽  
Inhibition Activity ◽  
Efflux Pump Inhibition

scholarly journals Evaluation of Anti Microbial and Anti Fungal Activity of Acalyphaindica L., Leaf Extract

2018 ◽  
Vol 10 (01) ◽  
Author(s):  
Sudhakar Chekuri ◽  
Arun Jyoti B ◽  
Saraswathi JSompaga ◽  
Shivaprasadi Panjala ◽  
Roja Ran Anupalli
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Ethanolic Extract ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Fungal Activity ◽  
Bacteria And Fungi ◽  
Anti Fungal ◽  
Acalypha Indica

Anti-microbial and anti-fungal activity of different solvent extracts of Acalypha indica (Euphorbeace family) was tested against bacterial pathogens (Pseudomonasaeruginosa, E.Coli, KlebsiellaPneumonia and Staphylococcus aureus) and fungal strains (Candida albicans, Aspergillus niger, Candida tropicalis andCandida kefyr) using the Agar Well diffusion method . It was observed that all the extracts showed positive activity) against bacteria and fungi. Ethanolic extract of Acalypha indica showed more potency against Staphylococcus aureus with an inhibition zone of12.46 (mm) and Methanolic extract exhibited higher activity against E.coli with an inhibition zone of11.26 (mm). Ethanolic extract of Acalypha indica showed prominent antifungal activity against candida albicans with an inhibition diameter of 12.53 (mm) and Aspergillus niger with a diameter of 9.21 (mm) when compared to other solvent extracts. Erythromycin and Ketoconazole were used as positive standards for antimicrobial and anti fungal experiments. In the present study, Ethanol extract showed a varying degree of inhibition to the growth of tested organisms compared to Methanol, Acetone and Chloroform against Bacteria and Fungi. The results confirmed the presence of antibacterial and antifungal compounds in shade dried extracts of Acalypha indica against human pathogenic organisms.

The “racemic approach” in the evaluation of the enantiomeric NorA efflux pump inhibition activity of 2-phenylquinoline derivatives

2016 ◽  
Vol 129 ◽  
pp. 182-189 ◽  
Author(s):  
Andrea Carotti ◽  
Federica Ianni ◽  
Stefano Sabatini ◽  
Alessandro Di Michele ◽  
Roccaldo Sardella ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Inhibition Activity ◽  
Efflux Pump Inhibition

scholarly journals Antifungal activity in the methanolic, aqueous and hexane extracts of Calligonum polygonoides

2019 ◽  
Vol 33 ◽  
pp. 205873841882127
Author(s):  
Saeed Ahmad ◽  
Muhammad Akram
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Ethyl Acetate ◽  
Inhibitory Concentration ◽  
Methanolic Extract ◽  
Ethyl Acetate Extract ◽  
Significant Activity ◽  
Hexane Extracts

Calligonum polygonoides is locally called as Phog which belongs to the Polygonaceae family. It is traditionally used as an antifungal. The methanolic extract, hexane extract, ethyl acetate extract and aqueous extract were screened against Candida albicans and Aspergillus niger in seven concentrations, that is, 1.8, 2.9, 6.5, 12.6, 25, 50 and 75 µg/mL/disc. Calligonum polygonoides showed significant activity against Candida albicans as the observed minimum inhibitory concentration (MIC) is 6.5 µg/mL for methanolic extract, 9.8 µg/mL for ethyl acetate extract, whereas aqueous and hexane extracts showed no activity. Calligonum polygonoides did not show any significant activity against Aspergillus niger.

COMPARATIVE STUDY OF ANTIMICROBIAL ACTIVITY OF TINOSPORA CORDIFOLIA FRUITS EXTRACT IN DIFFERENT SOLVENTS

2018 ◽  
Vol 24 (1) ◽  
Author(s):  
BIBHA KUMARI ◽  
MANORMA KUMARI
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Comparative Study ◽  
Ethyl Acetate ◽  
Methanolic Extract ◽  
Tinospora Cordifolia ◽  
Diffusion Method ◽  
Distilled Water

The present work was carried out to evaluate the antimicrobial activity of Tinospora cordifolia fruits extracts in three different solvents against Escherichia coli, Aspergillus niger, and Candida albicans. Extracts were prepared in 70% methenol, ethyl acetate and hot distilled water separately. Antimicrobial screenings were done through well diffusion method. Through the experiments it was found that methanolic extract posses highest antimicrobial potential followed with ethyl acetate and then distilled water.

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