scholarly journals EVALUATION OF DRUG THERAPY PROBLEMS IN ASTHMA PATIENTS RECEIVING CARE IN TWO HOSPITALS IN SOUTH-EASTERN NIGERIA

2018 ◽  
Vol 10 (2) ◽  
pp. 50
Author(s):  
Kosisochi Chinwendu Amorha ◽  
Anthony Chukwuma Onu ◽  
Chigozie Gloria Anene-okeke ◽  
Chinwe Victoria Ukwe
Keyword(s):  
Drug Therapy ◽  
Adverse Reactions ◽  
Tertiary Hospital ◽  
Medical Centre ◽  
New Drugs ◽  
Inappropriate Drug ◽  
Cross Sectional ◽  
South Eastern ◽  
Asthma Patients ◽  
Drug Therapy Problems

Objective: To evaluate drug therapy problems in asthma patients visiting a secondary and tertiary hospital in South-Eastern Nigeria.Methods: This study was a retrospective, cross-sectional analyses of the medical records of adult asthmatic patients receiving care in two hospitals in Enugu State, within a 15-year period. The Pharmaceutical Network Care Europe (PCNE) tool version 6.2 was used to assess drug therapy problems. The IBM Statistical Product for Services Solution (SPSS) version 20.0 was used for analysis. For all results, P ≤ 0.05 was considered statistically significant.Results: Majority of the patients were below 60 y old (81.2%); female (68.8%) and were on more than two drugs (95.3%). Majority of the identified drug therapy problems (DTPs) were adverse reactions (65.7%). The inappropriate drug combination was the major cause of DTPs (65.6%). Only about 23.4% of the intervention outcomes were known. University of Nigeria Teaching Hospital (UNTH) had more interventions (35.9%) than Medical Centre (8.0%) (χ2 = 6.323; df = 1; **P = 0.012); and more of the outcomes of their interventions known (38.5%) compared to Medical Centre (0.0%) (χ2 = 12.559; df = 1; **P ˂ 0.001).Conclusion: Adverse reactions and inappropriate drug selection were the major identified DTPs and major cause of DTPs, respectively. Most DTPs had no interventions. The documented interventions included stopping of the drugs, change of drugs or dosage, change of instructions for use and starting of new drugs. Most interventions had unknown outcomes. UNTH had more interventions with known outcomes than the University of Nigeria Medical Centre.

scholarly journals Drug therapy problems identified among older adults placed in a nursing home: the Croatian experience

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092879
Author(s):  
Katarina Fehir Šola ◽  
Iva Mucalo ◽  
Andrea Brajković ◽  
Ivona Jukić ◽  
Donatella Verbanac ◽  
...  
Keyword(s):  
Nursing Home ◽  
Drug Therapy ◽  
Medication Management ◽  
Institutional Care ◽  
Nursing Home Residents ◽  
Median Number ◽  
Cross Sectional ◽  
High Prevalence ◽  
Care Facilities ◽  
Drug Therapy Problems

Objective The aim of this study was to determine the frequency and type of drug therapy problems (DTPs) in older institutionalized adults. Method We conducted a cross-sectional observational study from February to June 2016 at a 150-bed public nursing home in Croatia, where comprehensive medication management (CMM) services were provided. A rational decision-making process, referred to as the Pharmacotherapy Workup method, was used to classify DTPs. Results Data were prospectively collected from 73 residents, among which 71% were age 75 years or older. The median number of prescribed medications per patient was 7 (2–16) and polypharmacy (> 4) was recorded for 54 (74.0%) patients. A total 313 DTPs were identified, with an average of 4.3 ± 2 DTPs per patient. The most frequent DTP was needing additional drug therapy (n = 118; 37.7%), followed by adverse drug reaction (n = 55; 17.6%). Lactulose (14.4%), tramadol (6.7%), and potassium (6.4%) were the medications most frequently related to DTPs. Conclusion The high prevalence of DTPs identified among older institutionalized adults strongly suggests the need to incorporate new pharmacist-led CMM services within existing institutional care facilities, to improve the care provided to nursing home residents.

scholarly journals Assessment of quality of life in asthma patients in 5 to 18 years of children

2020 ◽  
Vol 7 (11) ◽  
pp. 2214
Author(s):  
Nikhil Jain ◽  
Karan Joshi
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Tertiary Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Asthmatic Patients ◽  
Asthma Patients ◽  
Severity Of The Disease

Background: Asthma is a common cause of morbidity and mortality with prevalence of 300 million in world. The QOL of asthmatic patients cannot be determined only on the basis the severity of the disease, but requires a measurement of personal perception. This study was conducted with the aim to assess and compare the QOL using PedsQl scale in asthma patients between 5 to 18 years of age with different demographic and clinical variables.Methods: This was a cross-sectional observational study conducted at respiratory clinic in tertiary hospital, Rewa from October 2017 to June 2019. A total number of 150 asthmatic patients and their parents participated. Asthmatic patients (N=150) and their parents, presenting to asthma clinic of Gandhi Memorial Hospital, Rewa (after applying inclusion-exclusion criteria) were assessed for QOL using PedsQl scale 3.0. Statistical analysis was performed by SPSS version 20. Test of significance by student T-test and one way ANOVA.Results: The QOL is severely hampered by asthma with mean of 59 in intermittent asthma, 51 in mild, 44.74 in moderate and 40 in severe persistent asthma, significant p value of <0.05. Younger age, level of asthma control and severity were significantly related to QOL with p value of <0.05. Sex, socioeconomic status, were insignificantly related.Conclusions: QOL is impaired as the grading of asthma increases. Impairment of Quality of life are mostly associated with low level of asthma control, poly-therapy and frequent night attacks.

scholarly journals Assessment of drug therapy problem and associated factors among adult hypertensive patients at Ayder comprehensive specialized hospital, Northern Ethiopia

2019 ◽  
Vol 19 (3) ◽  
pp. 2571-2579
Author(s):  
Asgedom Solomon Weldegebreal ◽  
Fekadu Tezeta ◽  
Atey Tesfay Mehari ◽  
Wubetu Gashaw ◽  
Kassa Tesfaye Dessale ◽  
...  
Keyword(s):  
Substance Use ◽  
Drug Therapy ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Northern Ethiopia ◽  
Antihypertensive Medications ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Drug Therapy Problem ◽  
Drug Therapy Problems

Background: Drug-therapy problems(DTPs) among hypertensive patients can result in patient’s morbidity and mortality. The main aim of this study was to assess drug therapy problem and associated factors among <="" span="" style="font-family: hypertensive patients.Methods: A hospital based cross sectional study was conducted. The data was collected from patients’ medical charts and through interview. Drug therapy problem was categorized according to Cipolle methods of DTP classification. Thedata was analyzed using the Statistical Package for the Social Sciences (SPSS), version 21.Results: A total of 241 patients were studied. The mean number of antihypertensive medications prescribed were 1.41±0.53. A total of 357 drug therapy problems(DTPs) were identified. From the patients studied,134(55.6%) had at least one evidence of drug therapy problem. Non adherence was the most commonly identified drug therapy problem occurred in (143(59.3%)) patients. Substance use (AOR=0.445, 95% CI= 0.227-0.870, p=0.018) and comorbidity (AOR= 2.099, 95% CI= 1.192-3.694, p=0.010) werethe predictors of DTP.Conclusion: More than half of the participants had evidence of onset drug therapy problem. Thus efforts that could boost antihypertensive compliance and minimizes substance use should be adopted to reduce patients’s drug therapy problems.Keywords: assessment, drug, therapy, problem, Ethiopia.

scholarly journals Adverse drug reaction risk assessment with prescribed renal risk drugs among hospitalized patients attending a teaching hospital in South India

2020 ◽  
Vol 8 (3) ◽  
pp. 985
Author(s):  
Sadhna Sharma ◽  
Hari Babu Ramineni ◽  
K. Poornima Shahitha ◽  
K. Mounika ◽  
P. Ramyachandra ◽  
...  
Keyword(s):  
Continuous Monitoring ◽  
Renal Damage ◽  
Adverse Reactions ◽  
General Medicine ◽  
Inappropriate Drug ◽  
Cross Sectional ◽  
Medicine Department ◽  
High Incidence ◽  
One Year ◽  
Morbid Conditions

Background: Renal impairment is the primary cause of mortality and morbid conditions in patients. Inappropriate drug use in patients who are with risk of renal damage causes harmful and deleterious effects. Adjusting doses based on renal function is necessary for renal risk drugs, primarily to avoid adverse reactions of medications. Aim of the present study was to assess the risk of incidence on ADRs with drugs lowering the renal function.Methods: This is a cross-sectional observational study conducted in General Medicine department. 230 Patients constituted the sample in the study. The study was conducted for a period of one year and prescriptions with renal risk drugs were evaluated. Changes in the renal functional tests were compared to the normal range and adverse drug responses were monitored.Results: A total of 230 patients who fulfilled the inclusion criteria were included in the study. The meanage of the study subjects were 50.9±15.2 respectively. 56.39% patients were men and 43.6% were women. Renal risk drugs included in the study are anti-hypertensive, antibiotics, and analgesics. Paracetamol (24.77%) followed by telmisartan (20.85%) are the predominantly prescribed renal risk drugs with high incidence of adverse drug reactions. Causality assessment by Naranjo ADR probability scale showed out of 211 ADRs, 51.6% were possible, 25.59% were doubtful, 21.8% were probable and 0.94% was definite.Conclusions: The current study signifies that patients under high risk of renal damage require continuous monitoring and optimized therapy for better disease management.

scholarly journals Non-dispensing pharmacists’ actions and solutions of drug therapy problems among elderly polypharmacy patients in primary care

2019 ◽  
Vol 36 (5) ◽  
pp. 544-551 ◽  
Author(s):  
Ankie C M Hazen ◽  
Dorien L M Zwart ◽  
Judith M Poldervaart ◽  
Johan J de Gier ◽  
Niek J de Wit ◽  
...  
Keyword(s):  
General Practice ◽  
Drug Therapy ◽  
Medication Review ◽  
Cross Sectional Study ◽  
Online Data ◽  
Cross Sectional ◽  
Clinical Medication Review ◽  
Active Patient ◽  
General Practices ◽  
Drug Therapy Problems

Abstract Objective To evaluate the process of clinical medication review for elderly patients with polypharmacy performed by non-dispensing pharmacists embedded in general practice. The aim was to identify the number and type of drug therapy problems and to assess how and to what extent drug therapy problems were actually solved. Method An observational cross-sectional study, conducted in nine general practices in the Netherlands between June 2014 and June 2015. On three pre-set dates, the non-dispensing pharmacists completed an online data form about the last 10 patients who completed all stages of clinical medication review. Outcomes were the type and number of drug therapy problems, the extent to which recommendations were implemented and the percentage of drug therapy problems that were eventually solved. Interventions were divided as either preventive (aimed at following prophylactic guidelines) or corrective (aimed at active patient problems). Results In total, 1292 drug therapy problems were identified among 270 patients, with a median of 5 (interquartile range 3) drug therapy problems per patient, mainly related to overtreatment (24%) and undertreatment (21%). The non-dispensing pharmacists most frequently recommended to stop medication (32%). Overall, 83% of the proposed recommendations were implemented; 57% were preventive, and 35% were corrective interventions (8% could not be assessed). Almost two-third (64%) of the corrective interventions actually solved the drug therapy problem. Conclusion Non-dispensing pharmacists integrated in general practice identified a large number of drug therapy problems and successfully implemented a proportionally high number of recommendations that solved the majority of drug therapy problems.

Relationship between Asthma Drug Therapy Patterns and Healthcare Utilization

2002 ◽  
Vol 36 (4) ◽  
pp. 557-564 ◽  
Author(s):  
Theresa I Shireman ◽  
Pamela C Heaton ◽  
Wendy E Gay ◽  
Robert J Cluxton ◽  
Charles J Moomaw
Keyword(s):  
Emergency Department ◽  
Drug Therapy ◽  
Healthcare Utilization ◽  
Emergency Department Visits ◽  
Oral Steroid ◽  
Short Acting ◽  
Asthma Patients ◽  
Asthma Drug ◽  
Leukotriene Receptor ◽  
Drug Therapy Problems

BACKGROUND AND OBJECTIVE: Asthma drug therapy problems contribute significantly to preventable hospitalizations and increased healthcare use in asthmatics. Since asthma patients often require >1 medication for control of symptoms, concurrent asthma drug therapies may be important in predicting excessive healthcare utilization. The purpose of this study was to link inappropriate asthma drug therapy patterns and selected patient demographics to healthcare utilization. METHODS: This study was a retrospective, cross-sectional analysis of Ohio Medicaid medical, institutional, and prescription claims. We included ambulatory patients aged 15–65 years who had ≥2 claims for asthma (493.x) and who were continuously enrolled in the Medicaid fee-for-service program for the 12-month period from April 1998 through March 1999. We examined age, race, gender, metropolitan residence, presence of gastroesophageal reflux disease, and the usage patterns of inhaled corticosteroids, short-acting β2-agonists, long-acting β2-agonists, theophylline, and leukotriene receptor modifiers to identify asthma drug therapy problems based on national guidelines. The primary outcomes included the number of asthma-related hospitalizations, asthma-related emergency department visits, and oral steroid bursts. RESULTS: Among 10 959 asthma patients, only 46.8% of the study patients received >1 puff of inhaled corticosteroid per day. Forty-four percent of the patients received >3 puffs of short-acting β2-agonists per day. The most common outcome was an oral steroid burst (46.5%). Patients on high doses of short-acting β2-agonists had the greatest odds of receiving an oral steroid burst and were most likely to be hospitalized. African Americans were more likely to incur a hospitalization or emergency department visit. Women had greater odds of any undesirable asthma outcome. Higher use of short-acting β2-agonists led to higher odds of receiving a steroid burst or being hospitalized. Leukotriene receptor modifier use was related to higher levels of all outcomes. CONCLUSIONS: A large percentage of Ohio Medicaid patients were not receiving asthma medications in compliance with the National Heart, Lung, and Blood Institute guidelines. Despite nearly a decade of national efforts, asthma drug therapy patterns still have substantial room for improvement and continue to be associated with excess healthcare utilization.

Reporting Medication Errors and Drug Therapy Problems Through the Egyptian National Electronic Reporting System in 56 Governmental Hospitals during 2019

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hebatalla Mohamed AbdulAziz ◽  
Aya Mostafa ◽  
Sally Adel Hakim ◽  
Moustafa El- Houssine Moustafa
Keyword(s):  
Drug Therapy ◽  
Medication Errors ◽  
Reporting System ◽  
Cross Sectional Survey ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Drug Dosing ◽  
Clinical Pharmacists ◽  
The Usa ◽  
Drug Therapy Problems

Abstract Introduction Several countries have adopted national reporting systems of medication errors such as in the UK and the USA. Egypt has a new national reporting system of medication error (MEs) & drug therapy problems (DTPs), the NO HARMe (the National Office for Handling And Reduction of Medication errors) since October 2017. Objectives To determine the most common types of MEs and DTPs encountered by clinical pharmacists as the NO HARMe users in governmental hospitals. Methodology We conducted a cross-sectional survey using a self-administered online questionnaire in fifty-six governmental hospitals where clinical pharmacists use the NO HARMe, from October to December 2019. Results Most (96%) of the 206 participating clinical pharmacists were females with a mean age of 32.8 years (SD 4.32). The most common departments where participants worked are adult ICU (32.5%), neonatal ICU (14.6%), pediatric ICU (7%), and internal medicine (5%). The most common types of DTPs & MEs reported by clinical pharmacists were inappropriate doses or dosing intervals (38.3%), drugs with no valid indications (25.2%), antibiotics without indication (17.5%), and inappropriate selection of an antibiotic (13.6%). Conclusion Medication errors in drug dosing are prevalent in the hospitals included in this study. Also, drugs that are prescribed without need, while errors in antibiotics were very common in many hospitals either prescribed for no need or selected inappropriately.

scholarly journals Local and Systemic Adverse Reactions to mRNA COVID-19 Vaccines Comparing Two Vaccine Types and Occurrence of Previous COVID-19 Infection

Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1463
Author(s):  
Oleguer Parés-Badell ◽  
Xavier Martínez-Gómez ◽  
Laia Pinós ◽  
Blanca Borras-Bermejo ◽  
Sonia Uriona ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Online Survey ◽  
Adverse Reactions ◽  
Tertiary Hospital ◽  
Chronic Illnesses ◽  
Cross Sectional ◽  
Medical Leave ◽  
Group 12 ◽  
Vaccine Type ◽  
History Of

The aim of this study was to assess adverse reactions to COVID-19 vaccines, comparing the BNT162b2 or the mRNA-1273 COVID-19 vaccines and the presence and seriousness of a previous COVID-19 infection. We conducted a cross-sectional online survey of vaccinated healthcare workers at a tertiary hospital in Barcelona (Spain). Thirty-eight percent of vaccine recipients responded to the questionnaire. We compared the prevalence of adverse reactions by vaccine type and history of COVID-19 infections. A total of 2373 respondents had received the BNT162b2 vaccine, and 506 the mRNA-1273 vaccine. The prevalence of at least one adverse reaction with doses 1 and 2 was 41% and 70%, respectively, in the BNT162b2 group, and 60% and 92% in the mRNA-1273 group (p < 0.001). The BNT162b2 group reported less prevalence of all adverse reactions. Need for medical leave was significantly more frequent among the mRNA-1273 group (12% versus 4.6% p < 0.001). Interestingly, respondents with a history of allergies or chronic illnesses did not report more adverse reactions. The frequency of adverse reactions with dose 2 was 96% (95% CI 88–100%) for those with a history of COVID-19 related hospitalization, and 86% (95% CI 83–89%) for those with mild or moderate symptomatic COVID-19, significantly higher than for participants with no history of COVID-19 infections (67%, 95% CI 65–69%). Our results could help inform vaccine recipients of the probability of their having adverse reactions to COVID-19 vaccines.

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