scholarly journals SAPONINS AND SAPOGENINS OF AGAVE WITH RESPECT TO DIVERSE PHARMACOLOGICAL ROLE OF HECOGENIN

2020 ◽  
pp. 1-7
Author(s):  
DEEPA K. INGAWALE (MANDLIK)
Keyword(s):  
Potential Role ◽  
Web Of Science ◽  
Literature Survey ◽  
Special Focus ◽  
Steroidal Sapogenin ◽  
Pharmacological Activities ◽  
The Past ◽  
Agave Sisalana ◽  
Agave Cantala

The review outlines the current understandings of saponins and sapogenins in agave species with special focus on pharmacological role of hecogenin in numerous preclinical studies. A systematic literature survey was done on the pharmacological activities of hecogenin during the past 40 y with electronic databases like PubMed, Science Direct, Wiley, SciFinder, Google Scholar, Web of Science and Scopus. Hecogenin, a steroidal sapogenin found abundantly in the leaves of Agave genus species such as, Agave sisalana, Agave cantala, Agave aurea and many more. This phytosteroid (hecogenin) is used as initial material for the synthesis of steroidal drugs in the pharmaceutical industry. Hecogenin has exhibited potential role in the management of a number of disorders such as inflammation, arthritis, cancer, gastric ulcer, cardiotonic and larvicidal activity. In this review, we have summarized the saponins and sapogenins present in the Agave species and pharmacological roles of hecogenin with their mechanism of action.

Acid ceramidase, a double-edged sword in cancer aggression: A minireview

2020 ◽  
Vol 20 ◽  
Author(s):  
Helen Shiphrah Vethakanraj ◽  
Niveditha Chandrasekaran ◽  
Ashok Kumar Sekar
Keyword(s):  
Cell Fate ◽  
Cancer Progression ◽  
Potential Role ◽  
Tumour Progression ◽  
Acid Ceramidase ◽  
The Core ◽  
The Past ◽  
Sphingosine 1 Phosphate ◽  
Key Enzyme

: Acid ceramidase (AC), the key enzyme of the ceramide metabolic pathway hydrolyzes pro-apoptotic ceramide to sphingosine, which by the action of sphingosine-1-kinase is metabolized to mitogenic sphingosine-1-phosphate. The intracellular level of AC determines ceramide/sphingosine-1-phosphate rheostat which in turn decides the cell fate. The upregulated AC expression during cancerous condition acts as a “double-edged sword” by converting pro-apoptotic ceramide to anti-apoptotic sphingosine-1-phosphate, wherein on one end, the level of ceramide is decreased and on the other end, the level of sphingosine-1-phosphate is increased, thus altogether aggravating the cancer progression. In addition, cancer cells with upregulated AC expression exhibited increased cell proliferation, metastasis, chemoresistance, radioresistance and numerous strategies were developed in the past to effectively target the enzyme. Gene silencing and pharmacological inhibition of AC sensitized the resistant cells to chemo/radiotherapy thereby promoting cell death. The core objective of this review is to explore AC mediated tumour progression and the potential role of AC inhibitors in various cancer cell lines/models.

scholarly journals Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Moon Ley Tung ◽  
Bryce Tan ◽  
Robin Cherian ◽  
Bharatendu Chandra
Keyword(s):  
Endothelial Dysfunction ◽  
Severe Acute Respiratory Syndrome ◽  
Potential Role ◽  
Molecular Mimicry ◽  
Thromboembolic Events ◽  
The Past ◽  
High Prevalence ◽  
Connecting The Dots ◽  
Anti Phospholipid Syndrome

Abstract As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it has emerged as a leading cause of mortality, resulting in >1 million deaths over the past 10 months. The pathophysiology of COVID-19 remains unclear, posing a great challenge to the medical management of patients. Recent studies have reported an unusually high prevalence of thromboembolic events in COVID-19 patients, although the mechanism remains elusive. Several studies have reported the presence of aPLs in COVID-19 patients. We have noticed similarities between COVID-19 and APS, which is an autoimmune prothrombotic disease that is often associated with an infective aetiology. Molecular mimicry and endothelial dysfunction could plausibly explain the mechanism of thrombogenesis in acquired APS. In this review, we discuss the clinicopathological similarities between COVID-19 and APS, and the potential role of therapeutic targets based on the anti-phospholipid model for COVID-19 disease.

Nitric oxide: a new role in intensive care

2020 ◽  
Vol 22 (1) ◽  
pp. 72-79
Author(s):  
Alexandra Lee ◽  
◽  
Warwick Butt ◽  
◽  
◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Potential Role ◽  
Nitric Oxide Donors ◽  
Ischaemia Reperfusion Injury ◽  
Surface Receptors ◽  
The Past ◽  
Ischaemia Reperfusion ◽  
Human Experiments ◽  
Endogenous Nitric Oxide

Inhaled nitric oxide has been used for 30 years to improve oxygenation and decrease pulmonary vascular resistance. In the past 15 years, there has been increased understanding of the role of endogenous nitric oxide on cell surface receptors, mitochondria, and intracellular processes involving calcium and superoxide radicals. This has led to several animal and human experiments revealing a potential role for administered nitric oxide or nitric oxide donors in patients with systemic inflammatory response syndrome or ischaemia–reperfusion injury, and in patients for whom exposure of blood to artificial surfaces has occurred.

New Agendas for Special Education Policy: What the National Reports Haven't Said

1987 ◽  
Vol 53 (4) ◽  
pp. 295-299 ◽  
Author(s):  
Marleen Pugach ◽  
Mara Sapon-Shevin
Keyword(s):  
Special Education ◽  
Education Policy ◽  
Educational Reform ◽  
Special Focus ◽  
Special Education Policy ◽  
The Past ◽  
The Subject ◽  
The Impact ◽  
The Relationship

The calls for educational reform that have dominated the professional and lay literature for the past few years have been decidedly silent in discussing the role of special education either as a contributor or a solution to the problems being raised. As an introduction to this “Special Focus” on the relationship between general educational reform and special education, this article summarizes some of the more prominent reports with regard to their treatment (and nontreatment) of special education. The impact of proposed reforms for the conceptualization and operation of special education is the subject of the five articles that follow.

Fifty years ago: ‘The scope of occupational medicine in a university health service’

2020 ◽  
pp. 202-203
Author(s):  
Anthony Ryle
Keyword(s):  
Health Service ◽  
Physical Health ◽  
Occupational Medicine ◽  
Potential Role ◽  
Health And Safety ◽  
Academic Achievements ◽  
The Past ◽  
Selection Of

This series provides a selection of articles from the past. In Fifty years ago: The scope of occupational medicine in a university health service Anthony Ryle briefly explores the potential role of a University Health Service in relation to students’ academic achievements and failures, rather than their physical health and safety.

scholarly journals Exposure to emissions from Mount Etna (Sicily, Italy) and incidence of thyroid cancer: a geographic analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Paolo Boffetta ◽  
Lorenzo Memeo ◽  
Dario Giuffrida ◽  
Margherita Ferrante ◽  
Salvatore Sciacca
Keyword(s):  
Regression Analysis ◽  
Thyroid Cancer ◽  
Potential Role ◽  
Incidence Rates ◽  
Mount Etna ◽  
Sensitivity Analyses ◽  
Molecular Characteristics ◽  
Special Focus ◽  
Northeastern Sicily

AbstractAn increased incidence of thyroid cancer has been reported in the area close to Mount Etna, the largest volcano in Europe located in Northeastern Sicily. We tested the hypothesis that exposure to the emissions from the volcano is associated with thyroid cancer in 186 municipalities from three provinces surrounding the volcano (1.9 million inhabitants). We measured the angle between the bearing of the municipalities and each direction, with special focus on South-East, the prevalent direction of the plume, and conducted a regression analysis on 2003–2016 incidence rates of thyroid cancer, adjusting for distance from Mount Etna, population size, and income. A 10-degree increase in the angle with South-East was associated with a decrease in thyroid cancer rates in the whole population (− 0.67 cases/100,000, p = 0.002) and in women (− 1.54/100,000, p < 0.001), and were robust to several sensitivity analyses. Similar results were obtained for East-South-East direction. These results support the hypothesis of a potential role of exposure to the plume from Mount Etna in determining the high rates of thyroid cancer. The results need to be confirmed in analytical studies, in which information of exposure to chemicals originating from the volcano, as well as other possible causes, should be carefully measured, molecular characteristics of the tumors and taken into account.

scholarly journals Endocrine Significance of SARS-CoV-2’s Reliance on ACE2

Endocrinology ◽  
2020 ◽  
Vol 161 (9) ◽  
Author(s):  
Eric Lazartigues ◽  
Mirza Muhammad Fahd Qadir ◽  
Franck Mauvais-Jarvis
Keyword(s):  
Potential Role ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Angiotensin Converting Enzyme 2 ◽  
Global Impact ◽  
The Past ◽  
And Function ◽  
Endocrine Tissues

Abstract The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.

PIG, TONE SANDHI AND WUMIN

1989 ◽  
Vol 18 (2) ◽  
pp. 163-182
Author(s):  
William L. Ballard
Keyword(s):  
Potential Role ◽  
Historical Linguistics ◽  
Tone Sandhi ◽  
Basic Principles ◽  
The Past ◽  
Language History ◽  
History Of ◽  
Chinese Dialects ◽  
Historical Relationship

Several scholars have made various remarks about the language history of the Wu and Min areas. Some of these remarks concern non-Chinese languages that may have been spoken in the area(s) and that may have left some traces in the forms of Chinese spoken there now (substrata). Other remarks concern the possible prehistory of what appear now to be transitional or mixed forms, or features that may be present due to some ancient influence or borrowing. In considering such matters it is important to keep in mind the basic principles (and biases) of historical linguistics, and of the potential role of philological materials in the discussion. My fieldwork in China this spring, as well as my research in the past, point to some special historical relationship between southern Wu and northern Min. This appears to mean that the boundaries between the northern and southern types of each of the two dialect groups are stronger than they have been portrayed in the past, and that the traditional boundary between Wu and Min is considerably weaker than has been supposed. The total sum of dialect facts cannot be ignored in trying to ascertain the language history of this area; it would appear that various elements of the traditional view of the history of the southern dialects are in error in various ways. In particular, it is at least possible that Wu and Min, in some sense, share a common ancestor not common to any other Chinese dialects.

scholarly journals Populações Celulares Periféricas (CD4+, CD8+ e CD19+) em Indivíduos Dislipidémicos

2013 ◽  
Vol 26 (6) ◽  
pp. 676
Author(s):  
Jose Pereira de Moura ◽  
Manuel Santos Rosa ◽  
Vera Alves ◽  
Anabela Mota Pinto ◽  
Victor Rodrigues ◽  
...  
Keyword(s):  
Potential Role ◽  
Inflammatory Cells ◽  
Control Group ◽  
Cd4 Cells ◽  
Reactive Protein ◽  
The Past ◽  
Markers Of Inflammation ◽  
The People ◽  
Risk Predictors

Introduction: The past decade has witnessed an increasing recognition that inflammatory mechanisms play a central role in the pathogenesis of atherosclerosis and its complications. Recently, attention was focused on the potential role of plasma markers of inflammation as risk predictors among those at risk for cardiovascular events. Of these potential markers, C-reactive protein (CRP), IL6, metalloproteinases, ICAM, VCAM and other molecules, have been extensively studied. On the other hand, to our knowledge, there are only a few studies on the role of inflammatory cells, like T and B lymphocytes in the atherosclerosis.Material and Methods: By Flow Cytrometry analysis we have determined on dyslipidemic people and on a control group, the percentage of some peripheral inflammatory cells, like CD3+, CD4+, CD8+, CD19+, CD56+, CD56CD8+, DN, CD25+, CD26+, CD25CD3+, CD26CD3+, CD25CD26CD3+, CCR5+, CCR5CD3+, CCR5CD4+, HLADR+, HLADRCD4+, HLADRCD8h+, HLADRCD8low+, HLADRCD8+, CD95+, CD95CD95L+, CD3CD95+, CD3CD95L+, CD62L+, CD3CD62L+, CD69+, CD69CD3+ e CD69CD4+.Results: In the present study we have particularly studied the percentage of CD4+, CD8+ and CD19+ cells. The CD4+ cells have been significantly reduced in the people with dyslipidemia.Discussion: We do not know the peripheral numbers of the subtype Th1 and Th2, neither the percentage of CD4+CD25+ cells (regulatory T cells). We have not find any differences on the percentage from the CD8+ and CD19+ cells.Conclusions: In spite of the identified limitations resulting from the small-sized samples, it was possible to show a reduction of some molecules after application of acetylsalicylic acid.

scholarly journals The interplay of transverse degrees of freedom and axial-vector mesons with short-distance constraints in g−2

2021 ◽  
Author(s):  
Pere Masjuan ◽  
Pablo Roig ◽  
Pablo Sanchez Puertas
Keyword(s):  
Short Distance ◽  
Degrees Of Freedom ◽  
Axial Vector ◽  
Form Factors ◽  
Experimental Result ◽  
Special Focus ◽  
Vector Mesons ◽  
Distance Constraints ◽  
The Past

Abstract We revisit well-known short-distance constraints relating the hadronic light-by light Green's function to the〈VVA〉one, that have been a subject of debate over the past years in the context of the muon (g-2). Specifically, we identify a relation among the longitudinal and transverse degrees of freedom that is enforced by the axial anomaly that, by contrast, has not received attention in the past. Such relation allows, among other things, to overcome the problem of basis ambiguities when describing axial-vector mesons transition form factors, but further applications are discussed as well, with special focus on the role of axial-vector mesons in the HLbL contribution to the muon (g-2). Our results should also contribute to a better understanding of the, so far, controversial interplay among short-distance constraints with longitudinal and transverse degrees of freedom, such as axial-vector mesons. This is key to confront the theoretical and experimental result for the muon (g-2) that, currently, exhibits a 4.2σ tension.

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