Clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide grafts for regeneration of periodontal defects: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Muhammad S Shaikh ◽  
Shehriar Husain ◽  
Mohid A Lone ◽  
Muneeb A Lone ◽  
Humera Akhlaq ◽  
...  
Keyword(s):  
Periodontal Regeneration ◽  
Clinical Effectiveness ◽  
Gingival Recession ◽  
Cochrane Library ◽  
Cell Binding ◽  
Intrabony Defects ◽  
Binding Peptide ◽  
Probing Depth ◽  
Matrix Cell ◽  
Significant Difference

Aim: To ascertain clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (ABM/P-15) for regeneration of periodontal defects. Materials & methods: Electronic databases (National Library of Medicine [Medline by PubMed], Cochrane Library [Wiley], CINAHL [EBSCO] and Medline [EBSCO]) were systematically searched up to December 2019. Randomized controlled clinical trials comparing ABM/P-15 grafts to conventional surgery for intrabony and gingival recession defects were included and evaluated intrabony defects including clinical attachment level (CAL), probing depth and gingival recession. Results: A significant gain in CAL (1.37 mm), and reduction in probing depth (1.22 mm) were shown by ABM/P-15 grafts than open flap debridement (p < 0.00001). The subgroup analysis also showed better results for ABM/P-15 grafts in CAL gain for intrabony defects. For furcation and gingival recession defects, no significant difference was seen. Conclusion: The adjunct use of ABM/P-15 grafts in conventional periodontal surgery is useful for periodontal regeneration of intrabony defects.

scholarly journals Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation—A Narrative Review

Biology ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 317
Author(s):  
Eitan Mijiritsky ◽  
Haya Drora Assaf ◽  
Oren Peleg ◽  
Maayan Shacham ◽  
Loredana Cerroni ◽  
...  
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Periodontal Regeneration ◽  
Clinical Work ◽  
Gingival Recession ◽  
Vital Role ◽  
Facial Rejuvenation ◽  
Cochrane Library ◽  
The Past ◽  
Autologous Platelet

Growth factors (GFs) play a vital role in cell proliferation, migration, differentiation and angiogenesis. Autologous platelet concentrates (APCs) which contain high levels of GFs make them especially suitable for periodontal regeneration and facial rejuvenation. The main generations of APCs presented are platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) techniques. The purpose of this review is to provide the clinician with an overview of APCs’ evolution over the past decade in order to give reliable and useful information to be used in clinical work. This review summarizes the most interesting and novel articles published between 1997 and 2020. Electronic and manual searches were conducted in the following databases: Pubmed, Scopus, Cochrane Library and Embase. The following keywords were used: growth factors, VEGF, TGF-b1, PRP, PRF, CGF and periodontal regeneration and/or facial rejuvenation. A total of 73 articles were finally included. The review then addresses the uses of the three different techniques in the two disciplines, as well as the advantages and limitations of each technique. Overall, PRP is mainly used in cases of hard and soft tissue procedures, while PRF is used in gingival recession and the treatment of furcation and intrabony defects; CGF is mainly used in bone regeneration.

scholarly journals Treatment of Intrabony Defects with a Combination of Hyaluronic Acid and Deproteinized Porcine Bone Mineral

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 6795
Author(s):  
Darko Božić ◽  
Ivan Ćatović ◽  
Ana Badovinac ◽  
Larisa Musić ◽  
Matej Par ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bone Mineral ◽  
Gingival Recession ◽  
Intrabony Defects ◽  
Clinical Attachment Level ◽  
New Approach ◽  
Novel Approach ◽  
Probing Depth ◽  
Baseline Values ◽  
Attachment Level

Background: this study evaluates the clinical outcomes of a novel approach in treating deep intrabony defects utilizing papilla preservation techniques with a combination of hyaluronic acid (HA) and deproteinized porcine bone mineral. Methods: 23 patients with 27 intrabony defects were treated with a combination of HA and deproteinized porcine bone mineral. Clinical attachment level (CAL), pocket probing depth (PPD), gingival recession (REC) were recorded at baseline and 6 months after the surgery. Results: At 6 months, there was a significant CAL gain of 3.65 ± 1.67 mm (p < 0.001) with a PPD reduction of 4.54 ± 1.65 mm (p < 0.001), which was associated with an increase in gingival recession (0.89 ± 0.59 mm, p < 0.001). The percentage of pocket resolution based on a PPD ≤4 mm was 92.6% and the failure rate based on a PPD of 5 mm was 7.4%. Conclusions: the present findings indicate that applying a combined HA and xenograft approach in deep intrabony defects provides clinically relevant CAL gains and PPD reductions compared to baseline values and is a valid new approach in treating intrabony defects.

scholarly journals Surgical Treatment of Periodontal Intrabony Defects with Calcium Sulphate in Combination with Beta Tricalcium Phosphate – A 12-Month Retrospective Clinical Evaluation

2010 ◽  
Vol 53 (4) ◽  
pp. 229-234 ◽  
Author(s):  
Sujith Sukumar ◽  
Ivo Dřízhal ◽  
Josef Bukač ◽  
Vladimíra Paulusová ◽  
Shriharsha Pilathadka
Keyword(s):  
Tissue Regeneration ◽  
Tricalcium Phosphate ◽  
Gingival Recession ◽  
Calcium Sulphate ◽  
Intrabony Defects ◽  
Clinical Attachment Level ◽  
Beta Tricalcium Phosphate ◽  
Probing Depth ◽  
One Year ◽  
Attachment Level

Alloplastic bone graft materials are widely been used in combination with barrier membranes to achieve guided tissue regeneration in the treatment of periodontal intrabony defects. This study was designed to evaluate the clinical outcome of a composite material, beta tricalcium phosphate in combination with calcium sulphate in the treatment of periodontal intrabony defects. The combination of these materials is believed to aid in guided tissue regeneration owing to their properties. Thirty nine intrabony defects in 21 patients were treated with Fortoss® Vital (Biocomposites, Staffordshire, UK). Clinical parameters were evaluated including changes in probing depth, clinical attachment level/loss and gingival recession at baseline and one year postoperatively. The mean differences in measurements between the baseline and one year postoperatively are a reduction of 1.98±1.16 mm (p=0.000) in case of probing depth and a gain of 1.68±1.12 mm (p=0.000) in clinical attachment level and an increase of 0.31±0.67 mm (p=0.009) in gingival recession measurements. The study results show that the treatment with a combination of beta tricalcium phosphate and calcium sulphate led to a significantly favorable clinical improvement in periodontal intrabony defects one year postoperatively.

scholarly journals Assessment of the effect of vacuum-formed retainers and Hawley retainers on periodontal health: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253968
Author(s):  
Bowen Li ◽  
Yifeng Xu ◽  
Cailian Lu ◽  
Zhenheng Wei ◽  
Yongyue Li ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Grey Literature ◽  
Mean Difference ◽  
Cochrane Library ◽  
Periodontal Health ◽  
Probing Depth ◽  
Significant Difference ◽  
Orthodontic Patients ◽  
The Cochrane Library ◽  
Sulcus Probing Depth

Background Recently, increasing attention has been paid to the periodontal health of orthodontic patients in the maintenance stage in clinical practice. The focus of this meta-analysis was to compare the effects of vacuum-formed retainers (VFR) and Hawley retainers (HR) on periodontal health, in order to provide a reference for clinical selection. Methods From the establishment of the database until November 2020, a large number of databases were searched to find relevant randomized control trials, including the Cochrane Library databases, Embase, PubMed, Medline via Ovi, Web of Science, Scopus, Grey Literature in Europe, Google Scholar and CNKI. Related literature was manually searched and included in the analysis. Two researchers screened the literature according to relevant criteria. The size of the effect was determined using RevMan5.3 software, and the mean difference and 95% confidence intervals (CI) were used to estimate the results using a random effects model. Results This meta-analysis included six randomized controlled trials involving 304 patients. The results of the meta-analysis showed that there was no statistical difference in sulcus probing depth status between the VFR group and the HR group, including at 1, 3, and 6 months. Compared with the VFR group, the HR group showed a lower gingival index at 1 month (mean difference = 0.12, 95%CI: 0.06 to 0.19) and 3 months (mean difference = 0.11, 95%CI: 0.06 to 0.17), while there was no statistically significant difference at 6 months (mean difference = 0.10, 95%CI: -0.07 to 0.27). The plaque index of the HR group also showed a good state at 1 month (mean difference = 0.06, 95%CI: 0.01 to 0.12), 3 months (mean difference = 0.12, 95%CI: 0.08 to 0.16), and 6 months (mean difference = 0.19, 95%CI: 0.09 to 0.29). Subgroup analysis of PLI showed that when all teeth were measured, PLI status was lower in the HR group at 6 months (mean difference = 0.32, 95%CI: 0.18 to 0.46). PLI status was also low for the other teeth group (mean difference = 0.15, 95%CI: 0.08 to 0.22). Conclusion Our meta-analysis showed that patients using the Hawley retainer had better periodontal health compared with those using vacuum-formed retainers. However, more research is needed to look at the periodontal health of patients using these two retainers.

Use of Anorganic Bovine-Derived Hydroxyapatite Matrix/Cell-Binding Peptide (P-15) in the Treatment of Class II Furcation Defects: A Clinical and Radiographic Study in Humans

2007 ◽  
Vol 78 (12) ◽  
pp. 2277-2283 ◽  
Author(s):  
Ana L. Eto ◽  
Julio C. Joly ◽  
Marjorie Jeffcoat ◽  
Ney S. de Araújo ◽  
Vera C. de Araújo ◽  
...  
Keyword(s):  
Class Ii ◽  
Radiographic Study ◽  
Cell Binding ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Furcation Defects

Effects of Mixture of Fibrin-Fibronectin Sealant System and Calcium Carbonate in Periodontal Intrabony Defects

2006 ◽  
Vol 309-311 ◽  
pp. 1397-1400
Author(s):  
Ui Won Jung ◽  
S.J. Chang ◽  
Seong Ho Choi ◽  
C.S. Kim ◽  
Jung Kiu Chai
Keyword(s):  
Calcium Carbonate ◽  
Gingival Recession ◽  
Control Group ◽  
Intrabony Defects ◽  
Clinical Attachment Level ◽  
Intrabony Defect ◽  
Probing Depth ◽  
Group 2 ◽  
Attachment Level ◽  
Experimental Group

This study evaluated the effects of mixture of fibrin-fibronectin sealant system(FFSS) and calcium carbonate(CC) in periodontal intrabony defects. Thirty six sites with two or three wall intrabony defect were used. 14 defects treated with periodontal flap surgery were assigned as the control group. 11 defects treated with CC implantation were designed as experimental group 1 and 11 defects, treated with CC and FFSS implantation as experimental group 2. The control and experimental groups all achieved statistically significant improvements in probing depth and clinical attachment level from the baseline (P<0.01). In mean postsurgery probing depth and gingival recession reduction, there were no statiscally significant differences between the experimental groups and the controls. However, mean postsurgery clinical attachment levels of both experimental groups improved significantly more than that of the controls. As a result, we suggest that mixture of FFSS and CC can be used effectively in intrabony defect as osteoconductive materials.

Ridge Preservation With Acellular Dermal Matrix and Anorganic Bone Matrix Cell-Binding Peptide P-15 After Tooth Extraction in Humans

2011 ◽  
Vol 82 (1) ◽  
pp. 72-79 ◽  
Author(s):  
Patricia Garani Fernandes ◽  
Arthur B. Novaes ◽  
Adriana Correa de Queiroz ◽  
Sergio Luis Scombatti de Souza ◽  
Mario Taba ◽  
...  
Keyword(s):  
Tooth Extraction ◽  
Bone Matrix ◽  
Acellular Dermal Matrix ◽  
Ridge Preservation ◽  
Cell Binding ◽  
Dermal Matrix ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Acellular Dermal

scholarly journals Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years’ follow-up

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110445
Author(s):  
Hiroyuki Saida ◽  
Shunsuke Fukuba ◽  
Takahiko Shiba ◽  
Keiji Komatsu ◽  
Takanori Iwata ◽  
...  
Keyword(s):  
Case Report ◽  
Periodontal Regeneration ◽  
Gingival Recession ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Two Stage ◽  
Probing Depth ◽  
Keratinized Mucosa ◽  
Depth Reduction ◽  
Matrix Derivative

Periodontal regenerative treatment is useful for intrabony defects and furcation involvement, but is difficult when there is insufficient keratinized mucosa to cover and maintain the regenerative material, particularly in the mandibular molar region. We report the case of a 27-year-old woman who underwent a two-stage surgical approach for a class II furcation defect with gingival recession and insufficient keratinized mucosal width (KMW) and vestibular depth at the mandibular left first molar. We first improved the KMW and keratinized mucosal thickness using an epithelial embossed connective tissue graft with enamel matrix derivative, and then focused on periodontal regeneration at the furcation defect using an enamel matrix derivative and a bovine-derived xenograft. Probing depth reduction, clinical attachment gain, horizontal probing depth reduction, KMW gain, and gingival recession reduction were observed 3 years postoperatively. This case report suggests that this novel staged approach may be effective for treating furcation defects with insufficient keratinized mucosa, thus providing useful insights into periodontal regeneration therapy.

A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study

2007 ◽  
Vol 8 (6) ◽  
pp. 25-34 ◽  
Author(s):  
Manohar L. Bhongade ◽  
Ishan R. Tiwari
Keyword(s):  
Comparative Evaluation ◽  
Bone Matrix ◽  
Radiographic Study ◽  
Cell Binding ◽  
Binding Peptide ◽  
Matrix Cell ◽  
Defect Sites ◽  
Synthetic Cell ◽  
Infrabony Defects ◽  
Open Flap Debridement

Abstract Aim The development of biologic modalities designed to enhance bone regeneration and wound healing of specific periodontal sites continues to unfold. This is accomplished through the cell binding activity of Type-I collagen provided by a synthetic cell binding peptide (P-15) which is incorporated in a scaffold of anorganic bovine matrix (ABM). This combination is designed to facilitate the attachment, migration, and differentiation of cells. The objective of this study is to clinically and radiographically evaluate the effectiveness of the combination of ABM and P-15 (ABM/P-15) ‘putty’ during regenerative periodontal procedures. Methods and Materials A total of 20 interproximal intraosseous defects in 16 patients, (8 males, 8 females), age 22-48 years (mean 34.45) were recruited and divided equally into two experimental groups. Following open flap debridement (OFD), the defect sites in a test group were grafted with a bovine-derived xenograft enriched with a cell binding peptide. The defect sites in a control group were treated with only OFD. Appropriate periodontal maintenance schedules were followed; at six months, clinical and radiographic assessments for soft tissue and hard tissue were performed for documentation and finalization of results. Results Statistical analysis using student paired ‘t’ test analyses of the patient mean value from the 16 patients revealed the ABM/P-15 ‘putty’ graft group demonstrated significantly better mean defect fill of 3.4 + 0.7 mm (70.5%) versus mean defect fill of 0.9 mm (17.33%) for defects treated with only OFD. Soft tissue findings showed significant differences among treatment with ABM/P-15 compared to OFD. Conclusions These results indicate the use of P-15 synthetic cell binding peptide combined with ABM yields better clinical results in conjunction with OFD than with OFD alone. Citation Bhongade ML, Tiwari IR. A Comparative Evaluation of the Effectiveness of an Anorganic Bone Matrix/ Cell Binding Peptide with an Open Flap Debridement in Human Infrabony Defects: A Clinical and Radiographic Study. J Contemp Dent Pract 2007 September; (8)6:025-034.

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