scholarly journals Realitization and Testing of Mini Extruder for Biomaterial Filament in Biomedical Application

Author(s):  
Yudan Whulanza

The use of biomaterials in tissue engineering technique requires an engineered scaffold that allow the cells to be growth. Therefore, a specific biomaterial is required to provide a supportive environment for the seeding cell. This study focused on the design and realization of mini-extruder to produce a biocompatible filament material. Later, the filament is applied in a fused deposition modelling to realize biocompatible scaffold. The extruder uses a single screw extruder of 25mm diameter with compression ratio of 2. Moreover, the extruder has an effective length of 305mm with a screw length ratio of the feed zone and metering zone by 20% and 40%. A forming die used has a diameter of 1.7mm. At the end of the realization step, the device was tested to produce the filament with various parameters which are screw rotational speed, winding speed, temperature and torque. Characterization of the produced filaments were done by measuring the diameter of filaments using the material of polycaprolactone (PCL). The filament results have a range of 0.05-1.48mm in diameter during the testing process.

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 28 ◽  
Author(s):  
Amabel García-Domínguez ◽  
Juan Claver ◽  
Ana María Camacho ◽  
Miguel A. Sebastián

The lack of specific standards for characterization of materials manufactured by Fused Deposition Modelling (FDM) makes the assessment of the applicability of the test methods available and the analysis of their limitations necessary; depending on the definition of the most appropriate specimens on the kind of part we want to produce or the purpose of the data we want to obtain from the tests. In this work, the Spanish standard UNE 116005:2012 and international standard ASTM D638–14:2014 have been used to characterize mechanically FDM samples with solid infill considering two build orientations. Tests performed according to the specific standard for additive manufacturing UNE 116005:2012 present a much better repeatability than the ones according to the general test standard ASTM D638–14, which makes the standard UNE more appropriate for comparison of different materials. Orientation on-edge provides higher strength to the parts obtained by FDM, which is coherent with the arrangement of the filaments in each layer for each orientation. Comparison with non-solid specimens shows that the increase of strength due to the infill is not in the same proportion to the percentage of infill. The values of strain to break for the samples with solid infill presents a much higher deformation before fracture.


2015 ◽  
Vol 773-774 ◽  
pp. 267-271
Author(s):  
M. Hashim Rahman ◽  
Mohd Sallehuddin Yusof ◽  
Mohd Halim Irwan Ibrahim ◽  
S.A. Osman

Polymer nanocomposites (PNC) have emerged as new materials which can show significantly enhanced mechanical properties over other polymer based materials through the addition of relatively small amounts of nanoscale additives. Rapid prototyping is impacting biomedical in several important ways. This research aims to investigate the potential of using new polymer nanocomposites (PNC) as a raw material for fused deposition modelling machine (FDM). Here, PNCs materials containing a polyamide (PA) and nanoparticles (<5wt%) will be synthesis by mechanical blending using twin extruder compounder to produce 0.85mm diameter of PNC. Dispersion analysis of the nanoparticles in the polymer matrix will be analyzed during the preparation and synthesis process. Futhermore, molecular binding and mixture structure will be investigated by using XPS analysis & Laser Raman Spectroscopy. Material will be characterized for their thermal properties using DSC and processed using FDM, the commercial rapid prototyping (RP) machine. The RP processing parameters will be established and used to produce test specimens to evaluate the mechanical properties of the PNC.


2021 ◽  
Vol 7 (6) ◽  
pp. 57314-57334
Author(s):  
Kevin Sacramento Vivas Neres ◽  
Érica Cristina Almeida ◽  
José Carlos Camargo ◽  
Erickson Fabiano Moura Sousa Silva ◽  
Victor Hugo Martins De Almeida

2020 ◽  
Author(s):  
Kaushik V. Prasad ◽  
H. Adarsha ◽  
Ashutosh Pattnaik ◽  
B. Shashank ◽  
P. Sri Sai Kiran ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253181
Author(s):  
Caterina Amendola ◽  
Michele Lacerenza ◽  
Ileana Pirovano ◽  
Davide Contini ◽  
Lorenzo Spinelli ◽  
...  

The interest for Fused Deposition Modelling (FDM) in the field of Diffuse Optics (DO) is rapidly increasing. The most widespread FDM materials are polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS), thanks to their low cost and easiness-to-print. This is why, in this study, 3D printed samples of PLA and ABS materials were optically characterized in the range from the UV up to the IR wavelengths, in order to test their possible employment for probe construction in DO applications. To this purpose, measurements with Near Infrared Spectroscopy and Diffuse Correlation Spectroscopy techniques were considered. The results obtained show how the material employed for probe construction can negatively affect the quality of DO measurements.


Author(s):  
Sara Figueiredo ◽  
Ana I Fernandes ◽  
Fátima G Carvalho ◽  
João F Pinto

Abstract Objectives The objective of this study was to develop a method for the preparation and characterization of paroxetine (PRX) tablets, obtained by coupling hot-melt extrusion and fused deposition modelling (FDM)-based three-dimensional printing (3DP) technology. The impact of the printing process parameters on the drug stability and on the tablets performance was assessed. Methods Tablets were obtained by FDM of hot-melt extruded PRX-loaded filaments. Physicochemical, thermal, spectroscopic, diffractometric analysis and in-vitro dissolution tests of the intermediate products and the finished dosage forms were performed. Key findings The characterization of printed tablets evidenced mass and dimensions uniformity, and consistency of drug content and dissolution profile. The formation of amorphous solid dispersions and interaction of formulation components throughout the manufacturing process were demonstrated. Layer thickness, printing temperature, printing and travelling speeds, and infill were the most impacting process parameters on both the physicochemical properties and the in-vitro performance of the 3D-printed tablets. Conclusions PRX tablets, meeting compendial limits, were manufactured by 3DP, envisaging their clinical use as individually designed dosage forms. The assessment of the impact of processing parameters on the printed tablets provided insights, which will ultimately allow streamlining of the 3D process set-up for quicker and easier production of patient-centric medicines.


2020 ◽  
Vol 14 (3) ◽  
pp. 7296-7308
Author(s):  
Siti Nur Humaira Mazlan ◽  
Aini Zuhra Abdul Kadir ◽  
N. H. A. Ngadiman ◽  
M.R. Alkahari

Fused deposition modelling (FDM) is a process of joining materials based on material entrusion technique to produce objects from 3D model using layer-by-layer technique as opposed to subtractive manufacturing. However, many challenges arise in the FDM-printed part such as warping, first layer problem and elephant food that was led to an error in dimensional accuracy of the printed parts especially for the overhanging parts. Hence, in order to investigate the manufacturability of the FDM printed part, various geometrical and manufacturing features were developed using the benchmarking artifacts. Therefore, in this study, new benchmarking artifacts containing multiple overhang lengths were proposed. After the benchmarking artifacts were developed, each of the features were inspected using 3D laser scanner to measure the dimensional accuracy and tolerances. Based on 3D scanned parts, 80% of the fabricated parts were fabricated within ±0.5 mm of dimensional accuracy as compared with the CAD data. In addition, the multiple overhang lengths were also successfully fabricated with a very significant of filament sagging observed.


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