scholarly journals Use of Nanoparticles for the Treatment of Malignant Neoplasm As a Cancer Targeted Drug Delivery System

2019 ◽  
Vol 7 (4) ◽  
pp. 84-88
Author(s):  
Mohammad Khan Gayoor ◽  
Umama Yezdani ◽  
Ayush Kumar ◽  
Mayur Sadar ◽  
Shorabh Rav ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Cell Biology ◽  
Sequence Data ◽  
Malignant Neoplasm ◽  
Rational Approach ◽  
Optimal Drug ◽  
Dreaded Disease

The current situation of Malignant Neoplasm is very different it’s the fourth decade and despite much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this dreaded disease, Malignant Neoplasm commonly known as (Cancer) till now we did not understand the actual difference between the cancer cell and its normal counterpart. If we did not understand we cannot control, eliminate, treat cancer. The human genome sequence and its subsequent improvements in the sequence data are important steps to fully comprehend cancer cell biology. The current recent advances in the understanding of pharmacokinetic & pharmacodynamic behaviour of drug have offered a more rational approach to the development of optimal drug delivery system. The novel drug delivery systems (NDDS) are carriers which maintain the drug concentration in therapeutic range for a longer period of time. Nanotechnology, a new, novel focus of research evolved from the convergence and coalescence of many diverse scientific disciplines which includes Nanomedicine will have an impact on the key challenges in cancer therapy: nanotubes, Nanopores, and nanoparticles are the most promising applications for various Malignant Neoplasm treatments.  

scholarly journals Prepartion And Bio Pharmaceutical Evaluation Of Chronopharmaceutical Drug Delivery System Of Metoprolol

2021 ◽  
Vol 23 (09) ◽  
pp. 1052-1068
Author(s):  
Apollo James ◽  
◽  
Mohanraj Palanisamy ◽  
Jasmina Khanam ◽  
Mohanraj Palanisamy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Immediate Release ◽  
Early Morning ◽  
Optimal Drug ◽  
Basic Purpose ◽  
Pulsatile Drug Delivery ◽  
Preformulation Studies

The basic purpose of constructing drug delivery systems is to design when and where the drug will be released. The episode of many biological events is really important for such knowledge. Metoprolol pulsatile drug delivery system was developed for this purpose, which can release the drug when blood pressure needs to be modulated in the early morning. The Cup and core techniques were used to build this system, which included immediate release (IR), sustained-release (SR), and a polycaprolactone plug layer. The formulation of the ingredients was facilitated by various preformulation studies. The IR and SR tablets were bilayered, with polycaprolactone entirely coating the IR layer. The IR and SR tablet release profiles were optimised for the F5 batch, which was then used to construct a pulsatile drug delivery system. Clinical trials were conducted with the prepared tablet, which included the use of BaSO4 tagged tablets for X-ray examinations. All of the findings indicated the optimal drug release of metoprolol, which can be used for individuals who are more prone to blood pressure abnormalities in the morning.

Toward the optimal drug delivery system and cell manipulation using liposome

2007 ◽  
Vol 3 (4) ◽  
pp. 348
Author(s):  
Takayuki Nakayama ◽  
Takehisa Dewa ◽  
Masamichi Sakaguchi ◽  
Hiromi Mochiyama ◽  
Mamoru Nango ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Manipulation ◽  
Optimal Drug

scholarly journals Gram Scale Synthesis of Dual-Responsive Dendritic Polyglycerol Sulfate as Drug Delivery System

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 982
Author(s):  
Felix Reisbeck ◽  
Alexander Ozimkovski ◽  
Mariam Cherri ◽  
Mathias Dimde ◽  
Elisa Quaas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Laser Scanning Microscopy ◽  
Cell Uptake ◽  
Confocal Laser ◽  
Hydroxyl Groups ◽  
Polymer Backbone ◽  
Dual Responsive

Biocompatible polymers with the ability to load and release a cargo at the site of action in a smart response to stimuli have attracted great attention in the field of drug delivery and cancer therapy. In this work, we synthesize a dual-responsive dendritic polyglycerol sulfate (DR-dPGS) drug delivery system by copolymerization of glycidol, ε-caprolactone and an epoxide monomer bearing a disulfide bond (SSG), followed by sulfation of terminal hydroxyl groups of the copolymer. The effect of different catalysts, including Lewis acids and organic bases, on the molecular weight, monomer content and polymer structure was investigated. The degradation of the polymer backbone was proven in presence of reducing agents and candida antarctica Lipase B (CALB) enzyme, which results in the cleavage of the disulfides and ester bonds, respectively. The hydrophobic anticancer drug Doxorubicin (DOX) was loaded in the polymer and the kinetic assessment showed an enhanced drug release with glutathione (GSH) or CALB as compared to controls and a synergistic effect of a combination of both stimuli. Cell uptake was studied by using confocal laser scanning microscopy with HeLa cells and showed the uptake of the Dox-loaded carriers and the release of the drug into the nucleus. Cytotoxicity tests with three different cancer cell lines showed good tolerability of the polymers of as high concentrations as 1 mg mL−1, while cancer cell growth was efficiently inhibited by DR-dPGS@Dox.

scholarly journals Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?

Oncotarget ◽  
2017 ◽  
Vol 8 (63) ◽  
pp. 107176-107187 ◽  
Author(s):  
Kylie Van Hoesen ◽  
Sonia Meynier ◽  
Pascale Ribaux ◽  
Patrick Petignat ◽  
Florence Delie ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Cancer Patients ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Cell Targeting ◽  
Promising Tool ◽  
Cancer Cell Targeting

scholarly journals Multifunctional (3-in-1) cancer theranostics applications of hydroxyquinoline-appended polyfluorene nanoparticles

2017 ◽  
Vol 8 (11) ◽  
pp. 7566-7575 ◽  
Author(s):  
Sayan Roy Chowdhury ◽  
Sudip Mukherjee ◽  
Sourav Das ◽  
Chitta Ranjan Patra ◽  
Parameswar Krishnan Iyer
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Cell Imaging ◽  
Cancer Cell Imaging ◽  
Cancer Theranostics

A biocompatible fluorescent hydroxyquinoline-affixed polyfluorene (PF-HQ) nanoparticle-based drug delivery system (DDS: PF-HQ–DOX) is utilized for cancer cell imaging, transport and delivery of the FDA-approved drug doxorubicin (DOX), and theranostics applications.

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