Jurisprudential characterization of the person infected with the Corona epidemic and the jurisprudential rulings resulting from his disposal in financial compensation contracts: Sale contract as a model: التوصيف الفقهي للمصاب بوباء كورونا والأحكام الفقهية المترتبة على تصرفه في عقود المعاوضات المالية: عقد البيع أنموذجا

This research aims to clarify the jurisprudential characterization of the person infected with the Corona epidemic, and to clarify the jurisprudential provisions resulting from his disposal in the sales contract; This is because the patient may suffer from obsessions that affect his behavior, and the researcher has combined the inductive approach by following the issues related to the topic of research, collecting and categorizing them, and the descriptive approach in terms of mentioning the sayings of the jurists in each issue with its evidence, with mentioning the sayings of the considered schools of jurisprudence, and the discussions on them as possible, and clarifying The most correct, and the reason for the weightingThe researcher came out with results, the most important of which are: The Corona epidemic can be described by what is called jurisprudence as a dreaded disease, selling the person infected with the Corona epidemic if he is not indebted to a foreigner or buying it from him for the same price is valid without the heirs’ permission, whether debtor or not, and it is also true if it is a favoritism of one third or less Pre-emption is established for the partner in the case of the patient selling to an heir or someone else if the sale is made at the same price, pre-emption is established for the intercessor if the purchaser is from the patient by favoritism and the intercessor is foreign, and the option of the condition and the fault of the person suffering from the epidemic is not lost if there is an excuse such as loss of consciousness or the like.

Non-Pharmaceutical Interventions against COVID-19 Pandemic: Review of Contact Tracing and Social Distancing Technologies, Protocols, Apps, Security and Open Research Directions

The COVID-19 Pandemic has punched a devastating blow on the majority of the world’s population. Millions of people have been infected while hundreds of thousands have died of the disease throwing many families into mourning and other psychological torments. It has also crippled the economy of many countries of the world leading to job losses, high inflation, and dwindling Gross Domestic Product (GDP). The duo of social distancing and contact tracing are the major technological-based non-pharmaceutical public health intervention strategies adopted for combating the dreaded disease. These technologies have been deployed by different countries around the world to achieve effective and efficient means of maintaining appropriate distance and tracking the transmission pattern of the diseases or identifying those at high risk of infecting others. This paper aims to synthesize the research efforts on contact tracing and social distancing to minimize the spread of COVID-19. The paper critically and comprehensively reviews contact tracing technologies, protocols, and mobile applications (apps) that were recently developed and deployed against the coronavirus disease. Furthermore, the paper discusses social distancing technologies, appropriate methods to maintain distances, regulations, isolation/quarantine, and interaction strategies. In addition, the paper highlights different security/privacy vulnerabilities identified in contact tracing and social distancing technologies and solutions against these vulnerabilities. We also x-rayed the strengths and weaknesses of the various technologies concerning their application in contact tracing and social distancing. Finally, the paper proposed insightful recommendations and open research directions in contact tracing and social distancing that could assist researchers, developers, and governments in implementing new technological methods to combat the menace of COVID-19.

Fatalism and stigma amongst cancer patients in south western Punjab

The ideology and beliefs have a profound impact upon once lifestyle. Economic status, level of knowledge and awareness, beliefs and notions, social support system available, constitutes important determinants impacting to copeup strategies for cancer victims. The present study was conducted to assess the fatalism and stigma amongst cancer patients in south western Punjab. Two districts i.e. Bathinda and Sri Muktsar Sahib were randomly selected. Majority (87.5%) of the respondents believe that in cancer patients attributed cancer has caused due to their karmas. Forty six per cent of the respondents believed that cancer is contagious. One third (34.3%) of the respondents and their family members used the term ‘cancer’ as they believed that taking the name of disease had nothing to do with its curability versus non-curability or to describe the dreaded disease from which they were suffering. One third of the male respondents perceived imbalanced diet and sedentary lifestyle behind as a reasoning causing cancer and half of the male respondents and significantly majority of the female respondents (93.3%) perceived substance abuse as a reason behind causing cancer in the region. The study suggests that NGOs, religious bodies and philanthropists can contribute significantly towards treatment, management and rehabilitation of cancer victims. The use of recommended doses of pesticides/ insecticides and fertilizers and unprecedented use of chemicals should be monitored through government agencies and guilty should be punished.

Estimates of Prevalence of Pulmonary Hypertension according to Different International Definitions

Background. Pulmonary hypertension is a dreaded disease associated with considerable morbidity and mortality. The pulmonary hypertension developing due to chronic respiratory disease is a unique subset with symptoms often getting masqueraded by the underlying respiratory condition. The importance of early detection of this complication has been realized worldwide, and recently, the definition of pulmonary hypertension was revised to set the cutoff of mean pulmonary artery pressure (mPAP) at 20 mmHg instead of 25 mmHg at rest. In our study, we have tried to estimate the difference this new definition brings to the prevalence of pulmonary hypertension among interstitial lung disease patients at our centre. Methods. This was a cross-sectional study in which all the patients of ILDs (n = 239) attending the outdoor and indoor Department of Respiratory Medicine, King George’s Medical University, India, for the duration of one year were subjected to transthoracic echocardiography along with measurement of serum pro-B-type natriuretic peptide (BNP) and troponin T values. The data were analyzed using the different definitions, and the prevalence was compared. Result. Incidence of pulmonary hypertension among ILD patients at mPAP cutoff ≥ 25 was 28.9%, while that at value ≥20 mmHg, incidence of pulmonary hypertension increased to 46.0%. An increment of 15–20% in incidence of pulmonary hypertension was observed among different types of ILD when cutoff of mPAP was changed. Conclusion. The new definition helps in a significant increase in the detection of pulmonary hypertension, which certainly helps in earlier detection and better management of patients.

Biogenic metallic nanoparticles and their anticancer activities: Biotechnological perspectives

Cancer is considered to be a dreaded disease throughout the world. There are many different types of drugs available to treat this disease. Nowadays, scientists are engaged to develop drugs at the nanoscale. The nano-drugs are found to exhibit more efficiency and accuracy. Nanotechnology is an emerging technology dealing with the development of nano-particles and nanostructures. These substances have acquired significance because of their size, shape and potential efficiency as well as specificity. Nano-particles mediated drugs were very focusing, emerging objective regarding the use of different types of nanoparticles as carrier to treat cancerous tumors and cancer cells. Medicinal lysis or synthesis of nanoparticles with biological procedures has become very much significant due to their specific efficacy and lesser harms compared to other available medicines used for cancer. In this review, green plants, their active compounds and metallic nano-particles are discussed with emphasis on their anticancer activities and properties.

EFFICACY OF AYURVEDA THERAPEUTICS IN PREVENTION AND MANAGEMENT OF COVID 19 PANDEMIC AND POST COVID RECOVERY PHASE: AN EVIDENCE BASED REVIEW

Corona virus disease 19 (COVID 19) is a dreaded disease caused by Severe Acute Respiratory Syndrome corona virus 2(SARS CO V2). This wide spread pandemic had taken whole world into custody, alone in India as per data available on myGov (Govt of India website) more than 3 cr. people affected and 4 lac surplus fatalities reported till 17 September 2021. Post COVID complications are also severe and hospitalisation is needed in some cases. Despite all the prophylactic and therapeutic measures been taken to contain the disorder, strategies to cure it thoroughly without other complications, is still a challenge. Though vaccination drive against COVID 19 is running successfully in India, medicines to minimise the impact and sufferings because of COVID is indispensable. Approaching holistically based on Dosha sidhanta Ayurveda therapeutics had shown favourable results in COVID positive patients. Ayurveda believes that disease manifestation is the result of imbalanced doshas, if we become competent to manage and pacify those doshas, disease can be cured. Vyadhipratyanik chikitsha (disease and symptoms targeting therapy) and Hetupratyanik chikitsha (cause and dosha targeting therapy) are the modules that are approached in Ayurveda system. Reviewing the previous work done in this field and observing COVID19 on Ayurveda parameters, Ayurveda medicines and therapeutics have been anticipated here to heal the scar impacted by precarious COVID 19. Much more researches and clinical interventions are required to establish kind of effective therapy.

Covid-19 Infection in India: A Comparative Analysis of the Second Wave with the First Wave

Coronavirus disease 2019 (COVID-19) is considered as the most dreaded disease that has spread all over the world in the recent past. Despite its outbreak in December 2019–January 2020, a few continents and countries such as India started to experience a significant number of COVID-19-positive cases from March 2020. GISAID clade variation analysis in the period March 2020–February 2021 (period I) and March 2021–first week of April 2021 (period II) showed a rapid variation of SARS-CoV-2 in all continents and India over time. Studying the relationship of patient age or gender with viral clades in these two periods revealed that the population under 10 years of age was the least affected, whereas the 11–60-year-old population was the most affected, irrespective of patient gender and ethnicity. In the first wave, India registered quite a low number of COVID-19-positive cases/million people, but the scenario unexpectedly changed in the second wave, when even over 400,000 confirmed cases/day were reported. Lineage analysis in India showed the emergence of new SARS-CoV-2 variants, i.e., B.1.617.1 and B.1.617.2, during April–May 2021, which might be one of the key reasons for the sudden upsurge of confirmed cases/day. Furthermore, the emergence of the new variants contributed to the shift in infection spread by the G clade of SARS-CoV-2 from 46% in period II to 82.34% by the end of May 2021. Along with the management of the emergence of new variants, few factors viz., lockdown and vaccination were also accountable for controlling the upsurge of new COVID-19 cases throughout the country. Collectively, a comparative analysis of the scenario of the first wave with that of the second wave would suggest policymakers the way to prepare for better management of COVID-19 recurrence or its severity in India and other countries.

Advanced Breast Cancer in Nigeria: A Single Centre Experience

Background: Breast cancer is the most common cancer globally and in Nigeria, it constitutes about 12% of all new cancers and 25% of all cancers in women. In Nigeria, the majority of patients present with late disease and globally, advanced breast cancer is associated with a low survival rate among patients. This study seeks to review the presentation of advanced breast cancer as seen in the University of Port Harcourt Teaching Hospital, Southern Nigeria. Patients and Methods: This is a 5-year retrospective study conducted at the University of Port Harcourt Teaching Hospital. Records of patients that presented to the hospital within the study period with histologically proven breast cancer (stages 3 and 4) were retrieved, and relevant data extracted and analysed using SPSS version 22. Results: There were 47 patients with advanced breast cancer and they were all females. Their ages ranged from 25 to 72 years with a mean of 43.9 ± 4.7 and peak age of 31–50 years. Majority of the patients (72.3%) had stage 3 disease while 13 (27.7%) of them had stage 4. The lung was the commonest metastatic site and this was seen in 7 (14.9%) patients, followed by the liver in 1 (2.1%). Conclusion: Advanced breast cancer remains a dreaded disease that reduces patients’ quality of life significantly and may also be rapidly fatal. Community-based efforts in collaboration with Non-Governmental Organizations (NGOs) targeted at information dissemination to the public, and offering breast cancer screening and subsidized cancer treatment are essential to reduce the mortality associated with this deadly disease.

Technological Resources for Fighting COVID-19 Pandemic Health Issues

The COVID-19 pandemic has had a global effect with several people dying daily due to the dreaded disease. Therefore, each individual has a duty to support the efforts of their countries either financially, socially, technically, or by any other means to contribute to the fight against the COVID-19 pandemic. During this crisis, engineers can come up with innovations to fight the pandemic. One of the reasons for the death of a patient suffering from COVID-19 was the lack of resources required for patient care. The doctors who are taking care of COVID patients could get infected due to lack or the deficiency of available safety kits. Some of the resources required to fight COVID-19 are personal protective equipment (PPE) (e.g. gloves, gowns, face masks and shields for respiratory and eye protection respectively), mechanical ventilators and body vital monitoring devices. Engineers can contribute to the fight against COVID-19, by developing compact size ventilators, 3D printed face shield, masks, door handles, hand sanitizer, etc. The available medicines to fight the disease are still under development and trials with limited options at present has led to deaths among patients mostly those who are elderly or having any co-morbid condition. The deficiency of medicine availability can be resolved up to some extent by applying tools of supply chain management.

Caring for a Child with Cancer: Experiences of Jordanian Mothers

The diagnosis of childhood cancer is one of the most serious and unexpected experiences a mother can endure. A descriptive phenomenological approach was used to explore the experiences of mothers of children diagnosed with cancer in Jordan. Themes that emerged include (1) Emotional response on knowing the diagnosis (feelings of shock, lack of preparedness, denial, and feelings of “paralysis”), (2) Fear of the dreaded disease (fear of suffering and fear of death), and (3) The challenges of the treatment journey (inadequate financial resources, role transition, and feeling socially isolated). This study describes the experiences of Jordanian mothers who care for their children diagnosed with cancer so that health care providers can develop strategies to provide adequate psychological support to these mothers.