scholarly journals Evaluation of Selected Flavonoids for the Anthelmintic and Skeletal Muscle Relaxant Activity using Animal Models

2021 ◽  
Vol 11 (6) ◽  
pp. 127-134
Author(s):  
S Bala Yaswanth Kumar ◽  
Suranjan Bantupalli ◽  
Deekshit Atluri
Keyword(s):  
Skeletal Muscle ◽  
Animal Models ◽  
Muscle Relaxant ◽  
Fruits And Vegetables ◽  
Muscle Relaxants ◽  
Activity Levels ◽  
Skeletal Muscle Relaxant ◽  
Turn On ◽  
Photocell Beam ◽  
Muscle Relaxant Activity

Most fruits and vegetables contain flavonoids, a type of phytonutrient. As well as carotenoids, they're responsible for fruits and vegetable brilliant hues. Some other phytonutrients such as flavonoids are strong antioxidants with anti-inflammatory and immune properties. There are many flavonoids, including anthocyanins, flavones, flavonols, flavonoids, and isoflavonoids. Quercetin and chrysin were chosen for the investigation. Humans and other animals can contract Helminthiasis (helminthiases), sometimes known as worm infection. Tapeworms, roundworms, and flukes are only a few of the parasites that exist. Skeletal muscle relaxants are used to treat spasticity caused by upper motor neuron syndromes and muscle discomfort or musculoskeletal spasms created by peripheral disturbances. Samples of quercetin and chrysin were generated in the presence of 0.5% SCMC suspension at concentrations of 10, 20, 30, and 40 mg/ml, and then analyzed. To keep track of photocell beam disruptions, a six-digit counter was utilized (locomotor activity). It was time to turn on the actophotometer and examine the locomotor behavior of each rat for five minutes. The basal activity levels of all the animals were recorded. Keywords: Flavonoids, Anthelmintic, Skeletal Muscle relaxant, animal models

Glacial Acetic Acid Catalyzed Synthesis, Physicochemical and Biological Evaluation of Benzodiazepines as Potent CNS Agents

2019 ◽  
Vol 19 (2) ◽  
pp. 146-151
Author(s):  
Vipin Kumar ◽  
Shweta Verma ◽  
Sushil Kumar
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Treated Group ◽  
Biological Evaluation ◽  
Log P ◽  
Control Group ◽  
Skeletal Muscle Relaxant ◽  
Benzodiazepine Derivatives ◽  
Chloro Group ◽  
Muscle Relaxant Activity

Background: Approach for green chemistry for chemical synthesis is found to be very efficient as it makes the reaction more easily, less tedious, maximize desired products and minimize by-products. Materials & Methods: Utilizing this approach 1, 5-benzodiazepines and its derivatives have been synthesized and evaluated for skeletal muscle and antianxiety activity. 1, 5-benzodiazepine derivatives have attracted great attention due to its diversity of pharmacological activities and its application in heterocyclic synthesis and medicines. The target compounds were synthesized by first reacting o-phenylenediamine with acetophenone to yield 1, 5-benzodiazepines. In the next step the NH of 1, 5-benzodiazepines were chloroacetylated and then the chloro group was substituted with different anilines. The structures were confirmed on the basis of their TLC, IR, 1H NMR and CHN elemental studies. The physicochemical parameters were determined for BBB penetration through online software. Results: The Log P values of the compounds tested showed that compounds have the potential to be CNS active. The compounds were evaluated for the skeletal muscle relaxant activity and antianxiety activity. It was investigated that 1, 5-benzodiazepines derivatives possess significant differences between control group and treated group. Conclusion: Among these derivatives, the compound bearing chloro group possesses the highest skeletal muscle relaxant and antianxiety activity.

Evaluation of Skeletal Muscle Relaxant Activity of Apigenin in Animal Experimental Models

2021 ◽  
Vol 17 (6) ◽  
pp. 400-407
Author(s):  
Syed Mohammed Basheerudd ◽  
Basheerahmed Abdulaziz ◽  
Ahmad Alanazi ◽  
Bader Almusharra ◽  
Naif Alanazi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Experimental Models ◽  
Skeletal Muscle Relaxant ◽  
Muscle Relaxant Activity

EVALUATION OF CENTRALLY ACTING SKELETAL MUSCLE RELAXANT ACTIVITY OF ALCOHOLIC EXTRACTS OF ASHWAGANDHA (WITHANIA SOMNIFERA) ROOTS IN ALBINO MICE.

2021 ◽  
pp. 62-64
Author(s):  
Sarita Panigrahy ◽  
Sangeeta Panigrahy
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Withania Somnifera ◽  
Standard Drug ◽  
Alcohol Extract ◽  
Skeletal Muscle Relaxant ◽  
Albino Mice ◽  
Muscle Relaxant Activity ◽  
Off Time ◽  
Different Doses

BACKGROUND:Skeletal muscle relaxants are drugs that are used to relax and diminish tightness in muscles. Many medicinal plants have known to have skeletal muscle relaxant activity. In past studies some Polyherbal formulation containing Ashwagandha as one of the ingredients and its fat extract have shown to have skeletal muscle relaxant activity in experimental animal models. This study is intended to evaluate the skeletal muscle relaxant activity of alcoholic extracts of Withania Somnifera (Ashwagandha) roots in albino mice, as the literature regarding this extract is scarce. METHODOLOGY: Standard drug (diazepam), different doses of Alcohol extract of ashwagandha (50,100, 150 mg/kg) were given orally to mice and muscle relaxant activity was assessed by Rota-rod apparatus. The fall off time from the rotating rod was noted for each group after 1 hour of drug administration. The difference in fall off time among the standard drug and treated mice was taken as an index of muscle relaxation. RESULTS:The test extract at its different doses showed highly signicant reduction in the time spent by the animals on revolving rod in rotarod test when compared to baseline (p < 0.0001) which is highly signicant. On comparison with diazepam, different doses of Alcohol extract showed weak relaxant activity. CONCLUSIONS : The three different doses of Alcoholic extract showed a dose dependent rise in muscle relaxant action. The results are promising for further investigation of efcient skeletal muscle relaxant activity.

scholarly journals Evaluation of centrally acting skeletal muscle relaxant activity of aqueous extract of Withania somnifera (ashwagandha) roots in albino mice

2018 ◽  
Vol 8 (1) ◽  
pp. 157
Author(s):  
Sarita Panigrahy
Keyword(s):  
Skeletal Muscle ◽  
Aqueous Extract ◽  
Muscle Relaxant ◽  
Withania Somnifera ◽  
Standard Drug ◽  
Skeletal Muscle Relaxant ◽  
Albino Mice ◽  
The Difference ◽  
Muscle Relaxant Activity ◽  
Off Time

Background: Skeletal muscle relaxants are used to treat both muscle spasm and spasticity, acting both as antispasmodic and antispasticity agents. In past studies some polyherbal formulations containing ashwagandha have shown skeletal muscle relaxant activity and fat extract of ashwagandha showed skeletal muscle relaxant activity in experimental animal models. This study is designed to evaluate the skeletal muscle relaxant activity of aqueous extract of Withania somnifera (ashwagandha) roots in albino mice, as the literature regarding them is limited.Methods: Standard drug (diazepam) and different doses of Aqueous extract of ashwagandha (50, 100,150mg/kg) were given orally to albino mice. Skeletal muscle relaxant activity was assessed by Rota-rod apparatus. The fall off time from the rotating rod was noted for each group after 1 hour of drug administration. The difference in fall off time from the rotating rod between the standard and treated mice was taken as an index of muscle relaxation.Results: The test extract at doses (50mg/kg, 100mg/kg and 150mg/kg) showed highly significant reduction in the time spent by the animals on revolving rod in rota rod test when compared to baseline (p <0.0001). As compared with diazepam, aqueous extract (150mg/kg) showed almost equal reduction in the time spent by the animals on revolving rod in rota rod test.Conclusions: This study indicates that the aqueous extract of ashwagandha possess central skeletal muscle relaxant activity. The results are promising for further investigation of efficient skeletal muscle relaxant activity.

SYNTHESIS, CHARACTERIZATION AND SKELETAL MUSCLE RELAXANT ACTIVITY FOR NOVEL [1,4]DIAZEPINO[2,3-G]QUINOXALINE DERIVATIVES

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (09) ◽  
pp. 38-44
Author(s):  
D. Visagaperumal ◽  
Pemmadi Raghuveer Varma ◽  
R. Jayakumar ◽  
Vineeth Chandy
Keyword(s):  
Skeletal Muscle ◽  
Biological Activity ◽  
Muscle Relaxant ◽  
Functional Group ◽  
Spectroscopic Method ◽  
Skeletal Muscle Relaxant ◽  
Quinoxaline Derivatives ◽  
Group Variation ◽  
Muscle Relaxant Activity ◽  
The Relationship

Novel [1,4]diazepino[2,3-g]quinoxaline derivatives 5a-5i were designed, synthesized and characterized by spectroscopic method and elemental analysis. The title compounds were screened for skeletal muscle relaxant. Among the synthesized analogs, compound 5g and compound 5h revealed significant skeletal muscle relaxant activity. The relationship between the functional group variation and the biological activity of the synthesized compounds is discussed.

scholarly journals A study to evaluate the skeletal muscle relaxant property of Pregabalin and Gabapentin in albino rats

2019 ◽  
Vol 8 (6) ◽  
pp. 1381 ◽  
Author(s):  
Sushma V. Naidu ◽  
Vibha Rani
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Muscle Relaxation ◽  
Statistical Significance ◽  
Muscle Relaxants ◽  
Control Group ◽  
Albino Rats ◽  
Skeletal Muscle Relaxant ◽  
Significant Difference ◽  
Group 5

Background: Skeletal muscle relaxants are the drugs which reduce unwanted spasm without interfering with consciousness and voluntary movements. The centrally acting muscle relaxants like Diazepam, is known to be GABA mimetics and other antiepileptics like Gabapentin and Pregabalin also act through the release of GABA. This study is done to investigate skeletal muscle relaxant property of these drugs in comparison to Diazepam.Methods: T Models used in the experiment are Grip Strength Test, Rota Rod Method, Beam Walk Test, Photoactometer Test. Animals were divided into 6 groups of 6 rats each: Group 1: Control group treated with normal saline (0.1 ml/10gm), Group 2: Standard-15mg/kg of Diazepam, Group 3:T1-60 mg/kg of Gabapentin, Group 4:T2-10 mg/kg of Pregabalin, Group 5:T3-60 mg/kg of Gabapentin+Diazepam, Group 6:T4- 10 mg/kg of Pregabalin+Diazepam. Mean and standard deviation was calculated for each group. One way ANOVA was used for multiple group comparisons followed by post hoc Tukey’s test for statistical significance between the groups.Results: Treatment with the above test drugs produced significant muscle relaxation and caused decreased fall off, sliding time, increase climbing time and decreased locomotor activity in all models indicating motor incoordination. The results obtained from both standard and test groups showed a highly significant difference in muscle relaxation when compared with the control group.Conclusions: The test drugs showed skeletal muscle relaxant property in rats comparable to Diazepam. In view of these results, it can open a new avenue for these drugs to be used as skeletal muscle relaxants after conducting clinical trials.

Sign in / Sign up

Export Citation Format

Share Document