EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL

2017 ◽  
Vol 2 (3) ◽  
pp. 1-5
Author(s):  
M. Salim Mirza ◽  
Keyword(s):  
Blood Sugar ◽  
Methanolic Extract ◽  
Stem Bark ◽  
Preclinical Model ◽  
Tissue Lipids ◽  
Sugar Levels

Plasminogen Activation in Diabetes Mellitus: Normalization of Blood Sugar Levels Improves Impaired Enzyme Kinetics In Vitro

1985 ◽  
Vol 54 (02) ◽  
pp. 413-414 ◽  
Author(s):  
Margarethe Geiger ◽  
Bernd R Binder
Keyword(s):  
Plasminogen Activator ◽  
Blood Sugar ◽  
Metabolic Disorders ◽  
Normal Values ◽  
Diabetic Patients ◽  
Type I ◽  
Plasminogen Activation ◽  
Lag Period ◽  
Sugar Levels

SummaryWe have demonstrated previously that fibrin enhanced plasmin formation by the vascular plasminogen activator was significantly impaired, when components isolated from the plasma of three uncontrolled diabetic patients (type I) were used to study plasminogen activation in vitro. In the present study it can be demonstrated that functional properties of the vascular plasminogen activators as well as of the plasminogens from the same three diabetic patients are significantly improved after normalization of blood sugar levels and improvement of HbAlc values. Most pronounced the Km of diabetic vascular plasminogen activator in the presence of fibrin returned to normal values, and for diabetic plasminogen the prolonged lag period until maximal plasmin formation occurred was shortened to almost control values. From these data we conclude that the observed abnormalities of in vitro fibrinolysis are not primarily associated with the diabetic disease, but might be secondary to metabolic disorders caused by diabetes.

Effects of Rapid Infusion of Ethanol on some Factors Controlling Blood Sugar Levels in Man

1972 ◽  
Vol 33 (3) ◽  
pp. 722-733 ◽  
Author(s):  
John W. Dundee ◽  
Martin Isaac ◽  
Elizabeth A. Davis ◽  
Brian Sheridan
Keyword(s):  
Blood Sugar ◽  
Rapid Infusion ◽  
Sugar Levels

Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vanessa Mba Matah Marthe ◽  
Gilbert Ateufack ◽  
Marius Mbiantcha ◽  
William Yousseu Nana ◽  
Albert Donatien Atsamo ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Gastric Lesion ◽  
Stem Bark ◽  
Male Rats ◽  
Gastric Ulcers ◽  
Gastric Lesions ◽  
Mucus Production ◽  
Antisecretory Activity ◽  
Antisecretory Effect ◽  
Pylorus Ligation

AbstractObjectivesIn African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of the methanolic extract of the stem bark of this plant using different technics of gastric lesion induction.MethodsCytoprotective and antisecretory activity of the methanolic extract of D. benthamianus stem bark was evolved through six methods of gastric lesion induction in experimental Wistar male rats (150–200 g): (1) gastric lesions induced by HCl/ethanol, (2) gastric lesions induced by Indomethacin- HCl/ethanol, (3) gastric lesion induced by Indomethacin, (4) gastric lesions induced by Pylorus ligation, (5) gastric lesions induced by histamine-Pylorus ligation, (6) gastric lesions induced by carbachol-Pylorus ligation. Mucus and gastric mucosal ulceration were evaluated. pH, gastric volume, and acidity were quantified in all pylorus ligation induction technics. Nitric oxide (NO) level was determined in indomethacin induced gastric ulcers.ResultsAt different doses (125, 250 and 500 mg/kg), extract reduced significantly the ulcer index. In all models used, that is 100.00% with HCl/ethanol; 100.00% with HCl/ethanol/indomethacin; 95.70% with Indomethacin; 74.79% with pylorus ligation, 95.94% histamine-Pylorus ligation, 99.54% carbachol-Pylorus ligation at the highest dose of 500 mg/kg. The lesion formation reduces in all the methods used followed by a significant increase of mucus production. The pylorus ligation technic revealed that the extract has an antisecretory activity.ConclusionsThe methanolic extract of D. benthamianus stem bark has both cytoprotective and antisecretory effects. This extract exerts its antisecretory effect trough cholinergic and histaminergic pathways.

scholarly journals Acute and Sub-Acute Toxicity Evaluation of the Methanolic Extract of Alstonia scholaris Stem Bark

2016 ◽  
Vol 4 (1) ◽  
pp. 4 ◽  
Author(s):  
Idris Bello ◽  
Abdulmenem Bakkouri ◽  
Yasser Tabana ◽  
Bassel Al-Hindi ◽  
Majed Al-Mansoub ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract ◽  
Stem Bark ◽  
Toxicity Evaluation ◽  
Alstonia Scholaris

Effects of Myrtus communis leaf extracts on CdCl2-induced metabolic disturbance in male wistar rats

2020 ◽  
Vol 9 (5) ◽  
pp. 185-192
Author(s):  
Hafsa Dellaoui ◽  
Abdelkrim Berroukche ◽  
Bakhta Bouzouira ◽  
Narimen Taibi ◽  
Mohamed Zouidi ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Methanol Extract ◽  
Cadmium Accumulation ◽  
Male Rats ◽  
Myrtus Communis ◽  
Leaf Extracts ◽  
Male Wistar Rats ◽  
Sugar Levels ◽  
Induced Changes ◽  
Preventive Effects

Cadmium (Cd) is widespread in the environment. Cd toxicity targets liver and renal tissues and generates oxidative stress. Medicinal plants produce antioxidants scavenging reactive oxygen species (ROS) and chelate heavy metals. This study aimed to investigate the preventive effects of Myrtus communis leaves hydro-methanol extract (HME) and aqueous extract (AE) on Cdinduced toxicity. The experiments were carried out, during 30 days, on male rats; GR1 (controls), GR2 treated with CdCl2 (18 mg/kg), GR3 co-treated with HME (1 g/kg) and Cd (18 mg/kg), GR4 co-treated with AE (1 g/kg) and Cd (18 mg/kg), GR5 with HME and GR6 with AE. Cd induced changes in biochemical parameters (transaminases, urea, creatinine and blood sugar)related to hepato renal function, increased tissue mortification and decreased animals’ body weight. While the treatment animals, with M. communis leaves (HME) or (AE), regulated blood sugar levels. Hepatic steatosis and loss of glomeruli were particularly induced either by Cd or a co-treatment with Cd and plant extracts. M. communis extracts (HME and EA) can regulate blood sugar levels and prevent cadmium accumulation.

PLASMA FREE FATTY ACID AND BLOOD SUGAR LEVELS IN NEWBORN INFANTS AND THEIR MOTHERS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (4) ◽  
pp. 597-604
Author(s):  
Doman K. Keele ◽  
Jacob L. Kay
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Newborn Infants ◽  
Plasma Free Fatty Acid ◽  
Significant Negative Correlation ◽  
The Mean ◽  
Sugar Levels ◽  
Diabetic Mothers

Simultaneous plasma free fatty acid (FFA) and blood sugar levels were determined for fasting newborn infants during the first 24 hours of life, for their cord bloods, and for their mothers at delivery. The following observations were made. In control infants the mean FFA level rose about three times the cord level after birth and was accompanied by a 25% drop in the mean blood sugar level. Thereafter, the mean blood sugar level remained relatively constant, but the mean FFA level varied from 2½ to 3 times the cord level. There was no significant correlation between the length of maternal fasting prior to delivery and the infant FFA level; there was, however a significant negative correlation between the length of maternal fasting prior to delivery and the infant blood sugar level at 24 hours of age. High FFA levels occurred in the infants of obese mothers and low levels were observed in infants with delayed respirations, in infants of preeclamptic mothers, and in infants of diabetic mothers.

Sign in / Sign up

Export Citation Format

Share Document