scholarly journals Seroprevalence and risk factors associated with Helicobacter pylori infection among children aged less than 18 years old in Duhok Province, Iraq

2021 ◽  
Vol 7 (3) ◽  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Infection Rate ◽  
Side Population ◽  
Helicobacter Pylori Infection ◽  
Kurdistan Region ◽  
Serological Tests ◽  
Factors Associated ◽  
History Of ◽  
H Pylori

Objectives: Helicobacter pylori infection is predominantly acquired in early childhood and persists for decades before causing disease. This study aimed to detect the prevalence of H. pylori infection and identify potential factors associated with infection in Duhok province, Iraq. Methods: This cross-sectional study was conducted in Duhok Province, Kurdistan Region, Iraq. Over a four-year period from 2016 to 2020, a total of 381 children aged four to 18 years who attended the hospitals and were evaluated for specific IgG antibodies against H. pylori using serological tests were included. A questionnaire was completed at the start of the study. H. pylori serology data were analyzed using the chi-square test. Results: The seroprevalence of H. pylori IgG-specific antibodies among the study participants was 31%. The infection rate significantly increased with increasing age of the participants (p<0.001), from 19.8% among four to five-year-olds to 42.9% among 16 and 18-year-olds. The infection rate was significantly higher in girls (35.9%) than that in boys (26.5%) (p<0.047). Infections were also higher among university students (41%; p<0.001), children from the country-side population (41%; p<0.001), children from crowded households (67.3%; p<0.001), and children with a history of gastrointestinal pain (44.4%; p>0.001). Conclusion. The prevalence rate of H. pylori infection among children in Duhok province is quite similar to that reported in previous studies in the Kurdistan region, Iraq, and increases with age. University attendance, history of gastrointestinal pain, countryside population, and overcrowding were risk factors associated with H. pylori infection. Valuable approaches to improve sanitary purposes and educational and socioeconomic status should be emphasized and promoted to reduce the risk of H. pylori infection among children.

Environmental risk factors associated with Helicobacter pylori seroprevalence in the United States: a cross-sectional analysis of NHANES data

2015 ◽  
Vol 143 (12) ◽  
pp. 2520-2531 ◽  
Author(s):  
W. S. KRUEGER ◽  
E. D. HILBORN ◽  
R. R. CONVERSE ◽  
T. J. WADE
Keyword(s):  
United States ◽  
Risk Factors ◽  
Helicobacter Pylori ◽  
Environmental Risk ◽  
The United States ◽  
Environmental Risk Factors ◽  
Living Conditions ◽  
Well Water ◽  
Factors Associated ◽  
H Pylori

SUMMARYHelicobacter pylori imparts a considerable burden to public health. Infections are mainly acquired in childhood and can lead to chronic diseases, including gastric ulcers and cancer. The bacterium subsists in water, but the environment's role in transmission remains poorly understood. The nationally representative National Health and Nutrition Examination Survey (NHANES) was examined for environmental risk factors associated with H. pylori seroprevalence. Data from 1999–2000 were examined and weighted to represent the US population. Multivariable logistic regression estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) for associations with seropositivity. Self-reported general health condition was inversely associated with seropositivity. Of participants aged <20 years, seropositivity was significantly associated with having a well as the source of home tap water (aOR 1·7, 95% CI 1·1–2·6) and living in a more crowded home (aOR 2·3, 95% CI 1·5–3·7). Of adults aged ⩾20 years, seropositivity was not associated with well water or crowded living conditions, but adults in soil-related occupations had significantly higher odds of seropositivity compared to those in non-soil-related occupations (aOR 1·9, 95% CI 1·2–2·9). Exposures to both well water and occupationally related soil increased the effect size of adults' odds of seropositivity compared to non-exposed adults (aOR 2·7, 95% CI 1·3-5·6). Environmental exposures (well-water usage and occupational contact with soil) play a role in H. pylori transmission. A disproportionate burden of infection is associated with poor health and crowded living conditions, but risks vary by age and race/ethnicity. These findings could help inform interventions to reduce the burden of infections in the United States.

scholarly journals Verrucous antral gastritis in relation to Helicobacter pylori infection, nutrition, and gastric atrophy

2019 ◽  
Vol 8 (4) ◽  
pp. 293-298
Author(s):  
Naoko Tsuji ◽  
Yasuko Umehara ◽  
Mamoru Takenaka ◽  
Yasunori Minami ◽  
Tomohiro Watanabe ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Reflux Esophagitis ◽  
English Literature ◽  
Indigo Carmine ◽  
Gastric Atrophy ◽  
Helicobacter Pylori Infection ◽  
Antral Gastritis ◽  
Numerous Type ◽  
History Of ◽  
H Pylori

Abstract Background There have been few studies in the English literature regarding verrucous gastritis (VG). The present study investigated the clinical and endoscopic features of verrucous antral gastritis, especially focusing on Helicobacter pylori infection, nutrition, and gastric atrophy. Methods We performed a retrospective study of patients who underwent routine endoscopy with indigo carmine chromoendoscopy and a comparative study was conducted between VG-positive and VG-negative groups. VG was subdivided into classical and numerous types based on the number and distribution of verrucous lesions. Demographic, clinical, and endoscopic data including body mass index (BMI), serum albumin and cholesterol, gastric atrophy, reflux oesophagitis, Barrett’s oesophagus, and H. pylori status were collected. Univariate and multivariable analyses were performed to identify factors associated with VG. Results We analysed the data of 621 patients undergoing routine endoscopy and found that VG (n = 352) was significantly associated with increased BMI (1.12 [1.05–1.18], P &lt; 0.01), reflux esophagitis (1.96 [1.10–3.28], P &lt; 0.01), and H. pylori negativity with or without a history of eradication (9.94 [6.00–16.47] and 6.12 [3.51–10.68], P &lt; 0.001, respectively). Numerous-type (n = 163) VG was associated with both closed- and open-type gastric atrophy (9.9 [4.04–21.37] and 8.10 [3.41–19.24], P &lt; 0.001, respectively). There were no statistical differences between groups regarding age, sex, total cholesterol, albumin, and bile-colored gastric juice. Conclusions Verrucous antral gastritis was related to increased BMI, reflux esophagitis, and H. pylori negativity. Numerous-type verrucous lesions were associated with gastric atrophy. These indicate that VG may be a physiological phenomenon due to high gastric acidity, mechanical overload, and vulnerability of background mucosa.

scholarly journals Prevalence and factors associated with Helicobacter Pylori infection among children with sickle cell anemia attending Mulago hospital, in Uganda

2019 ◽  
Author(s):  
IDRIS SWALEH MUBIRU ◽  
Phillip Gita Kasirye ◽  
Heather Hume ◽  
Grace Ndeezi
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Epigastric Pain ◽  
Pneumococcal Vaccination ◽  
Helicobacter Pylori Infection ◽  
Mulago Hospital ◽  
Factors Associated ◽  
H Pylori

Abstract Background Children with sickle cell anemia (SCA) have a high predisposition to a range of infections and gastrointestinal disorders. Studies of children living in low income countries have shown high levels of infection with Helicobacter Pylori (H. Pylori), however, there are no reports in children with sickle cell anemia.Objectives We aimed to describe the prevalence and factors associated with Helicobacter pylori infection among children with sickle cell anemia at Mulago Hospital Sickle Cell Clinic, in Uganda.Methods A cross sectional design was employed to consecutively enroll 369 children with confirmed sickle cell anemia aged 5-18 years, attending the Mulago hospital sickle cell clinic. Assessments included; abdominal pain (current, recurrent, generalized or epigastric), dyspeptic symptoms, other relevant medical and social histories. Blood and stool samples were collected and an antigen test (test kit SD Bioline) was carried out on the latter to determine H.pylori infection. Ethical approval, consent and assent (for children above 8 years of age) were obtained. Data was entered using EPI DATA version 3.1 and analysed using STATA version 12.0. H. pylori prevalence was determined as a proportion of children with a positive stool test expressed as a percentage. Adjusted Odds ratios (aOR) were used to determine factors associated with H.pylori infection.Results H.pylori infection was detected in 47.7% (176/379), 95% CI (42.9-53.1) of the cases. Having epigastric pain was independently associated with H.pylori infection; aOR 2.22, 95%CI: (1.1 – 4.6), p-value= 0.03 . Pneumococcal vaccination aOR 0.41, 95% (CI 0.2-0.9; p=0.019 ) or H.pyroli combination therapy aOR 0.183, 95% (CI 0.1- 0.6; p=0.006 ) were protective against H.pylori. Recurrent abdominal pain did not predict H.pyroli infection. Conclusions H.pylori infection was common among children with sickle cell anemia and was independently associated with epigastric pain but not recurrent pain. Pneumococcal vaccination and combination H. pylori treatment were protective against the infection. Screening for H.Pylori should be carried out in sickle cell anaemia children with epigastric pain.

scholarly journals Tissue transglutaminase activity in human gastric mucosa according to Helicobacter pylori infection

2018 ◽  
Vol 243 (15-16) ◽  
pp. 1161-1164
Author(s):  
Maria Pina Dore ◽  
Giovanni Mario Pes ◽  
Alessandra Errigo ◽  
Alessandra Manca ◽  
Giuseppe Realdi
Keyword(s):  
Helicobacter Pylori ◽  
Animal Models ◽  
Gastric Mucosa ◽  
Natural History ◽  
Tissue Transglutaminase ◽  
Helicobacter Pylori Infection ◽  
Human Gastric Mucosa ◽  
Antral Mucosa ◽  
History Of ◽  
H Pylori

Tissue transglutaminase (t-TG) is a multifunctional protein involved in the healing of gastric erosions and ulcers in animal models. The aim of this study was to measure gastric t-TG activity in patients with dyspepsia according to Helicobacter pylori infection and cytotoxin-associated gene A (cagA) and vacuolating cytotoxin (vacA) subtype status. Patients undergoing upper endoscopy not taking any medications were enrolled. Tissue-TG activity was determined in homogenates of antral specimens using a radiometric assay and was expressed in pmol/mg. The cagA and vacA genotypes were determined by PCR amplification using gene-specific oligoprimers. Data from 46 patients were available (17 of them were positive for H. pylori). Antral t-TG activity was significantly increased in H. pylori positive patients compared to H. pylori negative patients (6437 ± 3691 vs. 3773 ± 1530 pmol/mg; P = 0.001) according to Mann–Whitney U test. Patients with H. pylori negative gastritis had higher t-TG activity than patients with normal gastric mucosa. The specimens infected with cagA positive strains (72%) displayed greater t-TG activity than cagA negative samples (7358 ± 4318 vs. 4895 ± 1062 pmol/mg; P = 0.237). Similarly, t-TG activity was higher in H. pylori vacA s1/m1 strains vs. vacA s1/m2 (7429 vs. 5045 pmol/mg; P = 0.744), and vacA s1/m1 vs. s2/m2 (7429 vs. 4489 pmol/mg; P = 0.651) but the results were not significant. No differences were found between histology, endoscopy features and t-TG activity. These results show that t-TG activity is significantly greater in gastritis associated with H. pylori infection, suggesting that this enzyme is induced by inflammation and may have an important role in the natural history of human gastritis. Impact statement Tissue transglutaminase (t-TG) is unique among TG enzymes because of its additional role in several physiological and pathological activities, including inflammation, fibrosis, and wound healing. The presence of t-TG has previously been described in the intestine of human and animal models, yet studies on t-TG activity in human gastric mucosa are missing. Helicobacter pylori infection is the major cause of gastritis and peptic ulcers. For the first time, our results show that t-TG activity was significantly higher in antral specimens of patients with chronic active gastritis associated with H. pylori infection compared to H. pylori negative chronic gastritis and normal antral mucosa. These findings suggest that t-TG has a role in the natural history of human gastritis, which requires further investigation but may be an avenue for new therapeutic options.

scholarly journals Sero-Prevalence and Risk Factors for Helicobacter pylori Infection Among Individuals with and those Without Dyspepsia in Zaria, Northwestern Nigeria

2020 ◽  
Vol 1 (1) ◽  
pp. 73-76
Author(s):  
Okonkwo Lilian Okwubenata ◽  
Musa Bolanle Olufunke Priscilla ◽  
Hali Bello ◽  
Mustapha Shettima Kagu
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Low Socioeconomic Status ◽  
Immunoglobulin G ◽  
Rural Areas ◽  
Urban Areas ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
H Pylori ◽  
Study Participants

Background Helicobacter pylori infection is prevalent in African region especially in areas with low socioeconomic status. This study aimed to determine the prevalence and risk factors for Helicobacter pylori Infection among individuals with and those without dyspepsia Materials and Methods The study was cross sectional in which individuals with and those without dyspepsia were enrolled. The prevalence for Helicobacter pylori infection was determined by the screening of Helicobacter pylori immunoglobulin G and this was compared across variables of interest. IBM SPSS was used for the data analysis. Results Overall prevalence of Helicobacter pylori immunoglobulin G was 44 (37.9 %). There was no association between H pylori infection and dyspepsia (0.894). There was statistically significant association between residing in rural areas and acquiring of Helicobacter pylori infection (P= 0.011). Study participants from rural areas had significantly higher and lower pit latrines and water closet toilets respectively than the study participants who reside in urban areas (P= 0.0001). Conclusion Modest prevalence of Helicobacter pylori infection was observed and no association between H pylori infection and dyspepsia was observed. There is a need to take strategic measures towards improving level of socio-economic status of the rural areas so as to reduce the risk of contracting Helicobacter pylori infection in people living in rural areas

scholarly journals Prevalence and Factors associated with Helicobacter pylori among Adults between 18 and 40 Years at Butembe Health Centre III Kyankwanzi district, Uganda.

2021 ◽  
Author(s):  
◽  
Shubeika Kakooza
Keyword(s):  
Helicobacter Pylori ◽  
Health Centre ◽  
Antibody Test ◽  
Population Based ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Face To Face ◽  
Factors Associated ◽  
Cross Sectional Design ◽  
H Pylori

Background: The prevalence of Helicobacter pylori infection varies by geography, ethnicity, and socioeconomic factors. Available data on the prevalence of Helicobacter pylori infection in Uganda are not representative of the general population. We sought to describe the prevalence and factors associated with H.pylori among adults between 18 and 40 years at Butemba Health Centre III. Methodology: Using a cross-sectional design, H. pylori infection was assessed by the H.pylori antibody test among 181respondents attending Butemba Health Centre III in Kyankwanzi. Data were collected by face-to-face interviews using a questionnaire. Associations between H. pylori infection and factors associated were analyzed using logistic regression. Results: The overall prevalence of H. pylori infection was 29.2%. However, H. pylori infection was highest (54.14%) in the age of 18 to 30 years study participants followed by 31 to 40 years (45.8%). H. pylori was associated with smoking of cigarettes (AOR = 0.732; 95% CI: 0.275-1.950), drinking alcohol (AOR = 4.373; 95% CI: 1.359-14.06), Poor sanitation (AOR = 5.33; 95% CI: 2.556-11.11) were also independently associated with H. pylori infection.    Conclusion and recommendation: The prevalence of H. pylori infection in Kyakwanzi at 29.2% calls for population-based studies in the region and offers an opportunity to study the transmission dynamics of H. pylori infection. Changes in public health measures need to be instituted in the management of H. pylori infection to include education of the population and health care workers on the non-specific and insidious clinical presentation of the condition. 

scholarly journals CagA-positive Helicobacter pylori infection is not associated with decreased risk of Barrett's esophagus in a population with high H. pylori infection rate

2003 ◽  
Vol 124 (4) ◽  
pp. A636 ◽  
Author(s):  
angel Lanas ◽  
Rafael Benito ◽  
Maria Asuncion Garcia-Gonzalez ◽  
Juan Arenas ◽  
Angel Ferrandez ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Barrett’S Esophagus ◽  
Infection Rate ◽  
Barrett's Esophagus ◽  
Helicobacter Pylori Infection ◽  
H Pylori

Helicobacter pylori infection in rehabilitation staff younger than 35 years: Infection surveillance for three years

2019 ◽  
Vol 20 (5) ◽  
pp. 240-245
Author(s):  
Kazuto Ikezawa ◽  
Takeshige Kanamori ◽  
Kentaro Iwai ◽  
Kouichirou Otsuka ◽  
Mariko Kobayashi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Infection Rate ◽  
Japanese Patients ◽  
Helicobacter Pylori Infection ◽  
Infection Rates ◽  
Initial Examination ◽  
Infection Surveillance ◽  
Elderly Japanese ◽  
Elderly Japanese Patients ◽  
H Pylori

Background: Screening for Helicobacter pylori infection is important because of the high risk of gastric cancer development. The H. pylori carrier rate among elderly Japanese patients is still high; therefore, rehabilitation (RH) workers who are in frequent contact with such individuals could be assumed to be at a higher risk of H. pylori infection. Aim/Objective: We surveyed RH workers to investigate the initial occurrence of H. pylori infections in adults. Methods: Urine samples of RH workers aged < 35 years were screened for H. pylori antibodies to confirm infection. H. pylori infection rates were stratified according to the type of RH work and duration of employment. Infection surveillance was performed at six-month intervals for H. pylori-negative individuals. Findings/Results: The H. pylori infection rate among 173 workers was 16.8%. Infection rates were 26.3%, 16.3% and 15.3% among speech, occupational and physiotherapists, respectively. The employment duration was divided into < 24, 24–47, 48–60 and ⩾ 61 months; the respective infection rates were 5.0%, 12.0%, 17.6% and 28.6%. However, no new H. pylori infection was detected in a total of seven surveillance studies of H. pylori-negative workers over a three-year period. Discussion: The results of the initial examination showed that the infection rate increased with the duration of employment. However, subsequent surveillance detected no new H. pylori infections.

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