scholarly journals Prevalence and factors associated with Helicobacter Pylori infection among children with sickle cell anemia attending Mulago hospital, in Uganda

2019 ◽  
Author(s):  
IDRIS SWALEH MUBIRU ◽  
Phillip Gita Kasirye ◽  
Heather Hume ◽  
Grace Ndeezi
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Epigastric Pain ◽  
Pneumococcal Vaccination ◽  
Helicobacter Pylori Infection ◽  
Mulago Hospital ◽  
Factors Associated ◽  
H Pylori

Abstract Background Children with sickle cell anemia (SCA) have a high predisposition to a range of infections and gastrointestinal disorders. Studies of children living in low income countries have shown high levels of infection with Helicobacter Pylori (H. Pylori), however, there are no reports in children with sickle cell anemia.Objectives We aimed to describe the prevalence and factors associated with Helicobacter pylori infection among children with sickle cell anemia at Mulago Hospital Sickle Cell Clinic, in Uganda.Methods A cross sectional design was employed to consecutively enroll 369 children with confirmed sickle cell anemia aged 5-18 years, attending the Mulago hospital sickle cell clinic. Assessments included; abdominal pain (current, recurrent, generalized or epigastric), dyspeptic symptoms, other relevant medical and social histories. Blood and stool samples were collected and an antigen test (test kit SD Bioline) was carried out on the latter to determine H.pylori infection. Ethical approval, consent and assent (for children above 8 years of age) were obtained. Data was entered using EPI DATA version 3.1 and analysed using STATA version 12.0. H. pylori prevalence was determined as a proportion of children with a positive stool test expressed as a percentage. Adjusted Odds ratios (aOR) were used to determine factors associated with H.pylori infection.Results H.pylori infection was detected in 47.7% (176/379), 95% CI (42.9-53.1) of the cases. Having epigastric pain was independently associated with H.pylori infection; aOR 2.22, 95%CI: (1.1 – 4.6), p-value= 0.03 . Pneumococcal vaccination aOR 0.41, 95% (CI 0.2-0.9; p=0.019 ) or H.pyroli combination therapy aOR 0.183, 95% (CI 0.1- 0.6; p=0.006 ) were protective against H.pylori. Recurrent abdominal pain did not predict H.pyroli infection. Conclusions H.pylori infection was common among children with sickle cell anemia and was independently associated with epigastric pain but not recurrent pain. Pneumococcal vaccination and combination H. pylori treatment were protective against the infection. Screening for H.Pylori should be carried out in sickle cell anaemia children with epigastric pain.

Low Incidence of Helicobacter pylori Infection in Children With Recurrent Abdominal Pain in Philadelphia

PEDIATRICS ◽  
1995 ◽  
Vol 95 (4) ◽  
pp. 618-618
Author(s):  
Uwe Blecker ◽  
Devendra I. Mehta ◽  
Sophie Lanciers ◽  
Idris D. Dahodwala ◽  
Emanuel Lebenthal
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Young Children ◽  
Recurrent Abdominal Pain ◽  
Helicobacter Pylori Infection ◽  
Antral Gastritis ◽  
The World ◽  
Low Incidence ◽  
H Pylori

Reports from many parts of the world show that Helicobacter pylori infection is widely distributed geographically.1 Both chronic active (antral) gastritis and H pylori colonization are common, even in an asymptomatic population2 and H pylori gastritis has been recognized as an important cause for recurrent abdominal pain (RAP) in children.3 Although the prevalence of H pylori positivity increases with age,4 an important number of relatively young children have been shown to be already infected with this bacteria.5

scholarly journals Relationship of Halitosis with Gastric Helicobacter Pylori Infection

2021 ◽  
Vol 15 (7) ◽  
pp. 2285-2288
Author(s):  
Rakhshinda Jabeen ◽  
Ajmaal Jami ◽  
Aiman Shahab ◽  
Armash Shahab
Keyword(s):  
Helicobacter Pylori ◽  
Epigastric Pain ◽  
Human Condition ◽  
Helicobacter Pylori Infection ◽  
University Hospital ◽  
Clear Correlation ◽  
P Value ◽  
Pathophysiological Mechanism ◽  
H Pylori ◽  
Relationship Of

Background: Halitosis is a common human condition; however, the pathophysiological mechanism of halitosis is still unclear. Halitosis is mostly attributed with oral pathological conditions, in addition, halitosis resulting from gastrointestinal disorders is not rare either. Halitosis is often reported with symptoms related to Helicobacter pylori infection, epigastric pain and gastroesophageal reflux disease. Objective: Halitosis can stem from a number of gastric conditions and one of the most common causes of halitosis include the presence of a gastric infection with Helicobacter pylori. This study was conducted to evaluate the incidence ofhalitosis in patients presenting with Helicobacter pylori infection and epigastric pain. Additionally, to review whether there is a correlation between H pylori infection and halitosis; moreover, to determine whether halitosis is a valid indication for H pylori infection. Methods and Materials: This case control, comparative study was done at Medicine department of Isra University hospital and Civil hospital, Karachi during the period of January 2019 to December 2019. Participants were enrolled only after taking verbal and signed consent. Prior permission from the hospital management was taken as well. Result: Halitosis and H pylori are statistically significant with p value of 0.026. There was a clear correlation between halitosis and H pylori infection, and it may be a common contributor to halitosis.

scholarly journals Haemagglutination (HA) test of Helicobacter pylori

2014 ◽  
Vol 11 (3) ◽  
pp. 1382-1386
Author(s):  
Baghdad Science Journal
Keyword(s):  
Helicobacter Pylori ◽  
Abdominal Pain ◽  
Epithelial Cell ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Epigastric Pain ◽  
Human Epithelial Cell ◽  
Specific Receptors ◽  
H Pylori ◽  
Pathogenic Process

Thirty clinical isolates of Helicobacter pylori bacteria obtained from patients attending endoscopy unit of Ibn-Sena teaching hospital in Mosul . These patients were complaining from epigastric pain , dyspepsia , acidity , vomiting , abdominal pain , flatulance , heart burn and melena . The H. pylori isolates were used for Haemagglutination assay (HA) , which involves the recognition of various glycoconjugates on the surface of red blood cells . In this study sheep red blood cells has been used in (HA) assay because the sheep erythrocytes surface resemble that of human epithelial cells . The results proved by (HA) assay, the ability of H. pylori to adherence to specific receptors on the surface of Human Epithelial Cell , which is the first step in the pathogenic process .

scholarly journals Prevalence and Factors associated with Helicobacter pylori among Adults between 18 and 40 Years at Butembe Health Centre III Kyankwanzi district, Uganda.

2021 ◽  
Author(s):  
◽  
Shubeika Kakooza
Keyword(s):  
Helicobacter Pylori ◽  
Health Centre ◽  
Antibody Test ◽  
Population Based ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Face To Face ◽  
Factors Associated ◽  
Cross Sectional Design ◽  
H Pylori

Background: The prevalence of Helicobacter pylori infection varies by geography, ethnicity, and socioeconomic factors. Available data on the prevalence of Helicobacter pylori infection in Uganda are not representative of the general population. We sought to describe the prevalence and factors associated with H.pylori among adults between 18 and 40 years at Butemba Health Centre III. Methodology: Using a cross-sectional design, H. pylori infection was assessed by the H.pylori antibody test among 181respondents attending Butemba Health Centre III in Kyankwanzi. Data were collected by face-to-face interviews using a questionnaire. Associations between H. pylori infection and factors associated were analyzed using logistic regression. Results: The overall prevalence of H. pylori infection was 29.2%. However, H. pylori infection was highest (54.14%) in the age of 18 to 30 years study participants followed by 31 to 40 years (45.8%). H. pylori was associated with smoking of cigarettes (AOR = 0.732; 95% CI: 0.275-1.950), drinking alcohol (AOR = 4.373; 95% CI: 1.359-14.06), Poor sanitation (AOR = 5.33; 95% CI: 2.556-11.11) were also independently associated with H. pylori infection.    Conclusion and recommendation: The prevalence of H. pylori infection in Kyakwanzi at 29.2% calls for population-based studies in the region and offers an opportunity to study the transmission dynamics of H. pylori infection. Changes in public health measures need to be instituted in the management of H. pylori infection to include education of the population and health care workers on the non-specific and insidious clinical presentation of the condition. 

scholarly journals Prevalence of AntiHelicobacter pylori Antibodies among Students of Cihan University, Erbil

2019 ◽  
Vol 3 (1) ◽  
pp. 66-70
Author(s):  
Sarah Hoshyar Maroof ◽  
Hadi Mahdi Alsakee ◽  
Gulistan Hussein Muhammad ◽  
Asia Sherzad Muhammad ◽  
Ilaf Abdulrazaq Rashid ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Abdominal Pain ◽  
Chronic Disease ◽  
University Students ◽  
Epigastric Pain ◽  
Tap Water ◽  
Human Stomach ◽  
Blood Samples ◽  
H Pylori

Helicobacter pylori is resident in human stomach and causes chronic disease (peptic ulcer and gastritis). The mouth and colon were both known to host a large number of microbes. This study was carried out to investigate the seroprevalence of H. pylori infection among Cihan University students. A total of 197 blood samples were collected from the students (53 females and 144 males) from 13 departments of Cihan University, Erbil, and tested for anti-H. pylori antibodies, using rapid immunochromatography assay. Among 197 students tested, 44 (22.3%) showed positive reaction for H. pylori, 32 males and 12 females. It was non-significantly higher among students with ages ranged between 29 and 32 years old. Twenty-one of infected students were using tap water for drinking. Twenty-six (59.1%) of positive students experienced no symptoms and 18 (40.9%) were symptomatic (13.63% epigastric pain and 27.2% abdominal pain).

scholarly journals Frequency of helicobacter pylori in patients with functional dyspepsia.

2019 ◽  
Vol 26 (08) ◽  
pp. 1261-1265
Author(s):  
Tooba ◽  
Riaz Hussain Awan ◽  
Seema Nayab ◽  
Khadim Hussain Awan ◽  
Faqir Muhammad Awan
Keyword(s):  
Helicobacter Pylori ◽  
Functional Dyspepsia ◽  
Histopathological Examination ◽  
Epigastric Pain ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Male Predominance ◽  
Duration Of Disease ◽  
The Mean ◽  
H Pylori

To evaluate the frequency of Helicobacter pylori in individuals with functional dyspepsia. Study Design: Cross sectional descriptive study. Period: Six months from 01-May-2014 to 31-10-2014. Setting: Liaquat National Hospital, Karachi. Materials and Methods: All the patients between 18 to 70 years of age diagnosed as functional dyspepsia for more than 03 months duration were admitted and evaluated for Helicobacter pylori infection through histopathological examination. Results: Total 121 subjects with functional dyspepsia were screened for Helicobacter pylori infection. The mean ±SD for age of subjects with functional dyspepsia was 41.74±08.87. The mean age ±SD of Helicobacter pylori infected individuals was 40.70±7.82 while the mean ±SD of age in helicobacter pylori negative patients was 40.55±10.63. Majority of the subjects were out-patients, 30-39 years of age with male predominance. The most common duration of disease observed was 6-9 months with epigastric pain and burning the predominant symptoms. The Helicobacter pylori infection was observed in 78(64.4%) individuals, of which 55 were males and 23 were males (p=<0.01). Conclusion: The functional dyspeptic patients are prone to acquire Helicobacter pylori infection therefore present study reported 64.4% prevalence for H. pylori infection with male gender predominance.

scholarly journals Seroprevalence and risk factors associated with Helicobacter pylori infection among children aged less than 18 years old in Duhok Province, Iraq

2021 ◽  
Vol 7 (3) ◽  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Infection Rate ◽  
Side Population ◽  
Helicobacter Pylori Infection ◽  
Kurdistan Region ◽  
Serological Tests ◽  
Factors Associated ◽  
History Of ◽  
H Pylori

Objectives: Helicobacter pylori infection is predominantly acquired in early childhood and persists for decades before causing disease. This study aimed to detect the prevalence of H. pylori infection and identify potential factors associated with infection in Duhok province, Iraq. Methods: This cross-sectional study was conducted in Duhok Province, Kurdistan Region, Iraq. Over a four-year period from 2016 to 2020, a total of 381 children aged four to 18 years who attended the hospitals and were evaluated for specific IgG antibodies against H. pylori using serological tests were included. A questionnaire was completed at the start of the study. H. pylori serology data were analyzed using the chi-square test. Results: The seroprevalence of H. pylori IgG-specific antibodies among the study participants was 31%. The infection rate significantly increased with increasing age of the participants (p<0.001), from 19.8% among four to five-year-olds to 42.9% among 16 and 18-year-olds. The infection rate was significantly higher in girls (35.9%) than that in boys (26.5%) (p<0.047). Infections were also higher among university students (41%; p<0.001), children from the country-side population (41%; p<0.001), children from crowded households (67.3%; p<0.001), and children with a history of gastrointestinal pain (44.4%; p>0.001). Conclusion. The prevalence rate of H. pylori infection among children in Duhok province is quite similar to that reported in previous studies in the Kurdistan region, Iraq, and increases with age. University attendance, history of gastrointestinal pain, countryside population, and overcrowding were risk factors associated with H. pylori infection. Valuable approaches to improve sanitary purposes and educational and socioeconomic status should be emphasized and promoted to reduce the risk of H. pylori infection among children.

scholarly journals Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

2008 ◽  
Vol 45 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Elisabete Kawakami ◽  
Rodrigo Strehl Machado ◽  
Silvio Kazuo Ogata ◽  
Marini Langner
Keyword(s):  
Helicobacter Pylori ◽  
Epigastric Pain ◽  
Helicobacter Pylori Infection ◽  
Rapid Urease Test ◽  
Infection Prevalence ◽  
Antral Mucosa ◽  
Chi Square ◽  
Old Patients ◽  
Urease Test ◽  
H Pylori

BACKGROUND: Decreasing prevalence of H pylori infection has been reported in some countries. AIM: To evaluate the prevalence of Helicobacter pylori infection in a 10-year period in children submitted to upper digestive endoscopy. METHODS: It was a retrospective observational study. The records of 1,165 endoscopies performed during a 10-year period in a public hospital of the City of São Paulo, SP, Brazil, in patients up to 18-year-old. Only the first endoscopy was considered. Helicobacter pylori infection was defined by the rapid urease test, performed with one fragment of antral mucosa. Chi-square for trend has been estimated to compare Helicobacter pylori prevalence across the period. RESULTS: The main indication for endoscopy was epigastric pain (47.4%). There were 392 patients with H pylori infection (33.6%), 12.8% being infants, 19.4% toddlers, 28.8% schoolchildren and 46.3% adolescents. Prevalence was 60.47% in the first year of the study and 30.43% in the last. Among the less than 6-year-old patients there was a decrease in infection prevalence from 25% for the 1993-6 period to 14.3% in the 2000-02 period, while among the over 12-year-old patients the decrease was from 55.5% in the first period to 39.6% in the latter. The decrease in H pylori infection prevalence was more intense within patients with epigastric pain, in which prevalence has decreased from 48.2% (92/191) in 1993-6, to 41.9% (65/155) in 1997-9 and 27.7% (57/206) in 2000-02. CONCLUSION: The study suggests a significant decrease in the prevalence of H pylori infection regarding the studied patients. The trend was mainly observed in the younger age group and in patients with epigastric pain.

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