The influence of different forms of administration of taurine and β-alanine on the formation of nonspecific resistance of milk calves

2019 ◽  
pp. 15-28
Author(s):  
L. V. Kharitonov ◽  
O. V. Kharitonova
Keyword(s):  
Nonspecific Resistance

scholarly journals T-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites.

1977 ◽  
Vol 145 (2) ◽  
pp. 275-292 ◽  
Author(s):  
R J North ◽  
D P Kirstein
Keyword(s):  
T Cell ◽  
Cell Mediated Immunity ◽  
Microbial Infection ◽  
Nonspecific Resistance ◽  
Normal Test ◽  
Concomitant Immunity ◽  
Progressive Growth ◽  
Concomitant Resistance ◽  
Growth Of Tumor ◽  
Syngeneic Tumors

Progressive growth of the SA1 sarcoma was shown to result in the generation of a state of concomitant resistance to growth of a second implant of the same tumor. The responding lymph nodes of concomitantly immune mice were shown to contain theta-positive T cells that could specifically neutralize the growth of tumor cells in a normal test recipient. Nevertheless, the concomitantly immune host itself was capable to a limited extent of suppressing the growth of unrelated tumors. The generation of immunity, moreover, was associated with the generation of a powerful state of macrophage-mediated, nonspecific resistance to the bacterial parasite, Listeria monocytogenes. It was concluded that systemic macrophage activation was the consequence of the generation of T-cell-mediated immunity to the progressively growing tumor, and that this not only gave the host the capacity to inhibit the growth of unrelated tumors, but also to protect itself against microbial infection. The results gives credence to the view that macrophages play a central role in defense against microbial and neoplastic growth.

Extent of Specific to Nonspecific Resistance in Mice: Parenteral Versus Aerosol Challenge

1970 ◽  
Vol 1 (3) ◽  
pp. 274-278
Author(s):  
Roberta J. Hackett ◽  
Stanley Marcus
Keyword(s):  
Klebsiella Pneumoniae ◽  
Salmonella Typhimurium ◽  
Survival Time ◽  
Intraperitoneal Injection ◽  
Quantitative Data ◽  
Control Group ◽  
Type I ◽  
Nonspecific Resistance ◽  
Significant Prolongation

Quantitative data were gathered concerning the extent of resistance induced in mice immunized by specific and nonspecific means and subsequently challenged both parenterally and by aerosol. Animals were immunized specifically by subcutaneous or intraperitoneal injection of Formalin-killed Klebsiella pneumoniae type I, which was also employed as a challenge organism. The intraperitoneal ld 50 was 30 bacilli. Nonspecific resistance was induced by injection of a Boivin preparation of Salmonella typhimurium endotoxin. Nonspecific resistance was highest 24 hr after injection of 10 μg of endotoxin. At this time, more than half of the mice survived challenge with 10 2 but not with 10 3 ld 50 . Specifically immunized mice were resistant to as much as 10 5 ld 50 , depending upon the route of immunization. Potency ratios for parenteral challenge were: nonspecific to normal, 100; specific to normal, 10 4 to 10 5 ; specific to nonspecific, 10 2 to 10 3 . Employing aerosol challenge, specific immunization protected in the ld 100 range; nonspecifically immunized animals showed significant prolongation of survival time, but the 30-day mortality was similar to the control group.

Iron deficiency anaemia due to constitutional menorrhagia as a risk factor of infectious and inflammatory diseases and use of phytotherapeutic medicines for its treatment

2020 ◽  
pp. 51-59
Author(s):  
Yulia Ivanovna Кorshikova
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Inflammatory Diseases ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Nonspecific Resistance ◽  
Deficiency Anaemia ◽  
Prophylactic Agent ◽  
Clinical Observations

The article presents clinical observations proving the importance of constitutional menorrhagia in the iron-deficiency anaemia genesis and a decrease in nonspecific resistance in women of childbearing age, as well as relevant use of phytotherapy method as a therapeutic and prophylactic agent.

Nonspecific Resistance Training and Swimming Performance

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Borja Muniz-Pardos ◽  
Alejandro Gomez-Bruton ◽  
Angel Matute-Llorente ◽  
Alejandro Gonzalez-Aguero ◽  
Alba Gomez-Cabello ◽  
...  
Keyword(s):  
Resistance Training ◽  
Swimming Performance ◽  
Nonspecific Resistance

scholarly journals Влияние периодической нормобарической гипоксии на функциональные резервы организма крыс в свободном двигательном режиме и при антиортостатической гипокинезии

2020 ◽  
Author(s):  
Zh.A. Donina ◽  
E.V. Baranova ◽  
N.P. Aleksandrova ◽  
V.P. Katuntsev ◽  
V.M. Baranov
Keyword(s):  
Simulated Microgravity ◽  
Normobaric Hypoxia ◽  
Physical Endurance ◽  
Nonspecific Resistance ◽  
New Methods ◽  
Rehabilitation Period ◽  
Extreme Factors ◽  
Intermittent Normobaric Hypoxia ◽  
Swimming Test

Введение. Снижение работоспособности и ортоустойчивости, наблюдаемых у космонавтов на разных этапах космического полета, диктует необходимость поиска новых методов, способствующих улучшению переносимости экстремальных факторов и восстановлению нарушенных функций организма, в реабилитационном периоде. Одним из перспективных направлений, повышающих общую неспецифическую резистентность организма являются гипоксические тренировки. Вместе с тем сведения о применении гипоксического воздействия непосредственно в условиях космического полета для нивелирования неблагоприятных эффектов невесомости отсутствует. Цель исследования - изучение влияния нормобарической периодической гипоксии на кардиореспираторные показатели и резервные возможности организма крыс при свободном двигательном режиме и в условиях антиортостатической гипокинезии (антиортостатическое вывешивание с углом наклона -30°), моделирующей физиологические эффекты невесомости. Методика. Проведено 4 серии экспериментов на 48 крысах Вистар, массой 280-300 г. Животные в течение 7 сут находились: в 1-й серии в свободном двигательном режиме с ежедневной 5-часовой нормобарической гипоксией (12% О2); во 2-й - в условиях антиортостатической гипокинезии после предварительного курса гипоксии; в 3-й - в антиортостатической гипокинезии без предварительной гипоксии (нормоксия 20,9% О2); в 4-й - в антиортостатической гипокинезии с ежедневной 5-часовой гипоксией. После завершения эксперимента у всех животных регистрировали кардиореспираторные показатели методом пневмотахографии, электрокардиографии, пульсоксиметрии, для оценки физической выносливости крыс использовали тест вынужденного плавания (по Порсолту). Результаты. Установлено, что эффективность НПГ в целях повышения функциональных резервов кардиореспираторной системы после длительного пребывания в условиях антиортостатической гипокинезии достигается только в результате предварительной адаптации (прекондиционирования) к периодической гипоксии в свободном двигательном режиме. Заключение. Воздействие нормобарической периодической гипоксии в условиях моделирования невесомости приводит к ухудшению функционального состояния организма и снижению физической выносливости крыс.Introduction. Restoring the physical condition of cosmonauts following a prolonged spaceflight requires new methods for improvement of resistance to extreme factors and recovery during the rehabilitation period. A promising approach to enhancing the general, nonspecific resistance to adverse environmental factors is hypoxic training. However, information about the use of hypoxia effects on the scene of a space flight to neutralize adverse effects of weightlessness is absent. Aim. To study the effect of intermittent normobaric hypoxia (INH) on cardiorespiratory parameters and reserve capacity of rats in free locomotion and in head-down tilt of -30°(HDT-30° ), a model of spaceflight. Methods. Experiments were performed on 48 Wistar rats weighing 280-300 g. For 7 days the animals were 1) in free locomotion with INH daily for 5-hours (12% O2); 2) in HDT-30o under normoxia following prior INH; 3) in HDT-30° under normoxia; 4) in HDT-30° in combination with INH. Cardiorespiratory parameters were recorded by pneumotachography, electrocardiography and pulse oximetry. Exercise tolerance was evaluated using the forced swimming test (Porsolt). Results. The effect of INH in increasing the cardiorespiratory functional reserve after long-term simulated microgravity is achieved only with prior adaptation (preconditioning) to INH in free locomotion. Conclusions. Intermittent normobaric hypoxia used in simulated microgravity leads to impairment of the functional state and decreases physical endurance of rats.

scholarly journals БРОНХОПНЕВМОНІЯ ТЕЛЯТ: ДІАГНОСТИКА ТА КОМПЛЕКСНА ТЕРАПІЯ

2016 ◽  
Vol 18 (3(71)) ◽  
pp. 95-99
Author(s):  
L. Slivinska ◽  
S. Demydjuk ◽  
А. Shcherbatyy ◽  
P. Mazurok
Keyword(s):  
Positive Impact ◽  
Specific Resistance ◽  
Inorganic Phosphorus ◽  
Integrated Treatment ◽  
Nonspecific Resistance ◽  
Carotene Content ◽  
The Third ◽  
Acid Base Status ◽  
Biochemical Research ◽  
Experimental Group

The results of nonspecific resistance indices, hematological, biochemical research on complex treatment of calves suffering from bronchopneumonia. It is established that the use of antibiotics (intramitsynu, tsefatoksymu and betamoksu LA), drugs that regulate the acid–base status, provide therapeutic efficacy, respectively – 75, 94 and 88% and shorten the duration of their treatment in 7 – 12 days. The treatment had a positive impact on the overall condition of the animals. In the blood have established probable increase in the number of red blood cells, respectively, 23.2% (p ˂ 0.001); 36.6 (p ˂ 0.001); 29.5% (p ˂ 0.05), hemoglobin contents to 8.04 (p ˂ 0.05); 17.3 (p ˂ 0.001) and 17.5% (p ˂ 0.001), reducing the number of leukocytes (p ˂ 0.001) according to 31.8; 34.3; 36.6%. The content of total protein in serum of calves experimental groups increased to 3.75 (p ˂ 0,001); 6.38 (p ˂ 0.05) and 6.93% (p ˂ 0.001), respectively, due to increased albumin fraction in the second experimental group 18.4% (p ˂ 0.001), the third – 14.8% (p ˂ 0,01). The results showed that the applied treatment had a positive impact on the carotene content in blood serum (to 43.5; 34.6; 46.0%; p ˂ 0.05), total calcium (respectively 15.0, 14.7; p ˂ 0.05; 18.3%; p ˂ 0.05) and inorganic phosphorus (6.4; 15.3; 15.8%; p ˂ 0.05).Integrated treatment of calves suffering from bluetongue bronchopneumonia, helped indexes increase non–specific resistance. The data obtained by the use of antibiotics (intramitsynu, tsefatoksymu and betamoksu LA) promoted faster normalization lizotsymnoyi and bactericidal activity of blood. Thus, in the first experimental group LASK increased by 25.6% (p ˂ 0.001); the second – by 26.3% (p ˂ 0.001) and the third at 35.3% (p ˂ 0.001). BASK calves tended to increase according to 11.7; 10.6 and 11.3%. 

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