A higiene bucal de bebês edêntulos e sua influência na microbiota bucal: os profissionais de saúde devem preconizá-la? – revisão crítica

Introduction: The indication of oral hygiene in edentulous babies is still controversial among health professionals, being necessary the search of this recommendation and the standardization of information. Objective: To investigate critically the evidence related to the indication of oral hygiene for edentulous babies. Methods: The search for articles was performed in the PUBMED, LILACS and GOOGLE SCHOLAR databases, in order to assess the following question: "Can oral cavity hygiene of edentulous babies influence oral microbiota? A search in 8 books of Pediatric Dentistry was also performed. Results: 317 articles were found (167-PUBMED, 146-GOOGLE SCHOLAR and 4-LILACS). There were no primary studies that evaluated the effect of oral hygiene of edentulous infants on microbiota, which impair the conduction of a systematic review. Thus, it was included for this review six studies that investigated microorganisms in the oral cavity of edentulous infants and the role of salivary immunoglobulins. Among the textbooks evaluated, only 4 indicated the oral hygiene in edentulous infants. Conclusion: According to the data, there are no primary studies that assessed the effect of oral hygiene in the oral microbiota of edentulous babies. It is relevant to conduct clinical studies in order to obtain scientific evidence about the indication or no of the oral hygiene in edentulous babies.

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Oral Cavity as an Extragastric Reservoir of Helicobacter pylori

ISRN Gastroenterology ◽

10.1155/2014/261369 ◽

2014 ◽

Vol 2014 ◽

pp. 1-16 ◽

Cited By ~ 22

Author(s):

Arwa Al Sayed ◽

Pradeep S. Anand ◽

Kavitha P. Kamath ◽

Shankargouda Patil ◽

R. S. Preethanath ◽

...

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Oral Cavity ◽

Oral Hygiene ◽

Dental Plaque ◽

Web Of Science ◽

Cochrane Library ◽

H Pylori ◽

The Impact

Background. Several studies were reported on the prevalence, and relationship between the existence of Helicobacter pylori (H. pylori) in oral cavity and in stomach of patients. The purpose of this study was to systematically review the existing literature on the presence of H. pylori in the oral cavity and its link to gastric infection, the existence of coinfection, and the impact of anti-H. pylori therapy on the dental plaque and vice versa. Method. Two authors independently searched the Medline, EMBASE, Cochrane Library, Web of Science, Google Scholar, and Scopus databases for relevant studies. The articles were analyzed critically and all qualified studies were included. The search was carried out by using a combined text and the MeSH search strategies: using the key words Helicobacter, Helicobacter pylori, and H. pylori in combination with dental plaque, periodontitis, and oral hygiene. Results. The data was presented in 8 tables and each topic separately discussed. Conclusion. Based on the systematic review of the available literature on H. pylori infection and its presence in the oral cavity, it can be concluded that dental plaque can act as a reservoir, and proper oral hygiene maintenance is essential to prevent reinfection. Due to the diversified methods and population groups involved in the available literature, no concrete evidence can be laid down. Further studies are necessary to establish the role of H. pylori in the oral cavity and its eradication on preventing the gastroduodenal infection.

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Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Cancers ◽

10.3390/cancers13092124 ◽

2021 ◽

Vol 13 (9) ◽

pp. 2124

Author(s):

Se-Young Park ◽

Byeong-Oh Hwang ◽

Mihwa Lim ◽

Seung-Ho Ok ◽

Sun-Kyoung Lee ◽

...

Keyword(s):

Oral Cavity ◽

Gut Microbiome ◽

Gastrointestinal Disease ◽

Oral Microbiota ◽

Microbial Interaction ◽

Barrier Dysfunction ◽

Gut Barrier ◽

Microbial Ecosystem ◽

Precise Diagnosis

It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.

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The influence of orthodontic fixed appliances on the oral microbiota: A systematic review

Dental Press Journal of Orthodontics ◽

10.1590/2176-9451.19.2.046-055.oar ◽

2014 ◽

Vol 19 (2) ◽

pp. 46-55 ◽

Cited By ~ 34

Author(s):

Amanda Osório Ayres de Freitas ◽

Mariana Marquezan ◽

Matilde da Cunha Gonçalves Nojima ◽

Daniela Sales Alviano ◽

Lucianne Cople Maia

Keyword(s):

Systematic Review ◽

Methodological Quality ◽

Data Extraction ◽

Scientific Evidence ◽

Statistical Treatment ◽

Fusobacterium Nucleatum ◽

Oral Microbiota ◽

Periodontal Pathogens ◽

Inclusion Criteria ◽

Fixed Appliances

Objective: To investigate whether there is scientific evidence to support the hypothesis that the presence of orthodontic fixed appliances influences the oral microbiota. Methods: The search for articles was conducted in PubMed; ISI Web of Knowledge and Ovid databases, including articles published in English until May 17th, 2012. They should report human observational studies presenting the following keywords: "fixed orthodontic appliance" AND "microbiological colonization"; OR "periodontal pathogens"; OR "Streptococcus"; OR "Lactobacillus"; OR "Candida"; OR "Tannerella forsythia"; OR "Treponema denticola"; OR "Fusobacterium nucleatum"; OR "Actimomyces actinomycetemcomitans"; OR "Prevotella intermedia", OR "Prevotella nigrescens"; OR "Porphyromonas gingivalis". Articles were previously selected by title and abstract. Articles that met the inclusion criteria were analyzed and classified as having low, moderate or high methodology quality. A new detailed checklist for quality assessment was developed based on the information required for applicable data extraction for reviews. The study design, sample, follow-up period, collection and microbial analysis methods, statistical treatment, results and discussion were assessed. Results: The initial search retrieved 305 articles of which 33 articles were selected by title and abstract. After full-text reading, 8 articles met the inclusion criteria, out of which 4 articles were classified as having low and 4 as moderate methodological quality. The moderate methodological quality studies were included in the systematic review. Conclusions: The literature revealed moderate evidence that the presence of fixed appliances influences the quantity and quality of oral microbiota.

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Oral Microbial Ecology and the Role of Salivary Immunoglobulin A

Microbiology and Molecular Biology Reviews ◽

10.1128/mmbr.62.1.71-109.1998 ◽

1998 ◽

Vol 62 (1) ◽

pp. 71-109 ◽

Cited By ~ 236

Author(s):

Harold Marcotte ◽

Marc C. Lavoie

Keyword(s):

Immune System ◽

Oral Cavity ◽

Microbial Ecology ◽

Periodontal Diseases ◽

Immunoglobulin A ◽

Basic Knowledge ◽

Oral Microbiota ◽

Indigenous Bacteria ◽

Indigenous Microbiota

SUMMARY In the oral cavity, indigenous bacteria are often associated with two major oral diseases, caries and periodontal diseases. These diseases seem to appear following an inbalance in the oral resident microbiota, leading to the emergence of potentially pathogenic bacteria. To define the process involved in caries and periodontal diseases, it is necessary to understand the ecology of the oral cavity and to identify the factors responsible for the transition of the oral microbiota from a commensal to a pathogenic relationship with the host. The regulatory forces influencing the oral ecosystem can be divided into three major categories: host related, microbe related, and external factors. Among host factors, secretory immunoglobulin A (SIgA) constitutes the main specific immune defense mechanism in saliva and may play an important role in the homeostasis of the oral microbiota. Naturally occurring SIgA antibodies that are reactive against a variety of indigenous bacteria are detectable in saliva. These antibodies may control the oral microbiota by reducing the adherence of bacteria to the oral mucosa and teeth. It is thought that protection against bacterial etiologic agents of caries and periodontal diseases could be conferred by the induction of SIgA antibodies via the stimulation of the mucosal immune system. However, elucidation of the role of the SIgA immune system in controlling the oral indigenous microbiota is a prerequisite for the development of effective vaccines against these diseases. The role of SIgA antibodies in the acquisition and the regulation of the indigenous microbiota is still controversial. Our review discusses the importance of SIgA among the multiple factors that control the oral microbiota. It describes the oral ecosystems, the principal factors that may control the oral microbiota, a basic knowledge of the secretory immune system, the biological functions of SIgA, and, finally, experiments related to the role of SIgA in oral microbial ecology.

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Obesity and dental caries: systematic review

Revista de Saúde Pública ◽

10.1590/s0034-8910.2013047004608 ◽

2013 ◽

Vol 47 (4) ◽

pp. 799-812 ◽

Cited By ~ 29

Author(s):

Alexandre Emidio Ribeiro Silva ◽

Ana Maria Baptista Menezes ◽

Flavio Fernando Demarco ◽

Fabiana Vargas-Ferreira ◽

Marco Aurelio Peres

Keyword(s):

Systematic Review ◽

Dental Caries ◽

Observational Studies ◽

Web Of Science ◽

Scientific Evidence ◽

Positive Association ◽

Sufficient Evidence ◽

Inverse Association

OBJECTIVE Identifying, through a systematic literature review, evidence of a possible association between obesity and dental caries. METHODS A search of articles published between 2005 and January 2012 was performed in the Medline/PubMed, LILACS and Web of Science databases. The quality of scientific evidence of the selected articles was assessed by the items proposed for observational studies in the Downs & Black instrument. RESULTS Initially, 537 references were found; after checking the titles and abstracts by two independent researchers, twenty-eight articles were selected for complete reading. Ten of them that assessed the primary and/or permanent dentition observed a positive association between obesity and dental caries and one study found an inverse association. According to the Downs & Black classification, thirteen articles with good scientific evidence were found. CONCLUSIONS The present review did not find sufficient evidence regarding the association between obesity and dental caries, and it did not clarify the possible role of diet and other possible effect modifiers on this association.

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The significance of collagen dressings in wound management: a review

Journal of Wound Care ◽

10.12968/jowc.2018.27.10.692 ◽

2018 ◽

Vol 27 (10) ◽

pp. 692-702 ◽

Cited By ~ 10

Author(s):

Frank Pallaske ◽

Anett Pallaske ◽

Kurt Herklotz ◽

Joachim Boese-Landgraf

Keyword(s):

Wound Healing ◽

Health Professionals ◽

Clinical Studies ◽

Critical Appraisal ◽

Wound Dressings ◽

Wound Management ◽

Complex Field ◽

The Right ◽

New Applications

Clinical experience and research has improved our understanding of wound healing which, in turn, has enabled health professionals to aid wound healing and manufacturers to develop modern wound dressings. The significant role of collagen in wound healing has led to the development of numerous products on the basis of this biological material. The main focus of this review is to provide a critical appraisal of publications about collagen and acellular collagen dressings with a fleece-like or spongy structure. It is intended for clinicians and researchers, and aims to keep them up-to-date in the complex field of interactive, collagen-based wound dressings, including their manufacture, combination possibilities, mechanisms of action, performance in the promotion of wound healing and indications. Despite the small number of clinical studies, the importance of acellular collagen dressings with a fleece- or sponge-like structure is likely to increase in the future. As there is no ideal wound dressing, the knowledge attained is meant to support health professionals in selecting the right product, and pave the way for new applications and clinical studies.

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The Oral Microbiota: A Literature Review for Updating Professionals in Dentistry. Part I

Odovtos - International Journal of Dental Sciences ◽

10.15517/ijds.2020.39178 ◽

2019 ◽

pp. 143-152

Author(s):

Cristina Barboza-Solís DDS, MSc, PhD ◽

Luis Alberto Acuña-Amador PhD

Keyword(s):

Oral Health ◽

Scientific Evidence ◽

Oral Microbiome ◽

Current Evidence ◽

Future Research ◽

Oral Microbiota ◽

Systemic Diseases ◽

Conceptual Background ◽

Keyword Searches

In recent decades, a body of literature examining the relationships between oral health and general health has rapidly developed. However, the biological mechanisms involved in explaining such relationships have not been fully described. Recent evidence has suggested that these relationships could be partially explained by the composition and interaction of the microbiome/microbiota between local and systemic body sites. For instance, it has been suggested that intestinal microbiota could have effects on non-communicable diseases, such as diabetes or cardiovascular diseases. The objective of this study is to explore current evidence of the link between oral and systemic diseases, to discuss whether oral microbiome/microbiota could represent an unexplored biological pathway partially explaining those relationships. A non-systematic review of the literature was carried out using keyword searches in Pubmed from February to May 2019. The ultimate goal was to present recent scientific evidence to update the general knowledge on this topic to professionals in dentistry. This review is divided in two parts for journal publication; however, it is intended to be used as one piece. In this first part, we will summarize the conceptual background of oral microbiome/microbiota, we will describe the main methods used in microbiology to characterize oral organisms, and will present the main composition of bacteria in oral microbiome/microbiota. The second part highlights the main evidence regarding the biological plausibility that links oral microbiome and systemic diseases and we will conclude with some future research recommendations. Taking into account the role of oral microbiota in the development of systemic diseases could change the main paradigm of how oral health is currently conceptualized by dental professionals.

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Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies

Neuroscience & Biobehavioral Reviews ◽

10.1016/j.neubiorev.2018.05.031 ◽

2018 ◽

Vol 92 ◽

pp. 477-485 ◽

Cited By ~ 33

Author(s):

Danilo Arnone ◽

Smita Saraykar ◽

Haitham Salem ◽

Antonio L. Teixeira ◽

Robert Dantzer ◽

...

Keyword(s):

Systematic Review ◽

Mood Disorders ◽

Clinical Studies ◽

Meta Analysis ◽

Kynurenine Pathway

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The use of surface electromyography in assessing the effectiveness of manual therapy: a systematic review

International Journal of Occupational and Environmental Safety ◽

10.24840/2184-0954_004.001_0008 ◽

2020 ◽

Vol 4 (1) ◽

pp. 89-107

Author(s):

Rui Santiago ◽

J. Santos Baptista ◽

André Magalhães ◽

J. Torres Costa

Keyword(s):

Systematic Review ◽

Health Care ◽

Data Collection ◽

Manual Therapy ◽

Clinical Studies ◽

Surface Electromyography ◽

Treatment Modality ◽

Reporting Standards ◽

Methodologic Quality

Research on the use of surface electromyography (sEMG) for analyzing the effects of Manual Therapy (MT) seems to have very dispersed intentions. The development of data collection protocols using sEMG might not be stable for conducting clinical studies. This study aimed to evaluate the current literature using surface sEMG in the context of MT and verify if it is a useful tool to verify its effectiveness. Also, to assess the methodologic quality and reporting standards and make a reflective analysis of how this technique has been used for this treatment modality. A computerized search was performed in May 2017 and repeated in June 2018, the search was performed in 8 electronic databases following PRISMA protocol. Thirty-one papers were included. More and better-designed studies are needed to create improved protocols. Further exploration and validation of these protocols may help to conduct more reliable clinically driven trials and it may inform policymakers of the role of MT in health care. The detection of clinically meaningful electrical alterations in muscles seems to be the main objective of most authors. Several sEMG items were not reported, and overall methodology quality was low.

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