scholarly journals Catheter Ablation of Ventricular Tachycardia in LMNA Cardiomyopathy: Out of Sight but not Out of Mind

2021 ◽  
Author(s):  
Ahmad Halawa ◽  
Paul Zei ◽  
Neal Lakdawala ◽  
William Sauer ◽  
Usha Tedrow ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Catheter Ablation ◽  
Success Rate ◽  
Ventricular Arrhythmias ◽  
Cycle Length ◽  
Electrical Storm ◽  
Arrhythmogenic Substrate ◽  
Ablation Success ◽  
Endocardial Mapping ◽  
Activation Mapping

Lamin Cardiomyopathy (LC) is associated with refractory ventricular arrhythmias. Catheter ablation success rate is low due to presence of multiple circuits and intramural substrate. We present a LC case presented with electrical storm. During catheter ablation, arrhythmia was easily inducible but activation mapping, including full epicardial and endocardial mapping, failed to demonstrate the full tachycardia cycle length (70% only) suggesting intramural activation. Critical isthmus was not identified even with successful concealed entrainment on both Endo/epicardial surfaces. This case shows that even combined endocardial and epicardial catheter approach can be ineffective in identifying the full arrhythmogenic substrate in LC.

Significance of post-pacing intervals shorter than tachycardia cycle length for successful catheter ablation of atypical flutter

EP Europace ◽  
2020 ◽  
Author(s):  
Pietro Bernardo Dall’Aglio ◽  
Nicolas Johner ◽  
Mehdi Namdar ◽  
Dipen C Shah
Keyword(s):  
Catheter Ablation ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Cycle Length ◽  
Inverse Correlation ◽  
Target Site ◽  
Time Difference ◽  
Effective Parameter ◽  
Ablation Success ◽  
Activation Mapping

Abstract Aims During entrainment mapping of macro-reentrant tachycardias, the time difference (dPPI) between post-pacing interval (PPI) and tachycardia cycle length (TCL) is thought to be a function of the distance of the pacing site to the re-entry circuit and dPPI < 30 ms is considered within the re-entry circuit. This study assessed the importance of PPI < TCL as a successful target for atypical flutter ablation. Methods and results A total of 177 ablation procedures were investigated. Surface electrocardiograms (ECGs) were evaluated and combined activation and entrainment mapping were performed to choose ablation sites. Each entrainment sequence immediately preceding static radiofrequency delivery at the same site was analysed. A total of 545 entrainment sequences were analysed. dPPI < 0 ms was observed in 45.3% (247/545) sequences. Ablation resulted in tachycardia termination more often at sites with dPPI < 0 (27.8% vs. 14.5%, P < 0.001) and with a progressively increasingly inverse correlation between dPPI duration and ablation success [odds ratio (OR): 0.974; 95% confidence interval (CI) 0.960–0.988; P < 0.001]. Tachycardia termination or cycle length prolongation also occurred more often at sites with dPPI < 0 (50.6% vs. 33.2%, P < 0.001) and with a similar inverse correlation with dPPI duration (OR: 0.972; 95% CI 0.960–0.984; P < 0.001). Twelve-lead synchronous isoelectric intervals were observed in 64.4% (163/253) flutter ECGs and were associated with a dPPI < 0 (75.3% vs. 55.8%, P < 0.001). Conclusion When combined with activation mapping, a negative dPPI is a more effective parameter for identifying a target for successful ablation compared to a dPPI = 0–30 ms. Its occurrence is associated with a critical small narrow slow-conducting isthmus at the target site.

scholarly journals Role of Electrophysiological Study and Catheter Ablation for Recurrent Ventricular Tachycardia Complicating Myocarditis

2012 ◽  
Vol 55 (2) ◽  
pp. 96-99
Author(s):  
Emanuele Cecchi ◽  
Serena Fatucchi ◽  
Elena Crudeli ◽  
Cristina Giglioli
Keyword(s):  
Ventricular Tachycardia ◽  
Cardiac Magnetic Resonance ◽  
Catheter Ablation ◽  
Ventricular Arrhythmias ◽  
Acute Myocarditis ◽  
Electrophysiological Study ◽  
Interventricular Septum ◽  
Arrhythmogenic Substrate ◽  
Rule Out

Here we report the case of a 31-year-old man admitted to our hospital with echocardiografic and Cardiac Magnetic Resonance signs of myocarditis complicated by ventricular tachycardia, initially resolved with direct current shock. After the recurrence of ventricular tachycardia the patient was submitted to electrophysiological study revealing a re-entrant circuit at the level of the medium segment of interventricular septum, successfully treated with transcatheter ablation. This case highlights how the presence of recurrent ventricular arrhythmias at the onset of acute myocarditis, suspected or proven, could be associated with a pre-existing arrhythmogenic substrate, therefore these patients should be submitted to electrophysiological study in order to rule out the presence of arrhythmogenic focuses that can be treated with transcatheter ablation.

scholarly journals Relationship of Arrhythmogenic Substrate and Frequent Ventricular Extrasystoles in Patients with Nonischemic Cardiomyopathy

2020 ◽  
Vol 33 (1) ◽  
pp. 46-50
Author(s):  
Cristiano de Oliveira Dietrich
Keyword(s):  
Ventricular Tachycardia ◽  
Case Report ◽  
Catheter Ablation ◽  
Ventricular Arrhythmias ◽  
Nonischemic Cardiomyopathy ◽  
Premature Ventricular Contractions ◽  
Ventricular Extrasystoles ◽  
Arrhythmogenic Substrate ◽  
Myocardial Fibers ◽  
Relationship Of

Cardiomyopathies (CMP) are related with scarring tissue due to fibrotic and disarrangement of myocardial fibers that promote an slowed conduction and substrate for sustained reentrant ventricular arrhythmias. Sometimes, CMP can be associated with ventricular extrasystoles but uncommonly originated from scarring tissue. The case report show a patient with nonischemic CMP, frequents premature ventricular contractions and sustained ventricular tachycardia submitted to catheter ablation.

scholarly journals Catheter Ablation of Life-Threatening Ventricular Arrhythmias in Athletes

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 205
Author(s):  
Nicola Tarantino ◽  
Domenico G. Della Rocca ◽  
Nicole S. De Leon De La Cruz ◽  
Eric D. Manheimer ◽  
Michele Magnocavallo ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Ventricular Arrhythmias ◽  
Individual Factors ◽  
Substantial Part ◽  
Arrhythmogenic Substrate ◽  
Life Threatening ◽  
History Of ◽  
Anatomic Distribution ◽  
Artery Disease ◽  
Surveillance Analysis

A recent surveillance analysis indicates that cardiac arrest/death occurs in ≈1:50,000 professional or semi-professional athletes, and the most common cause is attributable to life-threatening ventricular arrhythmias (VAs). It is critically important to diagnose any inherited/acquired cardiac disease, including coronary artery disease, since it frequently represents the arrhythmogenic substrate in a substantial part of the athletes presenting with major VAs. New insights indicate that athletes develop a specific electro-anatomical remodeling, with peculiar anatomic distribution and VAs patterns. However, because of the scarcity of clinical data concerning the natural history of VAs in sports performers, there are no dedicated recommendations for VA ablation. The treatment remains at the mercy of several individual factors, including the type of VA, the athlete’s age, and the operator’s expertise. With the present review, we aimed to illustrate the prevalence, electrocardiographic (ECG) features, and imaging correlations of the most common VAs in athletes, focusing on etiology, outcomes, and sports eligibility after catheter ablation.

Catheter Ablation of Scar-Related Ventricular Tachycardia in Patients with Electrical Storm Using Remote Magnetic Catheter Navigation

2010 ◽  
Vol 33 (11) ◽  
pp. 1312-1318 ◽  
Author(s):  
ARASH ARYA ◽  
CHARLOTE EITEL ◽  
ANDREAS BOLLMANN ◽  
ULRIKE WETZEL ◽  
PHILLIPP SOMMER ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Catheter Ablation ◽  
Electrical Storm ◽  
Catheter Navigation

Emergency catheter ablation of refractory ventricular tachycardia

1989 ◽  
Vol 9 (5) ◽  
pp. 36-40 ◽  
Author(s):  
LL Stevens ◽  
RM Redd ◽  
TA Buckingham
Keyword(s):  
Ventricular Tachycardia ◽  
Catheter Ablation ◽  
Ventricular Arrhythmias ◽  
Pharmacologic Therapy ◽  
Emergency Therapy

Catheter ablation, in extreme cases, can be used successfully as emergency therapy for VT in the CCU. In the hands of a physician experienced in electrophysiologic procedures, catheter ablation may prove to be an alternative to surgical or pharmacologic therapy in acutely ill patients with refractory ventricular arrhythmias.

scholarly journals Ventricular tachycardia storm management in a COVID-19 patient: a case report

2020 ◽  
Vol 4 (FI1) ◽  
pp. 1-6 ◽  
Author(s):  
Gianfranco Mitacchione ◽  
Marco Schiavone ◽  
Alessio Gasperetti ◽  
Giovanni B Forleo
Keyword(s):  
Ventricular Tachycardia ◽  
Ventricular Arrhythmias ◽  
Cardiac Involvement ◽  
Previous History ◽  
Left Ventricular ◽  
Electrical Storm ◽  
Increased Risk ◽  
History Of ◽  
Myocardial Involvement ◽  
Artery Disease

Abstract Background Coronavirus disease 2019 (COVID-19) has been associated with myocardial involvement. Among cardiovascular manifestations, cardiac arrhythmias seem to be fairly common, although no specifics are reported in the literature. An increased risk of malignant ventricular arrhythmias and electrical storm (ES) has to be considered. Case summary We describe a 68-year-old patient with a previous history of coronary artery disease and severe left ventricular systolic disfunction, who presented to our emergency department describing cough, dizziness, fever, and shortness of breath. She was diagnosed with COVID-19 pneumonia, confirmed after three nasopharyngeal swabs. Ventricular tachycardia (VT) storm with multiple implantable cardioverter defibrillator (ICD) shocks was the presenting manifestation of cardiac involvement during the COVID-19 clinical course. A substrate-based VT catheter ablation procedure was successfully accomplished using a remote navigation system. The patient recovered from COVID-19 and did not experience further ICD interventions. Discussion To date, COVID-19 pneumonia associated with a VT storm as the main manifestation of cardiac involvement has never been reported. This case highlights the role of COVID-19 in precipitating ventricular arrhythmias in patients with ischaemic cardiomyopathy who were previously stable.

P355Complete non-inducibility after radiofrequency ablation for electrical storm improves survival rates

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Nastasa ◽  
C Cojocaru ◽  
D A Radu ◽  
E Goanta ◽  
V Iliese ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Success Rate ◽  
Statistical Significance ◽  
Survival Rates ◽  
Electrical Storm ◽  
Programmed Ventricular Stimulation ◽  
Ventricular Stimulation ◽  
Threatening Condition ◽  
Acute Success

Abstract Background Electric storm is a life threatening condition, that can complicate multiple cardiac pathologies and is associated with high mortality.  Catheter ablation has been shown to reduce ventricular tachycardia (VT) burden in patients with electrical storm but the optimal procedural endpoint and the therapeutic particularities required by different etiologies are still under debate. Purpose Our objective was to determine if there are any periprocedural factors that influence midterm outcomes.  We also sought if there were any significant differences between the results for ischemic and nonischemic patients. Methods The study included 66 consecutive patients, mean age 60 years, 82% males, treated for electrical storm in our center with endocardial/endo-epicardial radiofrequncy catheter ablation (with or without remote magnetic navigation). Acute success was defined as elimination of the clinical tachycardia with complete non-inducibility (including ventricular fibrillation) or non-inducibility for monomorphic VT with programmed ventricular stimulation using up to 4 extrastimuli. Mean follow-up duration was 9.4 months and the type of recurrence was catalogued in 3 categories: initial VT (isolated), electric storm and other sustained VT. Results The overall acute success rate was 93%, complete non-inducibility was achieved in 64.5% and non-inducibility for monomorphic VT in 87.5% of the cases. Epicardial approach was used in 44% of the non-ischemic cases vs 10.5% of the ischemic ones (p = 0.005). There were no significant differences between complete noninducibility rates and recurrence/death rates of the ischemic vs nonischemic groups. Among the variables analysed for predicting noninducibility, only two reached statistical significance: mean QRS duration of the clinical tachycardia (160 ± 32 ms vs 240 ± 63.3ms, p = 0.02) and shortest RS complex (124 ± 14.7 ms vs 210 ± 12ms, p = 0.02). Recurrent ventricular arrhythmia occurred in 25% of the patients during follow up, from which: 27.2 % initial VT (isolated), 36.4% electric storm and 36.4% other sustained VT. Death rate was 10.6% (7 patients).  Kaplan Meier plot showed that the lot with complete noninducibility after programmed ventricular stimulation had better survival rates (p = 0.01). Conclusions Ablative therapy had a good acute success rate, without significant differences between ischemic and noninschemic patients in our study. Complete noninducibility after programmed ventricular stimulation  after ablation was associated with better survival rates. Unsuccessfull ablation is a predictor of inhospital death of these patients.

P992Incidence, predictors, and success of ventricular tachycardia catheter ablation in arrhythmogenic right ventricular cardiomyopathy (ARVC): A long-term cohort study from the Nordic ARVC registry

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M K Christiansen ◽  
K Haugaa ◽  
A Svensson ◽  
T Gilljam ◽  
T Madsen ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Catheter Ablation ◽  
Right Ventricular ◽  
Ventricular Arrhythmias ◽  
Task Force ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Young Age ◽  
Clinical Indication ◽  
Ventricular Cardiomyopathy ◽  
Vt Ablation

Abstract Background Catheter ablation may reduce ventricular tachycardia (VT) burden in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients. However, little is known about factors predicting need for ablation and various outcomes have been reported. Purpose We sought to investigate predictors and use of VT ablation and to evaluate the post-procedural outcome in ARVC patients. Methods We studied 435 patients from the Nordic ARVC registry including 220 probands with definite ARVC according to the 2010 task force criteria and 215 mutation-carrying relatives identified through cascade screening. Patients were followed until first-time VT ablation, death, heart transplantation, or January 1st 2018. Additionally, patients undergoing VT ablation were further followed from the time of ablation for recurrent ventricular arrhythmias. Results Cumulative use of VT ablation was 4% (95% CI 3%-6%) and 11% (95% CI 8%-15%) after 1 and 10 years. All procedures were performed in probands in whom the cumulative use was 8% (95% CI 5%-12%) and 20% (95% CI 15%-26%). In adjusted analyses restricted to probands, only young age predicted need for ablation. In patients undergoing ablation, risk of recurrent arrhythmias was 59% (95% CI 44%-71%) and 74% (95% CI 59%-84%) 1 and 5 years after the procedure. Despite high recurrence rates, the burden of ventricular arrhythmias was reduced after ablation (p=0.0042). Young age, use of several antiarrhythmic drugs and inducibility to VT immediately after ablation were associated with an unfavorable outcome. Conclusions Twenty percent of ARVC probands developed a clinical indication for VT ablation within 10 years after diagnosis whereas mutation-carrying relatives were without such need. Although the burden of ventricular arrhythmias decreased after ablation, risk of recurrence was substantial.

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