scholarly journals Clinical case of SARS-CoV-2-associated multisystem inflammatory syndrome

2021 ◽  
pp. 51-54
Author(s):  
Ye.Ye. Pohorila ◽  
Keyword(s):  
Clinical Course ◽  
Clinical Manifestations ◽  
Ethics Committee ◽  
Probable Case ◽  
General Weakness ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Helsinki Declaration ◽  
Course Features ◽  
Inflammatory Syndrome

The clinical course, features of diagnostic examinations and difficulties in verification of the new nosology of multisystem inflammatory syndrome associated with SARS-CoV-2 in 15-year-old girls are described. The girl was taken to the Kyiv Regional Children's Hospital No. 2 with complaints of fever, intoxication syndrome, general weakness, dizziness, vertigo, lack of urine during the day. The child was examined by a consilium of doctors, examined in the laboratory and instrumentally, after a carefully collected epidemiological history revealed possible contact with a patient with coronavirus infection at the place of study and identified a probable case of multisystem inflammatory syndrome associated with SARS-CoV-2. According to the results of our own observations during the pandemic, this nosology was found in patients who relapsed into coronavirus infection in clinical or subclinical form and for the period of hospitalization had a clinical symptom complex of Kawasaki with similar symptoms. This disease is new today, has a variety of clinical manifestations and pathological features that are a problem for clinicians. After all, at present there are no unified protocols for the diagnosis and treatment of MIS-C (multisystem inflammatory syndrome) and each doctor relies on their own experience and previously described cases. This case of multisystem inflammatory syndrome will help practicing clinicians in the early stages to diagnose the disease and provide qualified care to patients. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: multisystem used for setting fire syndrome, 15-year-old girl, kawasaky-like symptoms, SARS-CoV-2, intravenous immunoprotein, acetophene, glucocorticosteroids.

scholarly journals Features of the clinical course of a new coronavirus infection in students who were observed in the observator in the first and second wave of morbidity increasing

2021 ◽  
Vol 25 (1) ◽  
pp. 27-33
Author(s):  
Olga Yu. Kuznetsova ◽  
Anna V. Lubimova ◽  
Karina V. Ovakimyan ◽  
Olga I. Frolova ◽  
Olga S. Zamyatina ◽  
...  
Keyword(s):  
Primary Care Physicians ◽  
Clinical Course ◽  
Nasal Congestion ◽  
Clinical Manifestations ◽  
The North ◽  
Treatment And Prevention ◽  
General Weakness ◽  
Coronavirus Infection ◽  
Two Stages ◽  
Second Wave

INTRODUCTION: The sudden appearance of a new coronavirus infection in the world has posed difficult challenges for science to determine the main clinical manifestations of this disease, as well as to approve standards for diagnosis, treatment and prevention. Research of the symptoms of mild COVID-19 is continuing. The data obtained in such studies are particularly relevant for primary care physicians. THE AIM: To evaluate the features of the clinical course of COVID-19 among students of the North-Western State Medical University named after I.I. Mechnikov, placed in the observatory, during the first and second waves of rising morbidity. MATERIALS AND METHODS: The study was conducted on the basis of the observatory of the NWSMU named after I.I. Mechnikov in two stages: in the period from 21.04.2020 to 31.08.2020 (the first wave) and from 16.09.2020 to 31.12.2020 (the second wave). Demographic, epidemiological, and clinical-anamnestic data were recorded in all participants of the study. RESULTS: The study involved 309 people: 39.8% men (n = 123) and 58.9% women (n = 182). The average age of the respondents was 21.5 2.6 years. The number of participants in the first and second waves was 113 and 196 people, respectively. The average age of participants with COVID-19 in the first wave was 1.5 years less and was 21.2 2.5 years (р 0.001). There was a significant increase in the frequency of the following symptoms: dry cough, loss of smell, headache, general weakness, increased body temperature to 38.0 С, nasal congestion (р 0.05) in students who were monitored in the second wave of increased incidence of COVID-19 compared to the first. The frequency of symptoms such as chest congestion, lower back pain, and fever above 38.0 С significantly decreased (р 0.05). There was a significant decrease in the incidence of viral pneumonia in patients who were observed during the second wave, compared with the data obtained during the first wave (р 0.001).

scholarly journals Pediatric multisystem inflammatory syndrome associated with a new coronavirus infection: unresolved issues

2021 ◽  
Vol 13 (1) ◽  
pp. 13-20
Author(s):  
Yu. V. Lobzin ◽  
A. A. Vilnits ◽  
M. M. Kostik ◽  
M. K. Bekhtereva ◽  
A. N. Uskov ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Number Of Children ◽  
Treatment Regimens ◽  
Almost Everywhere ◽  
Laboratory Confirmation ◽  
High Incidence ◽  
Life Threatening ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome

Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock.In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19.The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill.

scholarly journals Clinical Characteristics of Rheumatic Diseases and Children Multisystem Inflammatory Syndrome Associated With COVID-19

2021 ◽  
Vol 7 (11) ◽  
pp. 170-183
Keyword(s):  
Connective Tissue ◽  
Clinical Manifestations ◽  
Pathological Process ◽  
Favorable Effect ◽  
Systemic Diseases ◽  
Clinical Observations ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Almost All ◽  
Inflammatory Syndrome

With a new coronavirus infection, almost all organism systems are involved in the pathological process, which leads to development during the disease or post-COVID period of both new diseases and complications of existing chronic diseases requiring treatment or rehabilitation. The remaining after the suffered disease symptom complex complaints and clinical manifestations can be disturbed without conducting therapy and rehabilitation over many months. Purpose of the study. Present on their own observations of the laws of the clinical picture and therapies of the treatment of children’s multisystem inflammatory syndrome and systemic diseases of the connective tissue associated with COVID-19. Research results. Presented in Kyrgyzstan series of own clinical observations of 31 patients with children’s multisystem inflammatory syndrome and 23 patients with systemic diseases of the connective tissue associated with COVID-19, and 29 — with exacerbation of the systemic diseases of the connective tissue due to the transferred coronavirus infection, demonstrates the etiological and pathogenic significance SARS COV2 in the emergence of a severe system of inflammatory response. Timely anti-inflammatory treatment of children’s multisystem inflammatory syndrome is crucial and must be adapted for each patient in order to achieve the most favorable effect. Patients of the systemic diseases of the connective tissue account for a risk group with regard to the disease COVID-19 and the unfavorable disease.

Features of mahagment of a patient with a new coronaviral infection in the observator on the basis of student’s dormitory

2020 ◽  
Vol 24 (2) ◽  
pp. 45-51
Author(s):  
Olga Yu. Kuznetsova ◽  
Alexandr V. Meltser ◽  
Anna V. Lubimova ◽  
Zhanna V. Pleshanova ◽  
Olga S. Zamyatina ◽  
...  
Keyword(s):  
Young Patients ◽  
Clinical Manifestations ◽  
Hypochromic Anemia ◽  
Lung Damage ◽  
Outpatient Basis ◽  
History Of ◽  
Complicated Course ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome ◽  
Severe Weakness

The article is devoted to the peculiarities of clinical manifestations and the severity of a new coronary virus infection in a university student transferred to an observatory organized in a hotel-type hostel to prevent the spread of COVID-19 among students living in hostels. The data on the epidemiological history of the patient, the results of clinical observation and examination are provided. The tactics of managing a patient with a suspected of COVID-19 on an outpatient basis, symptoms that determine the indications for hospitalization, the results of examination and treatment in a hospital, and further observation at the observatory are considered. A new coronavirus infection can lead to a rapid deterioration in the condition of young patients, which does not correlate with indicators indicating lung damage on the 5th day of the disease. Persistent hyperthermia and severe weakness with anorexia can be indicators of the complicated course of the disease, including the development of hyperactive inflammatory syndrome. Hypochromic anemia can be another disease, which is an unfavorable background for the development of COVID-19. The course of the new coronavirus infection in young patients requires careful attention and further study.

scholarly journals Peculiarities of clinical manifestations of the new COVID-19 coronavirus infection in patients hospitalized during the epidemic depending on their age

2021 ◽  
Vol 17 (7) ◽  
pp. 32-36
Author(s):  
V.I. Trykhlib ◽  
N.R. Tsiurak ◽  
K.P. Beliaeva ◽  
T.I. Lysenko ◽  
A.O. Yeroshenko ◽  
...  
Keyword(s):  
Chest Pain ◽  
Age Groups ◽  
Young Patients ◽  
Clinical Manifestations ◽  
Productive Cough ◽  
Thoracic Pain ◽  
Average Temperature ◽  
General Weakness ◽  
Significant Difference ◽  
Coronavirus Infection

This article presents a review of the literature and data from a personal study concerning the clinical manifestations of new coronavirus infection in patients hospitalized during the COVID-19 epidemic depending on their age. It was found that most patients complained about dry or low-productive cough, moderate general weakness. The patients aged 18–30 years old more frequently experienced no cough. The patients aged 31–40 years old significantly more frequently complained about dry cough (p < 0.05). Low-productive cough was less frequent but typical in all age groups and more frequent in patients aged 51–60 years. Moist cough was more frequent in patients over 60 years. Chest pain was registered in patients over 60 years (p < 0.05). The frequency of dyspnea was found to increase with age. More often dyspnea was registered in patients older than 60 years old. No dyspnea was noted in young patients aged 18–30 years. Half of the patients aged 18–30 years had no fever. At hospitalization, the average temperature was within normal or subfebrile, which predominated in patients aged 41–50 years (p < 0.05). The frequency of febrile fever increased in patients with age. There was no significant difference in the frequency of pyretic temperature among all age groups. The patients aged over 30 years complained more about moderate weakness, and patients aged over 40 years complained more about severe weakness. Younger patients more often complained about a sore throat, while older patients had practically no symptoms (p > 0.05). Thoracic pain was significantly more frequently registered in patients older than 60 years old. Young patients aged 18–30 years and 31–40 years had no chest pain.

NEW CORONAVIRUS INFECTION AS TRIGGER FACTOR FOR MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN: LITERATURE REVIEW AND ANALYSIS OF ORIGINAL DATA

2020 ◽  
Vol 99 (6) ◽  
pp. 127-134
Author(s):  
S.R. Rodionovskaya ◽  
◽  
L.N. Mazankova ◽  
I.M. Osmanov ◽  
E.R. Samitova ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Epidemiological Data ◽  
Original Data ◽  
Trigger Factor ◽  
Laboratory Markers ◽  
Systemic Glucocorticoids ◽  
Coronavirus Infection ◽  
Characteristic Features ◽  
Inflammatory Syndrome

The article presents data on the epidemiology, pathogenesis, features of clinical manifestations and diagnosis of multisystem inflammatory syndrome in children (MIS-C) associated with a new coronavirus infection. Objective of the research: to identify clinical manifestations and results of laboratory and instrumental examination of pediatric patients with confirmed MIS-C caused by a new coronavirus infection, the most characteristic features of this pathology and to analyze the amount of therapy based on the assessment of epidemiological data. Results: median age – 8 years (6; 9,5), median duration of the disease at the time of hospitalization – 6 days (3; 6). A positive result of SARS-CoV-2 analysis in rhinopharyngeal swabs by PCR was in 3 patients, antibodies to SARS-CoV-2 by ELISA were detected in 10. Clinical manifestations included prolonged febrile fever in 11 patients, gastrointestinal symptoms of varying severity – in 10, polymorphic rash was noted in 7 cases, conjunctivitis/scleritis – in 7, edema of the eyelids, face, extremities – in 4. CNS lesion manifested itself with general cerebral and meningeal symptoms. All patients had an increase in the level of inflammation laboratory markers. In 2 children chest MSCT revealed characteristic changes for SARS-CoV-2, interpreted as CT 3–4. Therapy included intravenous immunoglobulin infusions, systemic glucocorticoids, antiviral and antibacterial drugs, anticoagulants; two patients received tocilizumab infusions.

SKIN LESIONS IN CHILDREN WITH COVID-19-ASSOCIATED MULTISYSTEM INFLAMMATORY SYNDROME

2020 ◽  
Vol 99 (6) ◽  
pp. 259-265
Author(s):  
O.B. Tamrazova ◽  
◽  
I.M. Osmanov ◽  
A.S. Stadnikova ◽  
L.N. Mazankova ◽  
...  
Keyword(s):  
Clinical Observation ◽  
Clinical Manifestations ◽  
Chinese American ◽  
Skin Lesions ◽  
Disease Course ◽  
Skin Manifestations ◽  
Mucous Membranes ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome ◽  
First Time

The pandemic of the new coronavirus infection COVID-19, caused by SARS-CoV-2 coronavirus, continues to develop. The first data indicated that children tolerate this infection much easier than adults, the disease course is generally asymptomatic and mild. Chinese, American and European scientists described a variety of skin manifestations in children with COVID-19 coronavirus infection. The article presents literature data on skin manifestations in children, characteristic for COVID-19. In April 2020, the description of a new severe inflammatory syndrome in children associated with SARS-CoV-2, called multisystem inflammation syndrome (MIS), appeared for the first time. The article presents literature data on MIS clinical manifestations and its incidence. The authors describe clinical observation of MIS development in a 7-year-old child with COVID-19 and with lesions of the skin and mucous membranes.

scholarly journals Features of clinical manifestations of new coronavirus infection in patients at hospitalization during the COVID-19 epidemic depending on the severity

2021 ◽  
Vol 17 (8) ◽  
pp. 73-80
Author(s):  
V.I. Trykhlib ◽  
N.R. Tsiurak ◽  
K.P. Beliaeva ◽  
T.I. Lysenko ◽  
A.O. Yeroshenko ◽  
...  
Keyword(s):  
Respiratory Rate ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Clinical Manifestations ◽  
Normal Range ◽  
Average Temperature ◽  
General Weakness ◽  
Number Of Patients ◽  
Significant Difference ◽  
Coronavirus Infection

The article presents a review of the literature sources and results of a personal study. It was found that in our group, there were more persons aged 18–30 years among those who were in inpatient treatment, and among those who were treated in the ICU, the patients were aged 60 years or over. On average, patients who were treated in the ICU were admitted on the 6th day of illness. Most patients complained of dry or unproductive cough, moderate general weakness. Relatively more often moderate general weakness was registered in patients with a moderate course, and moderate and pronounced was typical for patients with a severe course (p < 0.05). Dyspnea was predominantly found in severely ill patients (in one-third of patients during exercise, in 17.7 % patients at rest). In patients with a non-serious course, a small number of patients had dyspnea on exertion (4.3 to 12.1 %). On admission, the average temperature was within normal or subfebrile, which predominated in patients with a moderate course (p < 0.05). With a mild course, half of the patients had a temperature within the normal range. Febrile fever was more often registered in the moderate and severe course. Pyretic body temperature was most typical for a severe course (p < 0.05). It is noteworthy that even in those patients who were treated in the intensive care unit, at admission a quarter of the patients had a normal temperature, and 41.2 % — subfebrile. On ave-rage, the duration of fever before admission in critically ill patients was 5 days, and in those who died — 2 days. Dry cough was significantly more common in severe patients (p < 0.05). In the mild course, only one-fifth of patients complained of dry or unproductive cough. In the moderate course, the dry or unproductive cough was symptomatic for one-third of patients. There was no significant difference in the frequency of complaints of sore throat (p > 0.05). On average, a respiratory rate on admission in critically ill patients did not differ between those who survived and those who died, while those who died more often presented with a respiratory rate of 30/min or more, tachycardia, and more reduced saturation values.

scholarly journals Kawasaki-multisystem inflammatory syndrome in children in the delayed period of coronavirus infection (covid-19): modern state of the problem and possible new approaches to treatment (plasmapheresis)

2021 ◽  
Vol 12 (4) ◽  
pp. 45-57
Author(s):  
O. S. Groznova ◽  
V. A. Warriors ◽  
D. Donich ◽  
V. V. Vetrov ◽  
D. O. Ivanov
Keyword(s):  
Interleukin 1 ◽  
Acute Infection ◽  
Clinical Manifestations ◽  
Adaptive Immune Response ◽  
Toxic Shock ◽  
New Associations ◽  
Temporary Connection ◽  
Adaptive Immune ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome

COVID-19 infection usually occurs in children in a mild form, but some of them in a delayed period (one or several weeks after acute infection with COVID-19) may develop a severe inflammatory disease with clinical manifestations similar to toxic shock syndrome (Kawasaki disease), classified as multisystem inflammatory syndrome in children (MISC). It is possible that the syndrome has only a temporary connection with the COVID-19 infection. In the future, new associations of such clinical manifestations with other infectious (or non-infectious) diseases may appear. But currently, all children in the described cohorts with MISC have an association with COVID-19 infection. It is believed that the syndrome is initiated by an excessive adaptive immune response with the formation of autoantibodies. Treatment is based on anti-inflammatory, including steroid therapy, the possible use of intravenous immunoglobulin, aspirin, interleukin 1 and 6 receptor antagonists. The article analyzes current views on Kawasaki-multisystem inflammatory syndrome in children in the delayed period of COVID-19 coronavirus infection in the aspects of diagnosis, pathogenesis, clinical manifestations (with a discussion of foreign and Russian studies) and approaches to therapy and possible prevention, including the possibility of using plasmapheresis in complex therapy.

CLINICAL, LABORATORY-INSTRUMENTAL CHARACTERISTICS, COURSE AND THERAPY OF PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH COVID-19

2020 ◽  
Vol 99 (6) ◽  
pp. 73-83
Author(s):  
Yu.Yu. Novikova ◽  
◽  
D.Yu. Ovsyannikov ◽  
A.A. Glazyrina ◽  
O.I. Zhdanova ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Intensive Therapy ◽  
Gastrointestinal Symptoms ◽  
Arterial Hypotension ◽  
Therapy Outcomes ◽  
Clinical Hospital ◽  
Severe Manifestation ◽  
Symptom Complex ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome

The most severe manifestation of the new coronavirus infection COVID-19 in children is the multisystem inflammatory syndrome in children (MIS-C). A systematic review of foreign publications as of July 25, 2020 contains an analysis of the disease course in 662 children with this syndrome and is used for comparison with the data obtained. Objective of the research: to characterize clinical manifestation, results of laboratory and instrumental studies, therapy, outcomes and consequences of the COVID-19- associated MIS-C, based on the observation of patients hospitalized to Morozov Children's City Clinical Hospital and Children’s clinical hospital of infectious diseases № 6 from May 1 to September 15, 2020. Materials and methods: the pilot study included 32 children aged 9 months – 15 years with COVID-19-associated MIS-C, verified based on WHO criteria (2020), including symptoms of Kawasaki disease (KD), arterial hypotension/shock, laboratory and instrumental signs of heart damage, signs of coagulopathy, gastrointestinal symptoms, increased inflammation markers, COVID-19 markers. Results: the median age of patients was 6 years, boys predominated among the patients (66%), all patients had antibodies to SARS-CoV-2 (31 children of the IgG class); MIS-C manifested itself as a combination of KD symptom complex (75% of patients) with arterial hypotension/shock (28%), neurological (50%), respiratory (41%), gastrointestinal (59%) symptoms; macrophage activation syndrome (MAS) was verified in 16% of patients. Therapy included intravenous immunoglobulin (75%), systemic glucocorticosteroids (88%), anticoagulants (91%), vasoactive/vasopressor support (31%). In 38% of cases treatment was performed in intensive care unit; one child died. According to echocardiography, 16% of patients had coronariitis, ectasia, and coronary arteries aneurysms. Conclusion: COVID-19-associated MIS-C is characterized by a severe course, cross-features with KD, shock syndrome with KD, MAS which requires intensive therapy and can cause acquired pathology of the cardiovascular system in children.

Sign in / Sign up

Export Citation Format

Share Document