scholarly journals Increased mean corpuscular volume as a predictor of response during bevacizumab treatment

2012 ◽  
Vol 20 (1-2) ◽  
pp. 15-16
Author(s):  
Lidia Zygulska ◽  
Krzysztof Krzemieniecki
Keyword(s):  
Mean Corpuscular Volume ◽  
Mean Value ◽  
University Hospital ◽  
Published Data ◽  
Percentage Increase ◽  
Corpuscular Volume ◽  
Multikinase Inhibitor ◽  
Bevacizumab Treatment ◽  
The Mean ◽  
Antiangiogenic Drug

Background: Remission during sunitinib (a multikinase inhibitor and antiangiogenic drug) treatment correlates with appearance of macrocytosis. There are some suggestions that bevacizumab, an antiangiogenic drug, may result in macrocytosis as well. There are no published data available on the influence of bevacizumab on macrocytosis. This paper attempted to answer the question: does bevacizumab induce macrocytosis being a predictor of the response? Methods: Between August 2008 and August 2011, 53 patients (29 male and 24 female) were treated with bevacizumab in the combination with chemotherapy at the Oncological Department, University Hospital in Krakow, Poland. Efficacy of bevacizumab was assessed on the basis of the computer tomography scans performed every 3 months within the period of 12 months. Concurrently, mean corpuscular volume (MCV) was evaluated and correlated to the response of the treatment. Results: The percentage increase of MCV compared to baseline at 3, 6, 9 and 12 months was 3.7%, 9.2%, 8.7% and 11.8% respectively. The mean value of baseline MCV was 85.3 fl. The mean value of MCV at 3, 6, 9 and 12 months was 90.5 fl, 93 fl, 91.8 fl and 93.1 fl respectively. Macrocytosis did not occur in our study but an increase of MCV was observed within bevacizumab therapy. It was closely related to the response of the treatment. It seems that an increase of MCV can be a predictive agent of bevacizumab response. Conclusion: Bevacizumab does not induce macrocytosis. Increased MCV after treatment with bevacizumab is related to the treatment response. MCV can be a predictor of the response during bevacizumab treatment. A small number of the observed patients requires further investigations.

scholarly journals Intra- and interindividual variability of carbohydrate-deficient transferrin, γ-glutamyltransferase, and mean corpuscular volume in teetotalers

1998 ◽  
Vol 44 (10) ◽  
pp. 2120-2125 ◽  
Author(s):  
Anders Helander ◽  
Erling Vabö ◽  
Klas Levin ◽  
Stefan Borg
Keyword(s):  
Mean Corpuscular Volume ◽  
Iron Concentration ◽  
Reference Interval ◽  
Reference Intervals ◽  
Mean Value ◽  
Corpuscular Volume ◽  
Mean Values ◽  
Reference Limit ◽  
Carbohydrate Deficient Transferrin ◽  
The Mean

Abstract Blood samples for determination of the biochemical alcohol markers carbohydrate-deficient transferrin (CDT) in serum, γ-glutamyltransferase (GGT) in serum, and erythrocyte mean corpuscular volume (MCV) were collected once every 1–2 weeks over ∼5 months from 10 female and 4 male teetotalers. Mean values for serum CDT (using the CDTectTM assay) ranged from 9.9 to 29.4 units/L (median, 14.2 units/L), and the highest results were obtained in the women. The mean values for serum GGT ranged from 0.15 to 0.49 μkat/L (median, 0.30 μkat/L, or 18 U/L) except for one woman with a very high mean of 3.07 μkat/L. For MCV, the mean values ranged from 79.5 to 91.5 fL. Two women showed several CDT results above the upper reference limit (mean values, 27.6 and 29.4 units/L, respectively); however, their GGT and MCV values fell within the reference intervals. One of these women exhibited an increased total transferrin concentration (mean value, 5.38 g/L), which was possibly related to the use of oral contraceptives and/or a low serum iron concentration. When the CDTect value was expressed relative to total transferrin, a ratio within the reference interval was observed for this woman but not for the other woman with increased CDTect values. The present study demonstrates a considerable variation between individuals in CDT, GGT, and MCV without drinking any alcohol. The results also show that these baseline values are fairly constant over time within the same individual.

scholarly journals RARE-04. INTELLECTUAL DEVELOPMENT IN CHILDREN WITH PEDIATRIC CRANIOPHARYNGIOMA AFTER TUMOR REMOVAL

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii442-iii442
Author(s):  
Tatsuki Oyoshi ◽  
Shingo Fujio ◽  
Nayuta Higa ◽  
Hajime Yonezawa ◽  
Koji Yoshimoto
Keyword(s):  
Intellectual Development ◽  
Mean Value ◽  
University Hospital ◽  
Electrolyte Imbalance ◽  
Surgical Removal ◽  
Tumor Removal ◽  
Full Scale Intelligence Quotient ◽  
Verbal Comprehension Index ◽  
The Mean ◽  
Perceptual Reasoning

Abstract INTRODUCTION Intellectual assessment in children with craniopharyngioma after tumor removal is still unknown. We assessed intellectual development in children who underwent microsurgical resection in our institute over the last twelve years. MATERIALS AND METHODS Ten children among 41 patients with craniopharyngioma treated and followed at Kagoshima University Hospital between 2007 and 2019 were reviewed. We also assessed intellectual development in 10 years or younger children with craniopharyngioma one year after tumor removal. Intelligence was assessed using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-Ⅳ). RESULTS Ten children underwent microsurgical tumor removal. The mean age at surgery was 5.8 (range 1–10) years. Transcranial approach was performed in 8 children, transsphenoidal approach in two children. The mean follow up period was 110 months. Gamma knife surgery (GKS) was performed in 6 children less than 6 months after first surgery. Regional recurrences occurred in 5 children, and additional GKS was performed in four children, second microsurgical removal in one child. Severe obesity with a transient electrolyte imbalance occurred in one child. Eight children with GH deficiency underwent GH replacement therapy. Eight children were assessed working memory index (WMI), processing speed index (PSI), Perceptual reasoning index (PRI), and verbal comprehension index (VCI) using WISC 4. Each mean value of WMI, PSI, and PRI was lower than VCI, except for 2 children with normal full scale intelligence quotient. CONCLUSION WMI, PSI and PRI in children with intellectual disabilities were lower tendency than VCI after surgical removal of craniopharyngiomas in the present study.

scholarly journals Prevalence of multidrug-resistant Acinetobacter baumannii in a critical care setting: A tertiary teaching hospital experience

2021 ◽  
Vol 9 ◽  
pp. 205031212110011
Author(s):  
Thabit Alotaibi ◽  
Abdulrhman Abuhaimed ◽  
Mohammed Alshahrani ◽  
Ahmed Albdelhady ◽  
Yousef Almubarak ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Mortality Rate ◽  
Acinetobacter Baumannii ◽  
Care Setting ◽  
Multidrug Resistant ◽  
University Hospital ◽  
Published Data ◽  
Tertiary Teaching ◽  
The Mean

Background: The management of Acinetobacter baumannii infection is considered a challenge especially in an intensive care setting. The resistance rate makes it difficult to manage and is believed to lead to higher mortality. We aim to investigate the prevalence of Acinetobacter baumannii and explore how different antibiotic regimens could impact patient outcomes as there are no available published data to reflect our population in our region. Methods: We conducted a retrospective review of all infected adult patients admitted to the intensive care unit at King Fahad University Hospital with a confirmed laboratory diagnosis of Acinetobacter baumannii from 1 January 2013 until 31 December 2017. Positive cultures were obtained from the microbiology department and those meeting the inclusive criteria were selected. Variables were analyzed using descriptive analysis and cross-tabulation. Results were further reviewed and audited by blinded co-authors. Results: A comprehensive review of data identified 198 patients with Acinetobacter baumannii. The prevalence of Acinetobacter baumannii is 3.37%, and the overall mortality rate is 40.81%. Our sample consisted mainly of male patients, that is, 68.7%, with a mean age of 49 years, and the mean age of female patients was 56 years. The mean age of survivors was less than that of non-survivors, that is, 44.95 years of age. We observed that prior antibiotic use was higher in non-survivors compared to survivors. From the review of treatment provided for patients infected with Acinetobacter baumannii, 65 were treated with colistin alone, 18 were treated with carbapenems, and 22 were treated with a combination of both carbapenems and colistin. The mean length of stay of Acinetobacter baumannii–infected patients was 20.25 days. We found that the survival rates among patients who received carbapenems were higher compared to those who received colistin. Conclusion: We believe that multidrug-resistant Acinetobacter baumannii is prevalent and associated with a higher mortality rate and represents a challenging case for every intensive care unit physician. Further prospective studies are needed.

scholarly journals Optical Properties of Dissolved Organic Matter in Finnish and Estonian Lakes

2003 ◽  
Vol 34 (4) ◽  
pp. 361-386 ◽  
Author(s):  
L. Sipelgas ◽  
H. Arst ◽  
K. Kallio ◽  
A. Erm ◽  
P. Oja ◽  
...  
Keyword(s):  
Organic Matter ◽  
Dissolved Organic Matter ◽  
Natural Waters ◽  
Mean Value ◽  
Published Data ◽  
Optical Parameters ◽  
Exponential Approximation ◽  
Absorption Coefficients ◽  
Specific Absorption ◽  
The Mean

The main objective of the present study is to test various methods for describing the absorption spectra of coloured dissolved organic matter (CDOM) and to determine the numerical values of some optical parameters of CDOM in lakes with diverse water quality. First, the parameters of an exponential model in different spectral intervals were determined. In addition, the suitability of some other models for the approximation of CDOM spectra was estimated. Specific absorption coefficients of CDOM were calculated from the absorption coefficients and dissolved organic carbon (DOC) concentrations. The experimental initial data were differences between spectral attenuation coefficients of filtered and distilled water. Two datasets were used: 1) for 13 Estonian and 7 Finnish lakes (altogether 404 spectra between 350 and 700 nm) measured by the Estonian Marine Institute (EMI); 2) for 10 Finnish lakes (73 spectra) measured by the Finnish Environment Institute (FEI). The spectra of CDOM absorption coefficients (aCDOM) were calculated from experimental data taking into account the correction due to scattering properties of colloids in the filtered water. The total content of CDOM in natural waters of Estonian and Finnish lakes was expressed by means of aCDOM at the wavelength of 380 nm. It varied significantly, from 0.71 to 19.5 m−1, the mean value (of all the investigated lakes) being around 6.6 m−1. Slopes of the exponential approximation varied widely, from 0.006 to 0.03 nm−1. Averaged over all lakes values of slope for the interval 380-500 nm obtained from the EMI dataset are close to those obtained from the FEI dataset: from 0.014 nm−1 (without correction) to 0.016-0.017 nm-1 (with different types of correction). These results are in good correspondence with most published data. Attempts to describe the spectra in the region of 350-700 nm by means of hyperexponential functions (∽ exp(-αλη)) show that: (1) η < 1 (in the case of traditional exponential approximation η = 1); (2) a promising idea is to seek the best fit only for wavelengths λ > λ1, where λ1 will be chosen taking into account the real shape of aCDOM spectra. The mean value of the specific absorption coefficient (a*CDOM) at the wavelength 380 nm obtained in this study (0.44 L mg−1 m−1) is close to the values published in the literature, if we assume that a*CDOM (380) is calculated using the data of dissolved organic matter (DOM). The optically non-active fraction of DOM in our study was high and therefore a*CDOM (380) was considerably higher (1.01 L mg−1 m−1) than a*CDOM (380). The results of the present work could be used in the modeling of underwater light field as well as in the interpretation of radiation measurements and optical remote sensing results.

scholarly journals Low Dose Vaginal Misoprostol in the Management of Women with Intrauterine Fetal Death

2010 ◽  
Vol 3 ◽  
pp. CMWH.S5797
Author(s):  
M.N. El-Gharib ◽  
M.T. El-Ebyary ◽  
T.S. Alhawary ◽  
S.H. Elshourbagy
Keyword(s):  
Fetal Death ◽  
Mean Value ◽  
University Hospital ◽  
Intrauterine Fetal Death ◽  
Third Trimester ◽  
Trimester Pregnancy ◽  
Observational Cohort ◽  
The Mean ◽  
Vaginal Misoprostol ◽  
Duration Of Gestation

Objectives The study was conducted to assess the effectiveness and side effects of vaginal misoprostol (Vagiprost® tablet) in termination of second and third trimester pregnancy complicated with intrauterine fetal death. Design A prospective observational cohort study. Setting Tanta University Hospital. Patients The study was carried out on 324 women with fetal demise in the second and third trimesters. Cases were collected during the period from January 2008 to December 2009. Intervention All patients were subjected to history taking, physical examination, Bishop Scoring. Application of 25 μg misoprostol in the posterior fornix of the vagina, this will be repeated every 4 hours over 24 hours. The adverse effects, progress, and outcomes were assessed. Results the success rate was 90% and 45% in women with third and second trimesters respectively. The mean induction-termination interval was 8.95 ± 2.63 and 15.3 ± 5.37 hours for women with third and second trimesters respectively. The induction termination interval correlated negatively with the duration of gestation. Approximately, 90% of second trimester and 55% of third trimester women required oxytocin augmentation. The mean value of total required dose of misoprostol was 166.3 ± 7.5 and 120 ± 28.79 μg for women with second and third trimesters respectively. Conclusion Vagiprost appears to be a safe, effective, practical, and inexpensive method for termination of third trimester pregnancy complicated with of intrauterine fetal death (IUFD), its effects increase with parity and duration of gestation.

Fluid and electrolyte shifts in women during +Gz acceleration after 15 days' bed rest

1977 ◽  
Vol 42 (1) ◽  
pp. 67-73 ◽  
Author(s):  
J. E. Greenleaf ◽  
H. O. Stinnett ◽  
G. L. Davis ◽  
J. Kollias ◽  
E. M. Bernauer
Keyword(s):  
Mean Corpuscular Volume ◽  
Body Position ◽  
Venous Blood ◽  
Bed Rest ◽  
Corpuscular Volume ◽  
The Third ◽  
Before And After ◽  
The Mean ◽  
Electrolyte Loss ◽  
Reduced Activity

Twelve women (23–34 yr), comprising a bed-rest (BR) group of eight subjects and an ambulatory (AMB) group of four subjects, were centrifuged after 14 days of ambulatory control (C),after 15 days of a 17-day BR period, and on the third day of recovery (R). Venous blood was taken before and after the third +3.0 G acceleration run (1.8 G/min). Relative to (C), the +Gz tolerance after BR was reduced -49.0% (P less than 0.05) in the BR group and -38.7% (NS) in the AMB group; during (R) the BR group regained up to 89.4% and the AMB group up to 87.1% of their (C) tolerances. In each of the three test periods, the shifts in plasma Na, Cl, PO4, and osmotic contents, which accompanied +Gz, followed the outward shift of plasma volume (PV). The correlation of the shift of PV during acceleration with the +Gz tolerance was 0.72 (P less than 0.01). During acceleration, the PV and electrolyte loss for both groups after BR was about half the loss of (C) and (R). Compared with (C) and (R) values, potassium shifts were variable but the mean corpuscular volume and mean corpuscular Hb contents and concentrations were unchanged during all +Gz runs; The results indicate that: 1) the higher the (C) + Gz tolerance, the greater the tolerance decline due to BR; 2) relative confinement and reduced activity contribute as much to the reduction in tolerance as does the horizontal body position during BR; 3) bed-rest deconditioning has no effect on the erythrocyte volume during +3.0 Gz; and 4) about one-half the loss in tolerance after BR can be attributed to PV and electrolyte shifts.

scholarly journals A Multi-Pollutant Air Quality Health Index (AQHI) Based on Short-Term Respiratory Effects in Stockholm, Sweden

2019 ◽  
Vol 16 (1) ◽  
pp. 105 ◽  
Author(s):  
Henrik Olstrup ◽  
Christer Johansson ◽  
Bertil Forsberg ◽  
Andreas Tornevi ◽  
Agneta Ekebom ◽  
...  
Keyword(s):  
Air Quality ◽  
Birch Pollen ◽  
Mean Value ◽  
Emergency Department Visits ◽  
Percentage Increase ◽  
Health Index ◽  
Mean Values ◽  
Quality Health ◽  
The Mean ◽  
Air Quality Health Index

In this study, an Air Quality Health Index (AQHI) for Stockholm is introduced as a tool to capture the combined effects associated with multi-pollutant exposure. Public information regarding the expected health risks associated with current or forecasted concentrations of pollutants and pollen can be very useful for sensitive persons when planning their outdoor activities. For interventions, it can also be important to know the contribution from pollen and the specific air pollutants, judged to cause the risk. The AQHI is based on an epidemiological analysis of asthma emergency department visits (AEDV) and urban background concentrations of NOx, O3, PM10 and birch pollen in Stockholm during 2001–2005. This analysis showed per 10 µg·m–3 increase in the mean of same day and yesterday an increase in AEDV of 0.5% (95% CI: −1.2–2.2), 0.3% (95% CI: −1.4–2.0) and 2.5% (95% CI: 0.3–4.8) for NOx, O3 and PM10, respectively. For birch pollen, the AEDV increased with 0.26% (95% CI: 0.18–0.34) for 10 pollen grains·m–3. In comparison with the coefficients in a meta-analysis, the mean values of the coefficients obtained in Stockholm are smaller. The mean value of the risk increase associated with PM10 is somewhat smaller than the mean value of the meta-coefficient, while for O3, it is less than one fifth of the meta-coefficient. We have not found any meta-coefficient using NOx as an indicator of AEDV, but compared to the mean value associated with NO2, our value of NOx is less than half as large. The AQHI is expressed as the predicted percentage increase in AEDV without any threshold level. When comparing the relative contribution of each pollutant to the total AQHI, based on monthly averages concentrations during the period 2015–2017, there is a tangible pattern. The AQHI increase associated with NOx exhibits a relatively even distribution throughout the year, but with a clear decrease during the summer months due to less traffic. O3 contributes to an increase in AQHI during the spring. For PM10, there is a significant increase during early spring associated with increased suspension of road dust. For birch pollen, there is a remarkable peak during the late spring and early summer during the flowering period. Based on monthly averages, the total AQHI during 2015–2017 varies between 4 and 9%, but with a peak value of almost 16% during the birch pollen season in the spring 2016. Based on daily mean values, the most important risk contribution during the study period is from PM10 with 3.1%, followed by O3 with 2.0%.

scholarly journals Storage of blood and the mean corpuscular volume.

1975 ◽  
Vol 28 (5) ◽  
pp. 345-349 ◽  
Author(s):  
A C Lawrence ◽  
J M Bevington ◽  
M Young
Keyword(s):  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
The Mean

scholarly journals A Method for the Measurement of Red Cell Dimensions and Calculation of Mean Corpuscular Volume and Surface Area

Blood ◽  
1958 ◽  
Vol 13 (12) ◽  
pp. 1185-1191 ◽  
Author(s):  
DONALD N. HOUCHIN ◽  
JOHN I. MUNN ◽  
BENJAMIN L. PARNELL
Keyword(s):  
Surface Area ◽  
Mean Corpuscular Volume ◽  
Red Cells ◽  
Corpuscular Volume ◽  
Cell Dimensions ◽  
Degree Of Confidence ◽  
Refractometric Determination ◽  
Normal Human ◽  
The Mean ◽  
High Degree

Abstract 1. A photomicrographic method was devised for the measurement of the dimensions of red cells in rouleaux in plasma. With normal blood valid conclusions were drawn from 80 cell measurements with a high degree of confidence. 2. The mean corpuscular volume and the surface area were computed from these dimensions by formulae which treated the cell as a spheroid. 3. The dimensions, mean corpuscular volume and surface area of normal human red cells were as follows: 8.28 µ diameter, 1.71 µ thickness, 82 µ3 volume and 134 µ2 surface area. 4. The computed mean corpuscular volume was in agreement with the refractometric determination.

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