scholarly journals RARE-04. INTELLECTUAL DEVELOPMENT IN CHILDREN WITH PEDIATRIC CRANIOPHARYNGIOMA AFTER TUMOR REMOVAL

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii442-iii442
Author(s):  
Tatsuki Oyoshi ◽  
Shingo Fujio ◽  
Nayuta Higa ◽  
Hajime Yonezawa ◽  
Koji Yoshimoto
Keyword(s):  
Intellectual Development ◽  
Mean Value ◽  
University Hospital ◽  
Electrolyte Imbalance ◽  
Surgical Removal ◽  
Tumor Removal ◽  
Full Scale Intelligence Quotient ◽  
Verbal Comprehension Index ◽  
The Mean ◽  
Perceptual Reasoning

Abstract INTRODUCTION Intellectual assessment in children with craniopharyngioma after tumor removal is still unknown. We assessed intellectual development in children who underwent microsurgical resection in our institute over the last twelve years. MATERIALS AND METHODS Ten children among 41 patients with craniopharyngioma treated and followed at Kagoshima University Hospital between 2007 and 2019 were reviewed. We also assessed intellectual development in 10 years or younger children with craniopharyngioma one year after tumor removal. Intelligence was assessed using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-Ⅳ). RESULTS Ten children underwent microsurgical tumor removal. The mean age at surgery was 5.8 (range 1–10) years. Transcranial approach was performed in 8 children, transsphenoidal approach in two children. The mean follow up period was 110 months. Gamma knife surgery (GKS) was performed in 6 children less than 6 months after first surgery. Regional recurrences occurred in 5 children, and additional GKS was performed in four children, second microsurgical removal in one child. Severe obesity with a transient electrolyte imbalance occurred in one child. Eight children with GH deficiency underwent GH replacement therapy. Eight children were assessed working memory index (WMI), processing speed index (PSI), Perceptual reasoning index (PRI), and verbal comprehension index (VCI) using WISC 4. Each mean value of WMI, PSI, and PRI was lower than VCI, except for 2 children with normal full scale intelligence quotient. CONCLUSION WMI, PSI and PRI in children with intellectual disabilities were lower tendency than VCI after surgical removal of craniopharyngiomas in the present study.

scholarly journals Low Dose Vaginal Misoprostol in the Management of Women with Intrauterine Fetal Death

2010 ◽  
Vol 3 ◽  
pp. CMWH.S5797
Author(s):  
M.N. El-Gharib ◽  
M.T. El-Ebyary ◽  
T.S. Alhawary ◽  
S.H. Elshourbagy
Keyword(s):  
Fetal Death ◽  
Mean Value ◽  
University Hospital ◽  
Intrauterine Fetal Death ◽  
Third Trimester ◽  
Trimester Pregnancy ◽  
Observational Cohort ◽  
The Mean ◽  
Vaginal Misoprostol ◽  
Duration Of Gestation

Objectives The study was conducted to assess the effectiveness and side effects of vaginal misoprostol (Vagiprost® tablet) in termination of second and third trimester pregnancy complicated with intrauterine fetal death. Design A prospective observational cohort study. Setting Tanta University Hospital. Patients The study was carried out on 324 women with fetal demise in the second and third trimesters. Cases were collected during the period from January 2008 to December 2009. Intervention All patients were subjected to history taking, physical examination, Bishop Scoring. Application of 25 μg misoprostol in the posterior fornix of the vagina, this will be repeated every 4 hours over 24 hours. The adverse effects, progress, and outcomes were assessed. Results the success rate was 90% and 45% in women with third and second trimesters respectively. The mean induction-termination interval was 8.95 ± 2.63 and 15.3 ± 5.37 hours for women with third and second trimesters respectively. The induction termination interval correlated negatively with the duration of gestation. Approximately, 90% of second trimester and 55% of third trimester women required oxytocin augmentation. The mean value of total required dose of misoprostol was 166.3 ± 7.5 and 120 ± 28.79 μg for women with second and third trimesters respectively. Conclusion Vagiprost appears to be a safe, effective, practical, and inexpensive method for termination of third trimester pregnancy complicated with of intrauterine fetal death (IUFD), its effects increase with parity and duration of gestation.

Analysis of a Laxity Index Database and Comparison with the Fédération Cynologique Internationale Grades of This Population

2020 ◽  
Author(s):  
Mileva Bertal ◽  
Aldo Vezzoni ◽  
Elke Van der Vekens ◽  
Ingeborgh Polis ◽  
Jimmy H. Saunders ◽  
...  
Keyword(s):  
Hip Joint ◽  
Mean Value ◽  
Joint Laxity ◽  
University Hospital ◽  
Grade Group ◽  
Stress Radiograph ◽  
Wide Range ◽  
The Mean ◽  
The University ◽  
Labrador Retrievers

Abstract Objective This study aimed to analyse the distribution of the laxity indices (LI) in a dog population, to compare the LI with the Fédération Cynologique Internationale (FCI) grades and to search for differences of LI between breeds. Study Design The database was composed of all dogs presented to the University Hospital of the Faculty of Veterinary Medicine in Ghent for obligatory hip screening between January 2016 and February 2019, and all patients presented to orthopaedic consultation between January 2017 and January 2019 for a complaint of hindlimb lameness, which underwent both a standard extended ventrodorsal radiograph of the hips and a stress radiograph revealing hip joint laxity. The latter was obtained by means of the Vezzoni-modified Badertscher distension device and the LI was calculated. For each dog of the population, the LI was then compared with the FCI grade. Results The LI values ranged between 0.15 and 1.04, with a mean of 0.46. The LI and the FCI grade increased together, and showed a moderate-to-good correlation. There was a highly significant overall difference in the mean value of LI per FCI grade group (p < 0.001). The mean LI of the Labrador Retrievers was slightly but significantly lower than the mean LI of the Golden Retrievers (p < 0.01). Conclusion The LI calculated on a stress radiograph taken with the Vezzoni-modified Badertscher distension device shows a good correlation with the FCI grade assigned on a standard extended ventrodorsal projection. A wide range of passive hip joint laxity exists in dogs considered to be phenotypically normal based on the FCI grading method.

scholarly journals Increased mean corpuscular volume as a predictor of response during bevacizumab treatment

2012 ◽  
Vol 20 (1-2) ◽  
pp. 15-16
Author(s):  
Lidia Zygulska ◽  
Krzysztof Krzemieniecki
Keyword(s):  
Mean Corpuscular Volume ◽  
Mean Value ◽  
University Hospital ◽  
Published Data ◽  
Percentage Increase ◽  
Corpuscular Volume ◽  
Multikinase Inhibitor ◽  
Bevacizumab Treatment ◽  
The Mean ◽  
Antiangiogenic Drug

Background: Remission during sunitinib (a multikinase inhibitor and antiangiogenic drug) treatment correlates with appearance of macrocytosis. There are some suggestions that bevacizumab, an antiangiogenic drug, may result in macrocytosis as well. There are no published data available on the influence of bevacizumab on macrocytosis. This paper attempted to answer the question: does bevacizumab induce macrocytosis being a predictor of the response? Methods: Between August 2008 and August 2011, 53 patients (29 male and 24 female) were treated with bevacizumab in the combination with chemotherapy at the Oncological Department, University Hospital in Krakow, Poland. Efficacy of bevacizumab was assessed on the basis of the computer tomography scans performed every 3 months within the period of 12 months. Concurrently, mean corpuscular volume (MCV) was evaluated and correlated to the response of the treatment. Results: The percentage increase of MCV compared to baseline at 3, 6, 9 and 12 months was 3.7%, 9.2%, 8.7% and 11.8% respectively. The mean value of baseline MCV was 85.3 fl. The mean value of MCV at 3, 6, 9 and 12 months was 90.5 fl, 93 fl, 91.8 fl and 93.1 fl respectively. Macrocytosis did not occur in our study but an increase of MCV was observed within bevacizumab therapy. It was closely related to the response of the treatment. It seems that an increase of MCV can be a predictive agent of bevacizumab response. Conclusion: Bevacizumab does not induce macrocytosis. Increased MCV after treatment with bevacizumab is related to the treatment response. MCV can be a predictor of the response during bevacizumab treatment. A small number of the observed patients requires further investigations.

The response of plasma arginine vasopressin to 14 h water deprivation in the elderly

1984 ◽  
Vol 105 (3) ◽  
pp. 314-317 ◽  
Author(s):  
Ching Huai Li ◽  
Shao Ming Hsieh ◽  
Isamu Nagai
Keyword(s):  
Arginine Vasopressin ◽  
Water Deprivation ◽  
The Elderly ◽  
Mean Value ◽  
Electrolyte Imbalance ◽  
Pathological State ◽  
Healthy Elderly ◽  
Post Test ◽  
The Mean ◽  
Plasma Arginine

Abstract. The response of plasma arginine vasopressin (AVP) to 14 h water deprivation was investigated in 30 healthy elderly individuals ranging in age from 63 to 87 years, with a mean age of 76.5 years. The mean AVP concentrations, both at normal hydration and after the water deprivation test, were significantly lower than those in the young. Moreover, the post-test mean value of Uosm/Posm in the elderly increased up to 1.55 ± 0.52, which is lower than that in the young in whom the value was greater than 2. These results suggest that the aged are prone to incomplete diabetes insipidus. This pathological state might predispose to electrolyte imbalance in the elderly.

scholarly journals AB0047 CLINICAL AND RADIOLOGICAL CHARACTERISTICS AND TREATMENTS OF A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS AND DIFFUSE INTERSTICIAL PULMONARY DISEASE FOLLOWED AT THE VIRGEN MACARENA UNIVERSITY HOSPITAL

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1056.1-1056
Author(s):  
P. Muñoz Reinoso ◽  
F. J. Toyos Sáenz de Miera ◽  
D. Ruiz-Montesinos ◽  
I. García Hernández ◽  
P. Guerrero Zamora ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Respir Crit ◽  
Usual Interstitial Pneumonia ◽  
Respiratory Function Tests ◽  
Mean Value ◽  
University Hospital ◽  
Radiological Pattern ◽  
The Mean

Background:Diffuse interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA)1,2. The most common pattern is the usual interstitial pneumonia (UIP), conditioning a worse prognosis3.Objectives:To describe epidemiological, clinical, and radiological characteristics and treatment used in a cohort of patients diagnosed with RA and ILD.Methods:Retrospective descriptive study, including patients with a diagnosis of RA and ILD, reviewed in the Rheumatology and Pneumology consultations of the Virgen Macarena University Hospital, from 2010 to 2019. Data obtained from medical records are analyzed. SPSS statistical software is used.Results:26 patients were included, 18 women (69.2%). Median age at diagnosis of ILD was 62 years (53-73). Twelve patients (46.6%) used to smoke. The mean time from RA diagnosis to ILD diagnosis was 79 months (8-264). The RF was positive in 91.3% cases (21) and 87% of them (20) were ACPA positive. Fourteen patients (53.8%) had erosions and 3 (11.5%) had an associated Sjögren’s Syndrome. When ILD was diagnosed, the RA activity by DAS28PCR was moderate (3.28; 2.34-3.28) and 13 patients (54.1%) suffered from dyspnea. The mean value of FVC and DLCO in the first assessment was 84% (63-108) and 71.7% (64-86), respectively. The most frequent radiological pattern of ILD was NINE in 15 patients (57.7%), 6 of them (23.1%) had UIP and 5 (19.3%) presented other patterns. Prior to ILD diagnosis, 24 (92.3%) patients received oral glucocorticoids, 18 (69.2%) cases started treatment with c-DMARD and 11 (42.3%) of them with b-DMARD; the most widely used were methotrexate (MTX) in 17 patients (65.4%) and anti-TNFα in 10 (38.5%). After diagnosis, treatment was changed to 12 patients (46.6%); the most used DMARD was leflunomide, in 11 (42.3%), MTX was maintained in 7 patients (26.9%); the number of anti-TNFα used decreased to 4 cases (15.4%), using instead drugs such as rituximab 5 (19.2%), abatacept 3 (11.5%), baricitinib 2 (7.7%) and anti-IL6 2 (7, 7%). During follow-up, 11 cases (57.9%) remained radiologically stable. A slight deterioration in DLCO was observed (66%; 51-80) and there was one death due to lung disease (UIP).Conclusion:In this study, the most frequent radiological pattern was NINE. Half of the patients used to smoke. At the diagnosis of ILD (at ILD diagnosis), dyspnea was the most relevant clinical symptom, with a slight deterioration in the? respiratory function tests. This represented a change in the therapeutic strategy.References:[1]Olson AL, Swigris JJ, Sprunger DB, et al. Rheumatoid arthritis-interstitial lung disease-associated mortality. Am J Respir Crit Care Med. 2011;183:372-78.[2]Fragoulis GE, Nikiphorou E, Larsen J, Korsten P and Conway R. Methotrexate-Associated Pneumonitis and Rheumatoid Arthritis-Interstitial Lung Disease: Current Concepts for the Diagnosis and Treatment. Front. Med. 2019;6:238.[3]Tanaka N, Kim JS, Newell JD, et al. Rheumatoid arthritis-related lung diseases: CT findings. Radiology. 2004;232:81-91.Disclosure of Interests:None declared

scholarly journals Nurses' exposure to verbal abuse at a university hospital in Crete, Greece

2021 ◽  
Author(s):  
Nikos Rikos ◽  
Demetra Telli ◽  
Athanasia Hatzinikolaou ◽  
Demetra Mantikou ◽  
Michael Rovithis ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Mean Value ◽  
Verbal Abuse ◽  
University Hospital ◽  
The Mean ◽  
Almost All

Background & Aim: The current study aimed to investigate workplace bullying, specifically verbal abuse of working nurses, and its consequences on the physical and psychological levels. Methods & Materials: A cross-sectional study was designed and implemented in 151 nurses working at a university hospital. The survey was conducted in 2018 at a university hospital in Greece, and the Verbal Abuse Scale (G-AVQ v.0/2015) was used to assess the verbal abuse level. Multiple linear regression analysis was applied, and distributions were tested for their symmetry using Blom's method (QQ plot). Results: 88.1% were women as the mean age of all was 41.7 years and 16.1 years the mean length of employment. Almost all nurses (94.7%) reported experiencing verbal abuse, as 77.6% reported that the perpetrator was a patient's relative (p<0.05). Among cognitive assessment, coping, severity of effects, and strength of feeling, coping had the highest mean value the highest mean value, while severity of effects had the lowest (2.52 vs. 1.83, p<0.05). Multiple linear regression analysis showed that frequency of verbal abuse type has a significant correlation with higher coping (β=0.28, p=0.007) and strength of feeling values (β=0.29, p=0.010). Similarly, the severity of verbal abuse type has a significant correlation with higher strength of feeling values (β=0.30, p=0.014). Conclusion: Almost all the nurses reported experiencing verbal abuse as the 'patients' relatives were the main perpetrators. Although the nurses seem to cope with verbal abuse successfully, this fact is described as stressful. Moreover, the frequency, severity of verbal abuse, and consequences are correlated to the emotions that arise from it.

scholarly journals Intellectual changes after radiation for children with brain tumors: which brain structures are most important?

2020 ◽  
Author(s):  
Derek S Tsang ◽  
Laurence Kim ◽  
Zhihui Amy Liu ◽  
Laura Janzen ◽  
Mohammad Khandwala ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Fixed Effects ◽  
Brain Structures ◽  
Brain Regions ◽  
Patient Specific ◽  
Full Scale Intelligence Quotient ◽  
Dosimetric Data ◽  
Left Hippocampus ◽  
Verbal Comprehension Index ◽  
Perceptual Reasoning

Abstract Background The objective of this study was to evaluate the contribution of radiation dose to different intracranial structures on changes in intellectual function for children with brain tumors. Methods We evaluated children with brain tumors treated in 2005–2017 who had longitudinal neuropsychological assessments and available photon dosimetric data (if radiation therapy [RT] given). Full Scale Intelligence Quotient (FSIQ) and index scores were evaluated (perceptual reasoning index [PRI], processing speed index [PSI], verbal comprehension index [VCI], and working memory index [WMI]). Multivariable linear mixed effects models were used to model endpoints, with age at RT and dose to different brain regions as fixed effects and patient-specific random intercepts. P-values (P*) were adjusted for multiple comparisons. Results Sixty-nine patients were included, 56 of whom received RT. Median neuropsychological follow-up was 3.2 years. Right temporal lobe mean dose was strongly associated with decline in FSIQ (P* = 0.005); with each gray increase in mean dose, there was a decrease of 0.052 FSIQ points per year. Dose to 50% (D50) of the supratentorial brain was associated with decline in PSI (P* = 0.006) and WMI (P* = 0.001). Right and left hippocampus D50 were individually strongly associated with declines in VCI (P* = 0.009 for each). Presence of a ventriculoperitoneal shunt decreased FSIQ by 10 points. Conclusions We reported associations between dosimetry to specific brain regions and intellectual outcomes, with suggested avoidance structures during RT planning. These models can help clinicians anticipate changes in neurocognition post-RT and guide selection of an optimal RT plan.

scholarly journals Foreign body ingestion in children

2019 ◽  
Vol 98 (9) ◽  
pp. 370-374
Keyword(s):  
Foreign Body ◽  
Digestive Tract ◽  
Foreign Bodies ◽  
Outpatient Setting ◽  
University Hospital ◽  
Surgical Removal ◽  
Tract Perforation ◽  
The Mean ◽  
The University ◽  
Swallowed Foreign Bodies

Introduction: Evaluation of results of the group of paediatric patients treated for swallowed foreign bodies in the digestive tract. Methods: Retrospective analysis of patients treated for foreign bodies in the digestive tract, managed at the University Hospital of Hradec Králové between 2011–2018. Results: 365 patients (182 boys, 183 girls) with a foreign body in the digestive tract have been evaluated. The mean age was 2.4 years. Most of the children were treated as outpatients (280 children, 76.7%) and only 85 children (23.3%) were hospitalized. The most commonly swallowed frequent bodies included coins (26%) and batteries (14.5%); sharp objects occurred in 5.2%. Unusual foreign bodies were noticed, too. We can mention for example a pen or a plant nutrition product. In 302 cases (82.7%) the foreign bodies passed easily per vias naturales. Endoscopy was necessary in 63 cases (17.2%) – in 51 children the object had to be removed from the oesophagus and in 12 children the object had to be removed from the stomach. None of the swallowed bodies caused complications such as digestive tract perforation or bowel obstruction. No patient in the group was indicated for laparotomy to remove the foreign body. Conclusion: Foreign bodies entrapped in the oesophagus have to be removed endoscopically. In most cases, foreign bodies in the stomach require only observation in the outpatient setting because they leave the stomach easily, without complications, per vias naturales. If a battery remains at the same place of the digestive tract for more than 24 hours, endoscopic removal is indicated at our department. In addition, endoscopy is done in cases of swallowed multiple magnets or bodies that are too large and remain in stomach for several weeks or months. Surgical removal of foreign bodies should be reserved only for complicated cases.

scholarly journals Characterization of Intelligence in Children with Exotropia

2019 ◽  
Vol 16 (17) ◽  
pp. 3008
Author(s):  
Tao Sun ◽  
Zhonghao Wang ◽  
Tao Shen ◽  
Jianhua Yan ◽  
Chuanbo Xie ◽  
...  
Keyword(s):  
Processing Speed ◽  
Normal Group ◽  
Duration Of Symptoms ◽  
Verbal Comprehension ◽  
Full Scale Intelligence Quotient ◽  
Normal Individuals ◽  
Significant Difference ◽  
Verbal Comprehension Index ◽  
Angle Of Deviation ◽  
Perceptual Reasoning

The effect of exotropia on the intelligence of children is unknown. This study aimed to assess the intelligence in children with exotropia and investigate the influence of the main clinical indexes of strabismus on intelligence. Eighty-four participants aged 8–12 years were enrolled, including 37 patients with exotropia (exotropia group) and 47 normal individuals (normal group). Intelligence was assessed by the Wechsler Intelligence Scale for Children—Fourth Edition (WISC-IV), including the Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working Memory Index (WMI), Processing Speed Index (PSI), and Full-Scale Intelligence Quotient (FSIQ). The exotropia group had a significantly lower PRI score but a higher PSI score than the normal group. However, there was no significant difference in the WMI, VCI, and FSIQ between groups. Multiple linear regression showed that PRI–WMI and PRI–PSI differences were significantly lower in the exotropia group. Inter-subscale correlations analysis showed that the pattern of intelligence structure was different between groups. The type of exotropia, angle of deviation, duration of symptoms, and stereoacuity had no effect on the intelligence of children with exotropia. Children with exotropia had a relatively worse performance in the perceptual reasoning skill but a better processing speed and a different pattern of intelligence structure.

scholarly journals Growth in early life and physical and intellectual development at school age: a cohort study

2019 ◽  
Vol 121 (8) ◽  
pp. 866-876 ◽  
Author(s):  
Chao Li ◽  
Lingxia Zeng ◽  
Duolao Wang ◽  
Stephen Allen ◽  
Shabbar Jaffar ◽  
...  
Keyword(s):  
Weight Gain ◽  
Nutritional Status ◽  
Early Life ◽  
Intellectual Development ◽  
Controlled Trial ◽  
Intellectual Function ◽  
Full Scale Intelligence Quotient ◽  
Height Gain ◽  
Randomised Controlled ◽  
Perceptual Reasoning

AbstractThe associations between growth during early life and subsequent cognitive development and physical outcomes are not widely known in low-resource settings. We examined postnatal weight and height gain through early life and related these measurements to the nutritional status and intellectual development of the same children when they were between 7 and 9 years old. Mothers had enrolled in an randomised controlled trial to evaluate the effect of prenatal micronutrient supplementation on birth weight. Their children were born in 2004, their height and weight were measured at 6, 12, 18 and 24 months of age and were followed up between October 2012 and September 2013 (at ages 7–9 years, n 650). Height-for-age, weight-for-age and BMI-for-age were used to describe the nutritional status, and the Wechsler Intelligence Scale for Children fourth edition was used to measure the intellectual function. Multilevel linear and logistic modelling was used to estimate the association between early growth and subsequent growth and intellectual function. After adjustment, weight gain from 6 to 12 months of age was associated with Full-scale Intelligence Quotient, Verbal Comprehension Index, Working Memory Index and Perceptual Reasoning Index. Weight gain during early life was associated with subsequent nutritional status. For every 1 kg increase in weight during the 0- to 6-month period, the OR for underweight, thinness and stunting at 7–9 years of age were 0·19 (95 % CI 0·09, 0·37), 0·34 (95 % CI 0·19, 0·59) and 0·40 (95 % CI 0·19, 0·83), respectively. Weight gain during the periods of 6–12 months of age and 18–24 months of age was also associated with a lower risk of being underweight. Weight gain during early life was associated with better growth outcomes and improved intellectual development in young school-aged children.

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