scholarly journals Long-term attitude towards follow-up colposcopy in women of reproductive age after excisional treatment for cervical dysplasia

2019 ◽  
Vol 147 (5-6) ◽  
pp. 321-326
Author(s):  
Radmila Sparic ◽  
Dimitrios Papoutsis ◽  
Svetlana Spremovic-Radjenovic ◽  
Sasa Kadija ◽  
Zoran Bukumiric ◽  
...  
Keyword(s):  
Condom Use ◽  
Cervical Dysplasia ◽  
Reproductive Age ◽  
Living Alone ◽  
Anxiety And Depression ◽  
Control Group ◽  
Study Group ◽  
Women Of Reproductive Age

Introduction/Objective. Very little is known about the factors influencing women?s attitude towards colposcopy follow-up after cervical treatment. The aim of the study was to investigate the long-term attitude to follow-up colposcopy in women of reproductive age after cervical excision and to evaluate if their attitude was related to their anxiety and depression levels. Methods. Women treated with cervical excision were interviewed after a follow-up colposcopy visit. Their socio-demographic and clinical characteristics were recorded. All women filled in the Beck?s anxiety and depression inventory. Results. A total of 160 women were divided into the study group of 42 (26.3%) women who felt discomfort during follow-up colposcopy and the control group of 118 (73.7%) women who did not report such feelings. The mean age of the total sample was 35.3 ? 5.4 years with median time after treatment being five years (range: 2?18). Women in the study group had a significantly lower BMI values, had higher rates of nulliparity and nulligravidity, were more often single or living alone, and had significantly changed their attitude towards condom use after treatment. Beck?s anxiety and depression scores were significantly higher in the study group. Multivariate analysis showed that independent predictors of discomfort during follow-up colposcopy were anxiety levels (OR: 1.06; 95% CI: 1?1.12), living alone or without a partner (OR: 2.65; 95% CI: 1.08?6.55), and the change in their practice of condom use after treatment (OR: 2.69; 95% CI: 1.02?7.07). Conclusion. Almost one third of women after excisional treatment reported discomfort during their follow-up colposcopy. These women exhibited higher levels of anxiety.

scholarly journals Anti-adhesion Gel versus No gel following Operative Hysteroscopy prior to Subsequent fertility Treatment or timed InterCourse (AGNOHSTIC), a randomised controlled trial: protocol

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
S van Wessel ◽  
T Hamerlynck ◽  
V Schutyser ◽  
C Tomassetti ◽  
C Wyns ◽  
...  
Keyword(s):  
Live Birth ◽  
Financial Support ◽  
Controlled Trial ◽  
Reproductive Age ◽  
Fertility Treatment ◽  
Control Group ◽  
Women Of Reproductive Age ◽  
Operative Hysteroscopy ◽  
Randomised Controlled

Abstract STUDY QUESTIONS Does the application of anti-adhesion gel, compared to no gel, following operative hysteroscopy to treat intrauterine pathology in women wishing to conceive increase the chance of conception leading to live birth? WHAT IS KNOWN ALREADY Intrauterine adhesions (IUAs) following operative hysteroscopy may impair reproductive success in women of reproductive age. Anti-adhesion barrier gels may decrease the occurrence of IUAs, but the evidence on their effectiveness to improve reproductive outcomes is sparse and of low quality. STUDY DESIGN, SIZE, DURATION This multicentre, parallel group, superiority, blinded and pragmatic randomised controlled trial is being carried out in seven participating centres in Belgium. Recruitment started in April 2019. Women will be randomly allocated to treatment with anti-adhesion gel (intervention group) or no gel (control group). Sterile ultrasound gel will be applied into the vagina as a mock-procedure in both treatment arms. The patient, fertility physician and gynaecologist performing the second-look hysteroscopy are unaware of the allocated treatment. Power analysis, based on a target improvement of 15% in conception leading to live birth using anti-adhesion gel, a power of 85%, a significance level of 5%, and a drop-out rate of 10%, yielded a number of 444 patients to be randomised. The baseline rate of conception leading to live birth in the control group is expected to be 45%. PARTICIPANTS/MATERIALS, SETTING, METHODS Women of reproductive age (18–47 years), wishing to conceive (spontaneously or by fertility treatment) and scheduled for operative hysteroscopy to treat intrauterine pathology (endometrial polyps, myomas with uterine cavity deformation, uterine septa, IUAs or retained products of conception) are eligible for recruitment. Women may try to conceive from 3 to 6 weeks after receiving allocated treatment with follow-up ending at 30 weeks after treatment. If the woman fails to conceive within this timeframe, a second-look hysteroscopy will be scheduled within 2–6 weeks to check for IUAs. The primary endpoint is conception leading to live birth, measured at 30 weeks after randomisation. The secondary endpoints are time to conception, clinical pregnancy, miscarriage and ectopic pregnancy rates, measured at 30 weeks after receiving allocated treatment. The long-term follow-up starts when the patient is pregnant and she will be contacted every trimester. STUDY FUNDING/COMPETING INTEREST(S) This work is funded by the Belgian Healthcare Knowledge Centre (KCE). The anti-adhesion gel is supplied at no cost by Nordic Pharma and without conditions. Dr. Tomassetti reports grants and non-financial support from Merck SA, non-financial support from Ferring SA, personal fees and non-financial support from Gedeon-Richter, outside the submitted work. None of the other authors have a conflict of interest.

scholarly journals Role and effectiveness of complex and supervised rehabilitation on overall and hand function in systemic sclerosis patients—one-year follow-up study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michał Waszczykowski ◽  
Bożena Dziankowska-Bartkowiak ◽  
Michał Podgórski ◽  
Jarosław Fabiś ◽  
Arleta Waszczykowska
Keyword(s):  
Systemic Sclerosis ◽  
Hand Function ◽  
Exercise Program ◽  
Rehabilitation Program ◽  
Long Term Results ◽  
Home Exercise ◽  
Control Group ◽  
Study Group

AbstractThe aim of this study was to estimate the long-term results of complex and supervised rehabilitation of the hands in systemic sclerosis (SSc) patients. Fifty-one patients were enrolled in this study: 27 patients (study group) were treated with a 4-week complex, supervised rehabilitation protocol. The control group of 24 patients was prescribed a home exercise program alone. Both groups were evaluated at baseline and after 1-, 3-, 6-, and 12-months of follow-up with the Disability of the Arm, Shoulder and Hand Questionnaire (DAHS) as the primary outcome, pain (VAS—visual analog scale), Cochin Hand Function Scale (CHFS), Health Assessment Questionnaire Disability Index (HAQ-DI), Scleroderma-HAQ (SHAQ), range of motion (d-FTP—delta finger to palm, Kapandji finger opposition test) and hand grip and pinch as the secondary outcomes. Only the study group showed significant improvements in the DASH, VAS, CHFS and SHAQ after 1, 3 and 6 months of follow-up (P = 0.0001). Additionally, moderate correlations between the DASH, CHFS and SHAQ (R = 0.7203; R = 0.6788; P = 0.0001) were found. Complex, supervised rehabilitation improves hand and overall function in SSc patients up to 6 months after the treatment but not in the long term. The regular repetition of this rehabilitation program should be recommended every 3–6 months to maintain better hand and overall function.

scholarly journals A Prospective 30-Year Follow-Up of ADHD Associated With Perinatal Risks

2014 ◽  
Vol 21 (10) ◽  
pp. 799-810 ◽  
Author(s):  
Timo Tervo ◽  
Katarina Michelsson ◽  
Jyrki Launes ◽  
Laura Hokkanen
Keyword(s):  
Control Group ◽  
Study Group ◽  
Adhd Symptoms ◽  
Learning Impairments ◽  
Adult Outcome ◽  
Psychiatric Problems ◽  
Motor Perception ◽  
Perinatal Risks

Objective: Longitudinal follow-up of ADHD suggests a poorer outcome in those affected. Studies extending to 30 years however are rare. We investigated the adult outcome of ADHD associated with perinatal risks (PRs), treated non-pharmacologically. Method: A study group of 122 participants (86 men, 36 women) with PR-associated ADHD was followed-up from birth and compared with a control group also prospectively studied. Results: The study group showed more cognitive, motor perception, and learning impairments as well as psychiatric problems at ages 5, 9, and 16. At age 30, the study group reported less education, more involuntary job dismissals and more alcohol abuse. Self-reported ADHD symptoms were still prevalent in adulthood. Conclusion: ADHD symptoms persist and impair the long-term educational, occupational, and psychiatric outcome. ADHD in participants with PR appears to follow a course seen in studies of unselected ADHD.

Pelvic Inflammatory Disease

2009 ◽  
Vol 2 (9) ◽  
pp. 517-521
Author(s):  
Alexander Hodson
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Female Genital Tract ◽  
Reproductive Age ◽  
Common Condition ◽  
Women Of Reproductive Age ◽  
Infection And Inflammation ◽  
Female Genital

Pelvic inflammatory disease (PID), infection and inflammation of the upper female genital tract, is a common condition managed by General Practitioners (GPs). It accounts for one in 60 consultations in women of reproductive age. Early diagnosis, management and, if necessary, referral is essential to help prevent serious long-term complications such as ectopic pregnancy, infertility and chronic pelvic pain. This article outlines the causes, clinical features, treatment and follow-up of PID.

Setting up a Pain Management Programme the Ayrshire Experience

2000 ◽  
Vol 45 (2) ◽  
pp. 45-48 ◽  
Author(s):  
C. Martin ◽  
T. Obonyo ◽  
T. Carney ◽  
L. Lamont
Keyword(s):  
Pain Management ◽  
Controlled Trial ◽  
Negative Mood ◽  
Management Programme ◽  
Self Report ◽  
Control Group ◽  
Study Group ◽  
Activity Levels

A controlled trial of an outpatient cognitive behavioural pain management programme for sufferers of non-cancer chronic pain is described. A multidisciplinary team set up a programme of ten half day sessions for groups of ten to fourteen patients aiming to improve activity levels and control over pain; to reduce maladaptive pain behaviours and drug intake; to mitigate negative mood; to modify unhelpful beliefs and to maintain treatment gains by operant and cognitive methods. Self report questionnaires were employed before and six weeks, six months and one year after the programme. Fifty-eight patients entered the study group and 39 patients completed the programme and initial follow up with further attrition in long term follow up. There were no changes in the waiting list control group of twelve subjects but the study group made significant short and long term improvements in pain severity, activity levels, mood, coping and experienced fewer catastrophizing thoughts.

Two-Year Follow-Up of a Sexual Health Promotion Program for Spanish Adolescents

2016 ◽  
Vol 40 (4) ◽  
pp. 483-504 ◽  
Author(s):  
Jose P. Espada ◽  
Silvia Escribano ◽  
Alexandra Morales ◽  
Mireia Orgilés
Keyword(s):  
Condom Use ◽  
Self Report ◽  
Health Promotion Program ◽  
Consistent Condom ◽  
Control Group ◽  
Long Term Effects ◽  
Experimental Conditions ◽  
Long Term Impact

The aim is to evaluate the effects of the Competencias para adolescentes con una sexualidad saludable (COMPAS) program and compare them with an evidence-based program ( ¡Cuídate!) and a control group (CG). Eighteen public high schools were randomly assigned to one of the three experimental conditions. Initially, 1,563 Spanish adolescents between 14 and 16 years of age participated, and 24 months after their implementation, 635 of them completed a survey. Self-report measures collected data on sexual behavior, knowledge, attitudes, intention, sexual risk perception, and perceived norm. Compared to the CG, COMPAS increased the level of knowledge about sexually transmitted infections and improved the attitudes toward people living with human immunodeficiency virus at the 2-year follow-up. Neither intervention had a long-term impact on behavioral variables. Results suggest that COMPAS has a comparable impact to the other intervention on the variables predicting consistent condom use. Reinforcing the messages and skills that have the greatest impact on condom use and adding booster sessions following program completion as strategies to maintain long-term effects are necessary.

scholarly journals Results of negative pressure wound therapy in compound grade 3 tibial fractures

2018 ◽  
Vol 4 (3) ◽  
pp. 428
Author(s):  
Atul Kantilal Patil ◽  
Ansari Muqtadeer Abdul Aziz ◽  
Rahul Devale
Keyword(s):  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Skin Grafting ◽  
Control Group ◽  
Study Group ◽  
Wound Therapy ◽  
Long Term Follow Up ◽  
Flap Cover

<p class="abstract"><strong>Background:</strong> Open fractures constitute major chunk of orthopaedic trauma in a busy tertiary hospital and involve lot of morbidity, efforts, cost and time. Negative pressure wound therapy (NPWT) is a relatively new treatment that has proven beneficial in various types of complex wounds. The purpose of our study is to see the utility of NPWT in compound type III tibial fractures and its impact on the outcome of the patients.</p><p class="abstract"><strong>Methods:</strong> 30 patients were included in the study with a mean age of 40.27 years ranging from 13 years to 62 years. There were 26 male patients and 4 female patients with 22 right sided fractures and 8 left sided fractures. The patients were then distributed into VAC/NPWT (study) group and control group using table of random numbers. Each group had 15 patients each. Scoring was carried out at before the first debridement.<strong></strong></p><p class="abstract"><strong>Results:</strong> In the study NPWT group it was estimated that 5 patients may need amputation or but of these only 1 (20%) patient went on to have amputation of the involved limb while the rest (80%) could be salvaged. In the control group, 1 patient was predicted to need amputation which indeed resulted in amputation. Of the 7 predicted to need flap cover in study group, 4 (57.1%) eventually needed flap cover while the 3 (42.9%) were covered with skin grafting. Contrary in the control group all the 8 patients predicted to need flap cover, all ended up having the same. In the control group, of the 6 patients who were prognosticated to needed skin grafting, 2 (33.3%) worsened and needed flap cover while in the rest 4 (66.7%) skin grafting sufficed.</p><p class="abstract"><strong>Conclusions:</strong> NPWT resulted in healthy granulation of the wound. The study undertaken was a prospective randomised control trial. However, the main drawbacks were the sample size and the inability to have long term follow up. More studies with larger sample size and a long term follow up are necessary to substantiate the findings of the study.</p>

scholarly journals Integrated approach to treatment of inoperable patients with critical lower limb ischemia and diabetes mellitus: results and prospects

2021 ◽  
Vol 9 (4) ◽  
pp. 559-572
Author(s):  
Roman E. Kalinin ◽  
◽  
Igor’ A. Suchkov ◽  
Andrey A. Krylov ◽  
Nina D. Mzhavanadze ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lower Limb ◽  
Group Versus ◽  
Limb Ischemia ◽  
Control Group ◽  
Study Group ◽  
Results Of Treatment ◽  
Stimulation Of

INTRODUCTION: The question of the optimal methods of conservative treatment of patients with critical lower limb ischemia (CLLI) and diabetes mellitus (DM) is still open. AIM: To evaluate the long-term results of therapeutic treatment of patients with CLLI and DM whose peripheral vascular bed is unsuitable for reconstruction, or who refused surgical treatment for different reasons, and to determine effectiveness of additional angiogenesis in this group of patients. MATERIALS AND METHODS: The work involved 65 patients with CLLI and DM who were divided to 2 groups. The control group of patients (40 individuals) received a course of conventional therapy. In the study group (25 individuals), additional exogenous stimulation of angiogenesis was used with angiogenic vascular endothelial growth factor. Subsequently, instrumental parameters of limb perfusion were assessed within 6 months, and in the long-term period (5 years), limb preservation and mortality in this group. RESULTS: Exogenous stimulation of angiogenesis permits to improve the following 6-month treatment results (8% of deaths and 20% of amputations in the study group versus 15% of deaths and 42.5% of amputations in the same period in the control group), and permits to maintain this trend within 5 years of follow-up (64% of deaths and 72% of amputations in the study group versus 80% of deaths and 87.5% of amputations in the control group). Reliable differences between the groups in the frequency of amputations were observed on visits in 6 months (p = 0.041) and in 1 year of follow-up (p = 0.048). According to instrumental data, the best parameters in terms of the painless walking distance (p = 0.032) and transcutaneous oxygen tension were obtained in the study group by 6 months of follow-up (p = 0.028). CONCLUSIONS: Therapeutic angiogenesis improves the results of treatment of patients with CLLI and diabetes mellitus, especially in 6 months — 2 years interval, however, conservative therapy still demonstrates unsatisfactory results of treatment in the near and in the long terms.

New approaches in complex therapy of inflammatory diseases of the pelvic organs in women of reproductive age

2017 ◽  
pp. 41-44
Author(s):  
O.V. Grischenko ◽  
◽  
T.A. Kozub ◽  
Keyword(s):  
Inflammatory Diseases ◽  
Reproductive Age ◽  
Control Group ◽  
Study Group ◽  
Complex Treatment ◽  
Women Of Reproductive Age ◽  
Urine Ph ◽  
Pelvic Organs ◽  
Standard Scheme ◽  
Group I

The objective: to study the efficacy of complex treatment of inflammatory diseases of the pelvic organs (vaginitis), occurring in conjunction with urinary tract infection (cystitis), with a combined medication of plant origin Tutukon produced by Miguel and Garriga, S. A. ("Grand medical Group AG", Spain/Switzerland) in women of reproductive age. Patients and methods. Were examined 60 women of reproductive age with the presence of vaginitis and associated cystitis. All the patients were divided into two clinical groups. In group I (control; n=30) treatment was carried out according to the standard scheme with the use of antimicrobial drugs, antispasmodics, local antiseptics for the sanitation of the vagina. In group II (study group; n=30) treatment was carried out according to the standard scheme with the inclusion of the drug Tutukon. All the patients were examined at 3-rd, 7-th, 10-th day of treatment and 30 days after discontinuation of therapy. Results. During the research was given the analysis of the dynamics of clinical and laboratory parameters in women of both groups before and after treatment. In patients of study group, the standard therapy which included Tutukon, the treatment was more effective than in patients of control group: a rapid onset of clinical effect, reducing the duration of the disease, a complete clinical response in 90% of cases versus 63%, alkalization of urine - pH 6.5±0.10, the absence of recurrence within 30 days after the end of therapy. Conclusion. Tutukon medicine is recommended for complex treatment of vaginitis, occurring in combination with cystitis in women of reproductive age. Key words: vaginitis, cystitis, dysuria, urine pH, Tutukon.

Comparison of long-term clinical evolution in highly myopic eyes with vertical oval-shaped dome with or without untreated serous retinal detachment

2018 ◽  
Vol 103 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Antonio García-Ben ◽  
Ignacio Garcia-Basterra ◽  
Ana González-Gómez ◽  
Isabel Baquero-Aranda ◽  
María José Morillo-Sanchez ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Serous Retinal Detachment ◽  
Control Group ◽  
Study Group ◽  
Foveal Thickness ◽  
Clinical Evolution ◽  
Central Foveal Thickness ◽  
And Control

BackgroundTo compare the long-term clinical evolution of highly myopic eyes with vertical oval-shaped dome associated with or without untreated serous retinal detachment.MethodsTwenty-eight patients with high myopia (40 eyes) with smooth macular elevations related to a vertical oval-shaped dome were recruited. Serous retinal detachment was investigated; 11 eyes had persistent submacular fluid (study group) and 29 eyes lacked submacular fluid (control group). All patients underwent complete ophthalmological examinations, including optical coherence tomography at baseline every 6 months for 2 years. Fluorescein angiographies were performed in cases with serous retinal detachment to rule out choroidal neovascularisation.ResultsThere were no statistical differences in baseline age, sex, spherical equivalence or axial length between the two groups. Serous retinal detachment always occurred at the top of the inward macular incurvation. Moreover, no statistically significant differences in mean best-corrected visual acuity were observed during the 24-month follow-up period in the study and control groups and between the two groups at all time points. The mean central foveal thickness was significantly higher in the study group at each visit (p=0.001, in all cases). At the final follow-up visit, complete resolution of the serous retinal detachment was achieved in 1 of the 11 study group’s eyes.ConclusionsSerous retinal detachment is a complication associated with vertical oval-shaped domes that seems to remain stable in terms of visual function over time without treatment.

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