Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study

Diabetes Care ◽  
1999 ◽  
Vol 22 (4) ◽  
pp. 562-568 ◽  
Author(s):  
S. M. Haffner ◽  
R. D'Agostino ◽  
L. Mykkanen ◽  
R. Tracy ◽  
B. Howard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Insulin Sensitivity ◽  
Cardiovascular Risk Factors ◽  
Insulin Resistance Atherosclerosis Study

scholarly journals Effect of thiazolidinediones on insulin resistance and cardiovascular risk factors

2008 ◽  
Vol 5 (2) ◽  
pp. 2-5 ◽  
Author(s):  
T Yu Demidova ◽  
E N Erokhina
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Clinical Management ◽  
Significant Risk ◽  
High Prevalence ◽  
Multivariate Control

The development of new, more effective ways of multivariate control of type 2 diabetes is currently the most important problem of endocrinology. This is caused by a high prevalence of this disease in the population, as well as a significant risk of complications leading to early morbidity and mortality of patients. Clinical management of patients with type 2 diabetes should be based on a thorough study of the mechanisms of this disease in order to correct the basic pathogenetic defects.

Insulin resistance and cardiovascular disease

2002 ◽  
Vol 2 (1_suppl) ◽  
pp. S9-S11 ◽  
Author(s):  
Markku Laakso
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Insulin Resistance Syndrome ◽  
Plasminogen Activator Inhibitor 1 ◽  
Factors Associated

Insulin resistance is characterised by a decreased rate of insulin-mediated glucose uptake and is associated with adverse changes in cardiovascular risk factors, such as high triglyceride levels, low levels of high-density lipoprotein cholesterol, raised blood pressure, obesity and increased levels of plasminogen activator inhibitor 1. The term `insulin resistance syndrome' (IRS) is used to describe the complex of factors associated with insulin resistance that is found in patients both with and without type 2 diabetes. Although the presence of insulin resistance syndrome is generally considered to be a risk factor for cardiovascular disease, there is a lack of definitive evidence for a causal link. Recently, however, a statistical method known as factor analysis has been applied to the cluster of cardiovascular risk factors associated with IRS. This has been able to show that the `insulin resistance factor' (high plasma insulin and glucose levels, body mass index, waist-to-hip ratio and triglyceride levels) predicted coronary heart disease events in elderly non-diabetic men as well as in patients with type 2 diabetes. Therefore, treatment of insulin resistance whether by pharmacological (eg. thiazolidinediones) or nonpharmacological means has the potential to offer both improvements in glycaemic control and in cardiovascular events.

Revisiting the Role of Physical Activity and Exercise in the Treatment of Type 2 Diabetes

2000 ◽  
Vol 25 (6) ◽  
pp. 466-491 ◽  
Author(s):  
Catrine E. Tudor-Locke ◽  
Rhonda C. Bell ◽  
Anita M. Myers
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Insulin Sensitivity ◽  
Glycemic Control ◽  
Cardiovascular Risk Factors ◽  
Treatment Modalities ◽  
Future Research

There is tremendous potential for improving glycemic control, insulin sensitivity, and cardiovascular risk factors through increased physical activity in individuals with Type 2 diabetes. The demonstrated effects of structured endurance exercise on select outcomes compare favourably with those of typical pharmacological treatment modalities. Adherence to these types of program is problematic, however. We know less about the expected effects of lifestyle-based physical activity. Preliminary results require further investigation, given the apparent acceptability of these programs in this population, however. The effects of resistance training on cardiovascular risk factors to date likely limit its application as an adjunctive therapy for individuals with Type 2 diabetes. The question is no longer "can exercise/physical activity benefit the individual with Type 2 diabetes?" The answer is yes. Future research needs to refine questions regarding type, dose, and magnitude of effects of physical activity (and its subcategory exercise) on glycemic control, insulin sensitivity, and on risk factors for cardiovascular disease within the context of program acceptability and feasibility. Key words: walking, obesity, glycemic control, insulin sensitivity, hypertension

scholarly journals Analysis of the Potential Genetic Links between Psoriasis and Cardiovascular Risk Factors

2021 ◽  
Vol 22 (16) ◽  
pp. 9063
Author(s):  
Dorota Purzycka-Bohdan ◽  
Anna Kisielnicka ◽  
Michał Bohdan ◽  
Aneta Szczerkowska-Dobosz ◽  
Marta Sobalska-Kwapis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Population Data ◽  
Genetic Pathways ◽  
Current State

Cardiovascular risk factors are one of the most common comorbidities in psoriasis. A higher prevalence of hypertension, insulin resistance and type 2 diabetes, dyslipidemia, obesity, metabolic syndrome, depression, as well as cardiovascular disease was confirmed in psoriatic patients in comparison to the general population. Data suggest that psoriasis and systemic inflammatory disorders may originate from the pleiotropic interactions with many genetic pathways. In this review, the authors present the current state of knowledge on the potential genetic links between psoriasis and cardiovascular risk factors. The understanding of the processes linking psoriasis with cardiovascular risk factors can lead to improvement of psoriasis management in the future.

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