Effectiveness of Dental Bleaching With 37.5% and 6% Hydrogen Peroxide and Its Effect on Quality of Life

2019 ◽  
Vol 44 (2) ◽  
pp. 146-155 ◽  
Author(s):  
C Bersezio ◽  
J Estay ◽  
G Jorquera ◽  
M Peña ◽  
C Araya ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Subjective Evaluation ◽  
Psychosocial Impact ◽  
Self Perception ◽  
Tooth Whitening ◽  
Double Blind ◽  
Anterior Teeth ◽  
Significant Difference ◽  
The Difference ◽  
Initial Color

SUMMARY Objective: This study investigated whether it is possible to achieve equally satisfactory results between 37.5% hydrogen peroxide (HP) gel and 6% HP gel. We also assessed the psychosocial impact and self-perception of esthetics generated by extracoronal tooth whitening. Methods and Materials: A prospective, double-blind, randomized clinical trial was carried out. A total of 33 patients were selected from the clinic of the Faculty of Dentistry at the University of Chile. The patients included men and women over 18 years old without prior tooth whitening treatments, tooth decay, or restorations of the maxillary anterior teeth. The patients had tooth colors of A3 or less according to the Vita Classical scale, which was determined with a Vita Easy Shade spectrophotometer. The study was carried out with a “split-mouth” design. One side of each mouth was randomly treated with 37.5% HP, and the other side was bleached with 6% HP. Each group received 3 to 12 minutes of treatment with the respective gel applications. Two sessions of bleaching were carried out each week. A spectrophotometer was used to measure the total variation of color (ΔE), and a subjective evaluation was made with Vita Classical scale (ΔSGU) between the baseline (session 1) and different measurement times. We compared ΔE and ΔSGU for both agents using the Mann-Whitney test (α=0.05). Results: In both groups, there was variation among the initial color and the color in the different measurement times. In the month after the treatment was completed, ΔE was 9.06 in the 37.5% HP group and 5.69 in the 6% HP group. The difference between the two groups was statistically significant starting in the second session (p=0.000). Conclusion: There was a significant difference between the effectiveness of the bleaching gel concentrations of 37.5% and 6% HP according to spectrophotometer measurements and subjective evaluations. There was also a positive effect on psychosocial impact and esthetic self-perception among patients.

scholarly journals Effect of exposure frequencies of pear juice on tooth whitening

2013 ◽  
Vol 25 (1) ◽  
Author(s):  
Gobalakrishna Munusamy ◽  
Endang Sukartini ◽  
Ayu Trisna Hayati
Keyword(s):  
Hydrogen Peroxide ◽  
Research Result ◽  
Control Group ◽  
Tooth Whitening ◽  
Whitening Effect ◽  
Significant Difference ◽  
Pear Juice ◽  
The Difference ◽  
Tooth Colour

Introduction: Tooth whitening (Bleaching) is a method to restore discoloured teeth to the original tooth colour with a chemical process. The materials used in the bleaching process are hydrogen peroxide, sodium perborates and carbamide peroxide. Pear fruit consists of hydrogen peroxide which is potentially an oxidizing compound that produces free radicals that react with unsaturated bonding teeth staining substances. This study aims to analyzed tooth whitening effect of exposure of pear juice with different frequencies. Methods: The type of research was true in vitro experiment where samples of 32 maxillary premolar teeth had cut the root to CEJ. The specimens divided into four groups. The first group was soaked in pear juice two times, the second group three times, a third group four times, and the fourth was the control group using only mineral water. Tooth colour was measure using a Spectrophometer, conducted before and after individual soaking. Results: The research result is tested with ANOVA and Newman- Keuls Range Test showed a significant difference of tooth whitening degree between the frequency exposure pear juice after 2 times soaking, 3 times soaking and 4 times soaking. Conclusion: There are difference degree of whitening from the difference frequency exposure of pear juice and Pear juice exposure of 4 times gives higher whitening effect compared to frequency of 3 times, 2 times and control group which is soaked in water.

scholarly journals Clinical effect of 3.0% hydrogen peroxide containing bleaching patch with primer in a double-blind randomized controlled trial

2020 ◽  
Author(s):  
Jin-Kyoung Kim ◽  
Ha-Young Youn ◽  
Myoung-Uk Jin ◽  
Jae-Hyun Ahn ◽  
Seung-Eun Bang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Controlled Trial ◽  
Gingival Index ◽  
Bleaching Effect ◽  
Double Blind ◽  
Tooth Sensitivity ◽  
Once Daily ◽  
Anterior Teeth ◽  
Significant Difference ◽  
Gingival Irritation

Abstract Background: To clinically evaluate the efficacy and safety of a primer that contains taurine and self-bleaching patches containing 3.0% hydrogen peroxide.Methods: Overall, 55 participants were selected in this double-blinded randomized clinical trial between March and May 2019. Bleaching patches containing 3.0% hydrogen peroxide were attached using the primer on the labial surface of the upper six anterior teeth for 30 min once daily. △E* values of color changes were measured using Shade Eye NCC for determining the efficacy of bleaching on days 3, 5, 7, and 10 before and after attachment. The safety was assessed using gingival index and visual analog scale for tooth sensitivity and gingival irritation, respectively.Results: △E* values were visibly detected from day 7 after the attachment of patches, and the bleaching effect was identifiable. No statistically significant difference was observed in the gingival index (p = 0.069), tooth sensitivity (p = 0.983), and gingival irritation (p = 0.518).Conclusions: When the self-bleaching patches using 3.0% hydrogen peroxide with the primers were attached for 30 min once daily, visible bleaching effect was observed from day 7 of attachment, and it was verified to be safe for use without any significant adverse effect.Clinical Relevance: This study was conducted after securing safety for clinical trials.Trial registration: ISRCTN63650330

scholarly journals Clinical Evaluation of the Effectiveness of Whitening Dentifrices

2019 ◽  
Vol 21 (1) ◽  
pp. 82
Author(s):  
Geisiele Aparecida Biscaia Justino ◽  
Ingrid Carletto Dalmolin ◽  
Naiana Mello Cançado ◽  
Anna Luiza Szesz ◽  
Eveline Claudia Martini
Keyword(s):  
Color Change ◽  
Subjective Evaluation ◽  
Objective Evaluation ◽  
Negative Control ◽  
Tooth Bleaching ◽  
Patient’S Satisfaction ◽  
Anterior Teeth ◽  
Significant Difference ◽  
Post Test ◽  
Initial Color

O objetivo deste estudo clínico foi avaliar, por 7 semanas, a eficácia de dentifrícios clareadores e a satisfação dos pacientes após o uso. Foram selecionados 30 pacientes que possuíssem todos os dentes anteriores nas arcadas superior e inferior, apresentando cor inicial A2, avaliados através da escala de cores Vita Classical (Vita Zahnfabrik, Bad Säckingen, Alemanha). Os participantes foram aleatoriamente divididos em 3 grupos (n=10): GA - Colgate® Máxima Proteção Anticáries (controle negativo), GB - Colgate® Luminous  White  e GC - Colgate® Luminous White Advanced. Os dentifrícios foram distribuídos em bisnagas idênticas e aleatorizados. As avaliações de cor foram realizadas inicialmente ao uso (baseline), após 7, 15, 30 e 60 dias, utilizando dois métodos: avaliação subjetiva com as escalas de cor Vita Classical (Vita Zahnfabrik, Bad Säckingen, Alemanha) e Vita Bleachedguide 3D-MASTER (Vita Zahnfabrik, Bad Säckingen, Alemanha), e avaliação objetiva através do espectrofotômetro VITA Easyshade Compact®, Vident, Brea, CA, USA). Foi considerada a satisfação do paciente quanto a mudança de cor dos dentes. Os dados foram submetidos à análise estatística, utilizando análise de variância (ANOVA) de três critérios e pós-teste de Tukey (α=0.05).  Os resultados demonstraram que houve diferença de cor estatisticamente significante nos grupos em que se utilizou os dentifrícios clareadores (GB e GC), nos períodos entre 15 e 30 dias. Conclui-se que ambos os dentifrícios GB e GC apresentaram ação clareadora, observado através das escalas subjetiva e objetiva. Porém, na percepção do paciente apenas no grupo GC houve mudança de cor.Palavras-chave: Dentifrícios. Clareamento Dental. Estética Dentária.AbstractThe objective of this clinical study was to evaluate, for 7 weeks, the efficacy of whitening dentifrices and the patients' satisfaction after use. 30 patients were selected who had all the anterior teeth in the upper and lower arches, presenting an initial color A2, evaluated through the Vita Classical color scale (Vita Zahnfabrik, Bad Säckingen, Germany). The participants were randomly divided into 3 groups (n = 10): GA - Colgate® Maximum Antibody Protection (Negative Control), GB - Colgate® Luminous White and GC - Colgate® Luminous White Advanced. The dentifrices were distributed in identical and randomized tubes. The color evaluations were performed at baseline after 7, 15, 30 and 60 days using two methods: subjective evaluation with the Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and Vita Bleachedguide 3D- MASTER (Vita Zahnfabrik, Bad Säckingen, Germany), and objective evaluation using VITA Easyshade Compact® spectrophotometer, Vident, Brea, CA, USA). The patient's satisfaction with the teeth  color change  was considered. The data were submitted to statistical analysis using ANOVA of three criteria and Tukey post-test (α = 0.05). The results showed that there was a statistically significant difference in color in the groups in which the whitening dentifrices were used (GB and GC), in periods between 15 and 30 days. It was concluded that both GB and CG dentifrices presented a whitening action, observed through the subjective and objective scales. However, in the perception of the patient only in the CG group there was a change of color.Keywords: Dentifrices. Tooth Bleaching. Esthetics, Dental.  

scholarly journals A double-blind randomized controlled trial of topical Curcuma xanthorrhiza Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions

2018 ◽  
Vol 27 (3) ◽  
pp. 178-84 ◽  
Author(s):  
Githa Rahmayunita ◽  
Tjut N.A. Jacoeb ◽  
Endi Novianto ◽  
Wresti Indriatmi ◽  
Rahadi Rihatmadja ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Clinical Manifestations ◽  
Effective Treatment Option ◽  
Psoriasis Area Severity Index ◽  
Double Blind ◽  
Old Patients ◽  
Mean Values ◽  
Significant Difference ◽  
Curcuma Xanthorrhiza ◽  
The Difference

Background: Curcuma xanthorrhiza Roxb. exerts its anti-inflammatory effects by reducing the concentration of IL-6, IL-8, and phosphorylase kinase, which has role in keratinocyte proliferation. Our study aimed to evaluate the efficacy of C. xanthorrhiza in psoriasis.Methods: From 18 to 59 year-old patients with mild psoriasis, 2 similar lesions were selected. The severity assessment was based on the psoriasis area severity index (PASI), Trozak score, and K6 expression. Using a double-blinded randomized method, lesion was treated with 1% C. xanthorrhiza ointment vs placebo for 4 weeks. The results were analyzed by the chi-square test using STATATM V.12 software (Stata Corp.).Results: The study was conducted in 2010 to 2012 with 17 subjects participated. The median of PASI score were reduced significantly in both lesions, either treated with 1% C. xanthorrhiza ointment vs placebo; however when compared between the group, it was not significant (p=0.520). The Trozak score were reduced in lesions treated with 1% C. xanthorrhiza ointment; but it was not significant (p = 0.306). In lesions treated with placebo, the Trozak score was increased significantly. The difference of Trozak score between lesions treated with C. xanthorrhiza and placebo was significant (p=0.024). There was no significant difference of K6 expression in lesions treated with 1% C. xanthorrhiza ointments or placebo as well as on the difference of mean values of K6 expression between the group (p=0.827).Conclusion: Based on the results, 1% C. xanthorrhiza ointment is effective treatment option for mild psoriasis, but longer follow-up period is suggested to confirm this results. C. xanthorrhiza ointment is safe for topical administration as there were no side effects reported in this study.

scholarly journals The Effect of Extract Supplements of Moringa Oleifera Leaves Plus Royal Jelly on Hemoglobin (Hb) Levels of Anemia Pregnant Mother in Takalar Regency

2020 ◽  
Vol 1 (2) ◽  
pp. 22-29
Author(s):  
Yulni Yulni ◽  
Veni Hadju ◽  
Burhanuddin Bahar ◽  
Citrakesumasari Citrakesumasari ◽  
Rahayu Indriasari ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Royal Jelly ◽  
P Value ◽  
Double Blind ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
Double Blind Design

The aim of this study was to determine the effect of Moringa oleifera leaf extract supplements, Moringa oleifera leaf extract plus royal jelly and placebo on hemoglobin levels in anemic pregnant women. This research is a randomized controlled double blind design study which was conducted in Polombangkeng Utara District, Takalar Regency for 2 months. The subjects of this study were pregnant women with anemia, the majority of which were 20-35 years old, primigravida parity, income less than UMR, unemployment, higher education, pregnancy distance of more than 2 years with p value> 0.05. Then divided into three groups, namely Moringa capsules plus royal jelly (KRJ) (n = 24), Moringa capsules (KTR) (n = 24) and placeco (PLC) (n = 21). Before and after the intervention, measurements of hemoglobin levels were carried out using the Hemocue tool and interviewing the characteristics of the respondents. The results showed that the average Hb level increased from each group (mean SD): KRJ 10.06 ± 0.75 to 11.42 ± 1.23, P = 0.001, KTR 10.40 ± 0.46 to 11.15 ± 0 , 90 P = 0.001 and PLC 10.43 ± 0.42 becomes 11.14 ± 0.88 P = 0.002. but there was no significant difference from the difference in the average increase in Hb levels in the three groups, but there was a tendency that KRJ was superior to the KTR and PLC groups with an increase of 1.36 gr / dl, KTR 0.75 gr / dl and PLC 0.71 gr / dl. So it can be concluded that KRJ is better than KTR and PLC in increasing Hb levels in anemic pregnant women in Takalar Regency.

scholarly journals Impact of Bleaching before or after Veneer Preparation on Color Masking Ability of Laminate Veneers: An In Vitro Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Gollshang Ahmad Mhammed Dalloo ◽  
Bestoon Mohammed Faraj ◽  
Abdulsalam Rasheed Al-Zahawi
Keyword(s):  
Hydrogen Peroxide ◽  
Color Change ◽  
In Vitro Study ◽  
Tooth Discoloration ◽  
Significant Difference ◽  
Color System ◽  
The Difference ◽  
Laminate Veneers ◽  
Cielab Color

Purpose. This study evaluates the effect of bleaching before or after veneer preparation and the depth of preparation on color masking ability of laminate veneers. Methods. Sixty extracted premolars were artificially stained to vita shade A4, verified by digital spectrophotometer (Vita Easy Shade V), and then divided into three groups: NB = nonbleached , BBP = bleaching before preparation, and BAP = bleaching after preparation. Based on the preparation depths, each group was further divided into two subgroups: S 1 = 0.5   mm and S 2 = 1.0   mm . BBP and BAP were subjected to one session of in-office bleaching using 35% hydrogen peroxide. IPS e-max CAD veneers of 0.5 and 1.0 mm thickness (corresponding to the preparation depths) of the same shade and translucency (HT A1) were cemented immediately to the bleached surfaces. Immediately after cementation, the color change Δ E between the baseline (after staining) and the resulted shades was measured using the Vita Easy Shade V digital spectrophotometer and CIELab color system. Results. Bleached groups exhibited a significant Δ E value compared to the nonbleached group ( p < 0.05 ). BAP showed the highest Δ E value. No significant difference was found between BBP and BAP. S2 revealed a significant Δ E value than S1 ( p < 0.05 ). No significant difference was found between S1of BAP and S2 of NB, BBP, and BAP ( p > 0.05 ). Regarding the color coordinates, the difference between the tested groups was highly significant in lightness ( Δ L ∗ ) ( p < 0.001 ), while no significant differences were found in green/red value ( Δ a ∗ ) and yellow/blue value ( Δ b ∗ ) ( p > 0.05 ). Conclusions. In cases of severe tooth discoloration, one session of in-office bleaching before or after veneer preparation and the preparation depth do not influence the color masking ability of laminate veneers.

Six-month Follow-up of the Effect of Nonvital Bleaching on IL-1β and RANK-L: A Randomized Clinical Trial

2019 ◽  
Vol 44 (6) ◽  
pp. 581-588 ◽  
Author(s):  
C Bersezio ◽  
J Estay ◽  
M Sáez ◽  
F Sánchez ◽  
R Vernal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Color Change ◽  
Double Blind ◽  
Time Points ◽  
Periodontal Tissues ◽  
Significant Difference ◽  
Spearman Test

SUMMARY Objectives: It has been reported that bleaching generates an increase in the activity of osteoclasts in vitro. We quantified the RANK-L and IL-1β biomarkers in a double-blind, randomized clinical trial evaluating the in vivo effect of hydrogen peroxide (35%) and peroxide carbamide (37%) six months after whitening. Methods and Materials: Fifty volunteers participated, each with color change in a nonvital tooth. Fifty teeth were randomly divided into two groups (n=25), and the teeth were bleached using either 35% hydrogen peroxide (G1) or 37% carbamide peroxide (G2). Intracoronal bleaching was carried out by a technical “walking bleach” over four sessions. Gingival crevicular fluid samples were collected and used to quantify the IL-1β and RANK-L secreted levels. Samples of six periodontal sites (three vestibular and three palatal) were collected for up to six months (at the beginning of the study [baseline] and at one week, one month, and six months posttreatment). The color change was visually monitored using the Vita Bleached Guide (ΔSGU). Results: Comparing each time to baseline assessment, a significant increase in the levels of IL-1β and RANK-L across time points was detected (p&lt;0.05). The color change was 4 in G1 and G2, and a statistically significant difference (p&lt;0.05) was found at the month time point between the groups. Using the Spearman test, a strong correlation (&gt;0.8) between the IL-1β and RANK-L levels in both groups at all time points was detected. Conclusions: Nonvital bleaching using a technical walking bleach induces an increase in the IL-1β and RANKL production in periodontal tissues, which persists for six months after treatment. Both biomarkers were highly correlated in both groups and at all time points.

F2695: A New Therapeutic Potential for Major Depression. A Phase II Double-blind Randomised Trial Results

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
L. Mansuy
Keyword(s):  
Major Depression ◽  
Depressive Disorders ◽  
Therapeutic Potential ◽  
Randomised Trial ◽  
Major Depressive ◽  
Double Blind ◽  
Efficacy Analysis ◽  
Significant Difference ◽  
Major Depressive Disorders ◽  
The Difference

F2695 is a novel antidepressant exerts simultaneous noradrenergic and serotoninergic neurotransmitter effects.F2695 SR was administered in patients with Major Depression in a randomized, multinational, double-blind, placebo-controlled 10-week study, assessing the efficacy and safety of F2695 SR progressive titration safety adapted doses from 75 mg to 100 mg od, in out-patients with Major Depressive Disorders. The 563 randomized patients fulfilled the diagnostic criteria for Major Depressive Disorders and presented moderate or severe Major Depressive Disorders. Efficacy analysis found a significant difference between F2695 and placebo in favour of the active treatment in term of a significantly greater improvement in MADRS total score with F2695 compared with placebo (p< 0.0001). In addition, significantly more patients achieved MADRS response (a decrease in total score equal or superior to 50%) and MADRS remission (defined as a total score inferiorior to10) in the F2695 group than in the placebo group such an effect being usually not seen on this measure in the relatively short time span of a ten-week study. At the doses tested, F2695 was effective from early in the treatment (week 2) and the difference in efficacy compared with placebo increased steadily throughout the study.The severity to entry in this study was relatively high and the mean MADRS entry score was 31, about 40% of patients were in the severe category of depression.This study: provided evidence of the efficacy of F2695 in major depression population. Therapeutic effect was sustained in term of effect-size, responders and remissions rate, in front of placebo.

scholarly journals Effect of Anodal-tDCS on Event-Related Potentials: A Controlled Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ahmed Izzidien ◽  
Sriharasha Ramaraju ◽  
Mohammed Ali Roula ◽  
Peter W. McCarthy
Keyword(s):  
Parietal Lobe ◽  
Event Related Potentials ◽  
Controlled Study ◽  
Oddball Paradigm ◽  
Anodal Tdcs ◽  
Neurologically Impaired ◽  
Double Blind ◽  
Significant Difference ◽  
Related Potentials ◽  
The Difference

We aim to measure the postintervention effects of A-tDCS (anodal-tDCS) on brain potentials commonly used in BCI applications, namely, Event-Related Desynchronization (ERD), Event-Related Synchronization (ERS), and P300. Ten subjects were given sham and 1.5 mA A-tDCS for 15 minutes on two separate experiments in a double-blind, randomized order. Postintervention EEG was recorded while subjects were asked to perform a spelling task based on the “oddball paradigm” while P300 power was measured. Additionally, ERD and ERS were measured while subjects performed mental motor imagery tasks. ANOVA results showed that the absolute P300 power exhibited a statistically significant difference between sham and A-tDCS when measured over channel Pz (p=0.0002). However, the difference in ERD and ERS power was found to be statistically insignificant, in controversion of the the mainstay of the litrature on the subject. The outcomes confirm the possible postintervention effect of tDCS on the P300 response. Heightening P300 response using A-tDCS may help improve the accuracy of P300 spellers for neurologically impaired subjects. Additionally, it may help the development of neurorehabilitation methods targeting the parietal lobe.

scholarly journals Low Dose Perioperative Intravenous Tranexamic Acid in Patients Undergoing Total Knee Arthroplasty: A Double-Blind Randomized Placebo Controlled Clinical Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mahdi Motififard ◽  
Mohammad Ali Tahririan ◽  
Mehdi Saneie ◽  
Sajad Badiei ◽  
Amin Nemati
Keyword(s):  
Tranexamic Acid ◽  
Primary Outcome ◽  
Low Dose ◽  
Study Groups ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Significant Difference ◽  
Duration Of Hospitalization ◽  
Slow Infusion ◽  
The Difference

Background and Objectives. The null hypothesis of this study was that TA has no effect on postsurgical bleeding in patients undergoing TKA. Methods. This study was a double-blind randomized trial. In the first group (T) patients received 500 mg of intravenous Tranexamic acid (TA) twice (once preoperatively and once 3 hours postoperatively) and in the second group (P) they received slow infusion of normal saline as placebo. The primary outcome of the study was the level of Hb 48 hours after surgery. Results. Hb levels 48 hours after surgery as the primary outcome were 10.92±0.97 and 10.23±0.98 (g/dL) in groups T and P, respectively, and the difference was statistically significant (P=0.001). Statistically significant differences were also observed in Hb levels 6 and 24 hours after surgery, the drain output 48 hours after surgery, and the number of units of packed cells transfused between study groups (P<0.05). There was no significant difference in duration of hospitalization between the study groups (P = n.s.). Conclusions. The low dose perioperative intravenous TA significantly reduces blood loss, requirement for blood transfusion, and drain output in patients undergoing TKA. However, duration of hospitalization did not change significantly.

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