A Rare Malignant Tumor of Gall Bladder

Background: C3 glomerulopathy is caused by dysregulation of the alternative complement pathway. Association with solid organ tumors is rare. However, there have been a few case reports of membranoproliferative glomerulonephritis secondary to gastrointestinal neoplasms. Case: A 38-year-old female presented with abdominal distension, loss of appetite, amenorrhea, and easy fatigability. She had been diagnosed 8 months back with C3 glomerulopathy and had received immunosuppression. On evaluation, she was incidentally detected to have Krukenberg tumor. The primary site of malignancy was gall bladder. Conclusion: Our case report highlights a possible association between C3 glomerulopathy and Krukenberg tumor secondary to gall bladder carcinoma and emphasizes the fact that even in cases of C3 glomerulopathy, occult malignancy should be considered as an underlying pathology.

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Adolescent with abdominal pain poorly responsive to analgesia

Archives of Disease in Childhood - Education and Practice ◽

10.1136/archdischild-2020-320772 ◽

2020 ◽

pp. edpract-2020-320772

Author(s):

Neil Chanchlani ◽

Philip Jarvis ◽

James W Hart ◽

Christine H McMillan ◽

Christopher R Moudiotis

Keyword(s):

Abdominal Pain ◽

Ct Scan ◽

White Cell Count ◽

Autism Spectrum ◽

Free Fluid ◽

List Type ◽

Reactive Protein ◽

Normal Limits ◽

History Of ◽

Normal Gallbladder

Case presentationA 14-year-old boy, with autism spectrum disorder, presented with a 1-day history of colicky abdominal pain, non-bilious vomiting, anorexia and loose normal-coloured stool. Two days previously, he had a poorly reheated takeaway chicken.On examination, body mass index (BMI) was >99th centile. He had inconsistent epigastric, periumbilical and umbilical tenderness, and guarding, with normal bowel sounds. Observations were within normal limits, but his pain was poorly responsive to paracetamol, ibuprofen, hyoscine butylbromide, codeine and morphine.Investigations are in table 1. On day 3, his temperature increased to 38.5° and a CT scan was performed, which showed concerning features (figure 1).Table 1Serology and further investigations throughout admissionDay 1Day 2Day 3Day 4Serology White cell count (3.8–10.6×109/L)7.514.615.713.6 Neutrophils (1.8–8.0×109/L)5.312.312.85.3 C reactive protein (<5 mg/L)12010398 Bilirubin (0–21 μmol/L)812Further investigations Urine dipstickNegative UltrasoundSmall volume of free fluid, normal gallbladder, pancreas and appendix not visualisedFigure 1CT scan of the abdomen (A) and pelvis (B).QuestionsWhat is the diagnosis?Appendicitis.Pancreatitis.Cholecystitis.Gastroenteritis.Which serology would have been most helpful at presentation?Renal function.Coagulation.Amylase and lipase.Gamma glutamyltransferase.What are the acute treatment principles?What is the the most common cause?Idiopathic.Gallstones.Medications.Genetic.Answers can be found on page 2.

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COVID-19 aus der Sicht der Gastroenterologie

DMW - Deutsche Medizinische Wochenschrift ◽

10.1055/a-1167-5825 ◽

2020 ◽

Vol 145 (15) ◽

pp. 1033-1038

Author(s):

Christian Schulz ◽

Julia Mayerle ◽

Hans Christian Stubbe ◽

Simon Sirtl ◽

Markus M. Lerch ◽

...

Keyword(s):

Abdominal Pain ◽

Respiratory Symptoms ◽

Gastrointestinal Symptoms ◽

Clinical Routine ◽

Fecal Samples ◽

Oral Transmission ◽

Number Of Patients ◽

New Variant ◽

Therapeutic Procedures ◽

Loss Of Appetite

AbstractCOVID 19, caused by SARS-CoV2, a new variant of coronaviruses, typically presents with respiratory symptoms. However, in a significat number of patients different organs are involved in the disease, often including gastrointestinal symptoms. These could include loss of appetite, vomiting, abdominal pain and diarrhea, with diarrhea being associated with a more severe course of COVID-19. Because viral RNA can be detected in fecal samples, some implications for clinical routine in diagnostic and therapeutic procedures are grown. Until yet, no clear evidence is given regarding fecal-oral transmission of SARS-CoV2.

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Novel deleterious sequence change in the NLRP12 gene in a child with autoinflammatory syndrome, joint hypermobility and cutis laxa from India.

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2019.018 ◽

2019 ◽

Vol 11 (1) ◽

pp. e2019018 ◽

Cited By ~ 3

Author(s):

Kanjaksha Ghosh ◽

Kanchan Mishra ◽

Avani Shah ◽

Parizad Patel ◽

Shrimati Shetty

Keyword(s):

Abdominal Pain ◽

Acute Intermittent Porphyria ◽

Joint Hypermobility ◽

Autoinflammatory Syndrome ◽

Healthy Male ◽

Diffuse Abdominal Pain ◽

Sequence Change ◽

Mediterranean Fever ◽

Loss Of Appetite ◽

Work Up

An otherwise healthy male child of 9 years presented with paroxysmal fever and diffuse abdominal pain along with loss of appetite and nausea lasting for 3-4days every 4-6 weeks for last 2 years. He also has stretchable skin and hypermobile joint which he inherited from his mother who never suffered any paroxysmal attack of the kind. Work up for acute intermittent porphyria, lead poisoning and familial mediterranean fever was negative. A novel harmful sequence change in NLRP12 gene was detected and a diagnosis of NLRP12 associated autoinflammatory syndrome was made. This sequence change with disease has not yet been reported in the literature and is the first such case of NLRP12 related autoinflammatory syndrome from India.

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Symptomatology of Advanced Gastrointestinal and Hepatobiliary Cancers in Palliative Care: Single Center Tertiary Care Experience from Eastern India

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2021.3.3.925 ◽

2021 ◽

Vol 3 (3) ◽

pp. 131-133

Author(s):

Chaitanya Patil ◽

Shrikant Atreya

Keyword(s):

Palliative Care ◽

Abdominal Pain ◽

Gall Bladder ◽

Medical Center ◽

Neuropsychiatric Symptoms ◽

Tertiary Care ◽

Eastern Cooperative Oncology Group ◽

Histopathological Diagnosis ◽

Common Symptom ◽

Female Ratio

The spectrum of symptoms for an oncologist or oncosurgeon about gastrointestinal (GI) and hepatobiliary (HB) cancers varies from the spectrum of symptoms that a palliative care physician ascertains. There is a paucity of data regarding GI and HB cancer symptomatology in a palliative care outset. Hence, we conducted this study to understand the same and identify the most common symptom clusters among these cancers. The present study was retrospective observational study conducted on patients referred to palliative care department of Tata medical center, Kolkata, India. A total of 495 patient’s case records were reviewed with GI and HB cancers. Age, gender, co-morbidities, Eastern Cooperative Oncology Group (ECOG) status, symptomatology, physical examination findings, and histopathological diagnosis were reviewed from the case records and documented. Symptomatology included pain, nausea, vomiting, anxiety, depression, constipation, anorexia, early satiety and loose stools. The mean age of the patients was 57.73 ± 12.50 years with male: female ratio of 1.60. The most common organ system involved was gall bladder (22.63%) followed by pancreas (16.97%). The most common symptom was abdominal pain (63.64%) followed by anorexia (28.08%) and constipation (21.62%) and the least common ones were loose stools (3.84%) and neuropsychiatric symptoms (4.85%). Nausea-vomiting cluster (38.10%) and abdominal pain-nausea/vomiting (28.38%) cluster were most common among stomach carcinomas. Abdominal pain-constipation cluster (23.21%) was more common among gall bladder carcinomas. Future studies directing to identify these symptoms and clusters over the quality of life of advanced cancer patients are warranted.

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Gallbladder motility in children with chronic functional abdominal pain

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20193721 ◽

2019 ◽

Vol 6 (5) ◽

pp. 2042

Author(s):

Raaghul C. ◽

Rajesh N. T. ◽

Vikrant Kanagaraju ◽

Bharathi Elangovan

Keyword(s):

Abdominal Pain ◽

Ejection Fraction ◽

Gall Bladder ◽

Chronic Abdominal Pain ◽

Gallbladder Motility ◽

P Value ◽

Functional Abdominal Pain ◽

Rome Iii ◽

The Mean ◽

Upper Abdominal

Background: Chronic abdominal pain is a common gastrointestinal symptom in children that significantly lowers their quality of life. In adults, Gall bladder (GB) hypomotility / dyskinesia is associated with many functional abdominal disorders but there is scarcity of evidence on its role in childhood gastro-intestinal disorders. Aim of the study is to evaluate the GB motility in children with chronic functional abdominal pain (FAP).Methods: Children aged 5-15 years with chronic abdominal pain fulfilling ROME-III criteria and healthy controls were included and all study participants were subjected to ultrasonographic evaluation of the gall bladder volume in fasting state and post - Fatty test meal (FTM) and its ejection fraction was calculated.Results: Sixtysix children including 31 with chronic FAP underwent sonographic evaluation for GB motility. The mean ejection fraction (EF) of cases and controls were 51.72±17.76% and 57.3±23.26% (p value - 0.158). The mean EF of cases with upper abdominal pain and lower/peri-umbilical abdominal pain were 41.7±17.1% and 57.2±15.9% respectively (p value < 0.0001). Increasing BMI had no significant association with GB motility among the participants.Conclusions: There is lack of significant association between children with chronic FAP and GB hypomotility. Children with upper abdominal pain have lesser GB EF, suggesting a possible abnormal GB motility.

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Case Report on Gastric Carcinoma

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i57a34009 ◽

2021 ◽

pp. 383-387

Author(s):

Prachi Kamble ◽

Samrudhhi Gujar ◽

Savita Pohekar ◽

Ranjana Sharma ◽

Sheetal Sakharkar ◽

...

Keyword(s):

Gastric Cancer ◽

Abdominal Pain ◽

Gastric Carcinoma ◽

Lower Limb ◽

Developed Countries ◽

Nausea And Vomiting ◽

Wall Thickening ◽

Incidence And Mortality ◽

Loss Of Appetite ◽

Black Color

Introduction: Gastric cancer or stomach cancer is an any malignant tumor arising from the region extending between the gastroesophageal (GE) junction and the pylorus. The incidence and mortality of gastric cancer have been declining in most developed countries. The age-adjusted risk fell 5% from 1985-1990.Clinical. Findings: Abdominal pain in an region, weakness and loss of appetite from 50 days, pain in lower limb from one month, nausea and vomiting, history of passage of black color stool (for two days, 50 days back), loss of weight five kg in last one month. Diagnostic Evaluation: Hb - 11.2 gm/dl Decreased , RBC 4.17cumm,CBC MCH- 22.6 Pico gm (decrease), Platelet -1.2 lakhs / cumm (decrease), Eosinophil- 9 % (increase )Monocytes-2% (decrease), KFT- sodium – 132 meq/L (decrease) LFT -bilirubin (conjugated) – 0.30 gm %(decrease)Bilirubin (unconjugated ) 0.33 gm %{ decrease}, CT scan, MRI, Upper GI endoscopy - showed abnormal mass ,Endoscopic ultrasound lesion as small as 2-3 mm in diameter, USG CECT Abdomen Report- showed enhancing wall thickening Involving body of gastric without obvious perigastric extension Or significant, consistent with gastric carcinoma. Histopathology report of gastrectomy specimen showed poorly Differentiated adenocarcinoma gastric mixed type – pT4a N1 M0. Therapeutic Interventions: Inf. Metrogyl 500 mg TDS, Inj. Amikacin 500 mg OD, Inj. Pantop 40 mg BD , Inj. Piptaz in 100ml NS 4.5 mg TDS, Inj. Levofloxacin 500 mg OD, Tab. Telma 40 mg OD, Inj. PCM in 100ml NS 500 mg TDS, Chemotherapy and Radiation therapy was also Done. Outcome: After treatment, the patient show improvement. His abdominal pain , nausea and vomiting , pain in lower limb were relieved and After all pharmacological, surgical and medical intervention , patient is now in stables condition his mental and it physical condition is improving and laboratory value are in normal range, and he is able to do his daily activities. Conclusion: My patient was admit in surgery Ward No- 28 , AVBRH with a known case of Gastric carcinoma and he had complaint of abdominal pain, nausea and vomiting ,pain in lower limb , weakness, black color stool and loss of appetite. After getting appropriate treatment his condition was improve.

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Sclerosing Stromal Tumour of Ovary- A Case Report

Bangladesh Journal of Obstetrics & Gynaecology ◽

10.3329/bjog.v30i1.30510 ◽

2016 ◽

Vol 30 (1) ◽

pp. 56-58

Author(s):

Fahmida Sharmin Joty ◽

Farhana Dewan ◽

Fahmida Khan Lima ◽

Bipul Biswas ◽

Eva Rani Nondi

Keyword(s):

Computed Tomography ◽

Abdominal Pain ◽

Case Report ◽

Pelvic Pain ◽

Malignant Tumor ◽

Stromal Tumor ◽

Hormonal Status ◽

Hormonal Activity ◽

Sclerosing Stromal Tumor ◽

Sex Cord Stromal Tumor

Sclerosing stromal tumor (SST) is an extremely rare and distinctive sex cord stromal tumor, which occurs predominantly in the second and third decades of life. Approximately 100 cases reported since first described in 1973. It typically present with pelvic/abdominal pain and tenderness, mass, and/or abnormal menses, and with hormonal activity reported predominantly in postmenarchal females. Only 5 cases of these tumors have been reported in premenarchal girls.We report a case of a 18-year-old girl who developed a sclerosing stromal tumor of ovary and presented with excessive menstruation, pelvic pain and increased frequency of menstruation. Her hormonal status was normal. She was suspected to have a malignant tumor on computed tomography and underwent unilateral salpingo-oopherectomy. It is therefore, necessary to keep in mind the possibility of sclerosing stromal tumor in a young womanBangladesh J Obstet Gynaecol, 2015; Vol. 30(1) : 56-58

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