scholarly journals The Improvement of Paclitaxel Cytotoxicity Using Nanocellulose Based Nature Resources

INSIST ◽  
2018 ◽  
Vol 3 (1) ◽  
pp. 138
Author(s):  
Ridho Nahrowi ◽  
Andi Setiawan ◽  
Noviany Noviany ◽  
Irza Sukmana ◽  
Suripto Dwi Yuwono1
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cancer Cells ◽  
Target Cell ◽  
Encapsulation Efficiency ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Efficiency Improve ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells by inhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use of nanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulation efficiency, improve the drug release to the target cell following nanomaterial degradation, and improve local accumulation of drug in the cell through endocytosis receptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymer derived from natural resources such as cellulose. The advantages of cellulose as a carrier of paclitaxel are nontoxic, biodegradable, and very abundant from various sources. One of the potential sources of cellulose for drug delivery system is cassava baggase.

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

Using Magnetic and Photic Stimuli-Responsive Liposomes to Serve Up Chemotherapy Drugs to Cancer Cells

2020 ◽  
Vol 16 (6) ◽  
pp. 867-875
Author(s):  
Junlin Li ◽  
Lingyun Hao ◽  
Xiaojuan Zhang ◽  
Qing Lin ◽  
Dong Liang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Uv Light ◽  
Atomic Ratio ◽  
Solution Temperature ◽  
Photothermal Effect ◽  
Chemotherapy Drugs

Liposome is a traditional drug-delivery system and most novel studies have focused on its drug release function. In this paper, a new drug-delivery system based on liposomes was prepared, which contains hydrophobic FeAg alloy nanoparticles (FeAgNPs) in their lipid bilayer and berberine as test drug in their middle water phase. The size of AgFe-Ls was about 200 nm, the encapsulation efficiency of drugs was 35% and the lower critical solution temperature (LCST) of AgFe-Ls was about 41.96 °C. FeAgNPs in the AgFe-Ls had a 1:1 iron-to-silver atomic ratio with both optical and superparamagnetic properties. The photothermal effect and magnetocaloric effect of FeAgNPs could serve up both photo-stimulated and magnetic- stimulated drug release to liposomes. Release experiments results showed that AgFe-Ls could easily release berberine when stimulated by UV light (45% drug release at 20 min) or alternating current electromagnetic field (AMF) (80% drug release at 4 h). AgFe-Ls with both photo-controlled and magnetic-controlled drug release functions are promising to serve up chemotherapy drugs to cancer cells.

Nanocarriers with multi-locked DNA valves targeting intracellular tumor-related mRNAs for controlled drug release

Nanoscale ◽  
2017 ◽  
Vol 9 (44) ◽  
pp. 17318-17324 ◽  
Author(s):  
Yanhua Li ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Zhengze Yu ◽  
Limin Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Normal Cells ◽  
Tremendous Challenge

The fabrication of well-behaved drug delivery systems that can transport drugs to specifically treat cancer cells rather than normal cells is still a tremendous challenge.

Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery

2021 ◽  
Vol 22 ◽  
Author(s):  
Tania Caputo ◽  
Angela Maria Cusano ◽  
Menotti Ruvo ◽  
Anna Aliberti ◽  
Andrea Cusano
Keyword(s):  
Drug Delivery ◽  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Encapsulation Efficiency ◽  
Kinase Inhibitor ◽  
Force Microscopy ◽  
Atomic Force

Background: Drug delivery systems based on Human Serum Albumin (HSA) have been widely investigated due to their capability to interact with several molecules together with their nontoxicity, non-immunogenicity and biocompatibility. Sorafenib (SOR) is a kinase inhibitor used as the first-line treatment in hepatic cancer. However, because of its several intrinsic drawbacks (low solubility and bioavailability), there is a growing need for discovering new carriers able to overcome the current limitations. Objective: To study HSA particles loaded with SOR as a thermal responsive drug delivery system. Method: A detailed spectroscopy analysis of the HSA and SOR interaction in solution was carried out in order to characterize the temperature dependence of the complex. Based on this study, the synthesis of HSA particles loaded with SOR was optimized. Particles were characterized by Dynamic Light Scattering, Atomic Force Microscopy and by spectrofluorometer. Encapsulation efficiency and in vitro drug release were quantified by RP-HPLC. Results: HSA particles were monodispersed in size (≈ 200 nm); encapsulation efficiency ranged from 25% to 58%. Drug release studies that were performed at 37 °C and 50 °C showed that HS5 particles achieved a drug release of 0.430 µM in 72 hours at 50 °C in PBS buffer, accomplishing a 4.6-fold overall SOR release enhancement following a temperature increase from 37 °C to 50 °C. Conclusion: The system herein presented has the potential to exert a therapeutic action (in the nM range) triggering a sustained temperature-controllable release of relevant drugs.

scholarly journals Mesoporous silica–chondroitin sulphate hybrid nanoparticles for targeted and bio-responsive drug delivery

2015 ◽  
Vol 39 (3) ◽  
pp. 1754-1760 ◽  
Author(s):  
Krishna Radhakrishnan ◽  
Jasaswini Tripathy ◽  
Akshay Datey ◽  
Dipshikha Chakravortty ◽  
Ashok M. Raichur
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Chondroitin Sulphate ◽  
Mesoporous Silica Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Intracellular Degradation

A polysaccharide based gatekeeper is attached to seal the nanopores of drug mesoporous silica nanoparticles, which facilitates uptake by cancer cells and undergoes intracellular degradation to initiate drug release.

scholarly journals Controlled release of targeted anti-leukemia drugs azacitidine and decitabine monitored using surface-enhanced Raman scattering (SERS) spectroscopy

2017 ◽  
Vol 6 (4) ◽  
pp. 125-132 ◽  
Author(s):  
Madison Smith ◽  
Maria Hepel
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Controlled Release ◽  
Drug Release ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A new targeted drug delivery system with controlled release of anti-cancer drugs, azacitidine and decitabine, was investigated to enhance the efficacy of cancer treatment and reduce the effects of high drug toxicity to healthy tissues. The proposed drug nanocarriers are based on gold nanoparticles (AuNPs) modified with mercaptobenzoic acid (MBA) linker to enable the immobilization of azacitidine (AZA) and decitabine (DAC) on AuNPs in the form of AuNP@MBA/AZA,DAC entities. The cancer cell recognition was accomplished by covalently binding folic acid (FA) ligands to para-aminothiophenol (PATP) in the mixed SAM shell on gold nanoparticle nanocarriers, AuNP@MBA,PATP. The FA ligand was used due to the strong expression of folic acid receptors (FR) in the membrane of cancer cells. This enables the functionalized carriers to target only cancer cells owing to the efficient FA-FR binding property. The amide bonds between the linkers and azacitidine/decitabine are pH sensitive and undergo acid hydrolysis in a low pH environment of the cytosol in cancer cells. Using the solutions of different pH, the release of azacitidine/decitabine was monitored by surface-enhanced Raman scattering spectroscopy (SERS) measurements of the MBA Raman modes at 1586 cm-1 and 1074 cm-1 . At pH 7.4, the release of the drug was found to be negligible, while at pH 4.0 and 5.5 a continuous drug release was observed over 3 hours. The utilization of SERS monitoring for the drug release was based on the strong Raman signals which are generated by the MBA linker when it is bound to a plasmonic AuNP. During the immobilization of azacitidine/decitabine on AuNP carriers, the SERS signals are strongly reduced due to the shielding by drug molecules but they increase sharply upon the drug release confirming the amide bond breakage and successful drug delivery.

scholarly journals Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery

2015 ◽  
Vol 51 (48) ◽  
pp. 9833-9836 ◽  
Author(s):  
Juan Zhou ◽  
Nanjing Hao ◽  
Thareendra De Zoyza ◽  
Mingdi Yan ◽  
Olof Ramström
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Delivery Vehicles

Stimuli-responsive, lectin-gated mesoporous glyconanoparticles have been developed as delivery vehicles for controlled drug release into cancer cells.

scholarly journals Glutathione-responsive homodithiacalix[4]arene-based nanoparticles for selective intracellular drug delivery

2018 ◽  
Vol 54 (58) ◽  
pp. 8128-8131 ◽  
Author(s):  
Qian Cheng ◽  
Hang Yin ◽  
Chen Sun ◽  
Ludan Yue ◽  
Yuanfu Ding ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Intracellular Drug Delivery

Glutathione-responsive, paclitaxel-loaded nanoparticles based on homodithiacalix[4]arene were successfully developed, exhibiting selective drug release in cancer cells.

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