scholarly journals PECULIARITIES OF CORONAVIRUS INFECTION CLINICAL COURSE CAUSED BY SARS-COV-2 IN NEWBORNS

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
L.V. Kolyubakina ◽  
O.V. Vlasova ◽  
N.M. Kretsu ◽  
Е.Z. Trekush
Keyword(s):  
Medical Records ◽  
Complete Blood Count ◽  
Inclusion Criteria ◽  
Newborn Child ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Acute Respiratory Viral Infection ◽  
Time Of Admission ◽  
Study Inclusion

A lot of data concerning the epidemiological features of the pathogen, clinical andparaclinical characteristics of the disease, principles of diagnosis and approaches tothe treatment have been published in the scientific literature during the year of pandemiacaused by SARS-CoV-2. But still there are many unresolved issues regarding theepidemiological and clinical characteristics of this coronavirus infection in newborns.Purpose – to conduct observational study of the peculiarities of SARS-CoV-2 coronavirusinfection in newborns treated during 2020 on the basis of RCNE "Chernivtsi RegionalChildren's Clinical Hospital", Chernivtsi.Material and methods. Analysis of medical records of 12 inpatient newborns wasconducted retrospectively to achieve the goal of the study. Inclusion criteria: age 0-28days of life, confirmed by positive test of polymerase chain reaction (PCR) for SARSCoV-2 coronavirus infection of a nasopharyngeal smear. The average age of childrenat the time of admission was 13.6 ± 2.1 days, every third newborn child (33.3%) wasadmitted before the age of 10 days old. The portion of rural residents was 66.6%, girls(75%) predominated among children who fell ill.Results. It has been revealed that in most cases the contact of newborns with COVID-19patients was confirmed. Mostly children were admitted from home on average onthe second day after the onset of the disease, predominantly with the typical clinicalsymptoms of acute respiratory viral infection, at the onset of the disease gastrointestinalmanifestations prevailed in only two of patients. The course of the disease was favorable.Conclusions. The detected changes in the follow-up infants’ complete blood count requirefurther dynamic clinical and paraclinical observation.

Stifle arthrodesis using a locking plate system in six dogs

2015 ◽  
Vol 28 (04) ◽  
pp. 288-293 ◽  
Author(s):  
T. Nicetto ◽  
M. Petazzoni
Keyword(s):  
Body Weight ◽  
Medical Records ◽  
Tibial Fracture ◽  
Locking Plate ◽  
Sagittal Plane ◽  
Inclusion Criteria ◽  
Radiographic Outcomes ◽  
Locking Plate System ◽  
Plate System

SummaryObjectives: To describe the use of the Fixin locking plate system for stifle arthrodesis in dogs and to retrospectively report the clinical and radiographic outcomes in six cases.[uni2028]Materials and methods: Medical records of dogs that had arthrodesis with the Fixin locking plate system were reviewed. For each patient, data pertaining to signalment and implant used were recorded. Plate series and thickness, number of screws placed, number of cortices engaged, and screw diameters were also recorded. The outcome was determined from clinical and radiographic followups. Radiographic outcomes assessed included the measurement of the postoperative femoral-tibial angle in the sagittal plane.Results: Six dogs met the inclusion criteria for the study. Mean body weight was 13 kg (range: 3 - 34 kg). Radiographic follow-up (mean: 32 weeks, range: 3 - 52 weeks) was available for all dogs. In one case, an intra-operative complication occurred. In another case, a tibial fracture occurred 20 days after surgery. All arthrodeses healed and no implant complication was detected although all cases had mechanical lameness.Clinical significance: Stifle arthrodesis can be performed successfully using a Fixin locking plate system.

scholarly journals The Efficacy of Chest X-Ray for the Diagnosis and Follow-up in Young Adult COVID-19 Patients with Mild Dyspnea No Comorbid Diseases

2021 ◽  
Author(s):  
ferhat cuce ◽  
deniz dogan ◽  
ugur bozlar ◽  
mustafa tasar ◽  
ervin gjoni ◽  
...  
Keyword(s):  
Young Adult ◽  
X Ray ◽  
Early Admission ◽  
Significant Difference ◽  
Chest X Ray ◽  
Polymerase Chain ◽  
Comorbid Diseases ◽  
Time Of Admission ◽  
Hospital Stay Duration

Purpose: We investigated whether Chest X-Ray (CXR) could replace CT modality in the diagnosis and during the treatment of young adult COVID-19 patients with mild dyspnea with no comorbid diseases. Materials and Method: This retrospective study involved an examination of the records of a total of 956 patients hospitalized between March 1 and May 15, 2020. The study included a total of 64 patients, aged 21–60 years with mild dyspnea with no comorbid diseases and with COVID-19 infection confirmed by a polymerase chain reaction, who underwent a CXR at admission and CT imaging within 24 hours. The first CXR and CT images at the time of admission were evaluated in terms of lesions and localization. The clinical-radiological course of the diseases with CXR were also statistically evaluated. Results: CT was normal in 18/64 (28.2%) patients, all of whom also had normal CXR. The rest of the patients 46/64 (71.8%) with an abnormal CT, the CXR was normal in 18/46 (39.1%) and abnormal in 28/46 (60.9%). The time between the onset of complaints and admission to the hospital in patients with abnormal and normal CXR was 3.5 ± 2.3 days and 2.1 ± 1.1, which was statistically significant (p = 0.004). The hospital stay duration of the patient with abnormal and normal CXR was 9.6 ± 3.5 and 9.5 ± 3.4 (p=0.928), respectively, and was not statistically significant. Conclusion: CXR could be used in the diagnosis and follow-up of young adult COVID 19 patients with mild dyspnea no comorbid disease. In the case of early admission to the hospital, there is not a significant difference between using CXR or CT in the management of these patients. Therefore, the use of CXR in these patients groups will reduce the burden of CT units in pandemic conditions with limited resources.

scholarly journals Outcome of Inferonasal Conjunctival Autograft in Pterygium Surgery

2021 ◽  
Vol 23 (4) ◽  
pp. 319-323
Author(s):  
Pragati Gautam Adhikari ◽  
Sagun Narayan Joshi
Keyword(s):  
Medical Records ◽  
Demographic Variables ◽  
Inclusion Criteria ◽  
Conjunctival Autograft ◽  
Donor Area ◽  
Mean Size ◽  
Pterygium Surgery ◽  
The Mean ◽  
Pterygium Excision

This study was done to evaluate the outcome of pterygium excision with inferonasal conjunctival autograft at a tertiary eye care centre. Retrospective analysis of medical records of primary pterygia patients operated by a single surgeon between 2017 to 2020 were analyzed. A total of 43 patients who met the inclusion criteria were included in the study. The demographic variables, along with size of pterygium and recurrence over a period of six month follow up was noted. The mean age of patients was 46.97 years (29-74 years). The mean size of pterygium was 3.17 mm. Recurrence was seen in 3 eyes over a period of 6 months. Graft edema was observed in 11 patients and graft hemorrhage along with congestion was seen in 8 cases which resolved over a 3 weeks follow up period. Mild conjunctival scarring was seen over donor area in 5 of the eyes. Pterygium excision with inferior conjunctival autograft is an effective alternative technique to superotemporal autograft technique.

Locking compression plate stabilization of 20 distal radial and ulnar fractures in toy and miniature breed dogs

2015 ◽  
Vol 28 (06) ◽  
pp. 441-447 ◽  
Author(s):  
G. R. Ragetly ◽  
R. J. Boudrieau ◽  
S. Gibert
Keyword(s):  
Distal Radius ◽  
Medical Records ◽  
Clinical Results ◽  
Locking Compression Plate ◽  
Inclusion Criteria ◽  
Compression Plate ◽  
Hybrid Construct ◽  
Mean Time ◽  
Radiographic Union

SummaryObjective: To evaluate retrospectively the effectiveness of the Locking Compression Plate® (LCP), in the form of either a straight or notched head T-plate, for the treatment of fractures of the distal radius and ulna in a series of 20 toy and miniature breed dogs.Methods: The medical records of toy and miniature breed dogs (<6 kg), greater than six months of age, with fractures of the distal radius and ulna from two veterinary hospitals were reviewed. The inclusion criteria included: fractures of the distal 1/3 of the radius and ulna and repair with open reduction and internal fixation utilizing an LCP (straight or notched head T-plate).Results: Twenty fractures (20 dogs) satisfied the inclusion criteria; eight straight and 12 notched head T-plates were used, either 2.0 mm (n = 13) or 2.4 mm (n = 7). Hybrid fixation was performed in all dogs in one or both fragments. Mean time to radiographic union was 6.9 ± 2.5 weeks (range: 4–12 weeks) in 18/20 dogs with radiographic follow-up. One complication was observed: infection that resolved with antibiotic medication and implant removal. No other major complications occurred by the time of last follow-up. In all cases (mean follow-up: 15 ± 7 months), the reported limb function as evaluated by the referring veterinarian or owner was excellent.Clinical significance: The LCP, used as a hybrid construct for the treatment of distal radial and ulnar fractures was shown to yield excellent clinical results with both uncomplicated healing and excellent functional outcomes in this series of toy and miniature breed dogs.

scholarly journals Coronaviral infection

2020 ◽  
Vol 11 (3) ◽  
pp. 109-117
Author(s):  
Dmitry O. Ivanov ◽  
Tatyana M. Chernova ◽  
Elena B. Pavlova ◽  
Vladimir N. Timchenko ◽  
Elena V. Barakina
Keyword(s):  
Viral Infections ◽  
Pathological Process ◽  
World Health ◽  
The World ◽  
Genetic Features ◽  
Long Time ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Acute Respiratory Viral Infection ◽  
Health Organization

Coronavirus infection (CVI) is a group of acute ubiquitous infectious diseases known since the 60s 19 century. The clinical picture of CVI is characterized by damage to the respiratory system from mild forms of acute respiratory viral infection to the development of a severe acute respiratory syndrome, as well as involvement of other organs in the pathological process of the gastrointestinal tract. For a long time, coronaviruses were not given attention, since it was believed that they were able to cause only mild respiratory diseases. It is known that children and adolescents are less susceptible to infection than adults. In the etiological structure of acute respiratory viral infections among hospitalized children, coronaviruses account for 69%. The introduction of multiplex polymerase chain reaction (PCR) with the inclusion of coronaviruses in practice has shown their role in the occurrence of severe diseases of the lower respiratory tract. Since 2002, outbreaks of coronavirus infection caused by previously unknown pathogens (SARS-CoV, MERS-CoV, SARS-CoV-2) have been observed in the world. New coronaviruses have genetic features and are relatively highly resistant in the environment. The diseases they cause are distinguished by the predominance of severe forms with high mortality due to the development of acute respiratory distress syndrome and sepsis. In December 2019, an outbreak of pneumonia caused by the SARS-CoV-2 virus began in China; in February 2020, the disease was called COVID-2019. In connection with the trend towards the global spread of new infections March 11, 2020, the World Health Organization announced a pandemic. The lecture covers the issues of epidemiology, pathogenesis, clinic, diagnosis and treatment of coronavirus infection, taking into account the emergence of new pathogens.

scholarly journals Hiponatremična hipokloremična dehidracija pri otrocih s cistično fibrozo v Sloveniji; pogostost in priporočila za preprečevanje in zdravljenje

2015 ◽  
Vol 84 (4) ◽  
Author(s):  
Marina Praprotnik ◽  
Gorazd Kalan ◽  
Nataša Bratina ◽  
Ivan Vidmar ◽  
Malena Aldeco ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Medical Records ◽  
Rare Complication ◽  
Hypovolemic Shock ◽  
Clinical Signs ◽  
Warning Signs ◽  
Outpatient Basis ◽  
The University ◽  
Time Of Admission

Background: Young children and rarely adolescents with cystic fibrosis can develop hyponatremic hypochloremic dehydration with metabolic alkalosis. The purpose of this article was to review the incidence of this metabolic disorder in our CF patients.Methods: We investigated the medical records of all children diagnosed with cystic fibrosis who are under follow-up in the CF center at the University Childrenʹs Hospital Ljubljana, and were hospitalised or treated on an outpatient basis due to hyponatremic, hypochloremic dehydration in the period from 2007–2012. Data analysis included clinical and laboratory findings.Results: A total of 4 children (7.2 %) from Ljubljana CF center (55 patients under the age of 19 years) were enrolled in the study. We observed 5 episodes of hyponatremic hypochloremic dehydration in 4 patients (one boy had two episodes). All were homozigous for ΔF 508 mutation. Two had episodes in summer and two in autumn, so that no season prevalence of its occurence was found. Median age at admission to the hospital due to hyponatremic hypochloremic dehydration was 7 months (range 4–34). One boy had a hypovolemic shock at the time of admission to the hospital.Conclusions: The results of our study show that dehydration with hypoelectrolytaemia is a rare complication in children with CF in Slovenia, but due to the severity of clinical signs it is an important disorder. Vomiting and fatigue are the warning signs that should alert parents and physicians to consider the possibility of this complication which can be prevented by proper hydration and salt replacement. If left untreated, it can cause seizures, arrhythmias and even death.

scholarly journals Clinical characteristics of patients with subacute thyroidits and factors affecting development hypothyroidism after subacute thyroiditis

2022 ◽  
Author(s):  
İNAN ANAFOROĞLU ◽  
Murat Topbas
Keyword(s):  
Neck Pain ◽  
Medical Records ◽  
Clinical Characteristics ◽  
Subacute Thyroiditis ◽  
Upper Respiratory Tract ◽  
Inclusion Criteria ◽  
Imaging Studies ◽  
Factors Affecting ◽  
Upper Respiratory

IntroductionSubacute thyroiditis (SAT) is typically a self-limiting, inflammatory disease. Patients can experience hypothyroidism during or after an episode. We examined the clinical characteristics based on laboratory and imaging studies in patients with SAT and possible factors contributing to the development of permanent hypothyroidism after SAT.Material and methodsWe retrospectively examined medical records of patients diagnosed with SAT at one medical facility in Turkey. Patients known to have previous thyroid disease, those with <6 months of follow-up after resolution of SAT, and those who lacked sufficient data for analysis were excluded. Of the 283 patients identified 119 met all inclusion criteria. We extracted data on demographics, laboratory tests, neck pain and other symptoms, ultrasonography findings, medication use, and SAT recurrence. We examined the relationships between these variables and development of permanent hypothyroidism.ResultsThe patients were 42 years old on average, and 78% were women. Most patients (70%) described flu-like symptoms before neck pain started; accordingly, 57% had initially visited a specialty other than endocrinology before SAT was diagnosed, and 28% had received antibiotics for misdiagnosed upper respiratory tract infection. In all, 10 patients (8.4%) developed permanent hypothyroidism after SAT. These patients had received steroids significantly longer than did those without permanent hypothyroidism (mean 17.7 vs. 8.9 weeks; P = .021). Development of hypothyroidism was significantly lower among patients with thyrotoxicosis.ConclusionsThe diagnosis of SAT can be challenging. Patients who require longer-term steroids after SAT and who have recurrent SAT should be closely monitored for development of hypothyroidism.

scholarly journals Prevalence and clinical characteristics of phenobarbitone-associated adverse effects in epileptic cats

2020 ◽  
pp. 1098612X2092492
Author(s):  
Oliver Marsh ◽  
Giulia Corsini ◽  
Jan Van Dijk ◽  
Rodrigo Gutierrez-Quintana ◽  
Luisa De Risio
Keyword(s):  
Adverse Effect ◽  
Adverse Effects ◽  
Medical Records ◽  
Clinical Characteristics ◽  
Idiopathic Epilepsy ◽  
Severe Neutropenia ◽  
Inclusion Criteria ◽  
Study Objective ◽  
Structural Epilepsy

Objectives The study objective was to investigate the prevalence and clinical characteristics of phenobarbitone-associated adverse effects in epileptic cats. Methods The medical records of two veterinary referral clinics from 2007 to 2017 were searched for cats fulfilling the inclusion criteria of a diagnosis of epilepsy, treatment with phenobarbitone and available follow-up information on the occurrence of adverse effects. Follow-up information was obtained from the medical records of the primary veterinarian and referral institutions and a questionnaire completed by the cats’ owners. Results Seventy-seven cats met the inclusion criteria. Fifty-eight were affected by idiopathic epilepsy and 19 by structural epilepsy. One or more of the following adverse effects were reported in 47% of the cats: sedation (89%); ataxia (53%); polyphagia (22%); polydipsia (6%); polyuria (6%); and anorexia (6%). Logistic regression analyses revealed significant associations between adverse effect occurrence and both phenobarbitone starting dosage and administration of a second antiepileptic drug (AED). For each 1 mg/kg q12h increment of phenobarbitone, the likelihood of adverse effects increased 3.1 times. When a second AED was used, the likelihood of adverse effects increased 3.2 times. No association was identified between epilepsy aetiology and adverse effect occurrence. An idiosyncratic adverse effect, characterised by severe neutropenia and granulocytic hypoplasia, was diagnosed in one cat. This resolved following phenobarbitone discontinuation. Conclusions and relevance The prevalence of phenobarbitone-associated adverse effects was 47%. Sedation and ataxia were most common. These are type A adverse effects and are predictable from phenobarbitone’s known pharmacological properties. In the majority of cases, adverse effects occurred within the first month of treatment and were transient. Idiosyncratic (type B) adverse effects, which were not anticipated given the known properties of the drug, occurred in one cat. Increased phenobarbitone starting dosage and the addition of a second AED were significantly associated with the occurrence of adverse effects.

Experiences using the Fixin locking plate system for the stabilization of appendicular fractures in dogs

2013 ◽  
Vol 26 (01) ◽  
pp. 61-68 ◽  
Author(s):  
T. Nicetto ◽  
A. Urizzi ◽  
M. Isola ◽  
M. Petazzoni
Keyword(s):  
Complication Rate ◽  
Medical Records ◽  
Locking Plate ◽  
Inclusion Criteria ◽  
Limb Function ◽  
Long Term Follow Up ◽  
Locking Plate System ◽  
Plate System

SummaryObjectives: To retrospectively evaluate the stabilization of appendicular fractures in dogs using the Fixin locking plate system.Materials and methods: Medical records and radiographs of dogs with fractures stabilized with the Fixin system in the period from May 2005 to September 2010 were reviewed. For each patient, data pertaining to signalment, the nature of the fracture, implants used, and evidence of fracture healing were recorded. The outcome and complications were determined from clinical and radiographic follow-up examinations. Limb function was evaluated between 40 days and 90 days postoperatively. Owners of pets with complications were contacted by phone for long-term follow-up.Results: Eighty-two fractures in seventy-five dogs met the inclusion criteria for the study. Radiographic re-examinations were carried out between eight days to two years (median 60 days) following surgery. Seventy-three out of 82 fractures (89%) reached union without complications. Major complications were seen in six dogs (7%). Limb function was graded as ‘normal’ in 73/75 (97%) dogs and ‘mild lameness’ in 2/75 (3%) cases.Clinical significance: Despite a modest complication rate, the Fixin locking bone plating system appears to be an acceptable choice of implant for the stabilization of appendicular fractures in dogs.

The Role of Tumor Size in the Radiosurgical Management of Patients with Ambiguous Brain Metastases

Neurosurgery ◽  
2003 ◽  
Vol 53 (2) ◽  
pp. 272-281 ◽  
Author(s):  
Eric L. Chang ◽  
Samuel J. Hassenbusch ◽  
Almon S. Shiu ◽  
Frederick F. Lang ◽  
Pamela K. Allen ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Brain Metastases ◽  
Local Control ◽  
Medical Records ◽  
Tumor Volume ◽  
Unknown Primary ◽  
Inclusion Criteria ◽  
Peripheral Dose

Abstract OBJECTIVE To identify a size cutoff below which it is safe to observe obscure brain lesions suspected of being metastases so that treatment of nonmetastases can be avoided. METHODS Medical records from patients who underwent linear accelerator-based radiosurgery from August 1991 to October 2001 were reviewed. Inclusion criteria were defined as brain metastasis tumor volume less than 5 cm3 (diameter, ∼2.1 cm) treated with a dose of 20 Gy or more. One hundred thirty-five patients had 153 evaluable brain metastases with follow-up imaging that met inclusion criteria. Median age was 54 years (range, 18–79 yr). Lesion primaries were non-small-cell lung (n = 39), melanoma (n = 44), renal (n = 37), breast (n = 18), colon (n = 3), sarcoma (n = 5), other (n = 5), and unknown primary (n = 2). Median tumor volume was 0.67 cm3 (range, 0.06–4.58 cm3). The minimum peripheral dose was 20 Gy (n = 132) or 21 to 24 Gy (n = 21). At the time of analysis, the median follow-up for all patients was 10 months (range, 0.2–99 mo). RESULTS The 1- and 2-year actuarial local control rates for all of the lesions were 69 and 46%, respectively. For lesions of 1 cm (0.5 cm3) or less, the corresponding local control rates were 86 and 78%, respectively, which was significantly higher than the corresponding rates of 56 and 24%, respectively, for lesions larger than 1 cm (0.5 cm3) (P = 0.0016). CONCLUSION A convincing brain metastasis measuring less than 1 cm should be pursued aggressively. If the suspected brain metastasis is ambiguous, observation is proposed up to a diameter of 1 cm. This is the first study in the literature to identify a 1-cm cutoff for radiosurgical control of small brain metastases, and validation by additional studies is required.

Sign in / Sign up

Export Citation Format

Share Document