scholarly journals Coronaviral infection

2020 ◽  
Vol 11 (3) ◽  
pp. 109-117
Author(s):  
Dmitry O. Ivanov ◽  
Tatyana M. Chernova ◽  
Elena B. Pavlova ◽  
Vladimir N. Timchenko ◽  
Elena V. Barakina
Keyword(s):  
Viral Infections ◽  
Pathological Process ◽  
World Health ◽  
The World ◽  
Genetic Features ◽  
Long Time ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Acute Respiratory Viral Infection ◽  
Health Organization

Coronavirus infection (CVI) is a group of acute ubiquitous infectious diseases known since the 60s 19 century. The clinical picture of CVI is characterized by damage to the respiratory system from mild forms of acute respiratory viral infection to the development of a severe acute respiratory syndrome, as well as involvement of other organs in the pathological process of the gastrointestinal tract. For a long time, coronaviruses were not given attention, since it was believed that they were able to cause only mild respiratory diseases. It is known that children and adolescents are less susceptible to infection than adults. In the etiological structure of acute respiratory viral infections among hospitalized children, coronaviruses account for 69%. The introduction of multiplex polymerase chain reaction (PCR) with the inclusion of coronaviruses in practice has shown their role in the occurrence of severe diseases of the lower respiratory tract. Since 2002, outbreaks of coronavirus infection caused by previously unknown pathogens (SARS-CoV, MERS-CoV, SARS-CoV-2) have been observed in the world. New coronaviruses have genetic features and are relatively highly resistant in the environment. The diseases they cause are distinguished by the predominance of severe forms with high mortality due to the development of acute respiratory distress syndrome and sepsis. In December 2019, an outbreak of pneumonia caused by the SARS-CoV-2 virus began in China; in February 2020, the disease was called COVID-2019. In connection with the trend towards the global spread of new infections March 11, 2020, the World Health Organization announced a pandemic. The lecture covers the issues of epidemiology, pathogenesis, clinic, diagnosis and treatment of coronavirus infection, taking into account the emergence of new pathogens.

Comparativa de modelos multivariados basados en aprendizaje automático para la predicción del riesgo de diabetes en etapas tempranas

2021 ◽  
Author(s):  
◽  
Zayra Ramírez Gaytán
Keyword(s):  
World Health ◽  
Degenerative Diseases ◽  
Decision Tree Algorithm ◽  
Data Set ◽  
The World ◽  
Long Time ◽  
Life Threatening ◽  
Health Organization ◽  
Logistic Regression Algorithm ◽  
Asymptomatic Phase

Diabetes is one of the fastest-growing, life-threatening, chronic degenerative diseases. According to the World Health Organization (WHO), it has affected 422 million people worldwide in 2018. Approximately 50% of all people who suffer diabetes are not diagnosed due to the asymptomatic phase which usually lasts a long time. In this work, a data set of 520 instances has been used. The data set has been analyzed with the next three algorithms: logistic regression algorithm, decision trees and random forest. The results show that the decision tree algorithm had better performance with an AUC of 98%. Also, it was found the most common symptoms that a person with a risk of diabetes presents are polyuria, polydipsia and sudden weight loss.

scholarly journals The Expression of miR-155-5p and Local Matrix Gla Protein in Meningiomas

2021 ◽  
Vol 29 (3) ◽  
pp. 299-306
Author(s):  
Simona Roxana Gheorghe ◽  
Cătălin Marian ◽  
Ligia Gabriela Tătăranu ◽  
Anica Dricu ◽  
Cees Vermeer ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Molecular Classification ◽  
Micro Rna ◽  
Matrix Gla Protein ◽  
World Health ◽  
Ectopic Calcification ◽  
Chain Reaction ◽  
The World ◽  
Polymerase Chain ◽  
Health Organization

Abstract Meningiomas are classified by the World Health Organization (WHO) in three grades, based on morphological features. Independent of this grading, the presence of calcification in meningiomas influences their growth rate. The messenger RNA of matrix Gla protein (MGP), an extra-hepatic protein with different conformations involved in the homeostasis of ectopic calcification has been found in meningiomas and was shown to be regulated in breast cancer by miR-155-5p, a specific micro RNA. Therefore, we investigated the expression of miR-155-5p and its relationship with local MGP conformations in different grade meningiomas. According to the WHO classification, our 41 samples of meningiomas were stratified in groups WHO I and WHO II. Using real time polymerase chain reaction, we observed a higher miR-155-5p expression in group WHO I versus group WHO II [with a fold change (FC) of 3.83, p=0.027)]. Moreover, the expression of miR-155-5p was higher in calcified tumors compared to non-calcified tumors in all samples (FC=3.01, p=0.047) and in group WHO I (FC=3.65, p=0.048). Utilizing immunohistochemistry, we determined the concurrent presence of all MGP conformations in calcified meningiomas. This study was the first to establish higher miR-155-5p expression in grade WHO I and calcified meningiomas, which could improve molecular classification and targeted therapy and also the presence of all MGP conformations in calcified meningiomas, confirming the existence of an anti-calcification mechanism in meningiomas..

CORONOVIRUS INFECTION COVID-19. MASKS (literature review)

2021 ◽  
Vol 7 (1) ◽  
pp. 24-32
Author(s):  
Semen Kireev ◽  
I. Popov ◽  
A. Ban'kovskiy ◽  
E. Litvinenko ◽  
E. Surova
Keyword(s):  
World Health Organization ◽  
Infectious Agent ◽  
International Committee ◽  
World Health ◽  
Vulnerable Communities ◽  
Regional Director ◽  
The World ◽  
Coronavirus Infection ◽  
Health Organization ◽  
The City

At the end of 2019, an outbreak of a new coronavirus infection occurred in the People's Re-public of China with an epicenter in the city of Wuhan (Hubei province). On February 11, 2020, the World Health Organization has assigned the official name of the infection caused by the new coronavirus - COVID-19 ("Coronavirus disease2019"). On February 11, 2020, the International Committee on Virus Taxonomy gave the official name to the infectious agent - SARS-CoV-2.Since the end of January 2020, cases of COVID-19 have begun to be registered in many coun-tries of the world, mainly associated with travel to the PRC. At the end of February 2020, the epidemiological situation with COVID-19 in South Korea, Iran and Italy sharply worsened, which subsequently led to a significant increase in the number of cases in other countries of the world associated with travel to these countries, incl. and in Russia. The World Health Organiza-tion announced the COVID-19 pandemic on 11 March 2020, and the pandemic's challenge to the world will remain so as long as people are not immune to it.The Regional Director of the World Health Organization Takeshi Kasai, on the basis of an epidemiological analysis, reports that the spread of coronavirus infection COVID-19 in July-August 2020 occurred mainly among people under 50 years old, and they often did not even know about it, because they had mild or no symptoms. In the future, these people then infect older people who are more difficult to tolerate COVID-19. And we need to redouble our efforts to prevent the spread of the virus in vulnerable communities.

scholarly journals Covid-19 and Pregnancy: An Overview

2020 ◽  
Vol 42 (07) ◽  
pp. 420-426
Author(s):  
Pedro Castro ◽  
Ana Paula Matos ◽  
Heron Werner ◽  
Flávia Paiva Lopes ◽  
Gabriele Tonni ◽  
...  
Keyword(s):  
Public Health ◽  
Pregnant Women ◽  
World Health Organization ◽  
Case Series ◽  
Public Health Emergency ◽  
Present Review ◽  
World Health ◽  
The World ◽  
Coronavirus Infection ◽  
Health Organization

AbstractSince the World Health Organization (WHO) declared coronavirus infection (COVID-19) a Public Health Emergency of International Concern in January 2020, there have been many concerns about pregnant women and the possible effects of this emergency with catastrophic outcomes in many countries. Information on COVID-19 and pregnancy are scarce and spread throughout a few case series, with no more than 50 cases in total. The present review provides a brief analysis of COVID-19, pregnancy in the COVID-19 era, and the effects of COVID-19 on pregnancy.

scholarly journals Vulvar Tuberculosis—A Rare Manifestation of the Disease

2019 ◽  
Vol 41 (09) ◽  
pp. 575-578 ◽  
Author(s):  
Cristina Bragança ◽  
Inês Gonçalves ◽  
Luísa Guerreiro ◽  
Maria Janeiro
Keyword(s):  
Rare Case ◽  
Causes Of Death ◽  
World Health ◽  
Histological Findings ◽  
Chain Reaction ◽  
Rare Manifestation ◽  
The World ◽  
History Of ◽  
Polymerase Chain ◽  
Health Organization

AbstractTuberculosis is an infectious disease caused by Mycobacterium tuberculosis. According to data from the World Health Organization, this disease remains one of the leading causes of death worldwide. Although it most commonly affects the lungs, tuberculosis can compromise any organ. The present study reports a rare case of vulvar tuberculosis in a postmenopausal woman with a history of asymptomatic pulmonary and pleural tuberculosis, with no prior documented contact with the bacillus. Diagnosis was based on vulvar lesion biopsies, with histological findings suggestive of infection and isolation of M. tuberculosis by microbiological culture and polymerase chain reaction (PCR) essays. The lesions reverted to normal after tuberculostatic therapy.

scholarly journals Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19

Metallomics ◽  
2020 ◽  
Author(s):  
Jemmyson Romário de Jesus ◽  
Tatianny de Araújo Andrade
Keyword(s):  
Trace Elements ◽  
Viral Infection ◽  
World Health Organization ◽  
Viral Infections ◽  
World Health ◽  
The World ◽  
Novel Virus ◽  
Health Organization ◽  
The Relationship

Recently, the World Health Organization (WHO) declared a pandemic situation due to a new viral infection (COVID-19) caused by a novel virus (Sars-CoV-2).

scholarly journals Presence of mismatches between diagnostic PCR assays and coronavirus SARS-CoV-2 genome

2020 ◽  
Vol 7 (6) ◽  
pp. 200636 ◽  
Author(s):  
Kashif Aziz Khan ◽  
Peter Cheung
Keyword(s):  
World Health ◽  
Current Standard ◽  
Policy Makers ◽  
Diagnostic Pcr ◽  
Diagnostic Assays ◽  
The World ◽  
Polymerase Chain ◽  
Pcr Assays ◽  
Health Organization ◽  
Viral Sequences

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; initially named as 2019-nCoV) is responsible for the recent COVID-19 pandemic and polymerase chain reaction (PCR) is the current standard method for its diagnosis from patient samples. This study conducted a reassessment of published diagnostic PCR assays, including those recommended by the World Health Organization (WHO), through the evaluation of mismatches with publicly available viral sequences. An exhaustive evaluation of the sequence variability within the primer/probe target regions of the viral genome was performed using more than 17 000 viral sequences from around the world. The analysis showed the presence of mutations/mismatches in primer/probe binding regions of 7 assays out of 27 assays studied. A comprehensive bioinformatics approach for in silico inclusivity evaluation of PCR diagnostic assays of SARS-CoV-2 was validated using freely available software programs that can be applied to any diagnostic assay of choice. These findings provide potentially important information for clinicians, laboratory professionals and policy-makers.

scholarly journals ASSESSMENT OF THE SPECIFIC CONTRIBUTION OF SOCIO-ENVIRONMENTAL CONDITIONS TO THE SPREAD OF COVIND-19 VIRUS IN THE RUSSIAN REGIONS

2020 ◽  
Vol 1 (5) ◽  
pp. 245-249
Author(s):  
S.A. Yeprintsev ◽  
◽  
O.V. Klepikov ◽  
S.V. Shekoyan ◽  
E.V. Zhigulina ◽  
...  
Keyword(s):  
Environmental Conditions ◽  
World Health ◽  
Russian Society ◽  
Financial Security ◽  
The World ◽  
Coronavirus Infection ◽  
Health Organization ◽  
Spread Of Infection ◽  
Specific Contribution

The spread of the dangerous Covid-19 infection caused by the SARS-CoV-2 coronavirus since the end of 2019 has become a great challenge to both the world and Russian society. For example, on January 30, 2020, the world health organization recognized the spread of a new infection as a public health emergency of international significance. On March 11, 2020, the same organization declared that the outbreak had become a pandemic. currently, the role of social and environmental factors (which determine the spread of many environmentally-related diseases) in the spread of coronavirus infection in the population has not been fully studied. The spread of Covid-19 infection in Russia can be divided into 3 stages. Stage 1 (31.01.2020–01.04.2020) – primary distribution. At this stage, the infection occurred mainly to Russian citizens visiting other countries. Stage 2 (1.04.2020– 12.05.2020) – active distribution within the country. By the end of this stage, the maximum spread of infection is recorded. Stage 3 (12.05.2020-present) – gradual decline in the appearance of new cases of coronavirus infection. To assess the specific contribution of socio-environmental conditions to the spread of coronavirus infection, data from the Federal information Fund for social and hygienic monitoring of the Federal CENTER for hygiene and epidemiology of Rospotrebnadzor were analyzed on indicators of financial security of citizens, quality of health care and sanitary and hygienic conditions. Research has shown that financial security of the population makes a significant contribution to the spread of infection at the first stages. The specific contribution of the quality of medical care, which has a wide differentiation within the regions of Russia, affects only the third stage of the spread of coronavirus infection. Environmental and hygiene indicators make a weak contribution to the spread of Covid-19 in all three stages of the epidemic.

scholarly journals Multisystem inflammatory syndrome in children - a clinical example in pediatrics

2021 ◽  
Vol 25 (2) ◽  
pp. 258-260
Author(s):  
V. M. Dudnyk ◽  
V. Н. Furman ◽  
I. I. Andrikevych ◽  
N. O. Buglova ◽  
O. V. Кutsak ◽  
...  
Keyword(s):  
Serological Test ◽  
World Health ◽  
Rt Pcr ◽  
The Us ◽  
Control And Prevention ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Health Organization ◽  
Inflammatory Syndrome

Annotation. Peculiarities of clinical course and differential diagnosis of multisystem inflammatory syndrome (MIS-C) in children with coronavirus infection are described. The main features of this disease are long-term fever, multiorgan dysfunction, laboratory signs of inflammation and positive tests for SARS-CoV-2 (polymerase chain reaction using reverse transcription (RT-PCR), antigen test or positive serological test). The criteria of the World Health Organization (WHO) and the US Centers for Disease Control and Prevention (CDC) are used to confirm the MIS-C diagnosis.

scholarly journals Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): Epidemiology and Vaccinology in Nigeria

2021 ◽  
Vol 9 (2) ◽  
pp. 60-69
Author(s):  
Ridwan Olamilekan Adesola ◽  
Oluwatobi Emmanuel Oladele ◽  
Ahmed Oluwasegun Tajudeen ◽  
Ogundepo Oluwatobi Moses ◽  
Murali Dinesh
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Viral Infections ◽  
World Health ◽  
Great Level ◽  
Global Public Health ◽  
Wuhan City ◽  
Health Authorities ◽  
Global Pandemic ◽  
The World ◽  
Health Organization

Coronavirus disease 2019 (COVID-19), confirmed as the global pandemic on March 11, 2020, by the World Health Organization (WHO), was caused by the outbreak of an emergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first reported in Wuhan city, China, in December 2019. Based on the previous pandemic, such as severe acute respiratory syndrome (SARS) from 2002 to 2003, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012. The scientific developments have fast-tracked our insights SARS-CoV-2 epidemiology, likewise vaccinology relevant for developing drugs for viral infections treatment. As there are not many detailed interventions and vaccines available for disease control, the pandemic COVID-19 poses countless threats to global public health, causing a great level of insecurity and unrest worldwide. To provide an inclusive overview to global health authorities and prospective readers worldwide, we detailed in this review the epidemiology and vaccinology of SARS-CoV-2 in Nigeria.

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