scholarly journals Osteoarticular system in children with bad posture on the background of hereditary disorders of connective tissue development

2021 ◽  
Vol 7 (3D) ◽  
pp. 264-272
Author(s):  
Anton Metalnikov ◽  
Еlena Romanova ◽  
Sergey Kokhan ◽  
Saule Nurgaliyeva ◽  
Togzhan Kunslyamova ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Frontal Plane ◽  
Preschool Age ◽  
Control Group ◽  
Healthy Children ◽  
Tissue Development ◽  
Internal Organs ◽  
Hereditary Disorders ◽  
And Gender ◽  
The City

The authors of the presented article analyze the pathological manifestations of the osteoarticular system against the background of an existing hereditary disorder of the development of connective tissue. In addition, other changes in the internal organs and the hematopoietic system have been studied. On the basis of the city children's polyclinic, 125 children were registered with a diagnosis of bad posture in the frontal plane against the background of hereditary disorders of the development of connective tissue. They were included in the main group. 30 children of the same age and gender presented a comparison group with a diagnosis of bad posture in the frontal plane without hereditary impairment of connective tissue development. The dynamic observation involved 30 healthy children as a control group.   Changes were observed among children of preschool age at preventive examinations in kindergartens, scheduled outpatient visits. Hypotension of the muscles that straighten the spine and bad posture was diagnosed.

scholarly journals Assessment of heart rate variability and tone of the autonomic nervous system in puberty-aged children with undifferentiated connective tissue dysplasia

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
O V Sidorovich ◽  
S Y U Elizarova ◽  
A V Khizhnyak ◽  
N A Kuznetsova ◽  
E E Prosova
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Connective Tissue ◽  
Control Group ◽  
Healthy Children ◽  
Autonomic Nervous ◽  
Connective Tissue Dysplasia ◽  
End Of Puberty

Abstract   Within the framework of the research into pathological conditions and syndromes associated with undifferentiated connective tissue dysplasia (UCTD), an emphasis needs to be placed on the changes in heart rhythm. In puberty, the severity of neurovegetative disorders caused by the presence of UCTD might increase manifold. The features of heart rate variability (HRV) in pubertal children against the background of UCTD have been studied insufficiently and require more detailed analysis. This study aims to assess heart rate variability and tone of the autonomic nervous system (ANS) in puberty-aged children with UCTD. Two groups of children were examined, with methods including electrocardiography and cardiointervalography. The main group consisted of 36 puberty-aged children with UCTD, the control group consisted of 30 healthy children. ANS tone was assessed based on the HRV. In the control group of children aged 11, the value of variation range (VR) was 0.18±0.4, mode amplitude (MA) 35.2±2.4, stress index (IN) 72.8±4.3, which corresponds to the state of vegetative balance. As the puberty progresses, the state of eutonia is replaced by the activation of the sympathetic division of the ANS, which becomes most pronounced at the age of 13 years. In the control group of children aged 13, the value of VR was 0.08±0.02, MA 61.7±2.1, SI 210.6±8.6, which corresponds to moderate sympathicotonia. By the end of puberty, in healthy children, the severity of sympathetic activation begins to decrease, and at the age of 15 years, vegetative balance is again observed. However, this pattern is violated in children with UCTD. Upon entering puberty, moderate activation of the sympathetic division of the ANS is already observed in children with UCTD. At the age of 11 years in this group, the value of VR is 0.06±0.02, MA 72.4±3.1, SI 211.2±8.6. At the age of 13, pronounced sympathicotonia is observed, which is confirmed by the values of VR - 0.04±0.01, MA 80.2±4.3 and SI 34.3±14.7. By the end of puberty in children with UCTD, in contrast to the control group, the analyzed parameters indicate not an equilibrium of the ANS, but the predominance of parasympathetic activation. The research provides an insight into heart rate variability in puberty-aged children with UCTD. It was established that healthy children enter puberty in a state of equilibrium of the autonomic nervous system, which in the middle of puberty is replaced by moderate sympathicotonia, and then returns to its original values. Children with the presence of UCTD enter puberty with moderately pronounced sympathicotonia, which gradually increases to pronounced values and is replaced by moderate vagotonia. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Effect of treatment on cognitive and attention problems in children with narcolepsy type 1

SLEEP ◽  
2020 ◽  
Vol 43 (12) ◽  
Author(s):  
Karin A M Janssens ◽  
Laury Quaedackers ◽  
Gert Jan Lammers ◽  
Pauline Amesz ◽  
Petra van Mierlo ◽  
...  
Keyword(s):  
Processing Speed ◽  
Attention Problems ◽  
Control Group ◽  
Healthy Children ◽  
Regular Treatment ◽  
Verbal Scale ◽  
Treatment Naïve ◽  
Healthy Control ◽  
And Gender

Abstract Study Objectives To ascertain the presence of cognitive and attention problems in treatment naïve children with narcolepsy type 1 (NT1) and to explore whether children recently diagnosed with NT1 improve with respect to cognition and attention problems 1 year after regular treatment for NT1. Methods A total of 15 treatment naïve children (7–15 years) with recently diagnosed NT1 were recruited from three sleep medicine centers in the Netherlands. The control group consisted of 15 healthy children, being frequency matched on age and gender. Both groups were investigated at baseline to examine intelligence profile (Wechsler Intelligence Scale for Children [WISC] III), attention problems, and processing speed (Bourdon Vos and sustained attention to respond task [SART]). These tests were repeated in children with NT1 1 year after regular (behavioral and medication) treatment for NT1. Results Children with NT1 scored significantly lower on the verbal scale and processing speed subscale of the WISC III, showed more fluctuations in reaction time of the Bourdon Vos and made more mistakes during the SART than the healthy control group at baseline. Children with NT1 significantly improved on total IQ score, and on the WISC indices processing speed, and perceptual organization 1 year after treatment. At follow-up, test scores of treated children were largely comparable to those of the control group at baseline. Conclusions Children with NT1 show improvement in several cognitive domains 1 year after start of treatment. Our findings stress the need for early detection and treatment of narcolepsy in childhood.

Motor development in children with congenital cardiac diseases compared to their healthy peers

2007 ◽  
Vol 17 (5) ◽  
pp. 487-498 ◽  
Author(s):  
Birna Bjarnason-Wehrens ◽  
Sigrid Dordel ◽  
Sabine Schickendantz ◽  
Constanze Krumm ◽  
Daniel Bott ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Motor Development ◽  
Control Group ◽  
P Value ◽  
Healthy Children ◽  
Parental Overprotection ◽  
Coordination Test ◽  
Congenital Cardiac Disease ◽  
The Mean ◽  
And Gender

AbstractTheir perceptual and motor experiences determine the physical and motor development of children, and impact also on their emotional, psychosocial, and cognitive development. Our aim, therefore, was to evaluate motor development in children with congenitally malformed hearts compared to their healthy peers.We compared 194 children, with a mean age of 10.0 years, and standard deviation of 2.7 years, representing the entire spectrum of congenital cardiac disease, to a control group of 455 healthy children, having a mean age 9.6 years, with standard deviation of 2.17 years. The bodily coordination test for children was used to examine motor development.Of the children with congenitally malformed hearts, 26.8% showed moderate, and 31.9% had severe disturbances of motor development, compared to 16.5% and 5.5% of the control group, the p-value for these differences being less than 0.001. The mean motor quotient adjusted for age and gender was lower in the children with congenitally malformed hearts than in their healthy peers, at 79.6, with standard deviation of 18.9 as opposed to 96.6, with standard deviation of 15, this difference having a p-value of less than 0.001. Depending on the presence, and/or the degree, of residual sequels, the children with congenitally malformed hearts were divided into two subgroups, with either no or mild residual sequels, or with significant sequels. The mean motor quotient was lower in those with significant residual sequels, at 75, with standard deviation of 19.3, as opposed to 83, with standard deviation of 17.9, the p-value for this difference being less than 0.01. In both subgroups, the mean motor quotient was lower, with a p-value of less than 0.01, than in the control group.Our findings show that children with congenitally malformed hearts have deficits in their motor development, these being found in the presence of no or mild sequels, as well as with significant residual sequels. Parental overprotection may contribute to these findings.

Seroprevalence of toxocariasis in hypereosinophilic individuals in Ahwaz, south-western Iran

2011 ◽  
Vol 86 (2) ◽  
pp. 241-244 ◽  
Author(s):  
S. Maraghi ◽  
A. Rafiei ◽  
R. Hajihossein ◽  
S. M. Sadjjadi
Keyword(s):  
Western Blot ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Infection Frequency ◽  
Serum Samples ◽  
Western Iran ◽  
And Gender ◽  
The City

AbstractEosinophilia in human peripheral blood is caused by different agents, including toxocariasis. The present study aimed to evaluate the prevalence of toxocariasis in hypereosinophilic individuals in the city of Ahwaz, located in south-western Iran, using enzyme-linked immunosorbent assay and Western blot techniques. Serum samples were examined from 100 individuals with peripheral blood eosinophilia and also from another 100 individuals without eosinophilia as the control group. In hypereosinophilic individuals seroprevalence antibodies against Toxocara were found in 19 (19%), of whom 12 (63.15%) were female and 7 (36.85%) were male. Positive sera were subsequently confirmed by Western blot. All of the observed bands ranged from 24 to 100 kDa. Antibodies against Toxocara were found in 1% of the control group, but were not confirmed by Western blot. The results showed significant differences between the frequency of infection within age and gender (P < 0.05); the highest prevalence of infection was observed in adults. Differences between the hypereosinophilic and healthy individuals, in terms of Toxocara infection frequency, also proved significant (P < 0.05).The present study thus confirmed the significant prevalence of toxocariasis as a hygienic problem among hypereosinophilic individuals in this area. It is, therefore, necessary to examine these individuals for toxocariasis.

The role of interleukin-9 and interleukin-17 in myocarditis with different etiologies

2019 ◽  
Vol 44 (6) ◽  
pp. 797-802
Author(s):  
Tuğba Kandemir Gülmez ◽  
Can Acipayam ◽  
Metin Kilinç ◽  
Nurten Seringeç Akkeçeci
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Troponin I ◽  
Control Group ◽  
Interleukin 17 ◽  
Healthy Children ◽  
Serum Samples ◽  
History Of ◽  
And Gender ◽  
Interleukin 9

Abstract Objective Myocarditis is an inflammatory disease of the cardiac muscle. Prognosis is most often good but, in some patients, the disease can be fulminant. Our aim with this study was to determine interleukin-9 (IL-9) and interleukin-17 (IL-17) levels in myocarditis cases with different etiologies. Materials and methods Thirty one patients with myocarditis and 30 healthy controls of similar age and gender without a history of chronic disease were included in the study. All 31 patients were clinically myocarditis. In some of these patients, the cause of myocarditis is acute rheumatic fever or Kawasaki disease. Serum samples of the patients were taken during diagnosis in order to analyze serum IL-9 and IL-17 levels and sedimentation rate, CRP, ASO, pro-BNP, CK-MB, and Troponin-I tests were performed. Results It was found that IL-17 levels were statistically significant in all acute rheumatic fever, Myocarditis and Kawasaki patients compared to the control group (p = 0.001) and that cut-off was 4.30 pg/mL. This value was determined to be 71% sensitive and 67% specific for IL-17 (AUC = 0.761). Conclusions Both of the mean and median levels of IL-17 were significantly higher in pediatric patients with myocarditis than in healthy children. Our study made us think that complications of myocarditis and associated morbidity can be prevented by IL17 inhibitors. The high levels of IL17 found in our study may be a reference for future study.

Ghrelin and leptin levels in children with anxiety disorders

2019 ◽  
Vol 32 (10) ◽  
pp. 1043-1047 ◽  
Author(s):  
Sevgi Ozmen ◽  
Asilay Şeker ◽  
Esra Demirci
Keyword(s):  
Anxiety Disorders ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Children ◽  
State Trait Anxiety Inventory ◽  
Anxiety Group ◽  
Significant Difference ◽  
Important Health ◽  
And Gender ◽  
Serum Ghrelin

Abstract Background Anxiety disorders are common psychiatric disorders in childhood and an important health problem that is associated with the risk of serious mental, educational and economical problems. Researchers have mentioned many different mechanisms in the etiopathology of anxiety disorders. This study aimed to investigate ghrelin and leptin levels in children with anxiety disorders and thus to contribute to the clarification of anxiety in children. Methods Forty-three children aged 6–12 years with a diagnosis of the Anxiety Disorder according to DSM 5 and 21 healthy children age- and gender-matched to the study group were included. All the subjects were assessed with Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL) and State-Trait Anxiety Inventory for Children (STAI-C) scale. Blood samples were obtained in the morning and serum ghrelin and leptin levels were measured with enzyme-linked immunosorbent assay (ELISA) kits. Results In the anxiety group the ghrelin levels were higher than the control group (p = 0.037) but there was no significant difference between the leptin levels (p = 0.430). Also, when the girls in the anxiety group and the girls in the control group were compared, ghrelin levels were higher in the anxiety group (p < 0.01). Conclusions These findings suggest that ghrelin may play a significant role in the etiologic mechanisms of anxiety disorders. However, more detailed studies are needed to explain the linkage between anxiety disorders and neuropeptides.

scholarly journals Pulse oximetry curves in healthy children living at moderate altitude: a cross-sectional study from the Ecuadorian Andes

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Vinicio Andrade ◽  
Felipe Andrade ◽  
Pablo Riofrio ◽  
Fúlvio B. Nedel ◽  
Miguel Martin ◽  
...  
Keyword(s):  
Pulse Oximetry ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Moderate Altitude ◽  
Sectional Study ◽  
Cross Sectional ◽  
Age And Gender ◽  
Percentile Curve ◽  
And Gender ◽  
The City

Abstract Background In populations above 3,000 meters above sea level (m.a.s.l.) normal values of oxygen saturation (SpO2) above 90% have been reported. Few studies have been conducted in cities of moderate altitude (between 2,500 and 3,000 m a.s.l). We set out to describe the range of SpO2 values measured with a pulse oximeter in healthy children between 1 month and 12 years of age living in an Ecuadorian Andean city. Methods A cross-sectional study was carried out in Quito, Ecuador, located at 2,810 m a.s.l. SpO2 measurement in healthy children of ages ranging from 1 month to 12 years of age residents in the city were recorded by pulse oximetry. Age and gender were recorded, and median and 2.5th and 5th percentile were drawn. Non parametric tests were used to compare differences in SpO2 values by age and gender. Results 1,378 healthy children were included for the study, 719 (52.2%) males. The median SpO2 for the entire population was 94.5%. No differences were observed between SpO2 median values by age and gender. The 2.5th percentile for global SpO2 measurements was 90%, in children under 5 years of age was 91% and it was 90% in children older than 7. Conclusions Our results provide SpO2 values for healthy children from 1 to 12 years old residents in Quito, a city of moderate altitude. The SpO2 percentile curve could contribute as a healthy range for the clinical evaluation of children residing at this altitude.

scholarly journals Pulse oximetry curves in healthy children living at moderate altitude: a cross-sectional study from the Ecuadorian Andes

2020 ◽  
Author(s):  
Vinicio Andrade Mayorga ◽  
Felipe Andrade ◽  
Pablo Riofrío ◽  
Fulvio Nedel ◽  
Miguel Martin ◽  
...  
Keyword(s):  
Pulse Oximetry ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Moderate Altitude ◽  
Sectional Study ◽  
Cross Sectional ◽  
Age And Gender ◽  
Percentile Curve ◽  
And Gender ◽  
The City

Abstract Background In populations above 3,000 meters above sea level (m.a.s.l.) normal values of oxygen saturation (SpO2) above 90% have been reported. Few studies have been conducted in cities of moderate altitude (between 2,500 and 3,000 m a.s.l). We set out to describe the range of SpO2 values measured with a pulse oximeter in healthy children between 1 month and 12 years of age living in an Ecuadorian Andean city. Methods A cross-sectional study was carried out in Quito, Ecuador, located at 2,810 m a.s.l. SpO2 measurement in healthy children of ages ranging from 1 month to 12 years of age residents in the city were recorded by pulse oximetry. Age and gender were recorded, and median and 2.5 th and 5 th percentile were drawn. Non parametric tests were used to compare differences in SpO2 values by age and gender. Results 1,378 healthy children were included for the study, 719 (52.2%) males. The median SpO2 for the entire population was 94.5%. No differences were observed between SpO2 median values by age and gender. The 2.5 th percentile for global SpO2 measurements was 90%, in children under 5 years of age was 91% and it was 90% in children older than 7. Conclusions Our results provide SpO2 values for healthy children from 1 to 12 years old residents in Quito, a city of moderate altitude. The SpO2 percentile curve could contribute as a healthy range for the clinical evaluation of children residing at this altitude.

scholarly journals CLINICAL-LABORATORY MARKERS OF FIBRILOGENESIS DISORDERS IN THE SEVERITY OF PYELONEPHRITIS IN CHILDREN

2018 ◽  
Vol 2 ◽  
pp. 30-38
Author(s):  
Natalia Lukyanenko ◽  
Mariana Iskiv
Keyword(s):  
Connective Tissue ◽  
Acute Pyelonephritis ◽  
Clinical Laboratory ◽  
Joint Hypermobility ◽  
Chronic Pyelonephritis ◽  
Control Group ◽  
Healthy Children ◽  
Laboratory Markers ◽  
Frequent Relapses ◽  
Connective Tissue Dysplasia

Aim of the research: to establish the role of undifferentiated connective tissue dysplasia, as a manifestation of violation of fibrillogenesis, in the severity of the course of pyelonephritis in children. 154 children with pyelonephritis from 3 to 18 years were examined. As a result of catamnestic surveillance, they were divided into 2 groups: I – 92 persons, children with chronic pyelonephritis in which were diagnosed 3 or more episodes of relapse of pyelonephritis during the year, and II – 56 children with acute pyelonephritis, in which during the year no relapses were noted. The control group were 65 somatically healthy children of the same age (III - health-control). All children had a routine comprehensive clinical and laboratory examination and clinical and laboratory markers of a fibrillogenic disorder were established. In children with chronic pyelonephritis, the frequency of all analyzed complaints was significantly higher than in children with acute pyelonephritis without relapses: frequent headaches – 56.52 % versus 25.0 %, appetite loss – 28.26 % vs. 19.64 %, frequent abdominal pain – 52.17 % vr. 32.14 %, increased fatigue – 41.30 % vr. 28.57 %. In children with chronic pyelonephritis, phenotypic signs of undifferentiated connective tissue dysplasia (UCTD) were significantly more marked, such as joint hypermobility (in 52.0 % of children versus 5.4 %), asthenic body structure (59.0 % vs. 26.78 %), visual disturbance (84.8 % vs. 32.14 %), chest deformity (42.4 % vs. 8.9 %), scoliosis (52.17 % vs 10.7 %), arachnodactyly and predisposition to bleeding were observed only in children of the 1st group (22.5 % and 4.34 % respectively). In practically all children with chronic pyelonephritis, the values of free and bound oxyproline fractions in blood plasma were significantly increased (47.14±0.03 μmol/l and 40.08±0.03 μmol/l, respectively), according to arithmetic meanings, reliably differing from the data of children with acute pyelonephritis (17.65±0.01 μmol/l and 17.22±0.02 μmol/l), in which these oxyproline fractions were elevated only in 12.0 % and 16.0 % of the subjects. In 97.0 % of children with chronic pyelonephritis, the level of oxyproline in urine was elevated and significantly exceeded the level of excretion of oxyproline in urine in children with acute pyelonephritis. The presence of UCTD in a child plays an important role in the process of chronic pyelonephritis, and children with its manifestations have a heavier course of disease with frequent relapses, therefore, the presence of signs UCTD is prognostically unsuccessful, which dictates the need for the appointment of metabolic therapy in the first episodes of the disease in children, if they have clinical and laboratory manifestations of UCTD.

scholarly journals Pulse oximetry curves in healthy children living at moderate altitude: a cross-sectional study from the Ecuadorian Andes

2020 ◽  
Author(s):  
Vinicio Andrade Mayorga ◽  
Felipe Andrade ◽  
Pablo Riofrío ◽  
Fulvio Nedel ◽  
Miguel Martin ◽  
...  
Keyword(s):  
Pulse Oximetry ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Moderate Altitude ◽  
Sectional Study ◽  
Cross Sectional ◽  
Age And Gender ◽  
Percentile Curve ◽  
And Gender ◽  
The City

Abstract Background In populations above 3,000 meters above sea level (m.a.s.l.) normal values of oxygen saturation (SpO2) above 90% have been reported. Few studies have been conducted in cities of moderate altitude (between 2,500 and 3,000 m a.s.l). We set out to describe the range of SpO2 values measured with a pulse oximeter in healthy children between 1 month and 12 years of age living in an Ecuadorian Andean city.Methods A cross-sectional study was carried out in Quito, Ecuador, located at 2,800 m a.s.l. SpO2 measurement in healthy children of ages ranging from 1 month to 12 years of age residents in the city were recorded by pulse oximetry. Age and gender were recorded, and median and 2.5th and 5th percentile were drawn. Non parametric tests were used to compare differences in SpO2 values by age and gender.Results 1,378 healthy children were included for the study, 719 (52.2%) males. The median SpO2 for the entire population was 94.5%. No differences were observed between SpO2 median values by age and gender. The 2.5th percentile for global SpO2 measurements was 90%, in children under 5 years of age was 91% and it was 90% in children older than 7. Conclusions Our results provide SpO2 values for healthy children from 1 to 12 years old residents in Quito, a city of moderate altitude. The SpO2 percentile curve could contribute as a healthy range for the clinical evaluation of children residing at this altitude.

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