Proving the Accuracy and Legal Liability of Clinical Laboratory Examination Results Using Automatic Tools

Abstract Background Coronavirus disease 2019 (COVID-19) has caused a global pandemic that has raised worldwide concern. This study aims to investigate the correlation between the extent of lung infection and relevant clinical laboratory testing indicators in COVID-19 and to analyse its underlying mechanism. Methods Chest high-resolution computer tomography (CT) images and laboratory examination data of 31 patients with COVID-19 were extracted, and the lesion areas in CT images were quantitatively segmented and calculated using a deep learning (DL) system. A cross-sectional study method was carried out to explore the differences among the proportions of lung lobe infection and to correlate the percentage of infection (POI) of the whole lung in all patients with clinical laboratory examination values. Results No significant difference in the proportion of infection was noted among various lung lobes (P > 0.05). The POI of total lung was negatively correlated with the peripheral blood lymphocyte percentage (L%) (r = − 0.633, P < 0.001) and lymphocyte (LY) count (r = − 0.555, P = 0.001) but positively correlated with the neutrophil percentage (N%) (r = 0.565, P = 0.001). Otherwise, the POI was not significantly correlated with the peripheral blood white blood cell (WBC) count, monocyte percentage (M%) or haemoglobin (HGB) content. In some patients, as the infection progressed, the L% and LY count decreased progressively accompanied by a continuous increase in the N%. Conclusions Lung lesions in COVID-19 patients are significantly correlated with the peripheral blood lymphocyte and neutrophil levels, both of which could serve as prognostic indicators that provide warning implications, and contribute to clinical interventions in patients.

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On similarity measures for cluster analysis in clinical laboratory examination databases

Proceedings 26th Annual International Computer Software and Applications ◽

10.1109/cmpsac.2002.1045170 ◽

2003 ◽

Cited By ~ 4

Author(s):

S. Hirano ◽

Xiaoguang Sun ◽

S. Tsumoto

Keyword(s):

Cluster Analysis ◽

Clinical Laboratory ◽

Similarity Measures ◽

Laboratory Examination

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APPLICATION OF NEURAL NETWORKS IN MEDICAL DIAGNOSTICS

Laboratornaya i klinicheskaya meditsina. Farmatsiya ◽

10.14489/lcmp.2021.01.pp.040-051 ◽

2021 ◽

pp. 40-51

Author(s):

V. A. Sapozhkov ◽

O. N. Budadin ◽

A. S. Churilova ◽

B. F. Falkov ◽

Zh. Yu. Sapozhkova

Keyword(s):

Artificial Intelligence ◽

Neural Networks ◽

Artificial Neural Networks ◽

Clinical Laboratory ◽

Medical Diagnostics ◽

Automation System ◽

Laboratory Examination ◽

Artificial Neural ◽

Personalized Approach ◽

Diagnostic Outcomes

This article discusses the possibilities of application of artificial neural networks to solve problems of increasing the diagnostic outcomes in clinical laboratory examination. High diagnostic sensitivity (96 %) and diagnostic accuracy (89.5 %) of the results were shown on a large amount of cellular material digitized by artificial intelligence microscopy automation system like the Vision Cyto Pap. The high resolution and sharpness of digital slides, the mode of viewing objects (cells) in the gallery, quick access to the results of preclassification, all of these factors together allow to reduce turnearound time in more than 2.5 times reducing disadvantages of the microscopy.<br>Application of artificial neural networks does not substitute a doctor’s skills. The role in validation of reports eligible only for cytopathologist. This concept indicates a carefully approach for staff working with a microscope, respectful attitude to them professional skills, and highlights a personalized approach to patients.

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THE ISSUE OF TUMOR MARKERS AND THEIR INTERPRETATION

Likarska sprava ◽

10.31640/jvd.3-4.2021(5) ◽

2021 ◽

pp. 42-44

Author(s):

Vira Kazmirchuk ◽

Alex Halkin

Keyword(s):

Tumor Markers ◽

Clinical Laboratory ◽

Progress Report ◽

Laboratory Examination ◽

Current State

The aim of the article is to discuss the current state of informativeness of tumor markers and errors in their interpretation. A progress report is devoted to the analysis of approaches to the interpretation of the results of the clinical laboratory examination of the patient, based on the presence of tumor markers. Particular attention is paid to fundamental errors in making a diagnosis on the basis of tests for tumor markers.

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Substantiation of personified approach to diagnostics, prevention and treatment of metabolic syndrome among inhabitants of Khakassia

Journal of New Medical Technologies eJournal ◽

10.12737/6531 ◽

2014 ◽

Vol 8 (1) ◽

pp. 0-0

Author(s):

Россова ◽

N. Rossova ◽

Иванова ◽

S. Ivanova ◽

Килина ◽

...

Keyword(s):

Metabolic Syndrome ◽

Indigenous People ◽

Additional Data ◽

Indigenous Population ◽

Clinical Laboratory ◽

Visceral Obesity ◽

Laboratory Examination ◽

Ethnic Populations ◽

Prevention And Treatment ◽

Clinically Significant

The article gives the justification of the personified approach to diagnostics, prevention and treatment of metabolic syndrome among inhabitants of Khakassia. The article reveals additional data confirming the phenomenon of a population dimorphism of metabolic syndrome referring to a complex clinical laboratory examination of two ethnic populations living in Khakassia – Khakas who represent the indigenous people originating from Mongoloids and non-indigenous population (Caucasians). The authors demonstrate statistically and clinically significant differences in the frequency of their occurrence and intensity of separate symptoms and cardiovascular complica-tions of metabolic syndrome. It is shown that indigenous people suffering from metabolic syndrome have less intensive visceral obesity in comparison with non-indigenous population. Multiagent metabolic syndrome is estab-lished to prevail among both indigenous and non-indigenous people. The combination of only two agents is consi-derably rarer among Khakas with metabolic syndrome than among non-indigenous inhabitants with this disease. The ultrasonic examination of carotids proves that Khakas suffering from metabolic syndrome have more intensive thickening of intima-media in comparison with the non-indigenous, with less intensive visceral obesity among Khakas. Visceral obesity of Khakas associates with high risk of intima-media thickening (OR=2,95).

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Ultrasound diagnosis of reticular diaphragmatic hernia in bovines

Pesquisa Veterinária Brasileira ◽

10.1590/1678-5150-pvb-6801 ◽

2021 ◽

Vol 41 ◽

Author(s):

Tatiane V. Silva ◽

Jobson Filipe P. Cajueiro ◽

Nivan A.A. Silva ◽

Maria Isabel de Souza ◽

Nivaldo A. Costa ◽

...

Keyword(s):

Diaphragmatic Hernia ◽

Clinical Laboratory ◽

Laboratory Data ◽

Abdominal Distension ◽

Ultrasound Diagnosis ◽

Thoracic Cavity ◽

Lung Sounds ◽

Laboratory Examination ◽

Diaphragmatic Muscle ◽

Bovine Species

ABSTRACT: A reticular diaphragmatic hernia is a congenital or acquired alteration resulting from protrusion of the reticulum into the thoracic cavity. In ruminants, lesions to the diaphragmatic muscle, due to penetration of sharp metallic objects, is the most common cause of this disease. Therefore, given the low number of reports on this disease in the bovine species, the current study aims to describe the clinical, laboratory, and anatomopathological findings, with special emphasis on the ultrasound diagnosis of five cattle with reticular diaphragmatic hernia. The laboratory data were analyzed using mean and standard deviation, and clinical, ultrasound, and pathological findings were evaluated using descriptive statistics. Clinically the animals exhibited varying degrees of dehydration, abdominal distension, tympany, and alterations in ruminal motility, in addition to cardiorespiratory alterations such as murmur, dyspnea, and muffling of lung sounds. The laboratory examination showed neutrophilic leukocytosis and hyperfibrinogenemia. The ultrasonographic images demonstrated reticulum inside the thoracic cavity adjacent to the lung and heart, although no reticular motility was observed. The pathological lesions confirmed the findings of the ultrasound exams. Thus, the current study demonstrated that ultrasonography was efficient in diagnosing reticular diaphragmatic hernia in the bovine species.

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Prevalensi Hiperkolesterolemia Pada Pasien Usia Remaja Di Laboratorium Klinik Thamrin Medan Tahun 2017

Jurnal Ilmiah Biologi UMA (JIBIOMA) ◽

10.31289/jibioma.v1i1.142 ◽

2019 ◽

Vol 1 (1) ◽

pp. 12-16

Author(s):

Dinur Isna Faridha ◽

Ida Fauziah ◽

Mugi Mumpuni

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Old Age ◽

Clinical Laboratory ◽

The State ◽

Laboratory Examination ◽

Normal Limits ◽

Cholesterol Levels ◽

Adolescent Patients ◽

Rule Out

Hypercholesterolemia is a condition where cholesterol levels in the blood exceed normal limits and are a cause of risk of coronary heart disease. Generaly hypercholesterolemia occurs in old age but does not rule out the possibility that it can occur in adolescence. The purpose of this study was to determine the prevalence of hypercholesterolemia in adolescent patients in the Thamrin clinical laboratory in Medan 2017. This study was conducted in June 2018 with descriptive methods obtained by collecting secondary nomina from the results of the patient's laboratory examination. Based on the results of the study of the prevalence of hypercholesterolemia that occurred in adolescents as many as 123 people with a percentage of 17.7% of the number of adolescent patients who visited. The conclusion of this study is the state of hypercholesterolemia can occur in adolescents not only in adulthood and old age.

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Correlation between lung infection severity and clinical laboratory indicators in patients with COVID-19: A cross-sectional study based on machine learning

10.21203/rs.3.rs-23270/v1 ◽

2020 ◽

Author(s):

Xingrui Wang ◽

Qinglin Che ◽

Xiaoxiao Ji ◽

Xinyi Meng ◽

Lang Zhang ◽

...

Keyword(s):

Peripheral Blood ◽

Blood Lymphocyte ◽

Clinical Laboratory ◽

Lung Infection ◽

Cross Sectional Study ◽

Sectional Study ◽

Laboratory Examination ◽

Cross Sectional ◽

Significant Difference ◽

Lung Lobes

Abstract Background: New coronavirus disease (COVID-19) has caused a global pandemic that has raised worldwide concern. This study aims to investigate the correlation between the extent of lung infection and relevant clinical laboratory testing indicators in COVID-19 and to analyse its underlying mechanism.Methods: Chest high-resolution computer tomography (CT) images and laboratory examination data of 31 patients with COVID-19 were extracted, and the lesion areas in CT images were quantitatively segmented and calculated using the deep learning (DL) system. A cross-sectional study method was used to explore the differences among the proportions of lung lobe infection and to correlate the percentage of infection (POI) of the whole lung in all patients with clinical laboratory examination values. Results: No significant difference in the proportion of infection was noted among various lung lobes (P > 0.05). The POI of total lung infection was negatively correlated with the peripheral blood lymphocyte percentage (L%) (r = -0.633, P < 0.0001) and lymphocyte count (LY) (r = -0.555, P = 0.001) but positively correlated with the neutrophil percentage (G%) (r = 0.565, P = 0.001). Otherwise, the POI was not significantly correlated with the peripheral blood leukocyte count (WBC), monocyte percentage (M%) or haemoglobin content (HGB). In some patients, the G% increased continuously and was accompanied by a progressive decrease in the L% and LY.Conclusions: No significant difference in infection propensity was noted among the lung lobes in COVID-19 patients. The peripheral blood lymphocyte and neutrophil levels are significantly correlated with the extent of lung lesions, and related indicator abnormalities serve as a warning, thus guiding the implications of clinical interventions in patients.

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