scholarly journals Development of Methodology of the Heat Sink Thermal Aspect for Low Cost Effective CFD Solutions for Reasonably High Quality Design

2018 ◽  
Vol 8 (3) ◽  
pp. 155-160
Author(s):  
Dasari Govardhan et al., Dasari Govardhan et al., ◽  
Keyword(s):  
Heat Sink ◽  
Low Cost ◽  
Cost Effective ◽  
High Quality ◽  
Quality Design

scholarly journals Indirect Laryngeal Surgery in the Clinical Voice Laboratory: The Renewal of a Lost Art

2000 ◽  
Vol 79 (5) ◽  
pp. 350-361 ◽  
Author(s):  
Norman D. Hogikyan ◽  
Melissa Pynnonen
Keyword(s):  
Cost Effectiveness ◽  
General Anesthesia ◽  
Recent Literature ◽  
Low Cost ◽  
Cost Effective ◽  
Topical Anesthesia ◽  
High Quality ◽  
Advantages And Disadvantages ◽  
Laryngeal Surgery ◽  
Type Of Surgery

Since the advent of precision instruments and safe techniques for direct laryngoscopic surgery under general anesthesia, indirect laryngeal surgery has become very uncommon. A review of the recent literature finds that few authors advocate indirect surgery under topical anesthesia, and many otolaryngologists dismiss this technique as being either of only historical interest or an idiosyncratic method practiced only by a handful of clinicians. The societal mandate for cost-effective healthcare and the availability of relatively low-cost, high-quality endoscopes and video equipment warrant a renewed and broader interest in this type of surgery. In this article, we review a series of 27 indirect surgical procedures performed under topical anesthesia in the clinical voice laboratory. We discuss the indications, outcomes, advantages, and disadvantages of this surgery, and we present a brief analysis of its cost-effectiveness. We conclude that indirect laryngeal surgery in the clinical voice laboratory is an effective, safe, efficient, and less costly alternative to some procedures routinely performed under general anesthesia.

Paarungsstrategien für hochpräzise Produkte*/Pairing strategies for high-precision products - Industrie 4.0 provides opportunities to produce at low cost while meeting growing demands for product precision

2016 ◽  
Vol 106 (11-12) ◽  
pp. 804-808
Author(s):  
R. Wagner ◽  
B. Häfner ◽  
G. Prof. Lanza
Keyword(s):  
Information And Communication Technologies ◽  
Low Cost ◽  
Cost Effective ◽  
Communication Technologies ◽  
Industrie 4.0 ◽  
High Quality ◽  
Quality Requirements ◽  
New Information ◽  
Production Strategies ◽  
Information And Communication

Steigende Anforderungen an die Produktqualität stellen Unternehmen vor die Herausforderung, günstige Produkte nahe der technologischen Fertigungsgrenzen zu produzieren. Die Paarung von Montagekomponenten mit angepassten Produktionsstrategien bietet in diesem Umfeld mögliche Lösungsansätze. Neue Informations- und Kommunikationstechnologien im Kontext von Industrie 4.0 eröffnen hierfür neuartige Möglichkeiten.   Companies are faced with increasing product quality requirements to manufacture high quality products close to technological limits in a cost-effective way. The pairing of assembly components provides an approach to cope with this challenge by adapted production strategies. New information and communication technologies offer novel opportunities within „Industrie 4.0“.

scholarly journals A simple and rapid method for isolating high-quality RNA from kenaf containing high polysaccharide and polyphenol contents

2020 ◽  
Author(s):  
Xiaofang Liao ◽  
Hongwei Li ◽  
Aziz Khan ◽  
Yanhong Zhao ◽  
Wenhuan Hou ◽  
...  
Keyword(s):  
Low Cost ◽  
Rna Extraction ◽  
Rna Isolation ◽  
Cost Effective ◽  
Spectrophotometric Analysis ◽  
Rt Pcr ◽  
High Quality ◽  
Time Saving ◽  
Ctab Method ◽  
Commercial Kits

AbstractThe isolation of high-quality RNA from kenaf is crucial for genetic and molecular biology studies. However, high levels of polysaccharide and polyphenol compounds in kenaf tissues could irreversibly bind to and coprecipitate with RNA, which complicates RNA extraction. In the present study, we proposed a simplified, time-saving and low-cost extraction method for isolating high quantities of high-quality RNA from several different kenaf tissues. RNA quality was measured for yield and purity, and the proposed protocol yielded high quantities of RNA (10.1-12.9 μg/g·FW). Spectrophotometric analysis showed that A260/280 ratios of RNA samples were in the range of 2.11 to 2.13, and A260/230 ratios were in the range of 2.04-2.24, indicating that the RNA samples were free of polyphenols, polysaccharides, and protein contaminants after isolation. The method of RNA extraction presented here was superior to the conventional CTAB method in terms of RNA isolation efficiency and was more sample-adaptable and cost-effective than commercial kits. Furthermore, to confirm downstream amenability, the high-quality RNA obtained from this method was successfully used for RT-PCR, real-time RT-PCR and Northern blot analysis. We provide an efficient and low-cost method for extracting high quantities of high-quality RNA from plants that are rich in polyphenols and polysaccharides, and this method was also validated for the isolation of high-quality RNA from other plants.

scholarly journals Efficient long single molecule sequencing for cost effective and accurate sequencing, haplotyping, and de novo assembly

2018 ◽  
Author(s):  
Ou Wang ◽  
Robert Chin ◽  
Xiaofang Cheng ◽  
Michelle Ka Wu ◽  
Qing Mao ◽  
...  
Keyword(s):  
Single Molecule ◽  
Genome Assembly ◽  
De Novo ◽  
Low Cost ◽  
Variant Calling ◽  
Cost Effective ◽  
High Quality ◽  
Single Molecule Sequencing ◽  
Single Tube ◽  
Complex Structural

Obtaining accurate sequences from long DNA molecules is very important for genome assembly and other applications. Here we describe single tube long fragment read (stLFR), a technology that enables this a low cost. It is based on adding the same barcode sequence to sub-fragments of the original long DNA molecule (DNA co-barcoding). To achieve this efficiently, stLFR uses the surface of microbeads to create millions of miniaturized barcoding reactions in a single tube. Using a combinatorial process up to 3.6 billion unique barcode sequences were generated on beads, enabling practically non-redundant co-barcoding with 50 million barcodes per sample. Using stLFR, we demonstrate efficient unique co-barcoding of over 8 million 20-300 kb genomic DNA fragments. Analysis of the genome of the human genome NA12878 with stLFR demonstrated high quality variant calling and phasing into contigs up to N50 34 Mb. We also demonstrate detection of complex structural variants and complete diploid de novo assembly of NA12878. These analyses were all performed using single stLFR libraries and their construction did not significantly add to the time or cost of whole genome sequencing (WGS) library preparation. stLFR represents an easily automatable solution that enables high quality sequencing, phasing, SV detection, scaffolding, cost-effective diploid de novo genome assembly, and other long DNA sequencing applications.

scholarly journals W2RAP: a pipeline for high quality, robust assemblies of large complex genomes from short read data

2017 ◽  
Author(s):  
Bernardo J. Clavijo ◽  
Gonzalo Garcia Accinelli ◽  
Jonathan Wright ◽  
Darren Heavens ◽  
Katie Barr ◽  
...  
Keyword(s):  
De Novo ◽  
Low Cost ◽  
Cost Effective ◽  
Data Generation ◽  
Sequencing Data ◽  
High Quality ◽  
Crop Species ◽  
Short Read ◽  
Link Type ◽  
Sequencing Technologies

AbstractProducing high-quality whole-genome shotgun de novo assemblies from plant and animal species with large and complex genomes using low-cost short read sequencing technologies remains a challenge. But when the right sequencing data, with appropriate quality control, is assembled using approaches focused on robustness of the process rather than maximization of a single metric such as the usual contiguity estimators, good quality assemblies with informative value for comparative analyses can be produced. Here we present a complete method described from data generation and qc all the way up to scaffold of complex genomes using Illumina short reads and its application to data from plants and human datasets. We show how to use the w2rap pipeline following a metric-guided approach to produce cost-effective assemblies. The assemblies are highly accurate, provide good coverage of the genome and show good short range contiguity. Our pipeline has already enabled the rapid, cost-effective generation of de novo genome assemblies from large, polyploid crop species with a focus on comparative genomics.Availabilityw2rap is available under MIT license, with some subcomponents under GPL-licenses. A ready-to-run docker with all software pre-requisites and example data is also available.http://github.com/bioinfologics/w2raphttp://github.com/bioinfologics/w2rap-contigger

Preparation of Nano α-Fe2O3 Powders and Characterization of their Photo-Catalysis Capacities

2015 ◽  
Vol 645-646 ◽  
pp. 232-237
Author(s):  
Nan Yang Sheng Zhang ◽  
Yan An Zen ◽  
Shuang Bao Wang ◽  
Bing Zhu
Keyword(s):  
Low Cost ◽  
Sol Gel ◽  
Cost Effective ◽  
High Quality ◽  
Gel Method ◽  
Sol Gel Method ◽  
Xrd Diffraction ◽  
Photo Catalysis

The hematite α-Fe2O3 is considered as low cost-effective semiconductor for photo-catalysis recently. We have prepared high quality α-Fe2O3 nanopowder by sol-gel method, as shown by XRD diffraction, we could find that the powder are as small as 5-10nm. We also characterize the photo-catalysis properties on such magnets, which show unique photo-induced catalysis capacity.

scholarly journals Improved de novo Genome Assembly: Linked-Read Sequencing Combined with Optical Mapping Produce a High Quality Mammalian Genome at Relatively Low Cost

2017 ◽  
Author(s):  
DW Mohr ◽  
A Naguib ◽  
NI Weisenfeld ◽  
V Kumar ◽  
P Shah ◽  
...  
Keyword(s):  
Genome Assembly ◽  
De Novo ◽  
Low Cost ◽  
Cost Effective ◽  
Conserved Synteny ◽  
High Quality ◽  
De Novo Genome Assembly ◽  
Optical Maps ◽  
Commercial Applications ◽  
Hybrid Scaffolds

AbstractCurrent short-read methods have come to dominate genome sequencing because they are cost-effective, rapid, and accurate. However, short reads are most applicable when data can be aligned to a known reference. Two new methods for de novo assembly are linked-reads and restriction-site labeled optical maps. We combined commercial applications of these technologies for genome assembly of an endangered mammal, the Hawaiian Monk seal.We show that the linked-reads produced with 10X Genomics Chromium chemistry and assembled with Supernova v1.1 software produced scaffolds with an N50 of 22.23 Mbp with the longest individual scaffold of 84.06 Mbp. When combined with Bionano Genomics optical maps using Bionano RefAligner, the scaffold N50 increased to 29.65 Mbp for a total of 170 hybrid scaffolds, the longest of which was 84.78 Mbp. These results were 161X and 215X, respectively, improved over DISCOVAR de novo assemblies. The quality of the scaffolds was assessed using conserved synteny analysis of both the DNA sequence and predicted seal proteins relative to the genomes of humans and other species. We found large blocks of conserved synteny suggesting that the hybrid scaffolds were high quality. An inversion in one scaffold complementary to human chromosome 6 was found and confirmed by optical maps.The complementarity of linked-reads and optical maps is likely to make the production of high quality genomes more routine and economical and, by doing so, significantly improve our understanding of comparative genome biology.

scholarly journals Upgrades Create Siate-Of-The-Art EPMA Facility

1996 ◽  
Vol 4 (4) ◽  
pp. 18-19
Author(s):  
Larry W. Sarver ◽  
Terry R. McCue
Keyword(s):  
Electron Microprobe ◽  
Driving Force ◽  
Low Cost ◽  
High Technology ◽  
Cost Effective ◽  
Small Companies ◽  
High Quality ◽  
X Ray ◽  
Corporate Customers ◽  
Increase Efficiency

A series of upgrades of an Electron Microprobe X-ray Analyzer (EPMA) were made to expand capabilities, increase efficiency, and cut costs. High technology EPUA features were acquired with cost effective expenditures. The driving force for our upgrade was to meet the continuing needs of corporate customers as well as many small companies which come to us for low-cost/high quality EPMA services.

ASSESSMENT OF THE PLATELET COUNT IN THE PREGNANT WOMEN IN IGIMS, PATNA, BIHAR

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Tanwi Singh ◽  
Anshuman Sinha
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Screening Test ◽  
Low Cost ◽  
Medical Science ◽  
Cost Effective ◽  
Platelet Indices ◽  
Increased Risk ◽  
Low Platelet Count ◽  
Severity Of The Disease

The major risk associated with low platelet count in pregnancy is the increased risk of bleeding during the childbirth or post that. There is an increased blood supply to the uterus during pregnancy and the surgical procedure requires cutting of major blood vessels. Women with thrombocytopenia are at increased risk of losing excessive blood. The risk is more in case of caesarean delivery as compared to vaginal delivery. Hence based on above findings the present study was planned for Assessment of the Platelet Count in the Pregnant Women in IGIMS, Patna, Bihar. The present study was planned in Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India. The present study was planned from duration of January 2019 to June 2019. In the present study 200 pregnant females samples received for the platelet estimation were enrolled in the present study. Clinically platelet indices can be a useful screening test for early identification of preeclampsia and eclampsia. Also platelet indices can assess the prognosis of this disease in pregnant women and can be used as an effective prognostic marker because it correlates with severity of the disease. Platelet count is a simple, low cost, and rapid routine screening test. Hence the data generated from the present study concludes that platelet count can be used as a simple and cost effective tool to monitor the progression of preeclampsia, thereby preventing complications to develop during the gestational period. Keywords: Platelet Count, Pregnant Women, IGIMS, Patna, Bihar, etc.

Janus – A New Approach to Air Combat Pilot Training

2019 ◽  
Vol 2019 (4) ◽  
pp. 7-22
Author(s):  
Georges Bridel ◽  
Zdobyslaw Goraj ◽  
Lukasz Kiszkowiak ◽  
Jean-Georges Brévot ◽  
Jean-Pierre Devaux ◽  
...  
Keyword(s):  
Low Cost ◽  
Cost Effective ◽  
High Energy ◽  
Training System ◽  
Embedded Sensors ◽  
Pilot Training ◽  
New Approach ◽  
Combat Aircraft ◽  
Air Combat ◽  
The Cost

Abstract Advanced jet training still relies on old concepts and solutions that are no longer efficient when considering the current and forthcoming changes in air combat. The cost of those old solutions to develop and maintain combat pilot skills are important, adding even more constraints to the training limitations. The requirement of having a trainer aircraft able to perform also light combat aircraft operational mission is adding unnecessary complexity and cost without any real operational advantages to air combat mission training. Thanks to emerging technologies, the JANUS project will study the feasibility of a brand-new concept of agile manoeuvrable training aircraft and an integrated training system, able to provide a live, virtual and constructive environment. The JANUS concept is based on a lightweight, low-cost, high energy aircraft associated to a ground based Integrated Training System providing simulated and emulated signals, simulated and real opponents, combined with real-time feedback on pilot’s physiological characteristics: traditionally embedded sensors are replaced with emulated signals, simulated opponents are proposed to the pilot, enabling out of sight engagement. JANUS is also providing new cost effective and more realistic solutions for “Red air aircraft” missions, organised in so-called “Aggressor Squadrons”.

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