scholarly journals Grupo de orientação multiprofissional para pacientes transplantados renais e familiares

2021 ◽  
Vol 11 (34) ◽  
pp. 296-306
Author(s):  
Beatriz Pinheiro da Mota Costa ◽  
Alessandra Rosa Vicari ◽  
Carla Elisabete da Silva Oliveira ◽  
Fernanda Guarilha Boni ◽  
Isabel Cristina Echer
Keyword(s):  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Personal Growth ◽  
Family Members ◽  
Structured Interview ◽  
University Hospital ◽  
Transplant Patients ◽  
Group I ◽  
Kidney Transplant Patients ◽  
The Impact

Conhecer a percepção de pacientes e familiares acerca do grupo de orientação multiprofissional para transplantados renais. Método: trata-se de um estudo qualitativo realizado em hospital universitário do sul do Brasil nos meses de fevereiro a maio do ano de 2019. As informações foram coletadas pelos pesquisadores por meio de entrevista estruturada com os participantes do grupo de orientação multiprofissional. Foi realizada a técnica de análise de conteúdo. Resultados: participaram 15 pacientes transplantados renais e quatro familiares. A análise dos depoimentos resultou em três categorias: “Motivação para participar do grupo”, “Sou transplantado renal, e agora?” e “Compreendendo as orientações: o impacto no autocuidado”. As orientações em grupo foram consideradas objetivas, claras e relevantes para a recuperação. Considerações finais: participar do grupo possibilitou estreitamento de laços familiares/profissionais, crescimento pessoal, maior conhecimento sobre o transplante renal, mudança de comportamento e comprometimento com o autocuidado.Descritores: Enfermagem, Transplante de Rim, Equipe de Assistência ao Paciente, Educação em Saúde. Multiprofessional guidance group for kidney and family transplant patientsAbstract: To know the perception of patients and family members about the multiprofessional guidance group for kidney transplant patients. Method: this is a qualitative study carried out at a university hospital in southern Brazil from February to May of 2019. The information was collected by the researchers through a structured interview with the participants of the multiprofessional guidance group. The content analysis technique was performed. Results: 15 kidney transplant patients and four family members participated. The analysis of the testimonies resulted in three categories: “Motivation to participate in the group”, “I am a kidney transplanted, what now?” and “Understanding the guidelines: the impact on self-care”. The group guidelines were considered objective, clear and relevant to recovery. Final considerations: to participate in the group allowed for closer family/professional ties, personal growth, greater knowledge about kidney transplantation, behavior change and commitment to self-care.Descriptors: Nursing, Kidney Transplantation, Patient Care Team, Health Education. Grupo de orientación multiprofesional para pacientes con trasplante renal y familiarResumen: Conocer la percepción de los pacientes y familiares sobre el grupo de orientación multiprofesional para pacientes con trasplante renal. Método: es un estudio cualitativo realizado en un hospital universitario del sur de Brasil de febrero a mayo de 2019. La información fue recolectada por los investigadores mediante una entrevista estructurada con los participantes del grupo de orientación multiprofesional. Se realizó la técnica de análisis de contenido. Resultados: participaron 15 pacientes con trasplante renal y cuatro familiares. El análisis de los testimonios resultó en tres categorías: “Motivación para participar en el grupo”, “Soy un trasplante de riñón, ¿ahora qué?” y “Comprender las pautas: el impacto en el autocuidado”. Las pautas del grupo se consideraron objetivas, claras y relevantes para la recuperación. Consideraciones finales: participar en el grupo permitió estrechar lazos familiares/profesionales, crecimiento personal, mayor conocimiento sobre trasplante de riñón, cambio de comportamiento y compromiso con el autocuidado.Descriptores: Enfermería, Trasplante de Riñón, Grupo de Atención al Paciente, Educación en Salud.

scholarly journals Clinical Relevance of Corticosteroid Withdrawal on Graft Histological Lesions in Low-Immunological-Risk Kidney Transplant Patients

2021 ◽  
Vol 10 (9) ◽  
pp. 2005
Author(s):  
Domingo Hernández ◽  
Juana Alonso-Titos ◽  
Teresa Vázquez ◽  
Myriam León ◽  
Abelardo Caballero ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Rejection Rate ◽  
Open Label ◽  
Post Transplantation ◽  
Protocol Biopsy ◽  
Corticosteroid Withdrawal ◽  
Transplant Patients ◽  
Prospective Phase ◽  
Kidney Transplant Patients ◽  
The Impact

The impact of corticosteroid withdrawal on medium-term graft histological changes in kidney transplant (KT) recipients under standard immunosuppression is uncertain. As part of an open-label, multicenter, prospective, phase IV, 24-month clinical trial (ClinicalTrials.gov, NCT02284464) in low-immunological-risk KT recipients, 105 patients were randomized, after a protocol-biopsy at 3 months, to corticosteroid continuation (CSC, n = 52) or corticosteroid withdrawal (CSW, n = 53). Both groups received tacrolimus and MMF and had another protocol-biopsy at 24 months. The acute rejection rate, including subclinical inflammation (SCI), was comparable between groups (21.2 vs. 24.5%). No patients developed dnDSA. Inflammatory and chronicity scores increased from 3 to 24 months in patients with, at baseline, no inflammation (NI) or SCI, regardless of treatment. CSW patients with SCI at 3 months had a significantly increased chronicity score at 24 months. HbA1c levels were lower in CSW patients (6.4 ± 1.2 vs. 5.7 ± 0.6%; p = 0.013) at 24 months, as was systolic blood pressure (134.2 ± 14.9 vs. 125.7 ± 15.3 mmHg; p = 0.016). Allograft function was comparable between groups and no patients died or lost their graft. An increase in chronicity scores at 2-years post-transplantation was observed in low-immunological-risk KT recipients with initial NI or SCI, but CSW may accelerate chronicity changes, especially in patients with early SCI. This strategy did, however, improve the cardiovascular profiles of patients.

scholarly journals Effect of Remdesivir on COVID-19 PCR Positivity and Cycle Threshold in Kidney Transplant Recipients

2021 ◽  
Vol 2 (3) ◽  
pp. 291-293
Author(s):  
Ryan J. Winstead ◽  
Johanna Christensen ◽  
Sara Sterling ◽  
Megan Morales ◽  
Dhiren Kumar ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cycle Threshold ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Polymerase Chain ◽  
New Diagnosis ◽  
The Impact ◽  
Median Change

Information regarding Coronavirus disease 2019 in the transplant population is lacking. Recently it has been suggested that cycle threshold values obtained on polymerase chain reaction tests may serve as a marker of disease severity with lower values (i.e., higher viral load) being associated with higher mortality. This study was done to assess the impact of remdesivir use on the time to a negative COVID-19 PCR as well as the degree of change between two Ct’s based on treatment. A total of 30 kidney transplant patients with a new diagnosis of COVID-19 were assessed. Serial PCR results were followed from the time of diagnosis then every 2–4 weeks until negative. In patients who received remdesivir immediately after COVID-19 confirmation compared to no remdesivir, time to negative PCR was not statistically different with a median duration of 57 days in both groups (p = 0.369). The change in the Ct between the first and the second PCR test was also not statistically different between groups with a median change of 18.4 cycles in the remdesivir group and 15.7 cycles without remdesivir (p = 0.516). The results of this small single-center analysis suggest that remdesivir may not be beneficial in shortening time to a negative COVID-19 PCR.

Evaluation of Quality of Life among Kidney Transplant Patients- A Cross Sectional Study

2021 ◽  
Vol 15 (11) ◽  
pp. 3087-3089
Author(s):  
Rashida Jabeen ◽  
Kousar Perveen ◽  
Muhammad Afzal ◽  
Sadia Khan
Keyword(s):  
Quality Of Life ◽  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Kidney transplantation is the famous and most important choice of treatment of renal replacement therapies (RRTs) because of its positive impact on morbidity, survival and cost. The health related quality of life is becoming important outcome. Quality of life is usually impaired in patients who have renal transplant because of renal transplant patients have anxiety, lack of social, physical and emotional support and diminished ability to take care of themselves. The basic purpose of renal transplantation is to achieve maximum quality of life with minimum side effects. Methods: A cross sectional study was conducted at Rukhsana Akhtar Bahria International Orchard Hospital Lahore after approval from institution board of university of Lahore. 36 patients were enrolled in study by using purposive sampling technique. After taking informed consent all Kidney transplant patients aged between 18 years to 60 years, visited the post-transplantation OPD and continuously in follow-up sessions were included in study. A validated and standard WHO questionnaire of “Kidney Disease and Quality of Life (KDQOL-36™)” was used for data collection. Data was entered and analyzed in SPSS version.21.Chi-square test was applied to find out significant association between qualitative variables. P -Value < 0.05will be considered as statistically significant. Results: Majority of patients were from 40-49 years 10(27.0%). Females were more as compared to men (20(55.6) vs 16(44.4%)). 10(27.8) patients can read and write and 8(22.2%) have done matriculation. More patients live in Urban area as compared to rural area(19(52.8%) vs 17(47.2%)).8(22.2%) patients have less than 1 year of post kidney transplantation time and 19(52.8%) have 1 to 3 years. All the seven domains of KDQOL show poor QOL. General Health, Physical function and physical and emotional function shows average QOL and Emotional, social, daily activities and overall KDQOL shows poor QOL. There was insignificant association with age, gender, education; residential area and Post kidney transplantation length of time (years)(p-value > 0.05). Conclusions: After renal transplantation HRQOL becomes very important factor. After kidney transplantation HRQOL depends on many factors. It was concluded from current study that the HRQOL was not as good as it should be. Over the period of transplantation time patient’s quality of life remain same. The society, government, family, and medical staff need to support patients so they can also improve their QOL. Key word: Renal Diseases, Kidney transplant, Quality of life, KDQOL-36

RETROSPECTIVE STUDY ON THE IMPACT OF HEPATITIS C VIRUS INFECTION ON KIDNEY TRANSPLANT PATIENTS OVER 20 YEARS

1998 ◽  
Vol 66 (4) ◽  
pp. 471-476 ◽  
Author(s):  
Touru Hanafusa ◽  
Yasuji Ichikawa ◽  
Hidefumi Kishikawa ◽  
Masahiro Kyo ◽  
Takanobu Fukunishi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Retrospective Study ◽  
Hepatitis C ◽  
Virus Infection ◽  
Kidney Transplant ◽  
Hepatitis C Virus Infection ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
The Impact

scholarly journals Effect of CYP3A4*22, POR*28, and PPARA rs4253728 on Sirolimus In Vitro Metabolism and Trough Concentrations in Kidney Transplant Recipients

2013 ◽  
Vol 59 (12) ◽  
pp. 1761-1769 ◽  
Author(s):  
Jean-Baptiste Woillard ◽  
Nassim Kamar ◽  
Sandra Coste ◽  
Lionel Rostaing ◽  
Pierre Marquet ◽  
...  
Keyword(s):  
Adverse Events ◽  
Kidney Transplant ◽  
Calcineurin Inhibitor ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Trough Concentrations ◽  
The Impact

BACKGROUND Recent studies have identified new candidate polymorphisms in the genes related to CYP3A activity or calcineurin inhibitor dose requirements in kidney transplant recipients. These genes and polymorphisms are CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) (rs35599367-C&gt;T; *22); POR [P450 (cytochrome) oxidoreductase] (rs1057868-C&gt;T; *28); and PPARA (peroxisome proliferator-activated receptor alpha) (rs4253728-G&gt;A). We investigated the impact of these polymorphisms on sirolimus (SRL) in vitro hepatic metabolism, SRL trough concentrations (C0), and SRL adverse events in kidney transplant recipients. METHODS The clinical study included 113 stable kidney transplant patients switched from a calcineurin inhibitor to SRL (SRL C0 measured at 1, 3, and 6 months thereafter). We investigated SRL metabolism in vitro using human liver microsomes derived from individual donors (n = 31). Microsomes and patients were genotyped by use of Taqman® allelic discrimination assays. The effects of polymorphisms and covariates were studied using multilinear regression imbedded in linear mixed-effect models or logistic regressions. RESULTS In vitro, the CYP3A4*22 allele resulted in approximately 20% lower metabolic rates of SRL (P = 0.0411). No significant association was found between CYP3A4, CYP3A5, or PPARA genotypes and SRL dose, C0, or C0/dose in kidney transplant patients. POR*28 was associated with a minor but significant decrease in SRL log-transformed C0 [CT/TT vs CC, β = −0.15 (0.05); P = 0.0197] but this did not have any impact on the dose administered, which limited the relevance of the finding. After adjustment for nongenetic covariates and correction for false discovery finding, none of the single-nucleotide polymorphisms tested showed significant association with SRL adverse events. CONCLUSIONS These recently described polymorphisms do not seem to substantially influence the pharmacokinetics of SRL or the occurrence of SRL adverse events in kidney transplant recipients.

scholarly journals Nursing Care for Kidney Transplant Patients: A Scoping Review

Aquichan ◽  
2021 ◽  
Vol 21 (3) ◽  
pp. 1-15
Author(s):  
Cintia Capistrano Teixeira Rocha ◽  
Alcides Viana da Lima Neto ◽  
Ana Beatriz Pereira da Silva ◽  
Victor Alexandre Silva Farias ◽  
Aurean D’Eça Junior ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Nursing Care ◽  
Scoping Review ◽  
Scientific Rigor ◽  
Transplant Patients ◽  
Primary Health ◽  
Study Results ◽  
Kidney Transplant Patients ◽  
Selection Of

Objectives: Mapping nursing care in kidney transplant patients. Materials and method: A scoping review was conducted according to the recommendations of the Joanna Briggs Institute Reviewers’ Manual. Data were collected through 13 national and international databases from December 2020 to January 2021, following scientific rigor in the selection of the material. The pre-selection was made by reading the title, abstract and introductory text in advance; the materials included in this stage were read in full to define the content for the study. Results: Fifteen studies were included. Of these, 60% are articles; dissertations, manuals, protocols, guidelines and bulletins totaled 40% of the material studied. 86.6% of the material has a quantitative approach. Regarding the methodological design, 73.3% were descriptive/transversal character studies. Regarding the mapping of nursing care, it was possible to divide them into two categories: nursing care after kidney transplantation (immediate, mediated and late) and nursing care after kidney transplantation in primary health/extra-hospital care. Conclusions: It is concluded that the study allowed mapping nursing care to kidney transplant patients in the immediate, late and primary health care periods.

scholarly journals The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients

2014 ◽  
Vol 29 (8) ◽  
pp. 1587-1597 ◽  
Author(s):  
A. P. Bouvy ◽  
M. Klepper ◽  
M. M. L. Kho ◽  
K. Boer ◽  
M. G. H. Betjes ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Kidney Transplant ◽  
Induction Therapy ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
And Function ◽  
The Impact

Group Therapy for Kidney Transplant Patients

1975 ◽  
Vol 6 (4) ◽  
pp. 523-531 ◽  
Author(s):  
Denton C. Buchanan
Keyword(s):  
Group Therapy ◽  
Kidney Transplant ◽  
Interpersonal Relations ◽  
Psychiatric Patients ◽  
Family Members ◽  
Transplant Patients ◽  
Therapy Program ◽  
The Future ◽  
Kidney Transplant Patients ◽  
General Experience

A short-term, open membership group therapy program for kidney transplant patients and their families is described. The content and process of this group is related to the ten curative factors described by Yalom for psychiatric patients. The primary benefits for the patients seemed to be the opportunity to observe others cope with similar problems and to learn of the adaptive strategies used by others. The patients were able to offer advice to others, to overcome their tendency toward seclusion and in general, experience a feeling of hope for the future. The family members gained more from a sense of group cohesiveness than did the patients. Both family and patients utilized the meetings to ventilate their anger and frustrations associated with chronic illness and to learn more about transplantation. A more realistic expectation of the future was provided. The group did not seem long enough to measurably improve the interpersonal relations between patients and their families nor did the group members comment upon maladaptive behaviors exhibited between family members within the meetings.

scholarly journals The impact of calcineurin inhibitors and mammalian target of rapamycininhibitors on anxiety and depression scores in kidney transplant patients

2016 ◽  
Vol 46 ◽  
pp. 1341-1347 ◽  
Author(s):  
Ebru GÖK OĞUZ ◽  
Gülay ULUSAL OKYAY ◽  
Hadim AKOĞLU ◽  
Güner KARAVELİ GÜRSOY ◽  
Zafer ERCAN ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Calcineurin Inhibitors ◽  
Anxiety And Depression ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
The Impact

scholarly journals Pretransplant dialysis treatment and vascular calcification of the iliac artery and abdominal aorta in kidney transplant patients

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kentaro Nakai ◽  
Shutaro Yamamoto ◽  
Megumi Inoue ◽  
Chiaki Kohara ◽  
Tomoya Shukuri ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Vascular Calcification ◽  
Treatment Modality ◽  
Rapid Progression ◽  
Dialysis Modality ◽  
Dialysis Treatment ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Abstract Introduction Patients with chronic kidney disease often suffer from cardiovascular disease, and vascular calcification has been identified as one of the risk factors for cardiovascular disease. We aimed to examine the effect of dialysis treatment before kidney transplantation on graft survival, vascular calcification, and its progression after kidney transplantation. Methods Among the 102 patients who underwent kidney transplant between 2008 and 2017, two patients were excluded for moved and lost to follow-up and primary nonfunction. The clinical characteristics and laboratory data were assessed according to pretransplant treatment modality. Rapid progression of vascular calcification was defined when patients showed an increase in the highest tertile of progression of each iliac artery calcification thickness (IACT) and aortic calcification index (ACI). Results Cox proportional hazard models did not show any significant association between pretransplant treatment modality and graft survival to the doubling of creatinine from nadir creatinine during the first 3 months after kidney transplantation. At baseline, the IACT was significantly higher in hemodialysis patients than in preemptive kidney transplant patients, whereas the ACI was comparable among the pretransplant treatment modality groups. IACT was independently associated with dialysis vintage. There was no significant association between rapid progression of vascular calcification (IACT and ACI) and dialysis modality. Conclusions Dialysis modality was an independent factor related to IACT, whereas there was no legacy effect for the progression of vascular calcification after kidney transplantation.

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