scholarly journals Efetividade da terapia com vitamina D em idosos com depressão

2021 ◽  
Vol 6 (10) ◽  
pp. 33-41
Author(s):  
André Oliveira Ferro ◽  
Mariana Soares de Araújo ◽  
Érika Ruanna Alencar da Silva ◽  
Flávia Thalia Guedes Farias ◽  
Ana Julya César Rodrigues ◽  
...  
Keyword(s):  
Vitamin D ◽  
Elderly People ◽  
Randomized Clinical Trials ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Eligibility Criteria ◽  
Vascular Depression ◽  
Vitamina D ◽  
Final Sample ◽  
Revisión Sistemática

Analisar a efetividade da terapia com vitamina D em idosos com depressão, em comparação ao uso de placebos. Revisão sistemática de literatura. Para seu desenvolvimento, efetuou-se pesquisa em bases de dados para a saúde, seguida da aplicação dos critérios de elegibilidade, considerando textos completos em inglês, português e Ensaios Clínicos Randomizados publicados entre 2008-2020. Em sequência, mediante leitura dos títulos e resumos aos pares, seis publicações compuseram a amostragem final. Os achados indicaram, majoritariamente, inexistir diferenças significativas entre os sintomas depressivos em idosos suplementados com a vitamina D em comparação ao uso do placebo. Os achados não mostraram evidências significativas, atestando que a suplementação da vitamina D não refletiu melhores resultados para a depressão em idosos. Contudo, importante mencionar que uma publicação registrou melhorias em pacientes dialíticos com depressão vascular, melhorando o funcionamento cardiovascular desses pacientes após a suplementação.Descritores: Vitamina D, Depressão, Idosos. Effectiveness of vitamin d therapy in elderly people with depressionAbstract: To analyze the effectiveness of vitamin D therapy in elderly people with depression, compared to the use of placebos. Systematic literature review. For the development of the study, a search was performed in the health’s databases, followed by the application of the eligibility criteria, considering the complete texts in English and Portuguese; Randomized Clinical Trials published between the 2008-2020. In sequence, through the reading of the titles and abstracts in pairs, six publications made up the final sample. The selected articles stated that there were no significant differences between depressive symptoms in the elderly related to vitamin D supplementation compared to the use of placebo. The findings showed no significant evidence, attesting that vitamin D supplementation did not reflect better results for depression in the elderly. However, it is important to mention that one publication recorded improvements in dialysis patients with vascular depression, improving the cardiovascular functioning of these patients after supplementation.Descriptors: Vitamin D, Depression, Seniors. Efectividad de la terapia con vitamina d en ancianos con depresiónResumen: Analizar la efectividad de la terapia con vitamina D en ancianos con depresión, en comparación con el uso de placebos. Revisión sistemática de la literatura. Para el desarrollo del estudio se realizó una búsqueda en las bases de datos de salud, seguida de la aplicación de los criterios de elegibilidad, considerando los textos completos en inglés y portugués; ensayos clínicos aleatorizados publicados entre 2008-2020. En secuencia, mediante la lectura de títulos y resúmenes por parejas, seis publicaciones conformaron la muestra final. Los artículos seleccionados indicaron que no hubo diferencias significativas entre los síntomas depresivos en los ancianos relacionados con la suplementación con vitamina D en comparación con el uso de placebo. Los hallazgos no mostraron evidencia significativa, lo que atestigua que la suplementación con vitamina D no reflejaba mejores resultados para la depresión en los ancianos. Sin embargo, es importante mencionar que una publicación registró mejoras en pacientes de diálisis con depresión vascular, mejorando el funcionamiento cardiovascular de estos pacientes después de la suplementación.Descriptores: Vitamina D, Depresión, Mayores.

scholarly journals Vitamin D deficiency in elderly people in Swedish nursing homes is associated with increased mortality

2014 ◽  
Vol 170 (5) ◽  
pp. 667-675 ◽  
Author(s):  
Maria Samefors ◽  
Carl Johan Östgren ◽  
Sigvard Mölstad ◽  
Christina Lannering ◽  
Patrik Midlöv ◽  
...  
Keyword(s):  
Vitamin D ◽  
Nursing Homes ◽  
Vitamin D Deficiency ◽  
Elderly People ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Hydroxyvitamin D ◽  
Northern Latitudes ◽  
Hazard Ratios ◽  
Vitamin D Levels

ObjectiveInstitutionalised elderly people at northern latitudes may be at elevated risk for vitamin D deficiency. In addition to osteoporosis-related disorders, vitamin D deficiency may influence several medical conditions conferring an increased mortality risk. The aim of this study was to explore the prevalence of vitamin D deficiency and its association with mortality.DesignThe Study of Health and Drugs in the Elderly (SHADES) is a prospective cohort study among elderly people (>65 years) in 11 nursing homes in Sweden.MethodsWe analysed the levels of 25-hydroxyvitamin D3(25(OH)D3) at baseline. Vital status of the subjects was ascertained and hazard ratios (HRs) for mortality according to 25(OH)D3quartiles were calculated.ResultsWe examined 333 study participants with a mean follow-up of 3 years. A total of 147 (44%) patients died within this period. Compared with the subjects in Q4 (25(OH)D3>48 nmol/l), HR (with 95% CI) for mortality was 2.02 (1.31–3.12) in Q1 (25(OH)D3<29 nmol/l) (P<0.05); 2.03 (1.32–3.14) in Q2 (25(OH)D330–37 nmol/l) (P<0.05) and 1.6 (1.03–2.48) in Q3 (25(OH)D338–47 nmol/l) (P<0.05). The mean 25(OH)D3concentration was 40.2 nmol/l (s.d. 16.0) and 80% had 25(OH)D3below 50 nmol/l. The vitamin D levels decreased from baseline to the second and third measurements.ConclusionsVitamin D deficiency was highly prevalent and associated with increased mortality among the elderly in Swedish nursing homes. Strategies are needed to prevent, and maybe treat, vitamin D deficiency in the elderly in nursing homes and the benefit of vitamin D supplementation should be evaluated in randomised clinical trials.

scholarly journals Vitamin D levels and risk of COVID-19 infection: A systematic review

2021 ◽  
Vol 19 (2) ◽  
pp. 83-90
Author(s):  
Ana C. Coelho-Oliveira ◽  
Bruno B. Monteiro-Oliveira ◽  
Rebeca B. M. Cavalcante ◽  
Daniel B. Santos ◽  
Anelise Sonza ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Randomized Clinical Trials ◽  
Vitamin D Supplementation ◽  
Eligibility Criteria ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Novel Coronavirus ◽  
Tract Infections

Objective: Consistent independent associations between lowserum 25-hydroxyvitamin D concentrations and susceptibilityto acute respiratory tract infections have suggested apossible involvement of vitamin D in reducing the risk ofrespiratory infections and proposing its replacement as apotential strategy for prevention or treatment in this context.However, the role of vitamin D supplementation in theinfection by the novel coronavirus named SARS-CoV-2 isstill under investigation and no clinical evidence has beenreported to date. Methods: Electronic searches in Pubmed,Embase and Scopus databases were conducted and threecohort studies that analyzed the effects of interaction ofvitamin D with COVID-19, published only in English, wereincluded. Two reviewers, which independently examinedtitles and abstracts, identified records through database searchand reference screening and irrelevant studies were excludedbased in eligibility criteria. Relevant full texts were analyzedfor eligibility, and all relevant studies were included in thesystematic review. Results: Three cohort studies were includedin this systematic review with a mean methodologicalquality low. Only one study demonstrated interaction of lowvitamin D concentration in patients with a positive diagnosisfor COVID-19. Randomized clinical trials and studies of goodmethodological quality are necessary to confirm the findingsof this systematic review. Conclusions: This systematic reviewhas not demonstrated consistent associations between lowlevels of vitamin D and susceptibility to COVID-19 infection.Further studies on vitamin D supplementation for the preventionof COVID-19 infection should be conducted..

scholarly journals Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Rolf Jorde ◽  
Moira Strand Hutchinson ◽  
Marie Kjærgaard ◽  
Monica Sneve ◽  
Guri Grimnes
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Lipids ◽  
Randomized Clinical Trials ◽  
High Sensitivity ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Negative Effects ◽  
The Mean ◽  
Hs Crp

Data were pooled from four randomized clinical trials with vitamin D performed in Tromsø with weight reduction, insulin sensitivity, bone density, and depression scores as endpoints. Serum lipids, glycated hemoglobin (HbA1c), and high sensitivity C-Reactive Protein, (HS-CRP) were measured at baseline and after 6–12 months of supplementation with vitamin D 20 000 IU–40 000 IU per week versus placebo. A total of 928 subjects who completed the interventions were included. At baseline the mean serum 25-hydroxyvitamin D (25(OH)D) level in those given vitamin D was 55.9 (20.9) nmol/L and the mean increase was 82.4 (40.1) nmol/L. Compared with the placebo group there was in the vitamin D group at the end of the studies a slight, but significant, increase in HbA1c of 0.04%, an increase in HS-CRP of 0.07 mg/L in those with serum 25(OH)D < 50 nmol/L, and in those with low baseline HDL-C and serum 25(OH)D < 50 nmol/L a slight decrease serum HDL-C of 0.08 mmol/L (P<0.05). No serious side-effects were seen. In conclusion, in subjects without vitamin D deficiency, there is no improvement in serum lipids, HbA1c, or HS-CRP with high dose vitamin D supplementation. If anything, the effect is negative.

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

Blood ◽  
2011 ◽  
Vol 117 (10) ◽  
pp. 2800-2806 ◽  
Author(s):  
Todd S. Perlstein ◽  
Reena Pande ◽  
Nancy Berliner ◽  
Gary J. Vanasse
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
World Health ◽  
Elderly Persons ◽  
Increased Risk ◽  
Health Organization ◽  
Anemia Of Inflammation

AbstractAnemia and vitamin D deficiency are conditions that both result in significant morbidity and increase with age. The potential relationship between them remains poorly understood, particularly in the elderly. We used the Third National Health and Nutrition Examination Survey to examine the association of vitamin D deficiency with anemia subtypes in persons aged ≥ 60 years. Vitamin D deficiency was defined as serum levels < 20 ng/mL, and anemia was defined according to World Health Organization criteria. Vitamin D deficiency was associated with anemia prevalence independent of age, sex, or race/ethnicity (odds ratio, 1.47; 95% confidence interval, 1.06-2.05; P = .02) and varied significantly by anemia subtype (P overall = .003). The prevalence of vitamin D deficiency was 33.3% in the nonanemic population, 56% in anemia of inflammation (AI; P = .008), and 33.0% in unexplained anemia (P = .55). Non-Hispanic blacks had a 7-fold increased risk of AI compared with whites, and this was partially attenuated after adjusting for vitamin D deficiency. These data show that vitamin D deficiency is associated with specific subtypes of anemia in the elderly, especially in those with AI. Vitamin D may suppress inflammatory pathways, and studies to determine whether vitamin D supplementation ameliorates AI are warranted.

scholarly journals Effectiveness of Vitamin D Supplementation in the Management of Multiple Sclerosis: A Systematic Review

2019 ◽  
Vol 20 (6) ◽  
pp. 1301 ◽  
Author(s):  
Monika Berezowska ◽  
Shelly Coe ◽  
Helen Dawes
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Eligibility Criteria ◽  
Serious Adverse Events ◽  
Baseline Serum ◽  
Lower Baseline ◽  
Vitamin D Levels ◽  
Disability Status ◽  
Randomised Control Trials

Objective: to examine the extent of effect vitamin D in Multiple Sclerosis (MS) on pathology and symptoms. Methods: A literature search was performed in November 2018 (CRD42018103615). Eligibility criteria: randomised control trials in English from 2012 to 2018; a clinical diagnosis of MS; interventions containing vitamin D supplementation (vitamin D3 or calcitriol) in disease activity compared to a control/placebo; improvement in: serum 25(OH)D, relapse rates, disability status by Expanded Disability Status Scale (EDSS) scores, cytokine profile, quality of life, mobility, T2 lesion load and new T2 or T1 Gd enhancing lesions, safety and adverse effects. Risk of bias was evaluated. Results: Ten studies were selected. The study size ranged from 40 to 94 people. All studies evaluated the use of vitamin D supplementation (ranging from 10 to 98,000 IU), comparing to a placebo or low dose vitamin D. The duration of the intervention ranged from 12 to 96 weeks. One trial found a significant effect on EDSS score, three demonstrated a significant change in serum cytokines level, one found benefits to current enhancing lesions and three studies evaluating the safety and tolerability of vitamin D reported no serious adverse events. Disease measures improved to a greater extent overall in those with lower baseline serum 25(OH)D levels. Conclusions: As shown in 3 out of 10 studies, improvement in disease measures may be more apparent in those with lower baseline vitamin D levels.

scholarly journals Vitamin D supplementation and growth in urban Mongol school children: Results from two randomized clinical trials

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0175237 ◽  
Author(s):  
Davaasambuu Ganmaa ◽  
Jennifer J. Stuart ◽  
Nyamjav Sumberzul ◽  
Boldbaatar Ninjin ◽  
Edward Giovannucci ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Trials ◽  
School Children ◽  
Randomized Clinical Trials ◽  
Vitamin D Supplementation
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