scholarly journals Correlation of C3c complement, NT-proBNP and Left Ventricle Ejection Fraction (LVEF) in Heart Failure

Author(s):  
Julious Julious ◽  
Jusak Nugraha ◽  
Mohammad Aminuddin

Introduction. Heart failure is a health problem in Indonesia. The 2013 Basic Health Research Data showed that the estimated heart failure in Indonesia was 530,068 people. Echocardiography examination which has been a routine examination of heart failure patients is not necessarily available in all hospitals, so that a more applicable and inexpensive alternative examination is needed. Previous studies have shown an increase in C3c levels associated with improved survival and better cardiac remodeling. On this basis, this research needs to be performed in order to determine the correlation between C3c complement levels, NT-proBNP and LVEF in heart failure patients. Method. A cross-sectional study was conducted at the Dr Soetomo Hospital between August 2018 to September 2018 with 30 samples. Samples were taken consecutively from patients with heart failure who were treated at the integrated heart service center. Examination of C3c complement, NT-proBNP and echocardiography (LVEF data) was carried out in all patients. Result. The result of this study showed no significant correlation between C3c complement and NT-proBNP (r = -0.253, p = 0.177). The correlation between C3c complement and LVEF was also not significant (r = -0.074, p = 0.696). A significant moderate correlation between NT-proBNP and LVEF was found (r = -0.444, p = 0.014). Conclusion. The C3c complement could not be used as an alternative examination for NT-proBNP and LVEF. The limitations of the study were heterogeneous sample characteristics. A further study with more stringent criteria is needed to minimize the bias of examination results.

2021 ◽  
Vol 15 (11) ◽  
pp. 3261-3264
Author(s):  
Syed Mohammad Haleem ◽  
Muhammad Hashim Kalwar ◽  
Muhammad Hassan Butt ◽  
Jehangir Hasan ◽  
Javed Khurshed Shaikh ◽  
...  

Background: An increasing number of people around the world suffer from cardiovascular diseases such as atrial fibrillation (AF) and heart failure (HF). Atrial fibrillation (AF) has been linked to poor prognosis in heart failure (HF) patients with mild to moderate LV dysfunction, and it is most prominent in these patients. Despite advancements in care and treatment options like catheter ablation, managing AF is still a therapeutic challenge even with these advances. Aim/Objective: To determine the frequency of atrial fibrillation in heart failure patients. Subjects and Methods: This cross-sectional study was conducted on 246 patients at Adult Cardiology, NICVD, Karachi for Six months after approval from 31-08-2019 till 29-02-2020. Patients' consent was obtained verbally before data were collected prospectively. There were 246 patients with heart failure who had been diagnosed and met the diagnostic criteria. An overview of the event's history was gathered, as well as demographic data. Qualitative variables were presented as frequency and percentages, while quantitative data were given as simple descriptive statistics such as mean and standard deviation. A p-value of 0.05 or lower is considered statistically significant. Results: A total of 246 patients with heart failure were included in this study. The mean age in our study was 56.78±2.81 years. Whereas, mean BNP and ejection fraction in our study was 1144±87.81 pg./ml and 34.65±4.14 %. 136 (55.3%) were male and 110 (44.7%) were female. Out of 246 patients with heart failure, 52 (21.1%) had atrial fibrillation and 194 (78.9%) did not have atrial fibrillation. Conclusion: The results of this research demonstrated that a large percentage of heart failure patients had atrial fibrillation. Thus, it is essential to focus on a comprehensive way of management of heart failure and its comorbidities rather than primarily treating the cardiac symptoms. Keywords: Heart failure and atrial fibrillation.


BMJ Open ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. e009775 ◽  
Author(s):  
Harriet Nankabirwa ◽  
Robert Kalyesubula ◽  
Isaac Ssinabulya ◽  
Elly T Katabira ◽  
Robert G Cumming

2017 ◽  
Vol 23 (10) ◽  
pp. S9
Author(s):  
Takuji Adachi ◽  
Kotaro Iwatsu ◽  
Ryoko Fujita ◽  
Kenta Kamisaka ◽  
Eisaku Nakane ◽  
...  

Author(s):  
Nazuk Eraj Qureshi ◽  
Simran Batra ◽  
Muhammad Tanzeel Ul Haque ◽  
Javeria Saquib ◽  
Noorulain Qureshi ◽  
...  

Aims: Congestive heart failure affects about five million Americans and has become an increasingly frequent reason for hospital admission during the last two decades. It represents a significant health problem. The aim of this study was to enumerate the frequency of self-care and to study the factors affecting adherence to self-care in patients with heart failure. Study Design: Cross-sectional study. Place and Duration of Study: Department of Cardiology and Department of Medicine in three public sector hospitals of Karachi, between March 2020 and September 2020. Methodology: In this study, 187 heart failure patients from three hospitals were surveyed with consent. Demographic details of the participants were also collected, which included gender, mean age, BMI, education, living and marital status, smoking history, an ejection fraction <40, cancer, chronic kidney disease, diabetes mellitus, hypertension, dyslipidemia, atrial fibrillation, and coronary artery bypass graft procedure in patients. The data were analyzed through SPSS v. 25.0 using an adherence scale. A cumulative score of ≥32/40 (80%) was termed as good adherence. In an individual question, a score of four or five and zero to three inclusive was taken as good and poor adherence, respectively. Results: It was found that patients who were not educated (65.8%, n=123), with age > 65years (67.4%, n=126) and with no history of coronary artery bypass grafting surgery (94.1%, n=176) had a significantly bad impact on heart-failure self-care (P-value<0.05). Good adherence was seen in 16.6% of the patients (n=31). Hence, most of the patients were non-adherent. Conclusion: There is an urgent need to counsel patients regarding heart failure self-care for a better prognosis of the disease. Government and doctors together should take part in enlightening the issue.


Sign in / Sign up

Export Citation Format

Share Document