scholarly journals Preparation, characterization, antibacterial and antifungal activities of some transition metal complexes with novel Schiff base ligand derived from N-amino rhodanine

2016 ◽  
Vol 11 (7) ◽  
pp. 3723-3728
Author(s):  
Soleiman Mahjoub ◽  
Sara Ansari ◽  
Felora Heshmatpour
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Bacterial Species ◽  
Inhibition Zone ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Fungal Species ◽  
Diffusion Method ◽  
Experimental Conditions

The Schiff base ligand (E)-3-(2-methoxy benzylidene amino)-2-thioxothiazolidin-4-one (L), was prepared from N-amino rhodanine and 2-methoxy benzaldehyde . Moreover, Its complexes were synthesized by mixing metal chloride Co(II), Cu(II), Ni(II) with the prepared Schiff base ligand. These compounds were characterized by FTIR, 1H NMR, and elemental analysis. The antimicrobial activity of the ligand and its complexes were tested using four pathogenic bacterial and two fungal species. The bacterial species used in the screening were Salmonella typhi and Vibrio cholera (gram negative) and Staphylococcus aureus and Bacillus subtilis (gram-positive). The fungal species were Aspergillus flavus and Aspergillus nigar. The antimicrobial activities of the ligand and its metal complexes were studied by disc agar diffusion method and compared with Ampicillin. Diameter of inhibition zone (mm) including the disc diameter was measured for each treatment. The findings indicated that the CuL, NiL and CoL complexes have good biological activity but the ligand (L) did not had any activity against the microorganisms under identical experimental conditions.

scholarly journals Synthesis, characterization, thermal, theoretical and antimicrobial studies of Schiff base ligand and its Co(II) and Cu(II) complexes

2020 ◽  
Vol 85 (2) ◽  
pp. 215-225 ◽  
Author(s):  
Palaniswamy Venkittapuram ◽  
Mahalakshmi Dhandapani ◽  
Jonekirubavathy Suyambulingam ◽  
Chitra Subramanian
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Bacterial Species ◽  
Thermal Analyses ◽  
Fungal Species ◽  
Basis Sets ◽  
Chloride Salt ◽  
Antimicrobial Studies ◽  
Ft Ir

A Schiff base ligand L was synthesized by condensation of 1,2-diaminoethane with creatinine. The reaction of the ligand with metal chloride salt gives Co(II) and Cu(II) complexes. The synthesized ligand and its metal complexes were characterized by elemental analysis, FT-IR, NMR, UV?Vis, conductivity and magnetic susceptibility measurements as well as thermal analyses. Based on spectral data, tetrahedral geometries have been proposed for the Co(II) and Cu(II) complexes. The molar conductivity data show that the complexes are non-electrolytic in nature. In DFT studies, the geometry of the Schiff base ligand and its Co(II) and Cu(II) complexes were fully optimized using the B3LYP functional together with 6-31g(d,p) and LANL2DZ basis sets. The ligand and its metal complexes were tested against four bacterial species and two fungal species. The results revealed that the metal complexes are more potent against the microbes than the parent ligand.

Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

Drug Research ◽  
2021 ◽  
Author(s):  
Preeti Sharma ◽  
Varun Kumar Singh ◽  
Gajendra Kumar
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Magnetic Measurements ◽  
Magnetic Moments ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Antimicrobial Evaluation ◽  
Aspergillus Sp ◽  
Bacteria And Fungi

AbstractSchiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine was synthesized by the condensation of 1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at 70 oC. The prepared Schiff base ligand doped with Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as [M(C34H32N8O4)X]X2. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential against Staphylococcus aureus, Bacillus subtilis (positive bacteria) and Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi (negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium sp. [Cr(C34H32N8O4)OAc](OAc)2 shows best antimicrobial activity against all the pathogens.

scholarly journals Solvent-free Synthesis, Characterization and Biological Activity of Transition Metal Complexes of Schiff Base Ligand Derived from 2-Amino Benzimidazole with 4, 4’Dibromobenzil

2021 ◽  
Vol 11 (3) ◽  
pp. 3834-3842
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Bacterial Species ◽  
Salmonella Typhi ◽  
Microwave Assisted Synthesis ◽  
Complexes Of Transition Metals

Microwave-assisted synthesis and characterization of Schiff base ligand complexes of transition metals such as Mn(II), Fe(III), Co(II), Ni(II),Cu(II), Zn(II) Cd(II), and Ag(I) (using Schiff base) prepared by irradiation of 2-Amino benzimidazole with 4,4’dibromo benzil. The Synthesized transition metal complexes and Schiff base ligand have been representatively characterized by elemental analysis and spectral methods such as UV, IR, 1H-NMR, LC-MS, and Thermal analysis. The synthesized ligand and its complexes were also screened for their biological activities, such as antibacterial activity against bacterial species Staphylococcus aureus, Escherichia coli, and Salmonella Typhi. The result indicated that the complexes exhibited octahedral geometry.

scholarly journals Amalgamation of Novel Schiff Base Ligand and Its Transition Metal Complexes and Their Biological Activity

2019 ◽  
pp. 1-13
Author(s):  
B. Akila ◽  
A. Xavier
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Electronic Spectroscopy ◽  
Antioxidant Properties ◽  
Salmonella Typhi ◽  
Metal Chelates ◽  
Schiff Base Complexes

Schiff base synthesized from 2-hydroxy-1-naphthaldehyde and 2-2’ (ethylene dioxy) bis ethylenediamine (L1) and its Metal complexes, [M (II) (L)6](where M= Mn(II), Ru(III), Cu(II)and V(V) L= Schiff base moiety), have been prepared and characterized by elemental analysis, spectroscopic measurements (infrared, electronic spectroscopy, 1H-NMR, EPR and Mass spectroscopy ). Elemental analysis of the metal complexes was suggested that the stoichiometry ratio is 1:1 (metal-ligand). The electronic spectra suggest an octahedral geometry for MC1and MC2 Schiff base complexes and distorted octahedral for MC3 and MC4 complexes. The Schiff base and its metal chelates have been screened for their invitro test antibacterial activity against three bacteria, gram-positive (Staphylococcus aureus) and gram-negative (Klebsiella pheneuammonia and Salmonella typhi). Two strains of fungus (Aspergillus niger and Candida albicans). The metal chelates were shown to possess more anti fungal activity compare then antibacterial activity and antioxidant properties. The complexes are highly active than the free Schiff-base ligand.    

scholarly journals GC-MS Analysis and Antimicrobial Assessment of Syzygium cumini (L.) Skeels Seed Ethanol Extract

2021 ◽  
pp. 271-283
Author(s):  
S. Mabel Parimala ◽  
A. Antilin Salomi
Keyword(s):  
Bacterial Species ◽  
Ethanol Extract ◽  
Microtiter Plate ◽  
Salmonella Typhi ◽  
Fungal Species ◽  
Gas Chromatography Mass Spectrometry ◽  
Diffusion Method ◽  
Syzygium Cumini ◽  
Microtiter Plate Assay ◽  
Agar Well Diffusion Method

People use plants to treat infections, and this has led to search of antimicrobials from medicinal plants. In this work, we evaluated the ethanol extract of Syzygium cumini seeds for their antibacterial and antifungal activities. Extraction was performed by maceration method using ethanol. The antimicrobial efficacy of the extract was assessed by agar well diffusion method against ten bacterial species, Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Serratia marcescens, Staphylococcus aureus and Streptococcus mutans, and five fungal species, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Mucor sp. Minimum inhibitory concentrations (MICs) of the extract were determined by resazurin microtiter plate assay.  Phytochemicals in the extract was identified by gas chromatography mass spectrometry (GC-MS) information.  In agar well diffusion method, Gram-negative bacteria such as P. aeruginosa and S. marcescens, Gram-positive bacteria such as B. subtilis and E. faecalis and fungi A. fumigatus were more susceptible showing larger zones of inhibition.  In resazurin method, low MICs were recorded for bacteria, B. cereus (<7.8 µg) and P. aeruginosa (15.6 µg) and fungi, A. fumigatus (31.2 µg).  Fifteen compounds were identified by GC-MS profiling of the extract.  The antimicrobial activity of the extract can be rightly related to the secondary metabolites in the ethanol extract of Syzygium cumini seeds.

scholarly journals Synthesis, Characterization and Antimicrobial studies of Schiff base Ligand from amino acid L-arginine and its Cu(II), Ni(II),Co(II) complexesIJCTR.2019.130201

2020 ◽  
Vol 13 (2) ◽  
pp. 1-8
Author(s):  
R.K. Sree Devi ◽  
S. SudhaKumari
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Metal Ion ◽  
Electronic Absorption Spectra ◽  
Magnetic Data ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Significant Activity ◽  
Antimicrobial Studies

Transition metal complexes of Cu(II), Ni(II), Co(II) with a Schiff base Ligand (R,Z)-2-(2-hydroxy-3-methoxybenzylideneamino)-5-guanidinopentanoic acid (HMA-GPA) was synthesized by the condensation of 2-hydroxy-3-methoxybenzaldehyde and L- Arginine. These were characterized by elemental analysis IR, UV, magnetic susceptibility and molar conductivity measurements. The IR spectra of the Ligand HMA-GPA and the metal complexes suggest that the Ligand coordinates the metal ion through azomethine nitrogen, carboxylate Oxygen and Oxygen of the phenolic -OH group. The electronic absorption spectra and magnetic data indicate the Cu(II), Ni(II)complexes to be square planar and Co(II) complex to be octahedral. The metal complexes and the ligand were subjected to antimicrobial studies by Kirby Bayer Disc-diffusion method and found to have significant activity against the selected bacterial and fungal strains under study.

scholarly journals Antitumor and Antimicrobial Potential of Manganese(II), Nickel(II) and Copper(II) Complexes of 4-Methoxy Benzohydrazide Derived Schiff Base Ligand

2021 ◽  
Vol 11 (1) ◽  
pp. 3249-3260
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Antimicrobial Activities ◽  
Molar Ratio ◽  
Gram Positive Bacteria ◽  
Ft Ir ◽  
Dose Dependent

Herein, we describe the synthesis and characterization of a Schiff base ligand (E)-N'-(2-hydroxybenzylidene)-4-methoxybenzohydrazide (HBMB) and its Mn(II), Ni(II), and Cu(II) metal complexes (C1-C3) respectively. The ligand HBMB was synthesized by reacting condensation of salicylaldehyde and 4-methoxy benzohydrazide in a 1:1 molar ratio. The structure of HBMB and its metal complexes (C1-C3) were evaluated by using UV-Vis, FT-IR, 1H-NMR, mass spectroscopy as well as on the basis of elemental analysis, conductivity measurements, and thermogravimetric techniques (TGA). The synthesized molecules' tumoricidal properties were performed against human breast cancer (MCF-7) and colon cancer (HT 29) cell lines. The biological results indicated that the ligand, HBMB, and metal complexes possess dose-dependent selective cytotoxicity against the tested carcinoma cells. The synthesized compounds were further evaluated for their in vitro antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), and fungal strains (Aspergillus niger).

scholarly journals Synthesis, Characterization and Antibacterial Activity of Schiff Base, 4-Chloro-2-{(E)-[(4-Fluorophenyl)imino]methyl}phenol Metal (II) Complexes

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
F. K. Ommenya ◽  
E. A. Nyawade ◽  
D. M. Andala ◽  
J. Kinyua
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Condensation Reaction ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Elemental Analysis Data ◽  
Ft Ir

A new series of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) complexes of the Schiff base ligand, 4-chloro-2-{(E)-[(4-fluorophenyl)imino]methyl}phenol (C13H9ClFNO), was synthesized in a methanolic medium. The Schiff base was derived from the condensation reaction of 5-chlorosalicylaldehyde and 4-fluoroaniline at room temperature. Elemental analysis, FT-IR, UV-Vis, and NMR spectral data, molar conductance measurements, and melting points were used to characterize the Schiff base and the metal complexes. From the elemental analysis data, the metal complexes formed had the general formulae [M(L)2(H2O)2], where L = Schiff base ligand (C13H9ClFNO) and M = Mn, Co, Ni, Cu, and Zn. On the basis of FT-IR, electronic spectra, and NMR data, “O” and “N” donor atoms of the Schiff base ligand participated in coordination with the metal (II) ions, and thus, a six coordinated octahedral geometry for all these complexes was proposed. Molar conductance studies on the complexes indicated they were nonelectrolytic in nature. The Schiff base ligand and its metal (II) complexes were tested in vitro to evaluate their bactericidal activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus typhi) using the disc diffusion method. The antibacterial evaluation results revealed that the metal (II) complexes exhibited higher antibacterial activity than the free Schiff base ligand.

In-vitro antimicrobial efficacy of certian herbal seeds essential oils against important poultry microbes

2015 ◽  
Author(s):  
Darshana B. Bhaisare ◽  
D. Thyagarajan ◽  
R. Richard Churchil ◽  
N. Punniamurthy
Keyword(s):  
Staphylococcus Aureus ◽  
Antiviral Activity ◽  
Essential Oils ◽  
Pasteurella Multocida ◽  
Antimicrobial Properties ◽  
Inhibition Zone ◽  
Salmonella Typhi ◽  
Fungal Species ◽  
Diffusion Method

Two in-vitro experiments were conducted to evaluate the antibacterial, antifungal and antiviral properties of essential oil of herbal seeds. In-vitro antimicrobial properties of essential oils of phytobiotics was determined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pasteurella multocida and Salmonella typhi and two fungi namely Aspergillus fumigatus and Candida albicans. Thyme oil had statistically similar or significantly (P<0.05) higher inhibition zone against all the bacterial and fungal species compared to standard antibiotic, chloramphenicol or antifungal drug, nystatin. Fenugreek oil was not found to be active against microbes compared to control. Fennel and cumin oils had statistically similar or significantly (P<0.05) higher inhibition zone against all microbes except Staphylococcus aureus and Salmonella typhi compared to control. Antiviral activity of essential oils was determined by anti-NDV assay against New Castle disease virus (LaSota). The results indicated that essential oils of herbal seeds do not possess antiviral activity against NDV LaSota virus at 1mg/ml concentration.

scholarly journals Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) complexes with biacetyl-derived Schiff bases

2010 ◽  
Vol 75 (8) ◽  
pp. 1075-1084 ◽  
Author(s):  
Muhammad Imran ◽  
Mitu Liviu ◽  
Shoomaila Latif ◽  
Zaid Mahmood ◽  
Imtiaz Naimat ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Bacterial Species ◽  
Electronic Spectroscopy ◽  
Salmonella Typhi ◽  
Schiff Base Ligands ◽  
No Donor

The condensation reactions of biacetyl with orthohydroxyaniline and 2-aminobenzoic acid to form bidendate NO donor Schiff bases were studied. The prepared Schiff base ligands were further utilized for the formation of metal chelates having the general formula [ML2.2H2O] where M = Co(II), Ni(II), Cu(II) and Zn(II) and L = HL1 and HL2. These new compounds were characterized by conductance measurements, magnetic susceptibility measurements, elemental analysis, and IR, 1H-NMR and electronic spectroscopy. Both Schiff base ligands were found to have a mono-anionic bidentate nature and octahedral geometry was assigned to all metal complexes. All the complexes contained coordinated water which was lost at 141-160 ?C. These compounds were also screened for their in-vitro antibacterial activity against four bacterial species, namely; Escherichia coli, Staphylococcus aureus, Salmonella typhi and Bacillus subtillis. The metal complexes were found to have greater antibacterial activity than the uncomplexed Schiff base ligands.

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