Personality Functioning in Patients with a Progressive Course of Multiple Sclerosis

2010 ◽  
Vol 107 (2) ◽  
pp. 629-646 ◽  
Author(s):  
Rita Lorio ◽  
Giuseppe Moressa ◽  
Francesca Meneghello ◽  
Silvia Salcuni ◽  
Alessandro Zennaro ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Self Esteem ◽  
Control Group ◽  
Rorschach Test ◽  
State Trait Anxiety Inventory ◽  
Personality Functioning ◽  
Self Image ◽  
Disability Status ◽  
Healthy Participants ◽  
Progressive Course

This study intended to describe general personality functioning in patients with a progressive course of multiple sclerosis. 55 consecutive rehabilitation inpatients with progressive course of multiple sclerosis were assessed with a multimethod test battery: the Expanded Disability Status Scale, the Beck Depression Inventory, the State-Trait Anxiety Inventory, the Rosenberg Self-esteem Scale, and the Rorschach Test administered and scored with Comprehensive System. The control group comprised 55 healthy participants with similar sociodemographic characteristics. Specific differences were found for both cognitive and affective aspects, as the patients with progressive course of multiple sclerosis had less positive self-image, less effective mediation processing, and an affective approach to reality. Present data illustrated the usefulness of examining patients with a progressive course of multiple sclerosis to identify abilities and difficulties in cognitive and affective patterns, and support better adaptation to relationships and the environment.

scholarly journals Relationship between Expanded Disability Status Scale scores and the presence of temporomandibular disorders in patients with multiple sclerosis

2018 ◽  
Vol 12 (01) ◽  
pp. 144-148 ◽  
Author(s):  
Lucas Senra Correa Carvalho ◽  
Osvaldo José Moreira Nascimento ◽  
Luciane Lacerda Franco Rocha Rodrigues ◽  
Andre Palma Da Cunha Matta
Keyword(s):  
Multiple Sclerosis ◽  
Temporomandibular Disorders ◽  
Control Group ◽  
Expanded Disability Status Scale ◽  
Exact Test ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Scale Scores ◽  
Axis I ◽  
Relapsing Remitting Multiple Sclerosis

ABSTRACTObjectives: The objectives of this study were to assess the prevalence of temporomandibular disorders (TMDs) in patients with relapsing-remitting multiple sclerosis (MS) and to investigate whether an association exists between the presence of TMD symptoms and the degree of MS-related disability. Materials and Methods: In all, 120 individuals were evaluated: 60 patients with a diagnosis of relapsing-remitting MS and 60 age- and sex-matched controls without neurological impairments. A questionnaire recommended by the European Academy of Craniomandibular Disorders for the assessment of TMD symptoms was administered. For those who answered affirmatively to at least one of the questions, the RDC/TMD Axis I instrument was used for a possible classification of TMD subtypes. The Expanded Disability Status Scale (EDSS) was the measure of the degree of MS-related disability. Statistical Analysis Used: Fisher’s exact test was used to analyze the data. ANOVA was used to detect significant differences between means and to assess whether the factors influenced any of the dependent variables by comparing means from the different groups. Results: The prevalence of TMD symptoms in patients with MS was 61.7% versus 18.3% in the control group (CG). A diagnosis of TMD was established for 36.7% in the MS group and 3.3% in the CG (P = 0.0001). There were statistically significant differences between degrees of MS-related disability and the prevalence of TMD (P = 0.0288). Conclusions: The prevalence of both TMD and TMD symptoms was significantly greater in the MS group. EDSS scores and TMD prevalence rates were inversely related.

Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis

2008 ◽  
Vol 14 (4) ◽  
pp. 557-560 ◽  
Author(s):  
M Kawajiri ◽  
M Mogi ◽  
M Osoegawa ◽  
T Matsuoka ◽  
K Tsukuda ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Angiotensin Ii ◽  
Neurological Diseases ◽  
Control Group ◽  
Autoimmune Encephalomyelitis ◽  
Disability Status ◽  
Scale Scores ◽  
Inflammatory Neuropathies ◽  
And Control

We previously demonstrated that angiotensin II acts as a crucial neuroprotective factor after neural injury through angiotensin II type-2 (AT2) receptor signaling. Although the pathway is known to play an important role in the development of experimental autoimmune encephalomyelitis, cerebrospinal fluid (CSF) angiotensin II levels in patients with multiple sclerosis (MS) have never been studied. To clarify the significance of angiotensin II in MS, we assayed angiotensin II concentrations using an established enzyme-linked immunoabsorbent assay in CSF samples from patients with MS ( n = 21), patients with inflammatory neuropathies (IN) ( n = 23) and control individuals who did not have either of the neurological diseases or any other disease that might affect the angiotensin II levels in the CSF (control) ( n = 24). Angiotensin II levels in the CSF were 3.79 ± 1.54 pg/ml in the MS group, 5.13 ± 2.27 pg/ml in the IN group and 6.71 ± 2.65 pg/ml in the control group. The angiotensin II levels in the CSF of the MS group were significantly lower than in the control group ( p = 0.00057). Angiotensin II concentration in the CSF tended to have a negative correlation with the Kurtzke’s Expanded Disability Status Scale scores during MS relapse ( p = 0.0847). These findings suggest that reduced levels of intrathecal angiotensin II may be related to the abnormal neural damage and repair processes in MS.

scholarly journals Functional and metabolic characteristics of peripheral blood mononuclear phagocytes in patients with different clinical courses of multiple sclerosis

2020 ◽  
Vol 11 (4) ◽  
pp. 494-500
Author(s):  
O. M. Koliada ◽  
N. I. Vdovichenko ◽  
T. I. Kolyada ◽  
O. P. Bilozorov
Keyword(s):  
Multiple Sclerosis ◽  
Peripheral Blood ◽  
Mononuclear Phagocytes ◽  
Arginase Activity ◽  
Control Group ◽  
Blood Monocytes ◽  
Arginine Metabolism ◽  
Peripheral Blood Monocytes ◽  
Relapsing Remitting ◽  
Progressive Course

Functional and metabolic features of intact and stimulated mononuclear phagocytes were studied in patients with different clinical courses of multiple sclerosis, the study included 66 patients with relapsing-remitting and 32 patients with progressive course of multiple sclerosis. The state of the mononuclear phagocytes was characterized by expression of costimulatory molecules and direction of L-arginine metabolism. Relative quantities of CD80, CD86 and PD-L1 positive monocytes were determined with Phycoerytrin-labeled monoclonal antibodies in immunofluorescence test in peripheral blood and after culture in parallel series with addition of: (a) E.coli lipopolysaccharide (a stimulator of TLR4), (b) a single-stranded RNA – preparation ssRNA40/LyoVec (a stimulator of TLR7/8), (c) IL-4 (an anti-inflammatory interleukin). The formation of NO was determined by the amount of nitrite in the culture supernatants, arginase activity was determined in cell lysates of the monocyte fraction. We showed that functional and phenotypic characteristics of monocytes depend on the clinical course of multiple sclerosis. In patients with progressive course, the relative number of CD86+ cells was significantly higher and PD-L1+ cells significantly lower than in patients with relapsing-remitting course and healthy persons, in patients with relapsing-remitting course the number of PD-L1+ cells was increased. The number of CD80+ cells did not show any significant difference in the investigated groups of patients relative to the control group. In vitro stimulation of peripheral blood monocytes with TLR4/8 produced a significant increase in the number of CD86+ and decrease in the number of PD-L1+ cells in patients with the progressive course. In patients with the relapsing-remitting course LPS produced an increase in number of PD-L1+ cells. We did not find any difference in activity of the arginase pathway of L-arginine metabolism in the intact monocyte fraction of peripheral blood in patients with multiple sclerosis versus the control group, but stimulation with TLR4 agonist of mononuclear cells of patients with progressive course caused significant increased arginase activity versus baseline. At the same time, versus control cells arginase activity in patients with the progressive course decreased after LPS treatment, but trended to increase after TLR7/8 treatment. In patients with the relapsing-remitting course these changes had a similar direction but were less expressed. The results may be considered as an indication of the activation of peripheral blood monocytes and their polarization trend in the M1 direction in patients with the progressive course of multiple sclerosis, these changes could be considered as signs of violation of autoimmune regulatory mechanisms in multiple sclerosis.

scholarly journals Phototest for neurocognitive screening in multiple sclerosis

2016 ◽  
Vol 10 (1) ◽  
pp. 12-18
Author(s):  
Joana Pinto ◽  
Emanuela Lopes ◽  
Gerly Gonçalves ◽  
Ângela Silva ◽  
Carnero-Pardo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Disorders ◽  
Area Under The Curve ◽  
Naming Task ◽  
Cognitive Test ◽  
Neurocognitive Impairments ◽  
Disability Status ◽  
Different Types ◽  
Fatigue Severity ◽  
Healthy Participants

Multiple Sclerosis (MS) is one of the most common neurological disorders. Cognitive dysfunction is considered a clinical marker of MS, where approximately half of patients with MS have cognitive impairment. Objective : The Phototest (PT) is a brief cognitive test with high diagnostic sensitivity, accuracy and cost-effectiveness for detecting cognitive deterioration. Our aim was to test the utility of the PT as a neurocognitive screening instrument for MS. Methods : The study enrolled 30 patients with different types of MS from an outpatient clinic as well as 19 healthy participants. In conjunction with the PT, the Montreal Cognitive Assessment (MoCA), Barthel Index (BI), Expanded Disability Status Scale (EDSS), and Fatigue Severity Scale (FSS) were administered. Results : The MS group obtained significantly lower results on all domains of the PT, except for the naming task. The PT showed good concurrent validity with the MoCA. In direct comparison to the MoCA, PT showed a greater area under the curve and higher levels of sensitivity and specificity for MS neurocognitive impairments. A cut-off score of 31 on the Phototest was associated with sensitivity of 100% and specificity of 76.7%. Conclusion : The PT is a valid, specific, sensitive and brief test that is not dependent on motor functions. The instrument could be an option for neurocognitive screening in MS, especially in identifying cases for further neuropsychological assessment and intervention.

Altered Effective Connectivity during a Processing Speed Task in Individuals with Multiple Sclerosis

2016 ◽  
Vol 22 (2) ◽  
pp. 216-224 ◽  
Author(s):  
E. Dobryakova ◽  
S.L. Costa ◽  
G.R. Wylie ◽  
J. DeLuca ◽  
H.M. Genova
Keyword(s):  
Multiple Sclerosis ◽  
Processing Speed ◽  
Effective Connectivity ◽  
Brain Regions ◽  
Brain Network ◽  
Connectivity Pattern ◽  
Control Group ◽  
Dynamic Representation ◽  
Speed Task ◽  
Healthy Participants

AbstractObjectives: Processing speed impairment is the most prevalent cognitive deficit in individuals with multiple sclerosis (MS). However, the neural mechanisms associated with processing speed remain under debate. The current investigation provides a dynamic representation of the functioning of the brain network involved in processing speed by examining effective connectivity pattern during a processing speed task in healthy adults and in MS individuals with and without processing speed impairment. Methods: Group assignment (processing speed impaired vs. intact) was based on participants’ performance on the Symbol Digit Modalities test (Parmenter, Testa, Schretlen, Weinstock-Guttman, & Benedict, 2010). First, brain regions involved in the processing speed task were determined in healthy participants. Time series from these functional regions of interest of each group of participants were then subjected to the effective connectivity analysis (Independent Multiple-Sample Greedy Equivalence Search and Linear, Non-Gaussian Orientation, Fixed Structure algorithms) that showed causal influences of one region on another during task performance. Results: The connectivity pattern of the processing speed impaired group was significantly different from the connectivity pattern of the processing speed intact group and of the healthy control group. Differences in the strength of common connections were also observed. Conclusions: Effective connectivity results reveal that MS individuals with processing speed impairment not only have connections that differ from healthy participants and MS individuals without processing speed impairment, but also have increased strengths of connections. (JINS, 2016, 22, 216–224)

scholarly journals Measuring Gait Stability in People with Multiple Sclerosis Using Different Sensor Locations and Time Scales

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 4001
Author(s):  
Roy Müller ◽  
Lucas Schreff ◽  
Lisa-Eyleen Koch ◽  
Patrick Oschmann ◽  
Daniel Hamacher
Keyword(s):  
Multiple Sclerosis ◽  
Time Scale ◽  
Inertial Sensors ◽  
Foot Kinematics ◽  
Gait Stability ◽  
Trunk Movements ◽  
Disability Status ◽  
Healthy Participants ◽  
Minute Walk ◽  
Sensor Locations

The evaluation of local divergence exponent (LDE) has been proposed as a common gait stability measure in people with multiple sclerosis (PwMS). However, differences in methods of determining LDE may lead to different results. Therefore, the purpose of the current study was to determine the effect of different sensor locations and LDE measures on the sensitivity to discriminate PwMS. To accomplish this, 86 PwMS and 30 healthy participants were instructed to complete a six-minute walk wearing inertial sensors attached to the foot, trunk and lumbar spine. Due to possible fatigue effects, the LDE short (~50% of stride) and very short (~5% of stride) were calculated for the remaining first, middle and last 30 strides. The effect of group (PwMS vs. healthy participants) and time (begin, mid, end) and the effect of Expanded Disability Status Scale (EDSS) and time were assessed with linear random intercepts models. We found that perturbations seem to be better compensated in healthy participants on a longer time scale based on trunk movements and on a shorter time scale (almost instantaneously) according to the foot kinematics. Therefore, we suggest to consider both sensor location and time scale of LDE when calculating local gait stability in PwMS.

scholarly journals Serum leptin and body mass index in a sample of Egyptian multiple sclerosis patients

2020 ◽  
Vol 56 (1) ◽  
Author(s):  
Mohamed A. Abd Elhafeez ◽  
Dina A. Zamzam ◽  
Mohamed M. Fouad ◽  
Hala M. Elkhawas ◽  
Hend A. Abdel Rahman
Keyword(s):  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Body Mass ◽  
Clinical History ◽  
Control Group ◽  
Case Group ◽  
Serum Leptin ◽  
Disability Status ◽  
Degree Of Disability ◽  
Multiple Sclerosis Patients

Abstract Background The adipose tissues release pro-inflammatory cytokines such as leptin that can be considered a link between obesity and autoimmunity. This study aimed to investigate a possible correlation between BMI, serum leptin, and multiple sclerosis (MS). Methods This case-control study recruited consecutively 169 patients from our MS Unit and 50 healthy controls. Clinical history and examination with Expanded Disability Status Scale (EDSS) scoring were done for all patients. Calculation of body mass index (BMI) and measurement of serum leptin level were done for patients and controls. Results The case group had significantly higher BMI (mean of 26.85 ± 6.06 versus 19.55 ± 1.62; P < 0.001) and higher serum leptin levels (median [IQR] of 280 pgm/ml [175–525] versus 102.5 pgm/ml [80–125]; P < 0.001) compared to the control group. Serum leptin levels did not have a correlation with either disease activity or degree of disability. Conclusions MS patients had significantly higher BMI and higher serum leptin levels compared to controls.

scholarly journals Three-Day Dietary Manipulation in Multiple Sclerosis: Exercise and Fatigue Outcomes

2021 ◽  
Author(s):  
Lacey E. Bromley ◽  
Peter J. Horvath ◽  
Susan E. Bennett ◽  
Bianca Weinstock-Guttman ◽  
Todd C. Rideout ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Exercise Performance ◽  
Submaximal Exercise ◽  
Peak Oxygen Consumption ◽  
Control Group ◽  
Dietary Manipulation ◽  
Expanded Disability Status Scale ◽  
Randomized Controlled ◽  
Disability Status ◽  
Improve Fatigue

Abstract Background: In persons with multiple sclerosis (MS), the effect of nutrition on exercise performance and fatigue remains unknown. The objective was to determine whether a 3-day diet high in triglycerides (FAT) compared with a 3-day diet high in carbohydrates (CARB) would improve fatigue and exercise performance in persons with MS. Methods: A randomized controlled crossover design was incorporated to study FAT versus CARB on submaximal cycling endurance (60% of peak oxygen consumption), substrate utilization, and fatigue in 12 persons with mild-to-moderate MS (Expanded Disability Status Scale score, 2.0–5.0) and 12 age- and sex-matched controls. Results: There were no differences in cycling time between diets in either group (P = .29). The MS group had no changes in fatigue between diets (P = .64); the control group demonstrated increased total mental fatigue after FAT (P = .05). The control group increased carbohydrate oxidation by 24% at rest and 13% during exercise after CARB. Similarly, the control group significantly increased fat oxidation after FAT by 22% at rest and 68% during exercise (P = .01). These changes were not seen in the MS group. Compared with controls, persons with MS oxidized approximately 50% less fat during exercise after FAT (P = .05). Conclusions: Neither CARB nor FAT altered submaximal exercise performance or baseline fatigue in the MS group. The results suggest that persons with MS are unable to adapt to dietary changes and oxidize fatty acids as efficiently as controls.

OCT as a monitoring tool for assessment of the stage and severity of multiple sclerosis

2020 ◽  
Vol 1 (3) ◽  
pp. 179-182
Author(s):  
Yoav Yechezkel Pikkel ◽  
◽  
Vadim Igal ◽  
Yael Sara Pikkel Igal ◽  
Adi Nov-Sharabi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Statistical Significance ◽  
Control Group ◽  
Double Blind Study ◽  
Monitoring Tool ◽  
Fiber Layer ◽  
Double Blind ◽  
Rnfl Thickness ◽  
Disability Status ◽  
The Mean

AIM: To identify a link between optical coherence tomography (OCT), length of multiple sclerosis (MS) and the expanded disability status scale (EDSS). METHODS: In a prospective double blind study, 29 patients with a diagnosis of MS were compared with 29 healthy patients, matched by age and sex. All participants underwent an OCT study and neurological EDSS test on the same day. RESULTS: The mean EDSS score was 3.2 in the MS group vs 0.03 in the control group, and the duration of MS is 11.7y. The mean retinal nerve fiber layer (RNFL) thickness was significantly thinner in those with MS (P<0.001). Correlation was found between duration of MS and RNFL thinning. EDSS and thinning of RNFL showed a tendency to correlate but without statistical significance.

scholarly journals Mobile phone-based e-diary for assessment and enhancement of medications adherence among patients with multiple sclerosis

2020 ◽  
Vol 6 (3) ◽  
pp. 205521732093930
Author(s):  
Daniel Golan ◽  
Smadar Sagiv ◽  
Lea Glass-Marmor ◽  
Ariel Miller
Keyword(s):  
Multiple Sclerosis ◽  
Poor Adherence ◽  
Control Group ◽  
Control Groups ◽  
Limits Of Agreement ◽  
Disease Modifying Drugs ◽  
Median Difference ◽  
Adherence Assessment ◽  
Disability Status ◽  
And Control

Background Adherence to multiple sclerosis (MS) disease-modifying drugs (DMDs) is essential for realization of their optimal effectiveness and benefits. Objective To evaluate the usefulness and validity of a smartphone-based e-diary as a tool for adherence assessment as well as its effectiveness as a promoter of adherence to DMDs. Methods An MS tailored e-diary (MyMS&Me) reminded patients to take their DMDs on time. DMD intake was self-recorded in the e-diary by the participants. Three methods of adherence evaluation were compared: e-diary derived, retrospective self-reported, and the medication possession rate (MPR). The proportion of patients with poor adherence to DMDs (defined as MPR <80%) among e-diary users was compared with a control group without intervention. Results Sixty-two patients downloaded the e-diary (Female: 41 (66%), Expanded Disability Status Scale 3.2 ± 2.2) and 55 controls were enrolled. The median difference between e-diary-derived adherence and the MPR was –3% (95% limits of agreement: −53% to 12%). The median difference between retrospective self-reported adherence and the MPR was 0.3% (95% limits of agreement: −20% to 42%). The proportion of participants with poor adherence to DMDs was similar in the e-diary and control groups (10% vs. 13%, p = 0.6). Conclusions Substantial and clinically important disagreement between methods of medication adherence evaluation was noted. Smartphone reminders did not significantly improve the MPR of DMDs.

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