Prior Shock Trauma and Test-Shock Intensity as Determinants of Escape Learning

1966 ◽  
Vol 19 (3) ◽  
pp. 771-778 ◽  
Author(s):  
D. Chris Anderson

The effects of prior traumatic shock (PS), administered under conditions designed either to maximize (Group 1) or to minimize (Group 2) transfer of trauma-produced learned responses from the treatment to the test chamber, were evaluated in the rat using a hurdle-jump escape situation. Another group (the control group) was not traumatized. 10 days following treatment each group was divided into three subgroups of 0.0-ma., 0.1-ma., and 0.4-ma. test shock, respectively. The performance of the control groups fluctuated systematically with variations in test-shock level while Groups 1 and 2 responded maximally to test shock regardless of intensity. However, under no-test-shock the control group and Group 2 performed identically and significantly more slowly than Group 1. Changes in group variability were similarly related to PS treatment.

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Sertan Goktas ◽  
Ender Erdogan ◽  
Rabia Sakarya ◽  
Yasar Sakarya ◽  
Mustafa Yılmaz ◽  
...  

Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization.Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days. Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically.Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2–55.8%) and 33.5% (95% CI, 26.6–39.2%), respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P=0.03andP<0.001, resp.). Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups.Conclusion. Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization. Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.


2015 ◽  
Vol 59 (3) ◽  
pp. 258-264 ◽  
Author(s):  
Zehra Safi Oz ◽  
Banu Doğan Gun ◽  
Mustafa Ozkan Gun ◽  
Sukru Oguz Ozdamar

Objectives: The aim of this study was to explore the cytomorphometric and morphological effects of Trichomonas vaginalis in exfoliated epithelial cells. Study Design: Ninety-six Pap-stained cervical smears were divided into a study group and two control groups as follows: T. vaginalis cases, a first control group with inflammation, and a second control group without inflammation. Micronucleated, binucleated, karyorrhectic, karyolytic, and karyopyknotic cells and cells with perinuclear halos per 1,000 epithelial cells were counted. Nuclear and cellular areas were evaluated in 70 clearly defined cells in each smear using image analysis. Results: The frequencies of morphological parameters in the T. vaginalis cases were higher than the values of the two control groups, and the difference among groups was found to be significant (p < 0.05). The nuclear and cytoplasmic areas of epithelial cells were diminished in patients with trichomoniasis. The mean nucleus/cytoplasm ratio in T. vaginalis patients was higher than the value in the control groups, and the difference between the study group and control group 1 was significant. However, there was no statistically significant increase between the study group and control group 2. Conclusions:T. vaginalis exhibited significant changes in the cellular size and nuclear structure of the cells. The rising frequency of micronuclei, nuclear abnormalities, and changing nucleus/cytoplasm ratio may reflect genotoxic damage in trichomoniasis.


Author(s):  
Hagar Abd Elrahman Deghaidy ◽  
Mona Khalid Omar Amira Youssef Ahmed ◽  
Elsayed Fetouh Rakha

Background: Polycystic ovary syndrome (PCOS) is a common condition in women at reproductive age associated with reproductive and metabolic dysfunction. It may be the most common cause of anovulation, early pregnancy loss, and later pregnancy complications. Adiponectin is the most abundant adipokine and is mainly secreted from visceral fat cells. It might be responsible for the metabolic and neuroendocrine derangements characteristic of obesity and obesity-related disease, such as PCOS. We aimed to evaluate the level of serum adiponectin in PCOS and the potential use of adiponectin as a biomarker for PCOS. Methods: This case control study was carried on 100 patients, aged between 20–35 years, who were equally divided into four groups based on the diagnosis of PCOS; 2 case groups and 2 control groups. Group 1 were non-obese PCOS subjects with body mass index (BMI) <25 kg/m2. Group 2 were obese PCOS subjects with BMI >25 kg/m2. Control groups were selected as; group 3 were non-obese control group with BMI <25 kg/m2. Group 4 were obese control group with BMI >25 kg/m2. Results: Adiponectin was significantly lower in group 1 than group 3 and 4 (P2 and P3 <0.001). While it was significantly lower in group 2 than group 1, 3 and 4 and was significantly lower in group 4 than group 3 (P1 = 0.021, P4 and P5 <0.001). Conclusion: Serum adiponectin level may be taken into consideration as a biomarker for confirmation of PCOS diagnosis. The relationship between adiponectin and BMI suggests that adiponectin could serve as a marker for disease risk and provide opportunity for earlier intervention.


2007 ◽  
Vol 22 (6) ◽  
pp. 436-440 ◽  
Author(s):  
Rogério Saad-Hossne ◽  
William Saad Hossne ◽  
Mario Rubens Guimarães Montenegro

PURPOSE: To investigate the histolytic action of a solution composed of phenol, glycerin and acetic acid for irresectable hepatic metastasis. METHODS: Thirty-two (n=32) guinea pigs were randomly distributed into two groups of 16 animals. The animals in group 1 (experimental) and group 2 (control) were redistributed in two subgroups of eight animals each, according to the day of sacrifice (24 hours and four weeks after injection). All the animals were submitted to median laparotomy, which was followed by the injection of solution E and saline into the livers of subjects in both the experimental and control groups, respectively. The animals were evaluated for biochemical and anatomopathological (liver) alterations after 24 hours and four weeks of the experiment. RESULTS: It was observed that solution E produced necrosis limited to the injected area and that hepatic tissue recovery occurred after four weeks with the formation of a small necrosis area. No biochemical parameters were altered either in the experimental or in the control group. CONCLUSION: In view of the obtained results, the possibility of using the proposed solution can be considered in cases of irresectable metastasis.


Author(s):  
V.Z. HAMITOVA ◽  
◽  
A.K. OSMANYAN ◽  
V.V. MALORODOV

Differentiated broiler feeding consists of four main phases: pre-starter, starter, growth, and finishing. Further improvement of the feeding schemes of meat chickens aims at dividing the main phases into shorter periods that differ in the nutritional value and energy value or physical structure of compound feeds. The most important are the pre-starter (the first seven days of the chicken life) and the final (25 days and before slaughter) phases of broiler feeding. In the performed studies, the practicality and effectiveness of meat chicken feeding schemes with the division of the finishing period into three phases (experiment 1) and the use of the super-starter period in the pre-starter phase (experiment 2) are scientifically justified in two experiments. The object of the study was broilers of the cross “Cobb-500”. In experiment 1, two groups of oneday-old chickens were formed: a control group and an experimental group with 6-and 7-phase feeding, respectively. In group 1, the finishing period was divided into two phases, in group 2 – into 91 three phases. The results of growing broilers showed that the growth rate, the safety of livestock, and the yield of meat per unit area in group 2, respectively, were 0.7 g; 0.6% and 1.1 kg were higher. The comprehensive final indicators – the broiler productivity and meat production efficiency indices were 11 and 13 units or 3.0 and 11.7% higher in group 2, respectively, and the level of profitability of meat production was 0.5% higher in group 2 compared to group 1. In experiment 2, six groups of one-day-old chickens were formed. Groups 1k, 2k, and 3k are the control ones, while groups 4, 5 and 6 – experimental ones. Broilers 1k and 4 were separated from the parent herd of 29 weeks of age, groups 2k and 5 – from the bird of 32 weeks, and groups 3k and 6 – from the parents of 34 weeks of age. In the control groups, pre-starter feed was fed to chickens from the daily to 7-day-old age. In the experimental groups, broilers received super–starter feed in the first four days and pre-starter feed in 5–7 days. In the future, the chickens of all groups will be fed equally according to the 6-phase feeding scheme. The study results showed that broilers who received superprestarter in the first four days on average reached 2528 g of live weight at the pre-slaughter age (39 days), which is 66 g or 2.6% more in comparison with chickens of the control groups. According to the average weight of gutted carcasses, there was a significant superiority of the experimental groups. The broiler productivity and meat production efficiency indices in the experimental groups averaged 385 and 116 units, respectively, which is 16 and 20 units more than in the control groups. The level of profitability of meat production in groups 4, 5, and 6 was 1.3%.; 2.4 and 0.1% higher than in groups 1k, 2k, and 3k, respectively. The results obtained in the studies allow us to conclude that the use of a 7-phase scheme in the feeding of broilers with the division of the finishing period into three phases (25–30, 31–34, and 35–39 days) with the level of metabolic energy of 318, 322 and 325 kcal per 100 g of feed and raw protein 19.0, 18.5 and 18.2%, respectively, is appropriate. The use of superstarter in the first four days of the prestarter phase and prestarter in 5–7-day-old meat chickens increases the zootechnical and economic efficiency.


2019 ◽  
Vol 45 (3) ◽  
pp. 143-148
Author(s):  
Mamun Al Mahtab ◽  
Shahina Tabassum ◽  
Afzalun Nesa ◽  
Munira Jahan ◽  
Md. Sakirul Islam Khan ◽  
...  

Background: Although several drugs are available for treatment of chronic hepatitis B (CHB), the outcome is still far from being satisfactory. The study was conducted to develop a therapeutic strategy for CHB by a combination therapy with reduced dose and duration of antiviral drugs. Objectives: Therapeutic effects of reduced dose and shorter duration of combination of pegylated interferon (Peg-IFN) and entecavir were evaluated in patients with CHB with two control groups. Methods: Fifty-four patients with CHB were treated with reduced dose of Peg-IFN (90 microgram in spite of standard dose of 180 microgram) and standard dose of entecavir (0.5 mg) for reduced duration of 24 weeks (Case of group). There were two control groups that adhered to inclusion and exclusion criteria. Patients of Control group-1 (n=50) received regular doses (180 microgram) of Peg-IFN, once weekly for 48 consecutive weeks. Patients of Control group-2 (n=50) were treated with regular does of entecavir (0.5 mg, daily) for 48 weeks. Results: The treatment regimens were safe for all patients. At the end of therapy (EOT), hepatitis B virus DNA negativity (HBV DNA <250 copies/mL) was found in 67%, 50% and 80% of patients of Control Group-1, Control group-2, and case group, respectively. HBV DNA negativity was found in more patients in cases (89% from 67%) 24 weeks after EOT. However, it declined in patients of Control group-1 (80% to 56%) and remained almost similar in Control group-2 (50% versus 56%). There was no significant difference in alanine transaminase (ALT) negativity and hepatitis E antigen (HBeAg) seronegativity among 3 groups at EOT and 24 weeks after EOT. Conclusion: A patient-friendlytherapeutic strategy with reduced dose of Peg-IFN and regular dose of entecavir for shortened duration for CHB patientshave been documented and it would be also cheap for usage of patients with CHB.


2017 ◽  
Vol 44 (12) ◽  
pp. 1559-1579
Author(s):  
Suzan Verweij ◽  
Bouke S. J. Wartna ◽  
Nikolaj Tollenaar ◽  
Marinus G. C. J. Beerthuizen

This article provides an evaluation of the effectiveness of the “CoVa” cognitive skills training program. A quasi-experimental design was used to compare the known reoffending behavior of 2,229 CoVa participants with that of two control groups of offenders: (1) one formed using the inclusion criteria of the program, and (2) one formed using propensity score matching (PSM). Outcome measures included the prevalence, frequency, and impact of new, adjudicated crimes, with the impact defined as the combined severity of the offenses. Results indicated that the participants in the CoVa group were reconvicted less frequently than those in Control Group 1. Moreover, the impact of their recidivism was lower than the impact of those of Control Group 2. However, the effect sizes were very small, and no significant differences were found regarding reconviction prevalence. Explanations for the absence of (large) effects are discussed.


2016 ◽  
Vol 11 (2) ◽  
pp. 82-88
Author(s):  
E. P Tarutta ◽  
N. V Khodzhabekyan ◽  
O. B Filinova ◽  
Sergei V. Milash ◽  
G. V Kruzhkova

Objective. To elucidate the long-term influence of constant slight myopic defocus prescribed in the binocular and the alternating monocular spectacle formats on the dynamics of refraction and its components in the children. Material and methods. The study involved 129 children (258 eyes) at the age varying from 5 to 12 years. The patients were divided into four groups. Group 1 was comprised of 48 children at the age of 5-8 years presenting with emmetropia and risk factors of the development of myopia. Group 2 consisted of 46 children at the age from 7 to 11 years with slight myopia between -0.75 and -2.25 D to whom the alternating continuous wearing of two pairs of spectacles was prescribed. The first control group was composed of 15 children (30 eyes) at the age from 6 to 9 (mean 7.5 ± 1.4) years presenting with pseudomyopia without correction. The second control group was comprised of 20 children (40 eyes) at the age from 7 to 12 (mean 9.7 ± 1.2) years having slight myopia and wearing conventional spectacle correction. Results. The children of group 1subjected to constant slight myopic defocus during one month experienced a shift of refraction toward hypermetropia attributable to the thinning of the lens and deepening of the anterior chamber. None of the children in this group developed myopia during the follow-up period of up to 9 years. In the patients of group 2, refraction remained unaltered during either 4 years (81.8% of the cases) or 7 years (66.6% of the cases). An insignificant increase in the length of the antero-posterior axis was documented in these children along with the significant increase of the horizontal diameter (HD) of the eyeball. The dynamic observation of the children of both control groups during 3 years has demonstrated the strengthening of cycloplegic refraction associated with the significant increase of the length of the antero-posterior axis and the insignificant increase of the transverse diameter of the eyeball. Conclusion. The permanent slight myopic defocusing of the image in the binocular spectacle format slows down the growth of the eyes and the shift of refraction toward myopia in the children with mild hypermetropia, emmetropia, and slight myopia. The proposed method for alternating monolateral constant slight myopic defocus inhibits progression of myopia in 81.8% of the children presenting with mild myopia during 4 years and in 66.6% of them during 7 years.


2017 ◽  
Vol 6 (2) ◽  
pp. 6
Author(s):  
Nurmawanti Nurmawanti ◽  
Ayly Soekanto

The aim of this research is to know the influence of anti mosquito electric gas that consisted Allethrin to the weight and colour of the rats liver. This research used an experimental method with the post test only  control group design.  The subject of this research is male rats weight of 150 grams each and total there was 24 rats that were divided to 4 groups. The first one, the  control groups (PO) was not given any of the gas, the second one, group 1 (P1) was given the gas for 4 hours everday, the third one, group  2 (P2), was given for 6 hours and last, group 3  (P3) was given 8 hours everyday. After later, on  30 Th day, the rats were terminated and being put in a surgery to remove their liver. This data was analyzed using SPPS for windows version 16. To see the differences in weight between the groups, it was analyzed using anova, and  to obtain the discoloration of the rats liver was analyzed using Kruskal Wallis Test. From the statistic tests, it show that there is significant difference in weight and color of liver in the group that α ≤ 0,05. According Anova Test, it shows that there is a significant difference α = 0,034 and from Kruskal Wallis test α = 0,013. In the conclusion anti mosquito electric gas that consist Allethrin affects the weight and the color of rats liver.


2021 ◽  
Author(s):  
Ceren Gurez ◽  
Şenay Aşık Nacaroğlu ◽  
Ahu Yılmaz

Abstract Purpose: The aim of this study is to evaluate the tear osmolarity(TO) in patients with epiphora caused by primary acquired nasolacrimal-duct obstructions(PANDOs), before and one month after an external dacryocystorhinostomy(E-DCR) and trans-canalicular laser-assisted endoscopic dacryocystorhinostomy(TLA-DCR).Material-Methods: Twenty eyes of 21 patients(16 women, 5 men) who suffered from epiphora and, 20 healthy eyes of the same subjects were included in this study. External(Group 1) or laser-assisted(Group 2) DCR were applied to all patients with PANDO.Results: The mean age of the subjects was 60.09±8.46 in Group 1, 57.50±9.41 in Group 2 and, 55.13±9.38 in healthy control subjects. The mean period for complaints of epiphora was 1.9±0.7 years. Nasolacrimal duct irrigation was successful in all patients at the first-month visit after surgery. Group 1 had a mean TO of 284.16±12.43 mOsm/l and, Group 2 had 286.70±10.46 mOsm/l before DCR, and this increased to 295.75±5.86 mOsm/l and, 298.70±8.76 mOsm/l one month after DCR, respectively. Preoperative TO values in both groups were significant hypoosmolar compared with the control group (292.27±9.65 mOsm/l). No significant differences were detected between postoperative and control group TO values.Conclusion: We found no significant osmolarity changes between surgery and control groups.


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